The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Management of paracetamol poisoning
Abstract
#### Summary points Paracetamol (acetaminophen) is an effective oral analgesic, with few adverse effects when used at the recommended dose. Nevertheless, paracetamol poisoning is common and potentially fatal.1 It is a leading cause of acute liver failure in the United Kingdom2 and the United States.3 Potential liver damage, predicted from blood paracetamol concentration and time from ingestion, can be prevented by prompt treatment with antidote. However, young and otherwise healthy patients still risk serious liver injury, especially if they present more than a few hours after overdose or take staggered overdoses over hours or days.4 #### Sources and selection criteria We based our review on a PubMed search for articles on paracetamol (or acetaminophen) and acetylcysteine or ( N- acetylcysteine) published between 1 January 1990 and 31 December 2010, without language limits. The search was limited to human clinical trials, meta-analyses, randomised controlled trials, reviews, and case reports. We also searched a newspaper database for reports published after 1988 of coroners’ inquests and procurators’ fiscal inquiries into fatal cases of paracetamol poisoning. In addition, we used a bibliography and our own collections of relevant references.5 The …
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Citations
Cites
Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Acetaminophen Poisoning and Toxicity
Rumack, B. H., & Matthew, H. (1975) · Pediatrics · doi:10.1542/peds.55.6.871 · Cited by 640
Cited by
Aronson, J. K., & Ferner, R. E. (2017) · Current Protocols in Pharmacology · doi:10.1002/cpph.19 · Cited by 417
Self-citationLong‐term adverse effects of paracetamol – a review
McCrae, J. C., Morrison, E. E., MacIntyre, I. M., Dear, J. W., & Webb, D. J. (2018) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13656 · Cited by 308
Self-citationBird, T. G., Müller, M., Boulter, L., Vincent, D. F., Ridgway, R. A., Lopez-Guadamillas, E., Lu, W.-Y., Jamieson, T., Govaere, O., Campbell, A. D., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aan1230 · Cited by 261
“Many patients present to medical services too late for this to be effective (35).”
Bateman, D. N., Carroll, R., Pettie, J., Yamamoto, T., Elamin, M. E. M. O., Peart, L., Dow, M., Coyle, J., Cranfield, K. R., Hook, C., et al. (2014) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12362 · Cited by 131
Self-citationWong, A., Sivilotti, M. L. A., Dargan, P. I., Wood, D. M., & Greene, S. L. (2015) · Clinical Toxicology · doi:10.3109/15563650.2015.1066507 · Cited by 41
Metadata
- Authors
- Ferner, R. E., Dear, J. W., & Bateman, D. N.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2011-04-19
- Volume
- 342
- Issue
- apr19 2
- Pages
- d2218-d2218
- ISSN
- 0007-1447 (ISSN-L)
- 0959-8138
- 1468-5833
- OpenAlex
- W2145856826
- Cited by
- 177
- References
- 2
- FWCI
- 14.32
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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