Cited by 555Probiotics and Fermented FoodsImmunotherapy and Immune ResponsesImmune Response and Inflammation

The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.

Modulation of human dendritic cell phenotype and function by probiotic bacteria

Open access

Hart, A L, Lammers, K, Brigidi, P, Vitali, B, Rizzello, F, Gionchetti, P, Campieri, M, Kamm, M A, Knight, S C, Stagg, A J·2004·Gut

DOI 10.1136/gut.2003.037325PMC PMC1774301

Open this paper in CoChat — free account Open PDF

Abstract

Background: “Probiotic” bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in mediating the effects of these bacteria. Aims: To assess effects of different probiotic bacteria on dendritic cell function. Methods: Human intestinal lamina propria mononuclear cells, whole blood, or an enriched blood dendritic cell population were cultured with cell wall components of the eight bacterial strains in the probiotic preparation VSL#3 (four lactobacilli, three bifidobacteria, and one streptococcal strains). Dendritic cells were identified and changes in dendritic cell maturation/costimulatory markers and cytokine production in response to probiotic bacteria were analysed by multicolour flow cytometry, in addition to subsequent effects on T cell polarisation. Results: VSL#3 was a potent inducer of IL-10 by dendritic cells from blood and intestinal tissue, and inhibited generation of Th1 cells. Individual strains within VSL#3 displayed distinct immunomodulatory effects on dendritic cells; the most marked anti-inflammatory effects were produced by bifidobacteria strains which upregulated IL-10 production by dendritic cells, decreased expression of the costimulatory molecule CD80, and decreased interferon-γ production by T cells. VSL#3 diminished proinflammatory effects of LPS by decreasing LPS induced production of IL-12 while maintaining IL-10 production. Conclusions: Probiotic bacteria differ in their immunomodulatory activity and influence polarisation of immune responses at the earliest stage of antigen presentation by dendritic cells.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gut.2003.037325

Cites

40 of 40 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Dendritic cells and the control of immunity
Banchereau, J., & Steinman, R. M. (1998) · Nature · doi:10.1038/32588 · Cited by 14,486
A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
Groux, H., O’Garra, A., Bigler, M., Rouleau, M., Antonenko, S. V., de Vries, J. E., & Roncarolo, M. G. (1997) · Nature · doi:10.1038/39614 · Cited by 3,588
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.
Cella, M., Scheidegger, D., Palmer-Lehmann, K., Lane, P. J. L., Lanzavecchia, A., & Alber, G. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.747 · Cited by 1,982
Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation
Asseman, C., Mauze, S., Leach, M. W., Coffman, R. L., & Powrie, F. M. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.995 · Cited by 1,617
Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.
Macatonia, S. E., Hosken, N. A., Litton, M. J., Vieira, P., Hsieh, C., Culpepper, J., Wysocka, M., Trinchieri, G., MURPHY, K. M. M., & O’Garra, A. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.154.10.5071 · Cited by 1,524
Treatment of Murine Colitis by Lactococcus lactis Secreting Interleukin-10
Steidler, L., Hans, W., Schotte, L., Neirynck, S., Obermeier, F., Falk, W., Fiers, W., & Remaut, E. (2000) · Science · doi:10.1126/science.289.5483.1352 · Cited by 1,513
Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: A double-blind, placebo-controlled trial
Gionchetti, P., Rizzello, F., Venturi, A., Brigidi, P., Matteuzzi, D., Bazzocchi, G., Poggioli, G., Miglioli, M., & Campieri, M. (2000) · Gastroenterology · doi:10.1053/gast.2000.9370 · Cited by 1,485
Self-citation
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?
Lutz, M. B., & Schuler, G. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02281-0 · Cited by 1,349

Flagged first, then by citations

Show all 41 references

1 of the 41 references couldn’t be matched to a known paper.

