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Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device
Open accessAbstract
Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents. Lactulose produced marked acidification of proximal colonic contents but this effect was not consistently maintained into the distal colon. Sodium sulphate acidified distal rather than proximal colonic contents. However, for a similar degree of laxation it was not possible to produce a significantly more uniform reduction of pH along the length of the colon by combining these laxatives compared with lactulose alone. Magnesium sulphate had little effect upon luminal pH except in the rectum where a significant rise occurred. These results are discussed in relation to both normal colonic physiology and to their possible relevance to the treatment of chronic hepatic encephalopathy by colonic acidification.
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Cited by
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Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P., & Macfarlane, G. T. (1987) · Gut · doi:10.1136/gut.28.10.1221 · Cited by 3,119
Diet–microbiota interactions as moderators of human metabolism
Sonnenburg, J. L., & Bäckhed, F. (2016) · Nature · doi:10.1038/nature18846 · Cited by 2,257
The control and consequences of bacterial fermentation in the human colon
Cummings, J. H., & Macfarlane, G. T. (1991) · Journal of Applied Bacteriology · doi:10.1111/j.1365-2672.1991.tb02739.x · Cited by 1,499
Measurement of gastrointestinal pH profiles in normal ambulant human subjects
Evans, D. F., Pye, G., Bramley, R., Clark, A. G., Dyson, T. J., & Hardcastle, J. D. (1988) · Gut · doi:10.1136/gut.29.8.1035 · Cited by 1,240
Duncan, S. H., Belenguer, A., Holtrop, G., Johnstone, A. M., Flint, H. J., & Lobley, G. E. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.02340-06 · Cited by 941
Metadata
- Authors
- Bown, R. L., Gibson, J. A., Sladen, G. E., Hicks, B., & Dawson, A. M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1974-12
- Volume
- 15
- Issue
- 12
- Pages
- 999-1004
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2041054048
- Cited by
- 232
- References
- 0
- FWCI
- 1.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bown, R. L., Gibson, J. A., Sladen, G. E., Hicks, B., & Dawson, A. M. (1974). Effects of lactulose and other laxatives on ileal and colonic pH as measured by a radiotelemetry device. Gut. https://doi.org/10.1136/gut.15.12.999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
