The DOI matches its Crossref record.
Posthypoxic cooling of neonatal rats provides protection against brain injury.
Open accessAbstract
AIM: To determine whether moderate hypothermia, applied after a hypoxic-ischaemic insult in neonatal rats, reduces cerebral damage. METHOD: Unilateral hypoxic-ischaemic brain damage was induced in 7 day old rats by left carotid ligation, followed by 120 minutes of normothermic exposure to 8% O2, followed by random selection to three hours of hypothermia (rectal temperature, mean (SD), 32.5 (0.4) degrees C) or normothermia (38.3 (0.4) degrees C). One hundred and one animals were used for brain temperature or blood chemistry studies and 24 for survival studies (7 days) with neuropathology, including cell counting as outcome measures. RESULTS: Thirty sections from each brain were histologically examined with respect to distribution and pattern of damage and given a score from 0 to 4. Animals treated with hypothermia had significantly less damage than normothermic animals (score 0.5 (0.3) vs 1.8 (0.5)). CONCLUSIONS: Posthypoxic hypothermia reduces brain damage in awake, unrestrained 7 day old rats.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862
Cooling for newborns with hypoxic ischaemic encephalopathy
Jacobs, S. E., Berg, M., Hunt, R., Tarnow-Mordi, W. O., Inder, T. E., & Davis, P. G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003311.pub3 · Cited by 2,328
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119153 · Cited by 622
Perinatal brain injury: From pathogenesis to neuroprotection
Volpe, J. J. (2001) · Mental Retardation and Developmental Disabilities Research Reviews · doi:10.1002/1098-2779(200102)7:1<56::aid-mrdd1008>3.0.co;2-a · Cited by 438
Bona, E., Hagberg, H., Løberg, E. M., Bågenholm, R., & Thoresen, M. (1998) · Pediatric Research · doi:10.1203/00006450-199806000-00005 · Cited by 340
Self-citation
Metadata
- Authors
- Thoresen, M., Bågenholm, R., Løberg, E. M., Apricena, F., & Kjellmer, I.
- Venue
- Archives of Disease in Childhood - Fetal and Neonatal Edition
- Publisher
- BMJ
- Published
- 1996-01
- Volume
- 74
- Issue
- 1
- Pages
- F3-F9
- ISSN
- 1359-2998 (ISSN-L)
- 1468-2052
- OpenAlex
- W2132866920
- Cited by
- 232
- References
- 0
- FWCI
- 13.09
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Posthypoxic cooling of neonatal rats provides protection against brain injury. https://app.cochat.ai/papers/10.1136/fn.74.1.f3
- The paper
- Thoresen, M., Bågenholm, R., Løberg, E. M., Apricena, F., & Kjellmer, I. (1996). Posthypoxic cooling of neonatal rats provides protection against brain injury. Archives of Disease in Childhood - Fetal and Neonatal Edition. https://doi.org/10.1136/fn.74.1.f3
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
