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Cited by 37Infection Control in HealthcareNosocomial Infections in ICUNeutropenia and Cancer Infections

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Incidence and risk factors for hospital-acquired infection among paediatric patients in a teaching hospital: a prospective study in southeast Ethiopia

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Sahiledengle, Biniyam, Seyoum, Fekadu, Abebe, Daniel, Geleta, Eshetu Nigussie, Negash, Getahun, Kalu, Abdurhaman, Woldeyohannes, Demelash, Tekalegn, Yohannes, Zenbaba, Demisu, Edward Quisido, Bruce John·2020·BMJ Open
DOI 10.1136/bmjopen-2020-037997PMC PMC7747586
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Abstract

Objectives: In order to maximise the prevention of hospital-acquired infections (HAIs) and antimicrobial resistance, data on the incidence of HAIs are crucial. In Ethiopia, data about the occurrence of HAIs among hospitalised paediatric patients are lacking. We aim to determine the incidence and risk factors of HAIs among paediatric patients in Ethiopia. Design: A prospective cohort study. Setting: A teaching hospital in southeast Ethiopia. Participants: 448 hospitalised paediatric patients admitted between 1 November 2018 and 30 June 2019. Primary and secondary outcome measures: Incidence and risk factors of hospital-acquired infections. Results: A total of 448 paediatric patients were followed for 3227 patient days. The median age of the patients was 8 months (IQR: 2–26 months). The incidence rate of HAIs was 17.7 per 1000 paediatric days of follow-up; while the overall cumulative incidence was 12.7% (95% CI 9.8% to 15.8%) over 8 months. Children who stayed greater than 6 days in the hospital (median day) (adjusted risk ratio (RR): 2.58, 95% CI 1.52 to 4.38), and children with underlying disease conditions of severe acute malnutrition (adjusted RR: 2.83, 95% CI 1.61 to 4.97) had higher risks of developing HAIs. Conclusions: The overall cumulative incidence of HAIs was about 13 per 100 admitted children. Length of stay in the hospital and underlying conditions of severe acute malnutrition were found to be important factors associated with increased risk of HAIs.

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  • In sub-Saharan Africa, high-risk populations for resistant Klebsiella pneumoniae are newborns and patients admitted to intensive care units, especially those with underlying comorbidities.

    “In SSA, high-risk populations are newborns and patients admitted to intensive care units (ICUs), especially those with underlying comorbidities.121,122”

    From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [122]

    The Discussion describes a high proportion of hospital-acquired infections in neonatal intensive care and paediatric wards and notes that neonates are vulnerable. The Introduction identifies underlying medical conditions as a risk factor for hospital-acquired infections in Ethiopia. Neither passage establishes these groups as high-risk for resistant Klebsiella pneumoniae specifically, or supports a conclusion covering all of sub-Saharan Africa. (LLM, conf=0.85)

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Metadata

Authors
Sahiledengle, B., Seyoum, F., Abebe, D., Geleta, E. N., Negash, G., Kalu, A., Woldeyohannes, D., Tekalegn, Y., Zenbaba, D., & Edward Quisido, B. J.
Affiliations
  • Madda Walabu University (ET)
  • Department of Nursing, School of Medicine, Madda Walabu University, Bale Goba, Ethiopia
Corresponding author
Sahiledengle, Biniyam
ORCID
Venue
BMJ Open
Publisher
BMJ
Published
2020-12
Volume
10
Issue
12
Pages
e037997
ISSN
2044-6055 (ISSN-L)
DOI
10.1136/bmjopen-2020-037997
PMC
PMC7747586
OpenAlex
W3112540642
Cited by
37
References
1
Citations by year
2026: 2 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 3
FWCI
0.46
Type
journal article
Language
en
Open access
Licence
Locations
  • BMJ Open (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • HighWire Press Open Archive (submittedVersion)
Funders
Madda Walabu University
Topics
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Health Sciences › Medicine › Critical Care and Intensive Care Medicine › Nosocomial Infections in ICU
  • Health Sciences › Medicine › Oncology › Neutropenia and Cancer Infections
Keywords
nosocomial infections, pediatric patients, infection incidence, risk factors, length of hospital stay, severe acute malnutrition, antimicrobial resistance, teaching hospitals, Ethiopia
MeSH terms
Child, Child, Preschool, Cross Infection, Ethiopia, Female, Hospitals, Teaching, Humans, Infant, Infant, Newborn, Male, Pediatrics, Prospective Studies, Risk Factors, Incidence

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