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Cited by 102Birth, Development, and HealthPrenatal Substance Exposure EffectsHealth, Environment, Cognitive Aging

Cohort Profile: The Dutch Famine Birth Cohort (DFBC)- a Prospective Birth Cohort Study in the Netherlands

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Bleker, Laura S, de Rooij, Susanne R, Painter, Rebecca C, Ravelli, Anita CJ, Roseboom, Tessa J·2021·BMJ Open
DOI 10.1136/bmjopen-2020-042078PMC PMC7934722
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Abstract

PURPOSE: The Dutch famine birth cohort study was set up to investigate the effects of acute maternal undernutrition of the 1944-1945 Dutch famine during the specific stages of gestation on later health, with a particular focus on chronic cardiovascular and metabolic diseases, ageing and mental health. PARTICIPANTS: The Dutch famine birth cohort consists of 2414 singletons born alive and at term in the Wilhelmina Gasthuis in Amsterdam around the time of the Dutch famine (1943-1947) whose birth records have been kept. The cohort has been traced and studied since 1994, when the first data collection started. The cohort has been interviewed and physically examined in several waves of data collection since that time, allowing repeated measures of a wide range of phenotypic information as well as the collection of biological samples (blood, urine, buccal swabs), functional testing (of heart, lungs, kidney, HPA axis) and imaging of the brain (MRI) and vasculature (ultrasound). Additionally, genetic and epigenetic information was collected. Through linkage with registries, mortality and morbidity information of the entire cohort has been obtained. FINDINGS TO DATE: Prenatal famine exposure had lasting consequences for health in later life. The effects of famine depended on its timing during the gestation and the organs and tissues developing at that time, with most effects after exposure to famine in early gestation. The effects of famine were widespread and affected the structure and function of many organs and tissues, resulted in altered behaviour and increased risks of chronic degenerative diseases and increased mortality. The effects of famine were independent of size at birth, which suggests that programming may occur without altering size at birth. FUTURE PLANS: As the cohort ages, we will be assessing the effects of prenatal undernutrition on (brain) ageing, cognitive decline and dementia, as well as overall morbidity and mortality. REGISTRATION: The Dutch famine birth cohort is not linked to a clinical trial.

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  • Studies on grandchildren of women exposed to famine in utero showed that grandsons of women malnourished during early pregnancy tended to have higher birth weights, while exposure in late pregnancy did not affect birth weight.

    “Studies on the grandchildren of women exposed to famine in utero showed that grandsons of women malnourished during early pregnancy tended to have higher birth weights, while exposure in late pregnancy did not affect birth weight [169,170,171,172].”

    From Maternal Overnutrition and Fetal Programming: Long-Term Metabolic, Cognitive, and Epigenetic Consequences (2026) · cites this paper as [171]

