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Cited by 114Birth, Development, and HealthPregnancy and preeclampsia studiesBlood Pressure and Hypertension Studies

The sex-specific effects of famine on the association between placental size and later hypertension

van Abeelen, A.F.M., de Rooij, S.R., Osmond, C., Painter, R.C., Veenendaal, M.V.E., Bossuyt, P.M.M., Elias, S.G., Grobbee, D.E. +3 more·2011·Placenta
DOI 10.1016/j.placenta.2011.06.012
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Abstract

Background People who had low birth weight are at increased risk of hypertension. This may reflect fetal programming by undernutrition. Placental size is also associated with hypertension. Maternal undernutrition during the Dutch famine reduced placental surface area. We examined whether maternal undernutrition altered the relationship between placental size and later hypertension.Methods Retrospective cohort study among 860 subjects born in Amsterdam during 1943-47. 216 subjects were taking anti-hypertensive medication. Birth records included placental length and breadth from which we calculated its area.Results Among men who were not in utero during the famine hypertension was associated with a small placental surface area due to a small placental breadth, and with an oval-shaped surface. The OR for hypertension was 0.83 (95% CI 0.70 to 1.00) for a 40 cm(2) increase in surface area. Among men who were in utero during the famine hypertension was associated with a large placental surface area due to a large placental breadth, and with a round-shaped surface. The OR for hypertension was 1.34 (95% CI 0.99 to 1.80) for a 40 cm(2) increase in surface area. The associations between placental size and hypertension in men who were and were not in utero during the famine were significantly different (p values for interaction = 0.008 for placental surface area, 0.001 for the breadth and 0.01 for the difference in the two diameters). Among women hypertension was not associated with placental size.Conclusions Our study provides the first direct evidence that changes in maternal diet during pregnancy alter the relationship between placental size and later hypertension among men but not women. We suggest that among men who were not in utero during the famine, hypertension was related to impaired implantation, whereas among men who were in utero during the famine it was related to compensatory expansion of the placental surface.

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  • Hypertension was predicted by a short placental width and a more oval shape in men who were born after the war.

    “However, hypertension was predicted by a short placental width and a more oval shape in men who were born after the war (471, 541).”

    From Placental Origins of Chronic Disease (2016) · cites this paper as [541]

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Authors
van Abeelen, A. F. M., de Rooij, S. R., Osmond, C., Painter, R. C., Veenendaal, M. V. E., Bossuyt, P. M. M., Elias, S. G., Grobbee, D. E., van der Schouw, Y. T., Barker, D. J. P., & Roseboom, T. J.
Affiliations
  • Southampton General Hospital (GB)
  • Amsterdam UMC Location University of Amsterdam (NL)
  • University Medical Center Utrecht (NL)
ORCID
Venue
Placenta
Publisher
Elsevier BV
Published
2011-09
Volume
32
Issue
9
Pages
694-698
ISSN
0143-4004 (ISSN-L)
DOI
10.1016/j.placenta.2011.06.012
OpenAlex
W2109120217
Cited by
114
References
30
Citations by year
2026: 2 · 2025: 2 · 2024: 10 · 2023: 7 · 2022: 10 · 2021: 13 · 2020: 8 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 7 · 2015: 10 · 2014: 8 · 2013: 9 · 2012: 2
FWCI
5.84
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Placenta (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • ePrints Soton (University of Southampton) (submittedVersion)
  • Pure Amsterdam UMC (submittedVersion)
Funders
The Netherlands Heart Foundation (2007B083)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
  • Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords
Dutch famine, maternal undernutrition, placental size, placental surface area, hypertension, fetal programming, sex differences, placental shape, low birth weight, pregnancy diet, placental implantation
MeSH terms
Adult, Female, Humans, Hypertension, Infant, Low Birth Weight, Infant, Newborn, Male, Netherlands, Organ Size, Placenta, Pregnancy, Prenatal Exposure Delayed Effects, Retrospective Studies, Sex Characteristics, Starvation, Malnutrition

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