Research works printed but not linked: 2

2003, Trends Immunol, 24, 314
2000, Gastroenterology, 118, A353

Sorted by citations

Items 101–200 of 553

Heat-treated colostrum feeding promotes beneficial bacteria colonization in the small intestine of neonatal calves
Malmuthuge, N., Chen, Y., Liang, G., Goonewardene, L. A., & Guan, L. L. (2015) · Journal of Dairy Science · doi:10.3168/jds.2015-9607 · Cited by 131
Th17 Cells as Potential Probiotic Therapeutic Targets in Inflammatory Bowel Diseases
Owaga, E., Hsieh, R., Mugendi, B., Masuku, S., Shih, C., & Chang, J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160920841 · Cited by 130
Dose–response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults
Larsen, C. N., Nielsen, S., Kæstel, P., Brockmann, E., Bennedsen, M., Christensen, H. R., Eskesen, D. C., Jacobsen, B. L., & Michaelsen, K. F. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602450 · Cited by 124
Dose-Dependent Immunomodulation of Human Dendritic Cells by the Probiotic Lactobacillus rhamnosus Lcr35
Evrard, B., Coudeyras, S., Dosgilbert, A., Charbonnel, N., Alamé, J., Tridon, A., & Forestier, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018735 · Cited by 123
Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohnʼs disease
Ng, S. C., Benjamin, J. L., McCarthy, N. E., Hedin, C. R. H., Koutsoumpas, A. L., Plamondon, S., Price, C. L., Hart, A. L., Kamm, M. A., Forbes, A., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21590 · Cited by 131
Self-citation
Mucosal immunity and allergic responses: lack of regulation and/or lack of microbial stimulation?
Prioult, G., & Nagler‐Anderson, C. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00277.x · Cited by 121
Microbiota, immunoregulatory old friends and psychiatric disorders
Rook, G. A. W., Raison, C. L., & Lowry, C. A. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_15 · Cited by 117
Potential Regulatory Role of MicroRNAs in the Development of Bovine Gastrointestinal Tract during Early Life
Liang, G., Malmuthuge, N., McFadden, T. B., Bao, H., Griebel, P. J., Stothard, P., & Guan, L. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092592 · Cited by 120
VSL#3 Probiotic Mixture
Chapman, T. M., Plosker, G. L., & Figgitt, D. P. (2006) · Drugs · doi:10.2165/00003495-200666100-00006 · Cited by 121
Potential Benefits of Dietary Fibre Intervention in Inflammatory Bowel Disease
Wong, C., Harris, P., & Ferguson, L. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17060919 · Cited by 116
The VSL# 3 Probiotic Mixture Modifies Microflora but Does Not Heal Chronic Dextran-Sodium Sulfate–Induced Colitis or Reinforce the Mucus Barrier in Mice
Gaudier, E. A., Michel, C., Segain, J., Cherbut, C., & Hoebler, C. (2005) · Journal of Nutrition · doi:10.1093/jn/135.12.2753 · Cited by 116
Human milk oligosaccharides promote immune tolerance via direct interactions with human dendritic cells
Xiao, L., van de Worp, W. R. P. H., Stassen, R., van Maastrigt, C., Kettelarij, N., Stahl, B., Blijenberg, B., Overbeek, S. A., Folkerts, G., Garssen, J., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201847971 · Cited by 115
The mechanisms and efficacy of probiotics in the prevention of Clostridium difficile-associated diarrhoea
Parkes, G. C., Sanderson, J. D., & Whelan, K. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70059-3 · Cited by 115
Anti-inflammatory and immunomodulatory efficacy of indigenous probiotic Lactobacillus plantarum Lp91 in colitis mouse model
Duary, R. K., Bhausaheb, M. A., Batish, V. K., & Grover, S. (2011) · Molecular Biology Reports · doi:10.1007/s11033-011-1269-1 · Cited by 109
Probiotic mixture VSL#3 reduces colonic inflammation and improves intestinal barrier function in Muc2 mucin-deficient mice
Kumar, M., Kissoon‐Singh, V., Leon‐Coria, A., Moreau, F., & Chadee, K. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00298.2016 · Cited by 114
Probiotics and immunology: separating the wheat from the chaff