    The Findings to date section reports greater neonatal adiposity among babies born to women exposed to famine in utero, but gives no birth-weight finding for grandsons by the grandmother’s timing of exposure. Its early- and late-gestation birth-weight comparisons concern babies directly exposed to famine, not their grandchildren. Searches for grandchildren, grandsons, birth weight, and gestational timing found no passage establishing the attributed result; page numbers were not available in our copy. (LLM, conf=0.72)

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  1. [1]Mu M, Wang S-F, Sheng J, et al. Birth weight and subsequent blood pressure: a meta-analysis. Arch Cardiovasc Dis 2012; 105: 99– 113. 10.1016/j.acvd.2011.10.006 22424328 · DOI
  2. [2]Davies AA, Smith GD, Ben-Shlomo Y, et al. Low birth weight is associated with higher adult total cholesterol concentration in men: findings from an occupational cohort of 25,843 employees. Circulation 2004; 110: 1258– 62. 10.1161/01.CIR.0000140980.61294.4D 15326068 · DOI
  3. [3]Whincup PH, Kaye SJ, Owen CG, et al. Birth weight and risk of type 2 diabetes: a systematic review. JAMA 2008; 300: 2886– 97. 10.1001/jama.2008.886 19109117 · DOI
  4. [4]Knop MR, Geng T-T, Gorny AW, et al. Birth Weight and Risk of Type 2 Diabetes Mellitus, Cardiovascular Disease, and Hypertension in Adults: A Meta-Analysis of 7 646 267 Participants From 135 Studies. J Am Heart Assoc 2018; 7: e008870. 10.1161/JAHA.118.008870 30486715 PMC6405546 · DOI
  5. [5]Mohseni R, Mohammed SH, Safabakhsh M, et al. Birth weight and risk of cardiovascular disease incidence in adulthood: a dose-response meta-analysis. Curr Atheroscler Rep 2020; 22: 12. 10.1007/s11883-020-0829-z 32328820 · DOI
  6. [6]Risnes KR, Vatten LJ, Baker JL, et al. Birthweight and mortality in adulthood: a systematic review and meta-analysis. Int J Epidemiol 2011; 40: 647– 61. 10.1093/ije/dyq267 21324938 · DOI · Paper page
  7. [7]Barker DJP, Osmond C. Infant mortality, childhood nutrition and ischeamic heart disease in England and Wales. Lancet 1986; 10: 1077– 81. 2871345
  8. [8]Hoffman DJ, Reynolds RM, Hardy DB. Developmental origins of health and disease: current knowledge and potential mechanisms. Nutr Rev 2017; 75: 951– 70. 10.1093/nutrit/nux053 29186623 · DOI
  9. [9]Van Abeelen AFM, Veenendaal MVE, Painter RC, et al. The fetal origins of hypertension: a systematic review and meta-analysis of the evidence from animal experiments of maternal undernutrition. J Hypertens 2012; 30: 2255– 67. 10.1097/HJH.0b013e3283588e0f 22990358 · DOI
  10. [10]Veenendaal MV, Thangaratinam S, Yates D. Is the fetal origins hypothesis of diabetes supported by animal research? A systematic review and meta-analysis of the evidence. Diabetes Metab J 2013; 2013: 1– 8.
  11. [11]Chavatte-Palmer P, Tarrade A, Rousseau-Ralliard D. Diet before and during pregnancy and offspring health: the importance of animal models and what can be learned from them. Int J Environ Res Public Health 2016; 13. 10.3390/ijerph13060586. [Epub ahead of print: 14 06 2016]. PMC4924043 27314367 · DOI
  12. [12]Dols MJL, van Arcken DJAM, Arcken D. Food supply and nutrition in the Netherlands during and immediately after World War II. Milbank Mem Fund Q 1946; 24: 319– 58. 10.2307/3348196 20282873 · DOI
  13. [15]Stare FJ. Nutritional conditions in Holland. Nutr Rev 1945; 3: 225– 7. 10.1111/j.1753-4887.1945.tb08647.x · DOI
  14. [17]Stein Z, Susser M, Saenger G. Famine and Human Development.: The Dutch hunger winter of 1944-45. New York: Oxford University Press, 1975.
