Is diabetes prevalence higher among HIV-infected individuals compared with the general population? Evidence from MMP and NHANES 2009–2010
Open accessAbstract
Background: Nationally representative estimates of diabetes mellitus (DM) prevalence among HIV-infected adults in the USA are lacking, and whether HIV-infected adults are at increased risk of DM compared with the general adult population remains controversial. Methods: We used nationally representative survey (2009–2010) data from the Medical Monitoring Project (n=8610 HIV-infected adults) and the National Health and Nutrition Examination Survey (n=5604 general population adults) and fit logistic regression models to determine and compare weighted prevalences of DM between the two populations, and examine factors associated with DM among HIV-infected adults. Results: DM prevalence among HIV-infected adults was 10.3% (95% CI 9.2% to 11.5%). DM prevalence was 3.8% (CI 1.8% to 5.8%) higher in HIV-infected adults compared with general population adults. HIV-infected subgroups, including women (prevalence difference 5.0%, CI 2.3% to 7.7%), individuals aged 20–44 (4.1%, CI 2.7% to 5.5%), and non-obese individuals (3.5%, CI 1.4% to 5.6%), had increased DM prevalence compared with general population adults. Factors associated with DM among HIV-infected adults included age, duration of HIV infection, geometric mean CD4 cell count, and obesity. Conclusions: 1 in 10 HIV-infected adults receiving medical care had DM. Although obesity contributes to DM risk among HIV-infected adults, comparisons to the general adult population suggest that DM among HIV-infected persons may develop at earlier ages and in the absence of obesity.
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Incidence of type II diabetes is increased in individuals with HIV compared to general population.
“Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Hernandez‐Romieu et al, 2017
Exposure to antiretroviral therapy drives the association between HIV and increased type II diabetes incidence, rather than HIV infection per se.
“Cohort studies have found that the incidence of type II diabetes is increased in individuals with HIV compared to the general population, but exposure to antiretroviral therapy is reported to drive this association, rather than HIV infection per se.”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Hernandez‐Romieu et al, 2017
The association between HIV and increased type II diabetes incidence is independent of age and obesity.
“Results were also independent on age or whether patients were obese, suggesting traditional risk factors are not involved (Tripathi et al, 2014; Samad et al, 2017; Hernandez‐Romieu et al, 2017).”
From The struggle of a good friend getting old: cellular senescence in viral responses and therapy (2021) · cites this paper as Hernandez‐Romieu et al, 2017
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Cites
Sontrop, J. M., Dixon, S. N., Garg, A. X., Jiménez, I. B., Dohein, O., Huang, S. S., & Clark, W. F. (2013) · American Journal of Nephrology · doi:10.1159/000350377 · Cited by 5,903 · see citing works
Economic Costs of Diabetes in the U.S. in 2002
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.3.917 · Cited by 4,147 · see citing works
Diagnosis, management, and treatment of hepatitis C: An update # † ‡
Ghany, M. G., Strader, D. B., Thomas, D. L., & Seeff, L. B. (2008) · Hepatology · doi:10.1002/hep.22759 · Cited by 2,971 · see citing works
Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death
The Emerging Risk Factors Collaboration (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1008862 · Cited by 2,726 · see citing works
Economic Costs of Diabetes in the U.S. in 2012