Shida, K., & Nanno, M. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.07.011 · Cited by 108
Probiotics, immunity and exercise: a review.
West, N. P., Pyne, D. B., Peake, J. M., & Cripps, A. W. (2009) · PubMed · Cited by 108
Quantification, isolation and characterization of Bifidobacterium from the vaginal microbiomes of reproductive aged women
Freitas, A. C., & Hill, J. E. (2017) · Anaerobe · doi:10.1016/j.anaerobe.2017.05.012 · Cited by 109
Probiotics and allergy
Furrie, E. (2005) · Proceedings of The Nutrition Society · doi:10.1079/pns2005466 · Cited by 108
Immunoregulatory Effect of Bifidobacteria Strains in Porcine Intestinal Epithelial Cells through Modulation of Ubiquitin-Editing Enzyme A20 Expression
Tomosada, Y., Villena, J., Murata, K., Chiba, E., Shimazu, T., Aso, H., Iwabuchi, N., Xiao, J., Saito, T., & Kitazawa, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059259 · Cited by 109
Anti-inflammatory potential of probiotics: lipoteichoic acid makes a difference
Lebeer, S., Claes, I. J. J., & Vanderleyden, J. (2011) · Trends in Microbiology · doi:10.1016/j.tim.2011.09.004 · Cited by 108
The Gut‒Breast Axis: Programming Health for Life
Rodríguez, J. M., Fernández, L., & Verhasselt, V. (2021) · Nutrients · doi:10.3390/nu13020606 · Cited by 110
Probiotics: Immunomodulation and Evaluation of Safety and Efficacy
Ezendam, J., & Loveren, H. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00168.x · Cited by 103
Intestinal dendritic cells: Their role in intestinal inflammation, manipulation by the gut microbiota and differences between mice and men
Mann, E. R., Landy, J., Bernardo, D., Peake, S. T. C., Hart, A. L., Al-Hassi, H. O., & Knight, S. C. (2013) · Immunology Letters · doi:10.1016/j.imlet.2013.01.007 · Cited by 104
Self-citation
Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation
Fonseca, W., Lucey, S., Jang, S., Fujimura, K. E., Rasky, A. J., Ting, H.-A., Petersen, J. H., Johnson, C. C., Boushey, H. A., Zoratti, E. M., et al. (2017) · Mucosal Immunology · doi:10.1038/mi.2017.13 · Cited by 102
Molecular crosstalk of probiotic bacteria with the intestinal immune system: Clinical relevance in the context of inflammatory bowel disease
Hörmannsperger, G., & Haller, D. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.08.006 · Cited by 101
IL‐10‐dependent partial refractoriness to Toll‐like receptor stimulation modulates gut mucosal dendritic cell function
Monteleone, I., Platt, A. M., Gyllenbäck, E. J., Agace, W. W., & Mowat, A. M. (2008) · European Journal of Immunology · doi:10.1002/eji.200737909 · Cited by 101
Selection of probiotic bacteria for prevention of allergic diseases: immunomodulation of neonatal dendritic cells
Niers, L. E. M., Hoekstra, M. O., Timmerman, H. M., van Uden, N. O. P., de Graaff, P. M. A., Smits, H. H., Kimpen, J. L. L., & Rijkers, G. T. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2007.03421.x · Cited by 101
Recent developments and perspectives in the investigation of probiotic effects
Wohlgemuth, S., Loh, G., & Blaut, M. (2009) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2009.08.003 · Cited by 100
Review article: faecal transplantation therapy for gastrointestinal disease
Landy, J., Al-Hassi, H. O., McLaughlin, S. D., Walker, A. W., Ciclitira, P. J., Nicholls, R. J., Clark, S. K., & Hart, A. L. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04737.x · Cited by 100
Self-citation
Probiotics and the Immune Response
Madsen, K. L. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00014 · Cited by 100
The Effect of Probiotics and Gut Microbiota on Th17 Cells
Tanabe, S. (2013) · International Reviews of Immunology · doi:10.3109/08830185.2013.839665 · Cited by 102
Probiotics for the airways: Potential to improve epithelial and immune homeostasis
Martens, K., Pugin, B., Boeck, I. D., Spacova, I., Steelant, B., Seys, S., Lebeer, S., & Hellings, P. W. (2018) · Allergy · doi:10.1111/all.13495 · Cited by 97
