Radioimmunoassay of cholecystokinin-pancreozymin
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A sensitive and specific radioimmunoassay for cholecystokinin-pancreozymin (CCK-PZ) has been developed, using rabbit antisera to crude porcine hormone. Highly purified porcine CCK-PZ, labelled with 131 I, and repurified by column chromatography on Sephadex G15, was used as tracer. Separation of free from antibody-bound labelled CCK-PZ was carried out using charcoal, ion-exchange resin, or a double antibody procedure. Non-specific interference with the assay system by serum factors was abolished (as judged by in-vitro and in-vivo recovery studies) by boiling and diluting the serum samples before assay. Ninety-nine per cent pure porcine CCK-PZ (standard), commercial CCK-PZ preparations, caerulein, the C-terminal 8- and 12-amino acid fragments of the CCK-PZ molecule, and endogenous human CCK-PZ all cross reacted in the assay system and showed parallel inhibition curves. No significant cross reaction was found with gastrin, secretin, glucagon, or insulin. The sensitivity of the assay is approximately 5 pg per ml of test solution, which proved adequate for measuring physiological levels of CCK-PZ in peripheral blood in man. The mean immunoreactive CCK-PZ concentration in 50 fasting normal subjects was 60·4 pg per ml. The distribution of individual values was skewed, however, so that the median was much lower (30 pg per ml). Older subjects had higher fasting levels of CCK-PZ than were found in young adults.
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Such interference has been recognised in immunoassays for cholecystokinin, parathyroid hormone, thyrotropic hormone, glucagon, secretin, angiotensin, growth hormone, vasoactive intestinal peptide, gonadotrophins and gonadotrophin-releasing hormone, all of which were resolved by sample extraction.
“Such interference has also been recognised in immunoassays for cholecystokinin 80, parathyroid hormone 81, thyrotropic hormone 82, glucagon 83, secretin 84, 85, angiotensin 86, growth hormone 87, vasoactive intestinal peptide 88, gonadotrophins 89 and gonadotrophin‐releasing hormone 90, all of which were resolved by sample extraction.”
From Measuring Oxytocin and Vasopressin: Bioassays, Immunoassays and Random Numbers (2016) · cites this paper as [80]
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Hökfelt, T. G. M., Barde, S. S., Zhong, W., & He, J. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-23720-1.00026-5 · Cited by 2 · see citing works
Harvey, R. F. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-379260-0.50031-5 · Cited by 2 · see citing works
Self-citationSpecificity of cholecystokinin antibody may influence choice of tracer for radioimmunoassay
Murphy, R. F., Balasubramaniam, A., Chen, M., Cardin, A. D., Rayford, P. L., Jackson, R. L., & Joffe, S. N. (1984) · Journal of Immunological Methods · doi:10.1016/0022-1759(84)90381-8 · Cited by 1 · see citing works
血漿のXAD-2 Resin 抽出による Cholecystokinin の Radioimmunoassay
敬子, 白., 伸一郎, 渡., & 正, 竹. (1985) · 日本消化器病学会雑誌 · doi:10.11405/nisshoshi1964.82.277 · Cited by 1 · see citing works
A radioimmunoassay for cholecystokinin (CCK)
Brooks, F. P. (1983) · Digestive Diseases and Sciences · doi:10.1007/bf02430536
and Measurement of Molecular Variants of Cholecystokinin in Duodenal Mucosa and Plasma
Calam, J., Ellis, A., & Dockray, G. J. (1982)
- Authors
- Harvey, R. F., Dowsett, L., Hartog, M., & Read, A. E.
- Affiliations
- Bristol Royal Infirmary (GB)
- ORCID
- Hartog, M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1974-09
- Volume
- 15
- Issue
- 9
- Pages
- 690-699
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1413038
- OpenAlex
- W2001896794
- Cited by
- 64
- References
- 46
- Citations by year
- 2025: 1 · 2024: 1 · 2016: 1
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Warwick
- Karolinska Institutet
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- cholecystokinin-pancreozymin, radioimmunoassay, antibody binding, caerulein, cross-reactivity, fasting, age differences
- MeSH terms
- Adult, Aged, Animals, Antibody Formation, Binding Sites, Antibody, Blood Proteins, Cholecystokinin, Cross Reactions, Gastrins, Glucagon, Guinea Pigs, Hot Temperature, Humans, Immune Sera, Insulin, Iodine Radioisotopes, Middle Aged, Protein Binding, Rabbits, Radioimmunoassay, Secretin, Sheep, Swine
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