Incidence of diabetes mellitus and factors associated with its development in HIV-positive patients over the age of 50
Open accessAbstract
Objective: We sought to determine the incidence and factors associated with development of diabetes mellitus (DM) in older HIV-infected individuals. Research design and methods: We analyzed data from people living with HIV (PLWH) ≥50 years of age enrolled in a large urban HIV outpatient clinic in Vancouver, British Columbia. Patients were categorized as having DM if they had random blood sugar ≥11.1 mmol/L, fasting blood sugar ≥7 mmol/L, HbA1C ≥6.5%, antidiabetic medication use during the follow-up period, or medical chart review confirming diagnosis of DM. We estimated the probability of developing DM, adjusting for demographic and clinical factors, using a logistic regression model. Results: Among 1065 PLWH followed for a median of 13 years (25th and 75th percentile (Q1–Q3): 9-18), the incidence of DM was 1.61/100 person-years follow-up. In the analysis of factors associated with new-onset DM (n=703), 88% were male, 38% had a history of injection drug use, 43% were hepatitis C coinfected, and median body mass index was 24 kg/m 2 (Q1–Q3: 21–27). Median age at antiretroviral therapy (ART) initiation was 48 years (Q1–Q3: 43–53) and at DM diagnosis was 55 years (Q1–Q3: 50–61). Patients who started ART in 1997–1999 and had a longer exposure to older ART were at the highest risk of developing DM. Conclusions: Among PLWH aged ≥50 years, the incidence of DM was 1.39 times higher than men in the general Canadian population of similar age. ART initiated in the early years of the epidemic and exposure to older ART appeared to be the main drivers of the development of DM.
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Exposure to antiretroviral therapy drives the association between HIV and increased type II diabetes incidence, rather than HIV infection per se.
“Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Samad et al, 2017
Incidence of type II diabetes is increased in individuals with HIV compared to general population.
“Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Samad et al, 2017
The association between HIV and increased type II diabetes incidence is independent of age and obesity.
“Results were also independent on age or whether patients were obese, suggesting traditional risk factors are not involved (Tripathi et al, 2014; Samad et al, 2017; Hernandez‐Romieu et al, 2017).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Samad et al, 2017
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The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
- Authors
- Samad, F., Harris, M., Puskas, C. M., Ye, M., Chia, J., Chacko, S., Bondy, G. P., Lima, V. D., Montaner, J. S., & Guillemi, S. A.
- Affiliations
- St. Paul's Hospital (CA)
- University of British Columbia (CA)
- BC Centre for Excellence in HIV/AIDS (CA)
- University of East Anglia (GB)
- Corresponding author
- Guillemi, Silvia A
- Venue
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Published
- 2017-11
- Volume
- 5
- Issue
- 1
- Pages
- e000457
- ISSN
- 2052-4897 (ISSN-L)
- PMC
- PMC5717418
- OpenAlex
- W2769207084
- Cited by
- 53
- References
- 42
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 3
- FWCI
- 6.26
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open Diabetes Research & Care (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Amgen
- Bristol-Myers Squibb
- AstraZeneca
- Sanofi
- Gilead Sciences
- Teva Pharmaceutical Industries
- McGill University
- ViiV Healthcare
- Providence Health Care
- Novo Nordisk
- Merck Canada
- National Institutes of Health
- University of California, San Francisco
- Amgen Canada
- National Institute on Drug Abuse (R01DA036307)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, HIV infection, older adults, incidence, risk factors, antiretroviral therapy, hepatitis C coinfection, intravenous drug use, age at ART initiation
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