American Diabetes Association (2013) · Diabetes Care · doi:10.2337/dc12-2625 · Cited by 2,153 · see citing works
Long-Term Complications of Diabetes Mellitus
Nathan, D. M. (1993) · New England Journal of Medicine · doi:10.1056/nejm199306103282306 · Cited by 1,495 · see citing works
HIV Infection and the Risk of Acute Myocardial Infarction
Freiberg, M. S., Chang, C.-C. H., Kuller, L. H., Skanderson, M., Lowy, E., Kraemer, K. L., Butt, A. A., Goetz, M. B., Leaf, D. A., Oursler, K. A., et al. (2013) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.3728 · Cited by 1,340 · see citing works
Guaraldi, G., Orlando, G., Zona, S., Menozzi, M., Carli, F., Garlassi, E., Berti, A., Rossi, E., Roverato, A., & Palella, F. (2011) · Clinical Infectious Diseases · doi:10.1093/cid/cir627 · Cited by 1,331 · see citing works
Okura, Y., Urban, L. H., Mahoney, D. W., Jacobsen, S. J., & Rodeheffer, R. J. (2004) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2004.04.005 · Cited by 1,237 · see citing works
Korn, E. L., & Graubard, B. I. (1999) · Wiley eBooks · doi:10.1002/9781118032619 · Cited by 1,052 · see citing works
Harpaz, R., Ortega‐Sanchez, I. R., & Seward, J. F. (2008) · PubMed · Cited by 1,018 · see citing works
(2001) · Technometrics · doi:10.1198/tech.2001.s612 · Cited by 990 · see citing works
Secular Trends in Cardiovascular Disease Risk Factors According to Body Mass Index in US Adults
Gregg, E. W. (2005) · JAMA · doi:10.1001/jama.293.15.1868 · Cited by 959 · see citing works
Brown, T. T. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.10.1179 · Cited by 850 · see citing works
Muller, C. J., & MacLehose, R. F. (2014) · International Journal of Epidemiology · doi:10.1093/ije/dyu029 · Cited by 775 · see citing works
Aberg, J. A., Gallant, J. E., Ghanem, K. G., Emmanuel, P. J., Zingman, B. S., & Horberg, M. A. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit665 · Cited by 497 · see citing works
Incidence and Risk Factors for New-Onset Diabetes in HIV-Infected Patients
Wit, S. D., Sabin, C. A., Weber, R. K., Worm, S. W., Reiss, P., Cazanave, C., El-Sadr, W. M., Monforte, A. D., Fontas, É., Law, M. G., et al. (2008) · Diabetes Care · doi:10.2337/dc07-2013 · Cited by 482 · see citing works
Schneider, E., Whitmore, S. K., Glynn, M. K., et al. (2008) · PubMed · Cited by 464 · see citing works
Estimating Model-Adjusted Risks, Risk Differences, and Risk Ratios From Complex Survey Data
Bieler, G. S., Brown, G. G., Williams, R. L., & Brogan, D. J. (2010) · American Journal of Epidemiology · doi:10.1093/aje/kwp440 · Cited by 461 · see citing works
Factors associated with specific causes of death amongst HIV-positive individuals in the D:A:D study
The Data Collection on Adverse Events of Anti-HIV drugs (D:A:D) Study Group (2010) · AIDS · doi:10.1097/qad.0b013e32833a0918 · Cited by 452 · see citing works
Hepatitis C infection and risk of diabetes: A systematic review and meta-analysis
White, D. L., Ratziu, V., & El‐Serag, H. B. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.08.006 · Cited by 446 · see citing works
Projected life expectancy of people with HIV according to timing of diagnosis
Nakagawa, F., Lodwick, R. K., Smith, C. J., Smith, R. D., Cambiano, V., Lundgren, J. D., Delpech, V., & Phillips, A. N. (2011) · AIDS · doi:10.1097/qad.0b013e32834dcec9 · Cited by 444 · see citing works
Lødrup Carlsen, K. C., Roll, S., Carlsen, K.-H., Mowinckel, P., Wijga, A. H., Brunekreef, B., Torrent, M., Roberts, G., Arshad, S. H., Kull, I., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043214 · Cited by 400 · see citing works
Hepatitis C in the United States