  15. [18]Smith CA. Effects of maternal undernutrition upon thenewborn infant in Holland (1944–1945). J Pediatr 1947; 30: 229– 43. 10.1016/S0022-3476(47)80158-1 20290346 · DOI
  16. [19]Sindram IS. De invloed van ondervoeding OP de groei van de vrucht. Nederlands Tijdschrift voor Verloskunde en Gynaecologie 1953; 53: 30– 48. 13099427
  17. [20]Stein Z, Susser M, Saenger G, et al. Nutrition and mental performance. Science 1972; 178: 708– 13. 10.1126/science.178.4062.708 5082838 · DOI
  18. [22]Susser ES, Lin SP. Schizophrenia after prenatal exposure to the Dutch hunger winter of 1944-1945. Arch Gen Psychiatry 1992; 49: 983– 8. 10.1001/archpsyc.1992.01820120071010 1449385 · DOI
  19. [23]Susser E, Hoek HW, Neugebauer R. Schizophrenia after prenatal famine. Arch Gen Psychiatry 1996; 53: 25– 31. 10.1001/archpsyc.1996.01830010027005 8540774 · DOI
  20. [24]Brown AS, van Os J, Driessens C, et al. Further evidence of relation between prenatal famine and major affective disorder. Am J Psychiatry 2000; 157: 190– 5. 10.1176/appi.ajp.157.2.190 10671386 · DOI
  21. [25]Brown AS, Susser ES, Lin SP, et al. Increased risk of affective disorders in males after second trimester prenatal exposure to the Dutch hunger winter of 1944-45. Br J Psychiatry 1995; 166: 601– 6. 10.1192/bjp.166.5.601 7620744 · DOI
  22. [26]Hoek HW, Brown AS, Susser E. The Dutch famine and schizophrenia spectrum disorders. Soc Psychiatry Psychiatr Epidemiol 1998; 33: 373– 9. 10.1007/s001270050068 9708024 · DOI
  23. [27]Hoek HW, Susser E, Buck KA, et al. Schizoid personality disorder after prenatal exposure to famine. Am J Psychiatry 1996; 153: 1637– 9. 10.1176/ajp.153.12.1637 8942466 · DOI
  24. [28]Neugebauer R, Hoek HW, Susser E. Prenatal exposure to wartime famine and development of antisocial personality disorder in early adulthood. JAMA 1999; 282: 455– 62. 10.1001/jama.282.5.455 10442661 · DOI
  25. [29]Barker DJ. The fetal origins of diseases of old age. Eur J Clin Nutr 1992; 46 Suppl 3: S3– 9. 1425543
  26. [30]Lumey LH, Ravelli AC, Wiessing LG, et al. The Dutch famine birth cohort study: design, validation of exposure, and selected characteristics of subjects after 43 years follow-up. Paediatr Perinat Epidemiol 1993; 7: 354– 67. 10.1111/j.1365-3016.1993.tb00415.x 8290375 · DOI
  27. [31]Ravelli AC, van der Meulen JH, Michels RP, et al. Glucose tolerance in adults after prenatal exposure to famine. Lancet 1998; 351: 173– 7. 10.1016/S0140-6736(97)07244-9 9449872 · DOI · Paper page
  28. [32]Barker DJ. Fetal nutrition and cardiovascular disease in later life. Br Med Bull 1997; 53: 96– 108. 10.1093/oxfordjournals.bmb.a011609 9158287 · DOI
  29. [33]Roseboom TJ et al. Coronary heart disease after prenatal exposure to the Dutch famine, 1944-45. Heart 2000; 84: 595– 8. 10.1136/heart.84.6.595 11083734 PMC1729504 · DOI · Paper page
  30. [34]Painter RC, de Rooij SR, Bossuyt PM, Roseboom TJ, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr 2006; 84: 322– 7. 10.1093/ajcn/84.2.322 16895878 · DOI · Paper page
  31. [35]Roseboom TJ, van der Meulen JH, Osmond C, et al. Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 2000; 72: 1101– 6. 10.1093/ajcn/72.5.1101 11063435 · DOI · Paper page
  32. [36]de Rooij SR, Painter RC, Roseboom TJ, et al. Glucose tolerance at age 58 and the decline of glucose tolerance in comparison with age 50 in people prenatally exposed to the Dutch famine. Diabetologia 2006; 49: 637– 43. 10.1007/s00125-005-0136-9 16470406 · DOI