Variable alterations of the microbiota, without metabolic or immunological change, following faecal microbiota transplantation in patients with chronic pouchitis
Landy, J., Walker, A. W., Li, J. V., Al-Hassi, H. O., Ronde, E., English, N. R., Mann, E. R., Bernardo, D., McLaughlin, S. D., Parkhill, J., et al. (2015) · Scientific Reports · doi:10.1038/srep12955 · Cited by 93
Self-citation
Pivotal Advance: Bifidobacteria and Gram-negative bacteria differentially influence immune responses in the proinflammatory milieu of celiac disease
De Palma, G., Cinova, J., Stepankova, R., Tuckova, L., & Sanz, Y. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0709471 · Cited by 90
Gut : liver : brain axis: the microbial challenge in the hepatic encephalopathy
Mancini, A., Campagna, F., Amodio, P., & Tuohy, K. M. (2018) · Food & Function · doi:10.1039/c7fo01528c · Cited by 89
Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine production
Dong, H., Rowland, I. R., Tuohy, K. M., Thomas, L. V., & Yaqoob, P. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04173.x · Cited by 90
Exploring the influence of the gut microbiota and probiotics on health: a symposium report
Thomas, L. V., Ockhuizen, T., & Suzuki, K. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001275 · Cited by 93
The Role of Exosomes in Infectious Diseases
Hosseini, H. M., Fooladi, A. A. I., Nourani, M. R., & Ghanezadeh, F. (2013) · Inflammation & Allergy - Drug Targets · doi:10.2174/1871528111312010005 · Cited by 99
Immune-stimulating effects of lactic acid bacteria in vivo and in vitro
Elmadfa, I., Klein, P., & Meyer, A. L. (2010) · Proceedings of the Nutrition Society · doi:10.1017/s0029665110001710 · Cited by 89
Evaluation of immunomodulation by Lactobacillus casei Shirota: Immune function, autoimmunity and gene expression
Baken, K. A., Ezendam, J., Gremmer, E. R., de Klerk, A., Pennings, J. L. A., Matthee, B., Peijnenburg, A., & Loveren, H. V. (2006) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2006.06.009 · Cited by 88
Probiotic treatments for induction and maintenance of remission in inflammatory bowel diseases: a meta-analysis of randomized controlled trials
Fujiya, M., Ueno, N., & Kohgo, Y. (2013) · Clinical Journal of Gastroenterology · doi:10.1007/s12328-013-0440-8 · Cited by 90
Oral administration of Lactobacillus paracasei L9 attenuates PM2.5-induced enhancement of airway hyperresponsiveness and allergic airway response in murine model of asthma
Wang, X., Yan, H., Zhao, L., Hao, Y., Guo, H., & Ren, F. (2017) · PLoS ONE · doi:10.1371/journal.pone.0171721 · Cited by 85
Probiotic Lactobacillus fermentum strain JDFM216 improves cognitive behavior and modulates immune response with gut microbiota
Park, M., Shin, M., Mun, D., Jeong, S.-Y., Jeong, D., Song, M., Ko, G., Unno, T., Kim, Y., & Oh, S. (2020) · Scientific Reports · doi:10.1038/s41598-020-77587-w · Cited by 88
Effect of the administration of a fermented milk containing Lactobacillus casei DN-114001 on intestinal microbiota and gut associated immune cells of nursing mice and after weaning until immune maturity
de LeBlanc, A. D. M., Dogi, C. A., Galdeano, C. M., Carmuega, E., Weill, R., & Perdigón, G. (2008) · BMC Immunology · doi:10.1186/1471-2172-9-27 · Cited by 86
Gut Microbiota and Probiotics in Modulation of Epithelium and Gut-Associated Lymphoid Tissue Function
Sanz, Y., & de Palma, G. (2009) · International Reviews of Immunology · doi:10.3109/08830180903215613 · Cited by 92
Intestinal dendritic cells in the pathogenesis of inflammatory bowel disease
Rutella, S. (2011) · World Journal of Gastroenterology · doi:10.3748/wjg.v17.i33.3761 · Cited by 85
Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence
van der Aa, L. B., Heymans, H. S. A., van Aalderen, W. M. C., & Sprikkelman, A. B. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2009.00915.x · Cited by 84
The Effects of Lactobacillus rhamnosus on the Prevention of Asthma in a Murine Model
