The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study
Open accessAbstract
OBJECTIVE: To determine whether use of intermediate acting neuromuscular blocking agents during general anesthesia increases the incidence of postoperative respiratory complications. DESIGN: Prospective, propensity score matched cohort study. SETTING: General teaching hospital in Boston, Massachusetts, United States, 2006-10. PARTICIPANTS: 18,579 surgical patients who received intermediate acting neuromuscular blocking agents during surgery were matched by propensity score to 18,579 reference patients who did not receive such agents. MAIN OUTCOME MEASURES: The main outcome measures were oxygen desaturation after extubation (hemoglobin oxygen saturation <90% with a decrease in oxygen saturation after extubation of >3%) and reintubations requiring unplanned admission to an intensive care unit within seven days of surgery. We also evaluated effects on these outcome variables of qualitative monitoring of neuromuscular transmission (train-of-four ratio) and reversal of neuromuscular blockade with neostigmine to prevent residual postoperative neuromuscular blockade. RESULTS: The use of intermediate acting neuromuscular blocking agents was associated with an increased risk of postoperative desaturation less than 90% after extubation (odds ratio 1.36, 95% confidence interval 1.23 to 1.51) and reintubation requiring unplanned admission to an intensive care unit (1.40, 1.09 to 1.80). Qualitative monitoring of neuromuscular transmission did not decrease this risk and neostigmine reversal increased the risk of postoperative desaturation less than 90% (1.32, 1.20 to 1.46) and reintubation (1.76, 1.38 to 2.26). CONCLUSION: The use of intermediate acting neuromuscular blocking agents during anesthesia was associated with an increased risk of clinically meaningful respiratory complications. Our data suggest that the strategies used in our trial to prevent residual postoperative neuromuscular blockade should be revisited.
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Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome
Papazian, L., Forel, J.-M., Gacouin, A., Penot-Ragon, C., Perrin, G., Loundou, A., Jaber, S., Arnal, J.-M., Perez, D., Seghboyan, J.-M., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1005372 · Cited by 2,432
General Anesthesia, Sleep, and Coma
Brown, E. N., Lydic, R., & Schiff, N. D. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0808281 · Cited by 1,350
A STUDY OF THE DEATHS ASSOCIATED WITH ANESTHESIA AND SURGERY
Beecher, H. K., & Todd, D. P. (1954) · Annals of Surgery · doi:10.1097/00000658-195407000-00001 · Cited by 764
Reducing bias in a propensity score matched-pair sample using greedy matching techniques
Parsons, L. (2001) · Medical Entomology and Zoology · Cited by 733
Kurth, T., Walker, A. M., Glynn, R. J., Chan, K. A., Gaziano, J. M., Berger, K., & Robins, J. M. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj047 · Cited by 730
Self-citationBERG, H., VIBY‐MOGENSEN, J., ROED, J., MORTENSEN, C. R., ENGBÆK, J., SKOVGAARD, L. T., & KRINTEL, J. J. (1997) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.1997.tb04851.x · Cited by 647
Residual Neuromuscular Blockade and Critical Respiratory Events in the Postanesthesia Care Unit
Murphy, G. S., Szokol, J. W., Marymont, J. H., Greenberg, S. B., Avram, M. J., & Vender, J. S. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e31816d1268 · Cited by 628
Persistent Paralysis in Critically Ill Patients after Long-Term Administration of Vecuronium
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Postoperative pulmonary complications
Miskovic, A., & Lumb, A. B. (2017) · British Journal of Anaesthesia · doi:10.1093/bja/aex002 · Cited by 1,123
Kirmeier, E., Eriksson, L. I., Lewald, H., Jonsson Fagerlund, M., Hoeft, A., Hollmann, M., Meistelman, C., Hunter, J. M., Ulm, K., Blobner, M., et al. (2019) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(18)30294-7 · Cited by 372
Metadata
- Authors
- Grosse-Sundrup, M., Henneman, J. P., Sandberg, W. S., Bateman, B. T., Uribe, J. V., Nguyen, N. T., Ehrenfeld, J. M., Martinez, E. A., Kurth, T., & Eikermann, M.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2012-10-15
- Volume
- 345
- Issue
- oct15 5
- Pages
- e6329-e6329
- ISSN
- 1756-1833 (ISSN-L)
- OpenAlex
- W2168157935
- Cited by
- 284
- References
- 29
- FWCI
- 22.95
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Grosse-Sundrup, M., Henneman, J. P., Sandberg, W. S., Bateman, B. T., Uribe, J. V., Nguyen, N. T., Ehrenfeld, J. M., Martinez, E. A., Kurth, T., & Eikermann, M. (2012). Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study. BMJ. https://doi.org/10.1136/bmj.e6329
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