  33. [37]Roseboom TJ, van der Meulen JH, Ravelli AC, et al. Plasma fibrinogen and factor VII concentrations in adults after prenatal exposure to famine. Br J Haematol 2000; 111: 112– 7. 10.1046/j.1365-2141.2000.02268.x 11091189 · DOI
  34. [38]Painter RC, Roseboom TJ, van Montfrans GA, et al. Microalbuminuria in adults after prenatal exposure to the Dutch famine. JASN 2005; 16: 189– 94. 10.1681/ASN.2004060474 15548563 · DOI
  35. [39]Lopuhaä CE, Roseboom TJ, Osmond C, et al. Atopy, lung function, and obstructive airways disease after prenatal exposure to famine. Thorax 2000; 55: 555– 61. 10.1136/thorax.55.7.555 10856314 PMC1745806 · DOI
  36. [40]Lussana F, Painter RC, Ocke MC, et al. Prenatal exposure to the Dutch famine is associated with a preference for fatty foods and a more atherogenic lipid profile. Am J Clin Nutr 2008; 88: 1648– 52. 10.3945/ajcn.2008.26140 19064527 · DOI
  37. [41]Roseboom TJ, Van Der Meulen JHP, Ravelli ACJ, et al. Perceived health of adults after prenatal exposure to the Dutch famine. Paediatr Perinat Epidemiol 2003; 17: 391– 7. 10.1046/j.1365-3016.2003.00516.x 14629322 · DOI
  38. [42]Roseboom TJ, van der Meulen JH, Ravelli AC, et al. Blood pressure in adults after prenatal exposure to famine. J Hypertens 1999; 17: 325– 30. 10.1097/00004872-199917030-00004 10100069 · DOI
  39. [43]Painter RC, de Rooij SR, Bossuyt PM, et al. Blood pressure response to psychological stressors in adults after prenatal exposure to the Dutch famine. J Hypertens 2006; 24: 1771– 8. 10.1097/01.hjh.0000242401.45591.e7 16915026 · DOI
  40. [45]Ravelli ACJ, van der Meulen JHP, Osmond C, et al. Obesity at the age of 50 Y in men and women exposed to famine prenatally. Am J Clin Nutr 1999; 70: 811– 6. 10.1093/ajcn/70.5.811 10539740 · DOI
  41. [46]Painter RC, De Rooij SR, Bossuyt PMM, et al. A possible link between prenatal exposure to famine and breast cancer: a preliminary study. Am J Hum Biol 2006; 18: 853– 6. 10.1002/ajhb.20564 17039469 · DOI
  42. [47]van Abeelen AFM, Veenendaal MVE, Painter RC, et al. Survival effects of prenatal famine exposure. Am J Clin Nutr 2012; 95: 179– 83. 10.3945/ajcn.111.022038 22170371 · DOI
  43. [48]de Rooij SR, Caan MWA, Swaab DF, et al. Prenatal famine exposure has sex-specific effects on brain size. Brain 2016; 139: 2136– 42. 10.1093/brain/aww132 27401522 · DOI
  44. [49]Franke K, Gaser C, Roseboom TJ, et al. Premature brain aging in humans exposed to maternal nutrient restriction during early gestation. Neuroimage 2018; 173: 460– 71. 10.1016/j.neuroimage.2017.10.047 29074280 · DOI
  45. [50]de Rooij SR, Mutsaerts HJMM, Petr J, et al. Late-Life brain perfusion after prenatal famine exposure. Neurobiol Aging 2019; 82: 1– 9. 10.1016/j.neurobiolaging.2019.06.012 31376728 · DOI
  46. [51]de Rooij SR, Painter RC, Phillips DI, et al. Self-Reported depression and anxiety after prenatal famine exposure: mediation by cardio-metabolic pathology? J Dev Orig Health Dis 2011; 2: 136– 43. 10.1017/S2040174411000055 25141038 · DOI
  47. [52]Bleker LS, de Rooij SR, Painter RC, et al. Prenatal undernutrition and physical function and frailty at the age of 68 years: the Dutch famine birth cohort study. J Gerontol A Biol Sci Med Sci 2016; 71: 1306– 14. 10.1093/gerona/glw081 27146370 · DOI
  48. [53]Painter RC, Osmond C, Gluckman P, et al. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG 2008; 115: 1243– 9. 10.1111/j.1471-0528.2008.01822.x 18715409 · DOI · Paper page
