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Cost-effectiveness of providing university students with a mindfulness-based intervention to reduce psychological distress: economic evaluation of a pragmatic randomised controlled trial

Wagner, Adam P, Galante, Julieta, Dufour, Géraldine, Barton, Garry, Stochl, Jan, Vainre, Maris, Jones, Peter B·2023·BMJ Open

Abstract

Objective: Increasing numbers of young people attending university has raised concerns about the capacity of student mental health services to support them. We conducted a randomised controlled trial (RCT) to explore whether provision of an 8 week mindfulness course adapted for university students (Mindfulness Skills for Students—MSS), compared with university mental health support as usual (SAU), reduced psychological distress during the examination period. Here, we conduct an economic evaluation of MSS+SAU compared with SAU. Design and setting: Economic evaluation conducted alongside a pragmatic, parallel, single-blinded RCT comparing provision of MSS+SAU to SAU. Participants: 616 university students randomised. Primary and secondary outcome measures: The primary economic evaluation assessed the cost per quality-adjusted life year (QALY) gained from the perspective of the university counselling service. Costs relate to staff time required to deliver counselling service offerings. QALYs were derived from the Clinical Outcomes in Routine Evaluation Dimension 6 Dimension (CORE-6D) preference based tool, which uses responses to six items of the Clinical Outcomes in Routine Evaluation Outcome Measure (CORE-OM; primary clinical outcome measure). Primary follow-up duration was 5 and 7 months for the two recruitment cohorts. Results: It was estimated to cost £1584 (2022 prices) to deliver an MSS course to 30 students, £52.82 per student. Both costs (adjusted mean difference: £48, 95% CI £40–£56) and QALYs (adjusted mean difference: 0.014, 95% CI 0.008 to 0.021) were significantly higher in the MSS arm compared with SAU. The incremental cost-effectiveness ratio (ICER) was £3355, with a very high (99.99%) probability of being cost-effective at a willingness-to-pay threshold of £20 000 per QALY. Conclusions: MSS leads to significantly improved outcomes at a moderate additional cost. The ICER of £3355 per QALY suggests that MSS is cost-effective when compared with the UK’s National Institute for Health and Care Excellence thresholds of £20 000 per QALY. Trial registration number: Australian and New Zealand Clinical Trials Registry, ACTRN12615001160527.

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Crossref · 10.1136/bmjopen-2023-071724

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Figure 1 Participant timeline. Reproduced from Galante et al (2016).12
Figure 1 Participant timeline. Reproduced from Galante et al (2016).12CC BY · PubMed Central
Figure 2 Cost-effectiveness acceptability curves (CEACs) for the base-case and scenario analyses: each curve shows the probability of cost-effectiveness at a particular willingness-to-pay (λ) threshold per unit of outcome (QALYs: base case, S1-3; CORE-OM point: S4; WEMWBS point: S5). CCA, complete case analysis; CORE-OM, Clinical Outcomes in Routine Evaluation Outcome Measure; QALYs, quality adjusted life years; WEMWBS, Warwick-Edinburgh Mental Well-being Scale.
Figure 2 Cost-effectiveness acceptability curves (CEACs) for the base-case and scenario analyses: each curve shows the probability of cost-effectiveness at a particular willingness-to-pay (λ) threshold per unit of outcome (QALYs: base case, S1-3; CORE-OM point: S4; WEMWBS point: S5). CCA, complete case analysis; CORE-OM, Clinical Outcomes in Routine Evaluation Outcome Measure; QALYs, quality adjusted life years; WEMWBS, Warwick-Edinburgh Mental Well-being Scale.CC BY · PubMed Central

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Cites

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Metadata

Authors
Wagner, A. P., Galante, J., Dufour, G., Barton, G., Stochl, J., Vainre, M., & Jones, P. B.
Venue
BMJ Open
Publisher
BMJ
Published
2023-11
Volume
13
Issue
11
Pages
e071724
ISSN
2044-6055
Cited by
7
References
13
Language
en
Funders
  • National Institute for Health Research (NIHR) Applied Research Collaboration East of England (N/A)
  • University of Cambridge Counselling Service (N/A)
  • University of Cambridge Vice-Chancellor’s Endowment Fund (N/A)

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