The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
Sepsis associated acute kidney injury
Open accessAbstract
Sepsis is defined as organ dysfunction resulting from the host’s deleterious response to infection. One of the most common organs affected is the kidneys, resulting in sepsis associated acute kidney injury (SA-AKI) that contributes to the morbidity and mortality of sepsis. A growing body of knowledge has illuminated the clinical risk factors, pathobiology, response to treatment, and elements of renal recovery that have advanced our ability to prevent, detect, and treat SA-AKI. Despite these advances, SA-AKI remains an important concern and clinical burden, and further study is needed to reduce the acute and chronic consequences. This review summarizes the relevant evidence, with a focus on the risk factors, early recognition and diagnosis, treatment, and long term consequences of SA-AKI. In addition to literature pertaining to SA-AKI specifically, pertinent sepsis and acute kidney injury literature relevant to SA-AKI was included.
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Cites
(2000) · New England Journal of Medicine · doi:10.1056/nejm200005043421801 · Cited by 12,941
Early goal-directed therapy in the treatment of severe sepsis and septic shock
Rivers, E., Nguyen, B., Havstad, S., Ressler, J., Muzzin, A., Knoblich, B., Peterson, E., & Tomlanovich, M. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa010307 · Cited by 10,743
The epidemiology of sepsis in the United States from 1979 through 2000
Martin, G. S., Mannino, D. M., Eaton, S., & Moss, M. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022139 · Cited by 5,841
Intensive versus Conventional Glucose Control in Critically Ill Patients
(2009) · New England Journal of Medicine · doi:10.1056/nejmoa0810625 · Cited by 5,119
(2012) · Kidney International Supplements · doi:10.1038/kisup.2012.1 · Cited by 4,326
Comparison of Two Fluid-Management Strategies in Acute Lung Injury
(2006) · New England Journal of Medicine · doi:10.1056/nejmoa062200 · Cited by 3,538
Targeting the KEAP1-NRF2 system to prevent kidney disease progression
Nezu, M., Suzuki, N., & Yamamoto, M. (2017) · American Journal of Nephrology · doi:10.1159/000475890 · Cited by 3,447
Intensive insulin therapy and pentastarch resuscitation in severe sepsis
Brunkhorst, F. M., Engel, C., Bloos, F., Meier-Hellmann, A., Ragaller, M., Weiler, N., Moerer, O., Gruendling, M., Oppert, M., Grond, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa070716 · Cited by 2,921
Diagnosis, evaluation, and management of acute kidney injury: a KDIGO summary (Part 1)
Kellum, J. A., Lameire, N., & for the KDIGO AKI Guideline Work Group (2013) · Critical Care · doi:10.1186/cc11454 · Cited by 2,827
High-Flow Oxygen through Nasal Cannula in Acute Hypoxemic Respiratory Failure
Frat, J.-P., Thille, A. W., Mercat, A., Girault, C., Ragot, S., Perbet, S., Prat, G., Boulain, T., Morawiec, E., Cottereau, A., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1503326 · Cited by 2,342
Vasopressin versus Norepinephrine Infusion in Patients with Septic Shock
Russell, J. A., Walley, K. R., Singer, J., Gordon, A. C., Hébert, P. C., Cooper, D. J., Holmes, C. L., Mehta, S., Granton, J. T., Storms, M. M., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa067373 · Cited by 1,924
Balanced crystalloids versus saline in critically ill adults.
Semler, M. W., Self, W. H., Wanderer, J. P., Ehrenfeld, J. M., Wang, L., Byrne, D. W., Stollings, J. L., Kumar, A. B., Hughes, C. G., Hernandez, A., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1711584 · Cited by 1,433
Initiation strategies for renal-replacement therapy in the intensive care unit.
Gaudry, S., Hajage, D., Schortgen, F., Martin-Lefevre, L., Pons, B., Boulet, E., Boyer, A., Chevrel, G., Lerolle, N., Carpentier, D., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1603017 · Cited by 1,243
High versus low blood-pressure target in patients with septic shock.
Asfar, P., Meziani, F., Hamel, J.-F., Grelon, F., Megarbane, B., Anguel, N., Mira, J.-P., Dequin, P.-F., Gergaud, S., Weiss, N., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1312173 · Cited by 1,239
Zarbock, A., Kellum, J. A., Schmidt, C., Van Aken, H., Wempe, C., Pavenstädt, H., Boanta, A., Gerß, J., & Meersch, M. (2016) · JAMA · doi:10.1001/jama.2016.5828 · Cited by 1,143
Adjunctive glucocorticoid therapy in patients with septic shock.
Venkatesh, B., Finfer, S., Cohen, J., Rajbhandari, D., Arabi, Y., Bellomo, R., Billot, L., Correa, M., Glass, P., Harward, M., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705835 · Cited by 1,037
Hydrocortisone plus fludrocortisone for adults with septic shock.