  49. [54]Veenendaal MVE, Painter RC, de Rooij SR, et al. Transgenerational effects of prenatal exposure to the 1944-45 Dutch famine. BJOG 2013; 120: 548– 54. 10.1111/1471-0528.12136 23346894 · DOI · Paper page
  50. [55]Gasser B, Mauss Y, Ghnassia JP, et al. A quantitative study of normal nephrogenesis in the human fetus: its implication in the natural history of kidney changes due to low obstructive uropathies. Fetal Diagn Ther 1993; 8: 371– 84. 10.1159/000263855 8286028 · DOI
  51. [56]Sparrow MP, Weichselbaum M, McCray PB. Development of the innervation and airway smooth muscle in human fetal lung. Am J Respir Cell Mol Biol 1999; 20: 550– 60. 10.1165/ajrcmb.20.4.3385 10100986 · DOI
  52. [57]Stefan Y, Grasso S, Perrelet A, et al. A quantitative immunofluorescent study of the endocrine cell populations in the developing human pancreas. Diabetes 1983; 32: 293– 301. 10.2337/diab.32.4.293 6131849 · DOI
  53. [59]Lumey LH, Stein AD, Kahn HS, et al. Cohort profile: the Dutch hunger winter families study. Int J Epidemiol 2007; 36: 1196– 204. 10.1093/ije/dym126 17591638 · DOI · Paper page
  54. [60]Susser M, Stein Z. Timing in prenatal nutrition: a Reprise of the Dutch famine study. Nutr Rev 1994; 52: 84– 94. 10.1111/j.1753-4887.1994.tb01395.x 8015751 · DOI
  55. [61]Gluckman PD, Beedle AS, Hanson MA, et al. Developmental perspectives on individual variation: implications for understanding nutritional needs. Nestle Nutr Workshop Ser Pediatr Program 2008; 62: 1– 9. 10.1159/000146243 18626189 · DOI
  56. [62]Hult M, Tornhammar P, Ueda P, et al. Hypertension, diabetes and overweight: looming legacies of the Biafran famine. PLoS One 2010; 5: e13582. 10.1371/journal.pone.0013582 21042579 PMC2962634 · DOI
  57. [63]Meng R, Lv J, Yu C, et al. Prenatal famine exposure, adulthood obesity patterns and risk of type 2 diabetes. Int J Epidemiol 2018; 47: 399– 408. 10.1093/ije/dyx228 29161448 PMC5913613 · DOI
  58. [64]Wang P-X, Wang J-J, Lei Y-X, et al. Impact of fetal and infant exposure to the Chinese great famine on the risk of hypertension in adulthood. PLoS One 2012; 7: e49720. 10.1371/journal.pone.0049720 23185416 PMC3504120 · DOI
  59. [65]Xu M-Q, Sun W-S, Liu B-X, et al. Prenatal malnutrition and adult schizophrenia: further evidence from the 1959-1961 Chinese famine. Schizophr Bull 2009; 35: 568– 76. 10.1093/schbul/sbn168 19155344 PMC2669578 · DOI
  60. [66]Thurner S, Klimek P, Szell M, et al. Quantification of excess risk for diabetes for those born in times of hunger, in an entire population of a nation, across a century. Proc Natl Acad Sci U S A 2013; 110: 4703– 7. 10.1073/pnas.1215626110 23487754 PMC3607051 · DOI
  61. [67]Lumey LH, Khalangot MD, Vaiserman AM. Association between type 2 diabetes and prenatal exposure to the Ukraine famine of 1932-33: a retrospective cohort study. Lancet Diabetes Endocrinol 2015; 3: 787– 94. 10.1016/S2213-8587(15)00279-X 26342852 · DOI
  62. [68]Painter RC, Westendorp RGJ, de Rooij SR, et al. Increased reproductive success of women after prenatal undernutrition. Hum Reprod 2008; 23: 2591– 5. 10.1093/humrep/den274 18658159 PMC2569844 · DOI
  63. [69]Roseboom TJ, van der Meulen JH, van Montfrans GA, et al. Maternal nutrition during gestation and blood pressure in later life. J Hypertens 2001; 19: 29– 34. 10.1097/00004872-200101000-00004 11204301 · DOI
