Adapting clinical guidelines to take account of multimorbidity

GRADE: an emerging consensus on rating quality of evidence and strength of recommendations

Guyatt, G. H., Oxman, A. D., Vist, G. E., Kunz, R., Falck-Ytter, Y., Alonso-Coello, P., & Schünemann, H. J. (2008) · BMJ · doi:10.1136/bmj.39489.470347.ad · Cited by 23,305

Epidemiology of multimorbidity and implications for health care, research, and medical education: A cross-sectional study

Barnett, K., Mercer, S. W., Norbury, M., Watt, G., Wyke, S., & Guthrie, B. (2012) · The Lancet · doi:10.1016/s0140-6736(12)60240-2 · Cited by 6,972

Effectiveness and efficiency of guideline dissemination and implementation strategies

Grimshaw, J., Thomas, R., MacLennan, G., Fraser, C., Ramsay, C., Vale, L., Whitty, P., Eccles, M., Matowe, L., Shirran, L., et al. (2004) · Health Technology Assessment · doi:10.3310/hta8060 · Cited by 3,044

Clinical Practice Guidelines and Quality of Care for Older Patients With Multiple Comorbid Diseases: Implications for Pay for Performance

Boyd, C. M., Darer, J., Boult, C., Fried, L. P., Boult, L., & Wu, A. W. (2005) · JAMA · doi:10.1001/jama.294.6.716 · Cited by 2,581

Collaborative care for patients with depression and chronic illnesses

Katon, W. J., Lin, E. H. B., Von Korff, M., Ciechanowski, P., Ludman, E. J., Young, B., Peterson, D., Rutter, C. M., McGregor, M., & McCulloch, D. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1003955 · Cited by 1,697

Eligibility Criteria of Randomized Controlled Trials Published in High-Impact General Medical Journals

Spall, H. G. C. V., Toren, A., Kiss, A., & Fowler, R. (2007) · JAMA · doi:10.1001/jama.297.11.1233 · Cited by 1,054

We need minimally disruptive medicine

May, C. R., Montori, V. M., & Mair, F. S. (2009) · BMJ · doi:10.1136/bmj.b2803 · Cited by 739

Guidelines for People Not for Diseases: The Challenges of Applying UK Clinical Guidelines to People with Multimorbidity

Hughes, L. D., McMurdo, M. E. T., & Guthrie, B. (2013) · Age and Ageing · doi:10.1093/ageing/afs100 · Cited by 506

Managing Medications in Clinically Complex Elders

Steinman, M. A., & Hanlon, J. T. (2010) · JAMA · doi:10.1001/jama.2010.1482 · Cited by 321

Depression in adults with a chronic physical health problem: Treatment and management

Haddad, M. (2009) · International Journal of Nursing Studies · doi:10.1016/j.ijnurstu.2009.08.007 · Cited by 271

Effects and mechanisms of low-frequency transcutaneous electrical nerve stimulation in relieving common multimorbidity in older adults: study protocol for a randomized controlled trialPreprint

Li, X., An, Y., Wang, L., Xie, M., Chen, X., Li, R., Gao, Y., Liang, B., Wu, Q., Zhang, W., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-5800105/v1

The impact of COVID-19 measures on health-related outcomes in people with dementia: A systematic review of reviews

Davies, A., Kafadar, A. H., & Jones, K. A. (2025) · Cogent Gerontology · doi:10.1080/28324897.2025.2506566

CR in HF: impact of frailty and mobility on proportion of inpatients eligible for CR referral at the point of discharge

Waterhouse, H., Squire, I., & Singh, S. (2025) · British Journal of Cardiology · doi:10.5837/bjc.2025.025

Prevalence, Analytical Methods, and Influencing Factors of Multimorbidity in China: A Scoping Review

Xue, X., Chen, N., Zhao, K., Qi, Y., Zhao, M., Shi, L., Li, Y., & Yu, J. (2025) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.70051

Co-production and implementation of an evidence collation strategy for a novel point-of-care information resource: gpevidence.org