Holmberg, S. D., Spradling, P. R., Moorman, A. C., & Denniston, M. M. (2013) · New England Journal of Medicine · doi:10.1056/nejmp1302973 · Cited by 321 · see citing works
Aberg, J. A., Gallant, J. E., Ghanem, K. G., Emmanuel, P. J., Zingman, B. S., & Horberg, M. A. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit757 · Cited by 267 · see citing works
Phase 2b Trial of Interferon-free Therapy for Hepatitis C Virus Genotype 1
Kowdley, K. V., Lawitz, E., Poordad, F. F., Cohen, D. E., Nelson, D. R., Zeuzem, S., Everson, G. T., Kwo, P. Y., Foster, G. R., Sulkowski, M., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1306227 · Cited by 255 · see citing works
Validity and Reliability of Self-reported Diabetes in the Atherosclerosis Risk in Communities Study
Schneider, A. L. C., Pankow, J. S., HEISS, G. M., & Selvin, E. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws156 · Cited by 239 · see citing works
Brown, T. T., Tassiopoulos, K., Bosch, R. J., Shikuma, C. M., & McComsey, G. A. (2010) · Diabetes Care · doi:10.2337/dc10-0633 · Cited by 236 · see citing works
Capeau, J., Bouteloup, V., Katlama, C., et al. (2011) · AIDS · doi:10.1097/qad.0b013e32834e8776 · Cited by 235 · see citing works
Glass, T., Ungsedhapand, C., Wolbers, M., Weber, R., Vernazza, P., Rickenbach, M., Furrer, H., Bernasconi, E., Cavassini, M., Hirschel, B., et al. (2006) · HIV Medicine · doi:10.1111/j.1468-1293.2006.00400.x · Cited by 156 · see citing works
The Prevalence of Type 1 Diabetes in the United States
Menke, A., Orchard, T. J., Imperatore, G., Bullard, K. M., Mayer-Davis, E., & Cowie, C. C. (2013) · Epidemiology · doi:10.1097/ede.0b013e31829ef01a · Cited by 144 · see citing works
Rasmussen, L. D., Mathiesen, E. R., Kronborg, G., Pedersen, C., Gerstoft, J., & Obel, N. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044575 · Cited by 140 · see citing works
Revised Surveillance Case Definitions for HIV Infection Among Adults, Adolescents, and Children Aged
Schneider, E., Whitmore, S. K., Glynn, K. M., et al. (2008) · Cited by 131 · see citing works
Buchacz, K. A., Baker, R. K., Palella, F. J., Shaw, L., Patel, P., Lichtenstein, K. A., Chmiel, J. S., Vellozzi, C. J., Debes, R., Henry, K., et al. (2012) · Antiviral Therapy · doi:10.3851/imp2450 · Cited by 123 · see citing works
Corser, W. D., Sikorskii, A. E., Olomu, A. B., Stommel, M., Proden, C., & Holmes-Rovner, M. M. (2008) · BMC Health Services Research · doi:10.1186/1472-6963-8-85 · Cited by 98 · see citing works
Association of HIV Infection With Incident Diabetes Mellitus
Tien, P. C., Schneider, M. F., Cox, C., Karim, R., Cohen, M. H., Sharma, A., Young, M., & Glesby, M. J. (2012) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0b013e31826bfc32 · Cited by 84 · see citing works
Frankel, M. R., McNaghten, A. D., Shapiro, M. F., et al. (2012) · The Open AIDS Journal · doi:10.2174/1874613601206010067 · Cited by 78 · see citing works
Tripathi, A., Liese, A. D., Jerrell, J. M., Zhang, J., Rizvi, A. A., Albrecht, H., & Duffus, W. A. (2014) · Diabetic Medicine · doi:10.1111/dme.12455 · Cited by 74 · see citing works
Slama, L., Palella, F. J., Abraham, A. G., Li, X., Vigouroux, C., Pialoux, G., Kingsley, L., Lake, J. E., Brown, T. T., Margolick, J. B., et al. (2014) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dku295 · Cited by 71 · see citing works
Glycated Hemoglobin A <sub>1c</sub> as Screening for Diabetes Mellitus in HIV-Infected Individuals
Eckhardt, B. J., Holzman, R. S., Kwan, C. K., Baghdadi, J., & Aberg, J. A. (2012) · AIDS Patient Care and STDs · doi:10.1089/apc.2011.0379 · Cited by 64 · see citing works
McComsey, G. A., Kitch, D. W., Sax, P. E., Tierney, C., Jahed, N. C., Melbourne, K. M., Ha, B., Brown, T. T., Bloom, A. A., Fedarko, N. S., et al. (2013) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/01.qai.0000437171.00504.41 · Cited by 64 · see citing works
