Diabetic retinopathy treatment cascade and care continuum in the USA: a systematic review
Open accessAbstract
Objectives: To characterise engagement across the diabetic retinopathy (DR) care continuum in the USA using a cascade-of-care framework and identify gaps contributing to preventable vision loss. Design: Systematic review. Data sources: From September to November 2025, with an updated search in March to April 2026 using the same eligibility criteria, we systematically searched Ovid MEDLINE and Ovid Embase supplemented by reviewing reference lists of relevant articles and opportunistic searches of the Centers for Disease Control and Prevention publications. Eligibility criteria: We included English - language US-based cross-sectional, cohort and case–control studies and systematic reviews containing US-based data published between 1 January 2018 and 31 December 2025 relevant to one of the defined DR cascade stages: (1) diagnosis of diabetes, (2) adherence to DR screening, (3) diagnosis of DR, (4) adherence to DR care and (5) DR-related blindness. We included systematic reviews only to inform DR-related blindness, where primary data were limited and excluded them from other stages to avoid double-counting. Exclusion criteria included studies not relevant to one of the defined DR cascade stages and editorial, perspective or commentary pieces. Data extraction and synthesis: Two reviewers independently screened studies, extracted data and assessed risk-of-bias using the Newcastle-Ottawa Scale and Risk of Bias in Systematic Reviews tool. We synthesised data narratively and organised via the DR treatment cascade framework. Results: Of 14 893 studies screened, 46 met the inclusion criteria. Cascade analysis revealed substantial losses in patient engagement at three stages: (1) only 15.5%–78.7% (median 59.4%, IQR 33.9%–74.0%) of individuals with diabetes obtain biennial DR screening; (2) a substantial 54.9%–88.5% (median 70.1%, IQR 62.5%–79.3%) of individuals with DR are unaware of their diagnosis; (3) only 30.9%–62.7% (median 52.0%, IQR 40.9%–59.1%) of individuals diagnosed with DR are initially linked to care and 55.3%–77.8% (median 70.3%, IQR 59.2%–77.7%) have a lapse in DR follow-up. Conclusions: This review identifies major gaps in the DR care continuum, particularly in diagnosis awareness, linkage to care and follow-up adherence. The cascade framework highlights key points of disengagement and provides a basis for prioritising future research.
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Recent care-cascade evidence shows persistent losses across screening, diagnosis, care adherence, and blindness prevention.
“Recent care-cascade evidence shows persistent losses across screening, diagnosis, care adherence, and blindness prevention (23).”
From From validation to public health impact: implementing equitable AI-enabled diabetic retinopathy screening (2026) · cites this paper as [23]
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Chen, J., & Chen, B. (2026) · Frontiers in Public Health · doi:10.3389/fpubh.2026.1976572
RETINOPATIA DIABÉTICA: ABORDAGEM CLÍNICA E NOV AS PERSPECTIV AS TERAPÊUTICAS
Porto, D. J., WESTPHALEN, S. L., Matter, D. C., Barboza, I. P., & Mello, L. R. D. M. (2026) · Editora Pasteur eBooks · doi:10.59290/5159320262
- Authors
- Fu, J. J., Applebaum, S. S., Granados, A., & Nwanyanwu, K.
- Affiliations
- Yale University (US)
- Corresponding author
- Nwanyanwu, Kristen
- Venue
- BMJ Open
- Publisher
- BMJ
- Published
- 2026-06
- Volume
- 16
- Issue
- 6
- Pages
- e117683
- ISSN
- 2044-6055 (ISSN-L)
- PMC
- PMC13264893
- OpenAlex
- W7164219225
- Cited by
- 1
- References
- 62
- Citations by year
- 2026: 1
- FWCI
- 1.76
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- BMJ Open (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- PubMed Central (publishedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- James G. Hirsch Endowed Medical Student Research Fellowship
- Research to Prevent Blindness
- National Eye Institute (1 K23 EY030530-01)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Health Sciences › Medicine › Epidemiology › Ophthalmology and Visual Impairment Studies
- Keywords
- diabetic retinopathy, continuum of care, cascade of care, diabetic retinopathy screening, screening adherence, diabetes diagnosis, retinopathy diagnosis, linkage to care, follow-up adherence, blindness prevention, patient engagement, United States, health service gaps, health equity, racial and ethnic disparities, geographic disparities, socioeconomic disparities, diabetes self-management education
- MeSH terms
- Blindness, Continuity of Patient Care, Diabetic Retinopathy, Humans, United States
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