  64. [70]Horenblas J, de Rooij SR, Roseboom TJ. The risk of stroke after prenatal exposure to famine. J Dev Orig Health Dis 2017; 8: 658– 64. 10.1017/S2040174417000472 28659214 · DOI
  65. [71]de Rooij SR, Painter RC, Swaab DF, et al. Sexual orientation and gender identity after prenatal exposure to the Dutch famine. Arch Sex Behav 2009; 38: 411– 6. 10.1007/s10508-008-9409-y 18784994 PMC2839486 · DOI
  66. [72]Klooker TK, Braak B, Painter RC, et al. Exposure to severe wartime conditions in early life is associated with an increased risk of irritable bowel syndrome: a population-based cohort study. Am J Gastroenterol 2009; 104: 2250– 6. 10.1038/ajg.2009.282 19513027 · DOI
  67. [74]de Rooij SR, Painter RC, Holleman F, et al. The metabolic syndrome in adults prenatally exposed to the Dutch famine. Am J Clin Nutr 2007; 86: 1219– 24. 10.1093/ajcn/86.4.1219 17921405 · DOI
  68. [75]Painter RC, de Rooij SR, Hutten BA, et al. Reduced intima media thickness in adults after prenatal exposure to the Dutch famine. Atherosclerosis 2007; 193: 421– 7. 10.1016/j.atherosclerosis.2006.07.009 16914156 · DOI
  69. [76]Painter RC, de Rooij SR, Bossuyt PM, et al. Maternal nutrition during gestation and carotid arterial compliance in the adult offspring: the Dutch famine birth cohort. J Hypertens 2007; 25: 533– 40. 10.1097/HJH.0b013e328012135b 17278968 · DOI
  70. [78]de Rooij SR, Painter RC, Phillips DIW, Osmond C, et al. Cortisol responses to psychological stress in adults after prenatal exposure to the Dutch famine. Psychoneuroendocrinology 2006; 31: 1257– 65. 10.1016/j.psyneuen.2006.09.007 17081701 · DOI
  71. [79]de Rooij SR, Jones A, Phillips DI, et al. Prenatal undernutrition and autonomic function in adulthood. Psychosom Med 2016; 78: 991– 7. 10.1097/PSY.0000000000000393 27606796 PMC5097462 · DOI
  72. [80]de Rooij SR, Painter RC, Phillips DIW, et al. The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine. Diabetes Care 2006; 29: 1052– 7. 10.2337/dc05-1993 16644636 · DOI
  73. [81]van Hoek M, Langendonk JG, de Rooij SR, et al. Genetic variant in the IGF2BP2 gene may interact with fetal malnutrition to affect glucose metabolism. Diabetes 2009; 58: 1440– 4. 10.2337/db08-1173 19258437 PMC2682678 · DOI
  74. [82]Botden IPG, Zillikens MC, de Rooij SR, et al. Variants in the SIRT1 gene may affect diabetes risk in interaction with prenatal exposure to famine. Diabetes Care 2012; 35: 424– 6. 10.2337/dc11-1203 22228742 PMC3263901 · DOI
  75. [83]Veenendaal MV, Costello PM, Lillycrop KA, et al. Prenatal famine exposure, health in later life and promoter methylation of four candidate genes. J Dev Orig Health Dis 2012; 3: 450– 7. 10.1017/S2040174412000396 25084298 · DOI
  76. [84]Lussana F, de Rooij SR, Veenendaal M, et al. Prevalence of factor V Leiden and G20210A prothrombin mutation in the Dutch famine birth cohort: a possible survival advantage? Thromb Haemost 2012; 108: 399– 401. 10.1160/TH12-03-0145 22627863 · DOI
  77. [85]de Rooij SR, Painter RC, Phillips DIW, et al. Impaired insulin secretion after prenatal exposure to the Dutch famine. Diabetes Care 2006; 29: 1897– 901. 10.2337/dc06-0460 16873799 · DOI
  78. [86]de Rooij SR, Painter RC, Phillips DIW, et al. Hypothalamic-Pituitary-Adrenal axis activity in adults who were prenatally exposed to the Dutch famine. Eur J Endocrinol 2006; 155: 153– 60. 10.1530/eje.1.02193 16793962 · DOI
