The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Duodenal adenomatosis in familial adenomatous polyposis
Open accessAbstract
BACKGROUND: The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS: To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic surveillance of the duodenum is indicated. METHODS: A prospective five nation study was carried out in the Nordic countries and the Netherlands. PATIENTS: A total of 368 patients were examined by gastroduodenoscopy at two year intervals during the period 1990-2001. RESULTS: At the first endoscopy, 238 (65%) patients had duodenal adenomas at a median age of 38 years. Median follow up was 7.6 years. The cumulative incidence of adenomatosis at age 70 years was 90% (95% confidence interval (CI) 79-100%), and of Spigelman stage IV 52% (95% CI 28-76%). The probability of an advanced Spigelman score increased during the study period (p<0.0001) due to an increasing number and size of adenomas. Two patients had asymptomatic duodenal carcinoma at their first endoscopy while four developed carcinoma during the study at a median age of 52 years (range 26-58). The cumulative incidence rate of cancer was 4.5% at age 57 years (95% CI 0.1-8.9%) and the risk was higher in patients with Spigelman stage IV at their first endoscopy than in those with stages 0-III (p<0.01). CONCLUSIONS: The natural course of duodenal adenomatosis has now been described in detail. The high incidence and increasing severity of duodenal adenomatosis with age justifies prophylactic examination, and a programme is presented for upper gastrointestinal endoscopic surveillance.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Longitudinal data analysis using generalized linear models
LIANG, K.-Y., & ZEGER, S. L. (1986) · Biometrika · doi:10.1093/biomet/73.1.13 · Cited by 18,550
UPPER GASTROINTESTINAL CANCER IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS
Spigelman, A., Talbot, I. C., Williams, C. B., Domizio, P., & Phillips, R. K. S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)90840-4 · Cited by 804
Nugent, K. P., Farmer, K. C. R., Spigelman, A. D., Williams, C. B., & Phillips, R. K. S. (1993) · Journal of British Surgery · doi:10.1002/bjs.1800801244 · Cited by 490
Phillips, R. K. S., Wallace, M. H., Lynch, P. M., Hawk, E., Gordon, G. B., Saunders, B. P., Wakabayashi, N., Shen, Y., Zimmerman, S., Godio, L., et al. (2002) · Gut · doi:10.1136/gut.50.6.857 · Cited by 441
Mortality in patients with familial adenomatous polyposis
Arvanitis, M. L., Jagelman, D. G., Fazio, V. W., Lavery, I. C., & McGannon, E. (1990) · Diseases of the Colon & Rectum · doi:10.1007/bf02150736 · Cited by 392
Groves, C. J., Saunders, B. P., Spigelman, A. D., & Phillips, R. K. S. (2002) · Gut · doi:10.1136/gut.50.5.636 · Cited by 388
Björk, J., Åkerbrant, H., Iselius, L., Bergman, A., Engwall, Y., Wahlström, J., Martinsson, T., Nordling, M., & Hultcrantz, R. (2001) · Gastroenterology · doi:10.1053/gast.2001.28707 · Cited by 253
Burke, C. A., Beck, G. J., Church, J. M., & van Stolk, R. U. (1999) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(99)70013-1 · Cited by 219
Gastroduodenal polyps in patients with familial adenomatous polyposis
Church, J. M., McGannon, E., Hull-Boiner, S., Sivak, M. V., Van Stolk, R., Jagelman, D. G., Fazio, V. W., Oakley, J. R., Lavery, I. C., & Milsom, J. W. (1992) · Diseases of the Colon & Rectum · doi:10.1007/bf02251971 · Cited by 159
Decision analysis in the management of duodenal adenomatosis in familial adenomatous polyposis.
Vasen, H. F. A., Bülow, S., Myrhøj, T., Mathus-Vliegen, L., Griffioen, G. G., Buskens, E., Taal, B. G., Nagengast, F. M., Slors, J. F. M., & de Ruiter, P. (1997) · Gut · doi:10.1136/gut.40.6.716 · Cited by 150
Cited by
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
Hereditary and Familial Colon Cancer
Jasperson, K. W., Tuohy, T. M., Neklason, D. W., & Burt, R. W. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.01.054 · Cited by 1,312
Familial adenomatous polyposis
Galiatsatos, P., & Foulkes, W. D. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00375.x · Cited by 757
The role of endoscopy in the management of premalignant and malignant conditions of the stomach
Evans, J. A., Chandrasekhara, V., Chathadi, K. V., Decker, G. A., Early, D. S., Fisher, D. A., Foley, K., Hwang, J. H., Jue, T. L., Lightdale, J. R., et al. (2015) · Gastrointestinal Endoscopy · doi:10.1016/j.gie.2015.03.1967 · Cited by 304
Metadata
- Authors
- Bulow, S.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2004-03-01
- Volume
- 53
- Issue
- 3
- Pages
- 381-386
- ISSN
- 0017-5749 (ISSN-L)
- OpenAlex
- W1893945215
- Cited by
- 444
- References
- 12
- FWCI
- 17.33
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Duodenal adenomatosis in familial adenomatous polyposis. https://app.cochat.ai/papers/10.1136/gut.2003.027771
- The paper
- Bulow, S. (2004). Duodenal adenomatosis in familial adenomatous polyposis. Gut. https://doi.org/10.1136/gut.2003.027771
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