Dooko, C. B. A., Wit, S. D., Neuhaus, J., Palfreeman, A., Pepe, R., Pankow, J. S., & Neaton, J. D. (2014) · JAIDS Journal of Acquired Immune Deficiency Syndromes · doi:10.1097/qai.0000000000000354 · Cited by 61 · see citing works
Obesity Among HIV-Infected Adults Receiving Medical Care in the United States
Thompson‐Paul, A. M., Wei, S. C., Mattson, C. L., Robertson, M. M., Hernández-Romieu, A. C., Bell, T. K., & Skarbinski, J. (2015) · Medicine · doi:10.1097/md.0000000000001081 · Cited by 61 · see citing works
Self-citationGhislain, M., Bastard, J., Meyer, L., Capeau, J., Fellahi, S., Gérard, L., May, T., Simon, A., Vigouroux, C., Goujard, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144317 · Cited by 41 · see citing works
Fink, P., Pflitsch, C., & Marin, K. (2012) · PLoS ONE · doi:10.1371/annotation/6d71b282-8e08-43ba-bef7-7ad45cd48784 · Cited by 37 · see citing works
HIV infection and glycemic response to newly initiated diabetic medical therapy
Han, J., Crane, H. M., Bellamy, S. L., Frank, I., Cardillo, S., & Bisson, G. P. (2012) · AIDS · doi:10.1097/qad.0b013e328359a8e5 · Cited by 28 · see citing works
Asao, K., McEwen, L. N., Lee, J. M., & Herman, W. H. (2015) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2015.03.019 · Cited by 13 · see citing works
Frasco, M. A., Karim, R., Berg, D. V. D., Watanabe, R. M., Anastos, K., Cohen, M. H., Gange, S. J., Gustafson, D., Liu, C., Tien, P. C., et al. (2014) · AIDS · doi:10.1097/qad.0000000000000366 · Cited by 8 · see citing works
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- [31]Brown TT, Tassioppoulos K, Bosch RJ Association between systemic inflammation and incident diabetes in HIV-infected patients after initiation of antiretroviral therapy. Diabetes Care 2010; 33: 2244– 9. 20664016 PMC2945167
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Samad, F., Harris, M., Puskas, C. M., Ye, M., Chia, J., Chacko, S., Bondy, G. P., Lima, V. D., Montaner, J. S., & Guillemi, S. A. (2017) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2017-000457 · Cited by 53 · see citing works
The struggle of a good friend getting old: cellular senescence in viral responses and therapy
Kohli, J., Veenstra, I., & Demaria, M. (2021) · The EMBO Reports · doi:10.15252/embr.202052243 · Cited by 52 · see citing works
- Authors
- Hernandez-Romieu, A. C., Garg, S., Rosenberg, E. S., Thompson-Paul, A. M., & Skarbinski, J.
- Affiliations
- Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
- Centers for Disease Control and Prevention (US)
- Emory University (US)
- Division of Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
- Venue
- BMJ Open Diabetes Research & Care
- Publisher
- BMJ
- Published
- 2017-01
- Volume
- 5
- Issue
- 1
- Pages
- e000304
- ISSN
- 2052-4897 (ISSN-L)
- PMC
- PMC5293823
- OpenAlex
- W2582774298
- Cited by
- 213
- References
- 48
- Citations by year
- 2026: 6 · 2025: 28 · 2024: 26 · 2023: 14 · 2022: 32 · 2021: 28 · 2020: 30 · 2019: 22 · 2018: 18 · 2017: 9
- FWCI
- 27.46
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- BMJ Open Diabetes Research & Care (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Funders
- Centers for Disease Control and Prevention (PS09-937)
- Topics
- Health Sciences › Medicine › Emergency Medicine › HIV-related health complications and treatments
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- diabetes mellitus, HIV infection, diabetes prevalence, HIV-infected adults, obesity, CD4 count, duration of HIV infection, sex differences, age differences, diabetes risk factors
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