  79. [87]Carroll D, Ginty AT, Painter RC, et al. Systolic blood pressure reactions to acute stress are associated with future hypertension status in the Dutch famine birth cohort study. Int J Psychophysiol 2012; 85: 270– 3. 10.1016/j.ijpsycho.2012.04.001 22522348 · DOI
  80. [88]Ginty AT, Carroll D, Roseboom TJ, et al. Depression and anxiety are associated with a diagnosis of hypertension 5 years later in a cohort of late middle-aged men and women. J Hum Hypertens 2013; 27: 187– 90. 10.1038/jhh.2012.18 22592133 · DOI
  81. [89]de Rooij SR, Veenendaal MVE, Räikkönen K, et al. Personality and stress appraisal in adults prenatally exposed to the Dutch famine. Early Hum Dev 2012; 88: 321– 5. 10.1016/j.earlhumdev.2011.09.002 21955503 · DOI
  82. [90]de Rooij SR, van Pelt AMM, Ozanne SE, et al. Prenatal undernutrition and leukocyte telomere length in late adulthood: the Dutch famine birth cohort study. Am J Clin Nutr 2015; 102: 655– 60. 10.3945/ajcn.115.112326 26178721 · DOI
  83. [91]Roseboom TJ, van der Meulen JH, Osmond C, et al. Adult survival after prenatal exposure to the Dutch famine 1944--45. Paediatr Perinat Epidemiol 2001; 15: 220– 5. 10.1046/j.1365-3016.2001.00336.x 11489148 · DOI
  84. [92]Painter RC, Roseboom TJ, Bossuyt PMM, et al. Adult mortality at age 57 after prenatal exposure to the Dutch famine. Eur J Epidemiol 2005; 20: 673– 6. 10.1007/s10654-005-7921-0 16151880 · DOI

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Authors
Bleker, L. S., de Rooij, S. R., Painter, R. C., Ravelli, A. C., & Roseboom, T. J.
Affiliations
  • Amsterdam University Medical Centers (NL)
  • Epidemiology and Data Science, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands
ORCID
Venue
BMJ Open
Publisher
BMJ
Published
2021-03
Volume
11
Issue
3
Pages
e042078
ISSN
2044-6055 (ISSN-L)
DOI
10.1136/bmjopen-2020-042078
PMC
PMC7934722
OpenAlex
W3135521923
Cited by
102
References
3
Citations by year
2026: 10 · 2025: 28 · 2024: 21 · 2023: 21 · 2022: 21 · 2021: 1
FWCI
15.83
Type
journal article
Language
en
Open access
Licence
Locations
  • BMJ Open (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion, cc-by)
  • Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Netherlands Heart Foundation (NHS2001B087, NHS2007B083)
  • Medical Research Council (NA)
  • Diabetes Fonds Nederland (NA)
  • Academisch Medisch Centrum (NA)
  • Nederlandse Hartstichting (NHS2007B083)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO Aspasia Project 015014039)
  • European Commission (Brainage (Seventh Framework Program Project 279281, Dynahealth (Horizon 2020 Project 633595), Longitools (Horizon 2020 Project 874739)
  • European Science Foundation, Project EUROSTRESS-DOME (NA)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Health, Environment, Cognitive Aging
Keywords
prenatal famine exposure, maternal undernutrition, pregnancy timing, developmental programming, cardiovascular disease, metabolic disorders, aging, mental health, brain aging, cognitive decline, dementia, mortality, epigenetics, hypothalamic-pituitary-adrenal axis, organ function
MeSH terms
Famine, Female, Humans, Hypothalamo-Hypophyseal System, Infant, Newborn, Netherlands, Pituitary-Adrenal System, Pregnancy, Prenatal Exposure Delayed Effects, Prospective Studies, Starvation, Cohort Studies

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Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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