The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis
Abstract
Twenty-four patients with familial adenomatous polyposis who had previously undergone prophylactic colectomy and had advanced duodenal polyposis were entered into a randomized trial to assess the effect of the non-steroidal anti-inflammatory drug sulindac on duodenal and rectal polyps. Polyp size and number were assessed by videotaped duodenoscopy (and rectoscopy in 14 patients) at entry and after 6 months of treatment; the tapes were compared by two assessors who were unaware of the randomization and the shuffled chronological order of the recordings. Mucosal cell proliferation was measured by in vitro incorporation of 5-bromo-2′-deoxyuridine. Sulindac therapy was associated with a reduction in epithelial cell proliferation in the duodenum (median labelling index (LI) 15·8 versus 14·4 per cent, P = 0·003) and a trend towards duodenal polyp regression (P = 0·12). In the rectum, cell proliferation showed a marked reduction (median LI8·5 versus 7·4 per cent, P = 0·018), and significant (P = 0·01) polyp regression was seen. Rectal polyposis was less severe than that in the duodenum and responded more dramatically. Sulindac is a possible treatment for patients in whom rectal polyps have failed to show significant regression after ileorectal anastomosis and who are unsuitable for pouch surgery; it may be useful in early duodenal polyposis or as an adjunct after duodenal clearance.
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Cites
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Self-citationSulindac causes regression of rectal polyps in familial adenomatous polyposis
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Effects of Long-term Sulindac Therapy on Colonic Polyposis
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The role of cyclooxygenases in inflammation, cancer, and development
Williams, C. S., Mann, M., & DuBois, R. N. (1999) · Oncogene · doi:10.1038/sj.onc.1203286 · Cited by 1,417
Self-citationCOX-2: A Molecular Target for Colorectal Cancer Prevention
Brown, J. R., & DuBois, R. N. (2005) · Journal of Clinical Oncology · doi:10.1200/jco.2005.09.051 · Cited by 444
Duodenal adenomatosis in familial adenomatous polyposis
Bulow, S. (2004) · Gut · doi:10.1136/gut.2003.027771 · Cited by 444
Cyclooxygenases in cancer: progress and perspective
Zha, S., Yegnasubramanian, V., Nelson, W. G., Isaacs, W. B., & De Marzo, A. M. (2004) · Cancer Letters · doi:10.1016/j.canlet.2004.06.014 · Cited by 389
Update on Bispectral Index monitoring
Johansen, J. W. (2006) · Best Practice & Research Clinical Anaesthesiology · doi:10.1016/j.bpa.2005.08.004 · Cited by 313
Metadata
- Authors
- Nugent, K. P., Farmer, K. C. R., Spigelman, A. D., Williams, C. B., & Phillips, R. K. S.
- Venue
- Journal of British Surgery
- Publisher
- Oxford University Press (OUP)
- Published
- 1993-12-01
- Volume
- 80
- Issue
- 12
- Pages
- 1618-1619
- ISSN
- 0007-1323 (ISSN-L)
- 1365-2168
- OpenAlex
- W2055951936
- Cited by
- 490
- References
- 11
- FWCI
- 10.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. https://app.cochat.ai/papers/10.1002/bjs.1800801244
- The paper
- Nugent, K. P., Farmer, K. C. R., Spigelman, A. D., Williams, C. B., & Phillips, R. K. S. (1993). Randomized controlled trial of the effect of sulindac on duodenal and rectal polyposis and cell proliferation in patients with familial adenomatous polyposis. Journal of British Surgery. https://doi.org/10.1002/bjs.1800801244
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