Treadwell, J. S., Armitage, L. C., Collins, K. K., Heath, L., Onyimadu, O., Payne, M., Wahedi, A., & Mahtani, K. R. (2025) · BMJ Evidence-Based Medicine · doi:10.1136/bmjebm-2025-113715

Culturally Tailored Diabetes Self-Management Education and Support Programs in Black African and Caribbean Adults With Type 2 Diabetes (HEAL-D): Protocol for a Multicenter, Pragmatic Randomized Controlled Trial

Goff, L. M., Johnson, D. A., Bell, V., Blyden, S. A., Bower, P., Dale, J. R., Harris, T. J., Healey, A., Hoverd, E., Jin, H., et al. (2025) · JMIR Research Protocols · doi:10.2196/71861

Quantifying cost and health-related quality of life outcomes in different multimorbidity trajectories: a systematic review protocol

Corcoran, N., Wilson, N., Mackinnon, S., Blake, A., Newport, H., Lawless, R., Jani, B., Mair, F. S., Taylor, R. S., & McIntosh, E. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-102096

Multimorbidity Patterns and Socioeconomic Determinants in a resource-limited setting: A Clustering AnalysisPreprint

Uthman, O. A., Hazell, M., Uthman, M. M. B., Wahab, K., Saravanan, P., Kengne, A. P., & Gill, P. S. (2025) · medRxiv · doi:10.1101/2025.10.15.25337896

Additional file 1 of Non-adherence to inhaled medications among adult asthmatic patients in Ethiopia: a systematic review and meta-analysis

Aberhe, W., Hailay, A., Zereabruk, K., Mebrahtom, G., & Haile, T. G. (2020) · Figshare · doi:10.6084/m9.figshare.13093838

Additional file 2 of Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review protocol

Berner, K., Tawa, N., & Louw, Q. (2022) · Figshare · doi:10.6084/m9.figshare.20267694

Additional file 1 of Experiences of hospital care for people with multiple long-term conditions: a scoping review of qualitative research

Bellass, S., Scharf, T., Errington, L., Bowden Davies, K., Robinson, S., Runacres, A., Ventre, J. P., Witham, M. D., Sayer, A. A., & Cooper, R. (2024) · Figshare · doi:10.6084/m9.figshare.25010372

Additional file 1 of Prevalence, patterns of multimorbidity and associations with health care utilization among middle-aged and older people in China

Zhong, Y., Qin, G., Xi, H., Cai, D., Wang, Y., Wang, T., & Gao, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22625651

Additional file 1 of Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review protocol

Berner, K., Tawa, N., & Louw, Q. (2022) · Figshare · doi:10.6084/m9.figshare.20267691

Additional file 1 of Primary care utilisation, adherence to guideline-based pharmacotherapy and continuity of care in primary care patients with chronic diseases and multimorbidity – a cross-sectional study

Maun, A., Björkelund, C., & Arvidsson, E. (2023) · Figshare · doi:10.6084/m9.figshare.24558058

Additional file 3 of Multimorbidity patterns and function among adults in low- and middle-income countries: a scoping review protocol

Berner, K., Tawa, N., & Louw, Q. (2022) · Figshare · doi:10.6084/m9.figshare.20267697

Additional file 3 of Experiences of hospital care for people with multiple long-term conditions: a scoping review of qualitative research

Bellass, S., Scharf, T., Errington, L., Bowden Davies, K., Robinson, S., Runacres, A., Ventre, J. P., Witham, M. D., Sayer, A. A., & Cooper, R. (2024) · Figshare · doi:10.6084/m9.figshare.26668593

Additional file 2 of Experiences of hospital care for people with multiple long-term conditions: a scoping review of qualitative research

Bellass, S., Scharf, T., Errington, L., Bowden Davies, K., Robinson, S., Runacres, A., Ventre, J. P., Witham, M. D., Sayer, A. A., & Cooper, R. (2024) · Figshare · doi:10.6084/m9.figshare.25010518

How Can We Better Take Person-Centered Needs into Account? The Integrated Care Trajectory Approach and Intersectoral Collaboration in Primary Care to Support People Living with Diabetes