Annane, D., Renault, A., Brun-Buisson, C., Megarbane, B., Quenot, J.-P., Siami, S., Cariou, A., Forceville, X., Schwebel, C., Martin, C., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1705716 · Cited by 939
Angiotensin II for the Treatment of Vasodilatory Shock
Khanna, A., English, S. W., Wang, X. S., Ham, K., Tumlin, J., Szerlip, H., Busse, L. W., Altaweel, L., Albertson, T. E., Mackey, C., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1704154 · Cited by 916
Timing of renal-replacement therapy in patients with acute kidney injury and sepsis.
Barbar, S. D., Clere-Jehl, R., Bourredjem, A., Hernu, R., Montini, F., Bruyère, R., Lebert, C., Bohé, J., Badie, J., Eraldi, J.-P., et al. (2018) · New England Journal of Medicine · doi:10.1056/nejmoa1803213 · Cited by 777
Gordon, A. C., Mason, A. J., Thirunavukkarasu, N., Perkins, G. D., Cecconi, M., Cepkova, M., Pogson, D. G., Aya, H. D., Anjum, A., Frazier, G. J., et al. (2016) · JAMA · doi:10.1001/jama.2016.10485 · Cited by 728
Young, P., Bailey, M., Beasley, R., Henderson, S., Mackle, D., McArthur, C., McGuinness, S., Mehrtens, J., Myburgh, J., Psirides, A., et al. (2015) · JAMA · doi:10.1001/jama.2015.12334 · Cited by 728
Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis
The PRISM Investigators (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701380 · Cited by 600
Recovery after Acute Kidney Injury
Kellum, J. A., Sileanu, F. E., Bihorac, A., Hoste, E. A. J., & Chawla, L. S. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201604-0799oc · Cited by 520
Dellinger, R. P., Bagshaw, S. M., Antonelli, M., Foster, D. M., Klein, D. J., Marshall, J. C., Palevsky, P. M., Weisberg, L. S., Schorr, C. A., Trzeciak, S., et al. (2018) · JAMA · doi:10.1001/jama.2018.14618 · Cited by 502
Levosimendan for the Prevention of Acute Organ Dysfunction in Sepsis
Gordon, A. C., Perkins, G. D., Singer, M., McAuley, D. F., Orme, R. M. L., Santhakumaran, S., Mason, A. J., Cross, M., Al-Beidh, F., Best-Lane, J., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1609409 · Cited by 372
A comparison of epinephrine and norepinephrine in critically ill patients
Myburgh, J. A., Higgins, A., Jovanovska, A., Lipman, J., Ramakrishnan, N., Santamaria, J., & the CAT Study investigators (2008) · Intensive Care Medicine · doi:10.1007/s00134-008-1219-0 · Cited by 368
Mao, Q., Jay, M., Hoffman, J. L., Calvert, J., Barton, C., Shimabukuro, D., Shieh, L., Chettipally, U., Fletcher, G., Kerem, Y., et al. (2018) · BMJ Open · doi:10.1136/bmjopen-2017-017833 · Cited by 336
Readmission diagnoses after hospitalization for severe sepsis and other acute medical conditions
Prescott, H. C., Langa, K. M., & Iwashyna, T. J. (2015) · JAMA · doi:10.1001/jama.2015.1410 · Cited by 286
Blood Purification and Mortality in Sepsis: A Meta-Analysis of Randomized Trials*
Zhou, F., Peng, Z., Murugan, R., & Kellum, J. A. (2013) · Critical Care Medicine · doi:10.1097/ccm.0b013e31828cf412 · Cited by 189
Identifying Patients With Sepsis on the Hospital Wards
Bhattacharjee, P., Edelson, D. P., & Churpek, M. M. (2017) · Chest · doi:10.1016/j.chest.2016.06.020 · Cited by 120
Cited by
miR-129-5p alleviates LPS-induced acute kidney injury via targeting HMGB1/TLRs/NF-kappaB pathway
Huang, X., Hou, X., Chuan, L., Wei, S., Wang, J., Yang, X., & Ru, J. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107016 · Cited by 47
Ye, J., Feng, H., & Peng, Z. (2022) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2021e11571 · Cited by 17
Koyner, J. L., Martin, J., Carey, K. A., Caskey, J., Edelson, D. P., Mayampurath, A., Dligach, D., Afshar, M., & Churpek, M. M. (2025) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.0000000695 · Cited by 10
Self-citation
Metadata
- Authors
- Poston, J. T., & Koyner, J. L.
- Venue
- BMJ
- Publisher
- BMJ
- Published
- 2019-01-09
- Volume
- 364
- Pages
- k4891
- ISSN
- 1756-1833 (ISSN-L)
- 0959-8138
- OpenAlex
- W2910674778
- Cited by
- 818
- References
- 30
- FWCI
- 49.28
- Type
- journal article
- Language
- en
- Open access
- green
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