The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs.
Open accessAbstract
Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of this study was to determine whether prolonged head cooling, delayed into the late postinsult period, improves outcome from severe ischemia. Unanesthetized near term fetal sheep were subject to 30 min of cerebral ischemia. 90 min later they were randomized to either cooling (n = 9) or sham cooling (n = 7) for 72 h. Intrauterine cooling was induced by a coil around the fetal head, leading initially to a fall in extradural temperature of 5-10 degrees C, and a fall in esophageal temperature of 1.5-3 degrees C. Cooling was associated with mild transient systemic metabolic effects, but not with hypotension or altered fetal heart rate. Cerebral cooling reduced secondary cortical cytotoxic edema (P < 0.001). After 5 d of recovery there was greater residual electroencephalogram activity (-5.2+/-1.6 vs. -15.5+/-1.5 dB, P < 0.001) and a dramatic reduction in the extent of cortical infarction and neuronal loss in all regions assessed (e.g., 40 vs. 99% in the parasagittal cortex, P < 0.001). Selective head cooling, maintained throughout the secondary phase of injury, is noninvasive and safe and shows potential for improving neonatal outcome after perinatal asphyxia.
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Busto, R., Dietrich, W. D., Globus, M. Y.-T., Valdés, I., Scheinberg, P., & Ginsberg, M. D. (1987) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1987.127 · Cited by 1,787
Busto, R., Globus, M. Y., Dietrich, W. D., Martinez, E., Valdés, I., & Ginsberg, M. D. (1989) · Stroke · doi:10.1161/01.str.20.7.904 · Cited by 1,089
Transformations towards the normal distribution of broad band spectral parameters of the EEG
Gasser, T., Bächer, P., & Möcks, J. (1982) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(82)90112-2 · Cited by 581
Dietrich, W. D., Busto, R., Alonso, O., Globus, M. Y.-T., & Ginsberg, M. D. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.71 · Cited by 470
Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil
Colbourne, F., & Corbett, D. (1994) · Brain Research · doi:10.1016/0006-8993(94)90488-x · Cited by 418
Thoresen, M., Penrice, J., Lorek, A., Cady, E. B., Wylezinska, M., Kirkbride, V, Cooper, C. E., Brown, G. C., Edwards, A. D., Wyatt, J. S., et al. (1995) · Pediatric Research · doi:10.1203/00006450-199505000-00019 · Cited by 400
Beilharz, E. J., Williams, C. E., Dragunow, M., Sirimanne, E. S., & Gluckman, P. D. (1995) · Molecular Brain Research · doi:10.1016/0169-328x(94)00217-3 · Cited by 356
Self-citationStatus epilepticus in well–oxygenated rats causes neuronal necrosis
Nevander, G., Ingvar, M., Auer, R., & Siesjö, B. K. (1985) · Annals of Neurology · doi:10.1002/ana.410180303 · Cited by 310
Specific Inhibition of Apoptosis after Cerebral Hypoxia-Ischemia by Moderate Post-Insult Hypothermia
Edwards, A. D., Yue, X., Squier, M. V., Thoresen, M., Cady, E. B., Penrice, J., Cooper, C. E., Wyatt, J. S., Reynolds, E. O. R., & Mehmet, H. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2895 · Cited by 284
Posthypoxic cooling of neonatal rats provides protection against brain injury.
Thoresen, M., Bågenholm, R., Løberg, E. M., Apricena, F., & Kjellmer, I. (1996) · Archives of Disease in Childhood - Fetal and Neonatal Edition · doi:10.1136/fn.74.1.f3 · Cited by 232
Cited by
Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy
Shankaran, S., Laptook, A. R., Ehrenkranz, R. A., Tyson, J. E., McDonald, S. A., Donovan, E. F., Fanaroff, A. A., Poole, W. K., Wright, L. L., Higgins, R. D., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmcps050929 · Cited by 2,862
Cooling for newborns with hypoxic ischaemic encephalopathy
Jacobs, S. E., Berg, M., Hunt, R., Tarnow-Mordi, W. O., Inder, T. E., & Davis, P. G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd003311.pub3 · Cited by 2,328
Gluckman, P. D., Wyatt, J. S., Azzopardi, D., Ballard, R., Edwards, A. D., Ferriero, D. M., Polin, R. A., Robertson, C. M., Thoresen, M., Whitelaw, A., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17946-x · Cited by 2,270
Self-citationHypoxic-Ischemic Encephalopathy: A Review for the Clinician
Douglas-Escobar, M., & Weiss, M. D. (2015) · JAMA Pediatrics · doi:10.1001/jamapediatrics.2014.3269 · Cited by 778
Bona, E., Hagberg, H., Løberg, E. M., Bågenholm, R., & Thoresen, M. (1998) · Pediatric Research · doi:10.1203/00006450-199806000-00005 · Cited by 340
Metadata
- Authors
- Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-01-15
- Volume
- 99
- Issue
- 2
- Pages
- 248-256
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2121087310
- Cited by
- 622
- References
- 26
- FWCI
- 16.13
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gunn, A. J., Gunn, T. R., de Haan, H. H., Williams, C. E., & Gluckman, P. D. (1997). Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. Journal of Clinical Investigation. https://doi.org/10.1172/jci119153
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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