Layani, G. (2025) · Springer proceedings in mathematics & statistics · doi:10.1007/978-3-031-95659-1_9

Bayesian machine learning enables discovery of risk factors for hepatosplenic multimorbidity related to schistosomiasis

Zhi, Y.-C., Anguajibi, V., Oryema, J. B., Nabatte, B., Opio, C., Kabatereine, N. B., & Chami, G. F. (2026) · Nature Communications · doi:10.1038/s41467-026-69528-4

Management of diabetes when comorbid with dementia

Dening, K. H. (2026) · British Journal of Community Nursing · doi:10.12968/bjcn.2026.0042

Pain and its management: a precise summary

Ghosh, D., Mukherjee, C. G., & Kumar, A. (2026) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20260993

Applications of Pharmacoepidemiology and Pharmacovigilance Studies

Chinzowu, T., & Nishtala, P. S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26472-6.00090-5

Why family medicine requires a paradigm shift from linear guidelines to complexity science

İnan, M., & Aypak, C. (2026) · Family Medicine and Community Health · doi:10.1136/fmch-2025-003864

PERsonalised Medicine for Intensification of Treatment (PERMIT) in type 2 diabetes mellitus: a target trial emulation from routine data

Lugo-Palacios, D. G., Bidulka, P., Charlton, P., Huston, B., Carnegie, A. C., Carroll, O., O’Neill, S., Adler, A., Basu, A., Silverwood, R. J., et al. (2025) · Health Technology Assessment · doi:10.3310/asdb8011

RACPR: Generative AI-Enhanced Risk-Aware Causal Path Re-Ranking for Interpretable Multimorbidity Risk Identification in Elderly Health Consultation Scenarios

Lin, S., Wang, S., Huang, Z., & Su, H. (2026) · Big Data and Cognitive Computing · doi:10.3390/bdcc10080248

Nonspecific symptoms explain functional limitations in older adults better than disease-specific symptoms

Wezeman, S. L., Melis, R. J. F., Hourican, C., Quax, R., Gill, T. M., Rikkert, M. G. M. O., & Peeters, G. M. E. E. (2026) · European Geriatric Medicine · doi:10.1007/s41999-026-01583-y

Public Perceptions of Multiple Long‐Term Conditions: An Analysis of Mass Observation Accounts

Bellass, S., Scharf, T., Bartle, V., Sayer, A. A., & Cooper, R. (2026) · Health Expectations · doi:10.1111/hex.70868

Aging Populations and Medicines Use: A Sociological Approach

Gnanasan, S., Karuppannan, M., & Farooqui, M. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-26472-6.00205-9

Age-Stratified Multimorbidity Architectures at the Physiological System Level: An Integrated NetworkPreprint

Tang, S., Tan, G., Ouyang, Y., Wang, C., Kuang, X., & Jiang, L. (2026) · Research Square · doi:10.21203/rs.3.rs-10590605/v1

An Evaluation of the Impact of Physician Education on Prescribing for Hypertension in a Nursing Home

Duncan, J. (2014) · DalSpace (Dalhousie University)

S59– A framework to improve guidelines for patients with multimorbidity

Boyd, C. M., Leff, B. A., Kent, D. M., & Uhlig, K. (2010) · Otolaryngology · doi:10.1016/j.otohns.2010.04.181 · Cited by 1

Better guidelines for better care: accounting for multimorbidity in clinical guidelines

Guthrie, B., Payne, K., Alderson, P., McMurdo, M. E. T., & Mercer, S. W. (2012) · Research Explorer (The University of Manchester) · Cited by 1

Clinical guidelines: what happens when people have multiple conditions?

Millar, E., Dowell, T., Lawrenson, R. A., Mangin, D. A., & Sarfati, D. (2018) · PubMed · Cited by 9

Guideline recommended treatments in complex patients with multimorbidity

Muth, C., & Glasziou, P. P. (2015) · BMJ · doi:10.1136/bmj.h5145 · Cited by 28

NICE multimorbidity guideline: coping with complexity in care

Barnett, N. L., Payne, R., & Rutherford, A. (2016) · Prescriber · doi:10.1002/psb.1523 · Cited by 2