Yu, J., Jang, S.-O., Kim, B., Song, Y.-H., Kwon, J., Kang, M., Choi, W., Jung, H.-D., & Hong, S. (2010) · Allergy Asthma and Immunology Research · doi:10.4168/aair.2010.2.3.199 · Cited by 83
Microbiota/Host Crosstalk Biomarkers: Regulatory Response of Human Intestinal Dendritic Cells Exposed to Lactobacillus Extracellular Encrypted Peptide
Bernardo, D., Sánchez, B., Al-Hassi, H. O., Mann, E. R., Urdaci, M. C., Knight, S. C., & Margollés, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036262 · Cited by 86
Self-citation
Transcriptome analysis reveals regional and temporal differences in mucosal immune system development in the small intestine of neonatal calves
Liang, G., Malmuthuge, N., Bao, H., Stothard, P., Griebel, P. J., & Guan, L. L. (2016) · BMC Genomics · doi:10.1186/s12864-016-2957-y · Cited by 84
Prebiotics to Fight Diseases: Reality or Fiction?
Bartolomeo, F. D., Startek, J. B., & den Ende, W. V. (2012) · Phytotherapy Research · doi:10.1002/ptr.4901 · Cited by 85
Effects of probiotic supplementation for the first 6 months of life on allergen‐ and vaccine‐specific immune responses
Taylor, A. L., Hale, J., Wiltschut, J., Lehmann, H. S., Dunstan, J. A., & Prescott, S. L. (2006) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2006.02553.x · Cited by 81
Lamina propria dendritic cells in the physiology and pathology of the gastrointestinal tract
Niess, J. H., & Reinecker, H. (2005) · Current Opinion in Gastroenterology · doi:10.1097/01.mog.0000181710.96904.58 · Cited by 80
Potentially probiotic bacteria induce efficient maturation but differential cytokine production in human monocyte-derived dendritic cells
Latvala, S., Pietilä, T. E., Veckman, V., Kekkonen, R. A., Tynkkynen, S., Korpela, R., & Julkunen, I. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.5570 · Cited by 79
Epigenome targeting by probiotic metabolites
Licciardi, P. V., Wong, S., Tang, M. L. K., & Karagiannis, T. C. (2010) · Gut Pathogens · doi:10.1186/1757-4749-2-24 · Cited by 79
Microbiota Manipulation With Prebiotics and Probiotics in Patients Undergoing Stem Cell Transplantation
Andermann, T. M., Rezvani, A. R., & Bhatt, A. S. (2016) · Current Hematologic Malignancy Reports · doi:10.1007/s11899-016-0302-9 · Cited by 78
Unraveling the ties between irritable bowel syndrome and intestinal microbiota
Hong, S. N. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2470 · Cited by 76
The gut mucosal immune system in the neonatal period
Battersby, A., & Gibbons, D. L. (2013) · Pediatric Allergy and Immunology · doi:10.1111/pai.12079 · Cited by 75
Human Intestinal Lamina Propria CD1c+ Dendritic Cells Display an Activated Phenotype at Steady State and Produce IL-23 in Response to TLR7/8 Stimulation
Dillon, S. M., Rogers, L. M., Howe, R., Hostetler, L. A., Buhrman, J. D., McCarter, M. D., & Wilson, C. C. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000041 · Cited by 75
Modulation of dendritic cell phenotype and functionin an in vitro model of the intestinal epithelium
Butler, M., Ng, C., van Heel, D. A., Lombardi, G., Lechler, R. I., Playford, R. J., & Ghosh, S. K. (2006) · European Journal of Immunology · doi:10.1002/eji.200535497 · Cited by 75
Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies
Hudson, L. E., Anderson, S. E., Corbett, A. H., & Lamb, T. J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00049-16 · Cited by 76
Effects of Multispecies Probiotic Combination on Helicobacter pylori Infection In Vitro
Myllyluoma, E., Ahonen, A.-M., Korpela, R., Vapaatalo, H., & Kankuri, E. M. (2008) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00080-08 · Cited by 77
Interactomics in the Human Intestine
Boesten, R. J., & de Vos, W. M. (2008) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e31817dbd62 · Cited by 74
The Immunological Basis of the Hygiene Hypothesis
Pfefferle, P. I., Teich, R., & Renz, H. (2008) · Springer eBooks · doi:10.1007/978-4-431-72802-3_19 · Cited by 73
Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis
Philippe, D., Heupel, E., Blum-Sperisen, S., & Riedel, C. U. (2011) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2010.12.020 · Cited by 73
Probiotic Therapy in the Prevention of Pouchitis Onset: Decreased Interleukin-1β, Interleukin-8, and Interferon-γ Gene Expression
Lammers, K. M., Vergopoulos, A., Babel, N., Gionchetti, P., Rizzello, F., Morselli, C., Caramelli, E., Fiorentino, M., D’Errico, A., Volk, H., et al. (2005) · Inflammatory Bowel Diseases · doi:10.1097/01.mpa.0000160302.40931.7b · Cited by 73
Self-citation
Regulation of the IL-10/IL-12 axis in human dendritic cells with probiotic bacteria
Gad, M., Ravn, P., Søborg, D. A., Lund-Jensen, K., Ouwehand, A. C., & Jensen, S. S. (2011) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2011.00835.x · Cited by 73
Lactic acid bacteria as adjuvants for sublingual allergy vaccines
Overtvelt, L. V., Moussu, H., Horiot, S., Samson, S., Lombardi, V., Mascarell, L., van de Moer, A., Bourdet‐Sicard, R., & Moingeon, P. E. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.02.009 · Cited by 72
Disease managing capacities and mechanisms of host effects of lactic acid bacteria
Ren, C., Faas, M. M., & de Vos, P. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1758625 · Cited by 68
Dietary Components and Immune Function
WATSON, R. R., Preedy, V. R., & Zibadi, S. (2010) · Humana Press eBooks · doi:10.1007/978-1-60761-061-8 · Cited by 73
Protective effects of Lactobacillus reuteri and Bifidobacterium infantis in murine models for colitis do not involve the vagus nerve
van der Kleij, H. P. M., O’Mahony, C., Shanahan, F., O’Mahony, L., & Bienenstock, J. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90434.2008 · Cited by 69
A double‐blind, placebo‐controlled study to assess the effect of a probiotic mixture on symptoms and inflammatory markers in women with diarrhea‐predominant IBS
Hod, K., Sperber, A. D., Ron, Y., Boaz, M., Dickman, R. M., Berliner, S. A., Halpern, Z., Maharshak, N., & Dekel, R. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13037 · Cited by 74
Intestinal dendritic cells
Ng, S. C., Kamm, M. A., Stagg, A. J., & Knight, S. C. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21247 · Cited by 71
Self-citation
Probiotics, Nuclear Receptor Signaling, and Anti-Inflammatory Pathways
Yoon, S. S., & Sun, J. (2011) · Gastroenterology Research and Practice · doi:10.1155/2011/971938 · Cited by 67
Cytokine expression in an ex vivo culture system of duodenal samples from dogs with chronic enteropathies: Modulation by probiotic bacteria
Sauter, S. N., Allenspach, K., Gaschen, F. P., Gröne, A., Ontsouka, E. C., & Blum, J. W. (2005) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2005.04.006 · Cited by 66
Probiotic Lactobacillus and Bifidobacterium Strains Counteract Adherent-Invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in Ulcerative Colitis, but Not in Crohn’s Disease
Leccese, G., Bibi, A., Mazza, S., Facciotti, F., Caprioli, F., Landini, P., & Paroni, M. (2020) · Cells · doi:10.3390/cells9081824 · Cited by 66
Immunomodulation of dendritic cells byLactobacillus reuterisurface components and metabolites
Engevik, M. A., Ruan, W. H., Esparza, M., Fultz, R., Shi, Z., Engevik, K. A., Engevik, A. C., Ihekweazu, F. D., Visuthranukul, C., Venable, S. F., et al. (2021) · Physiological Reports · doi:10.14814/phy2.14719 · Cited by 69
Human Gut Dendritic Cells Drive Aberrant Gut-specific T-cell Responses in Ulcerative Colitis, Characterized by Increased IL-4 Production and Loss of IL-22 and IFNγ
Mann, E. R., Bernardo, D., Ng, S. C., Rigby, R. J., Al-Hassi, H. O., Landy, J., Peake, S. T. C., Spranger, H., English, N. R., Thomas, L. V., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000223 · Cited by 65
Self-citation
The role of intestinal bifidobacteria on immune system development in young rats
Dong, P., Yang, Y., & Wang, W. (2010) · Early Human Development · doi:10.1016/j.earlhumdev.2010.01.002 · Cited by 65
Immuno-stimulatory activity of Astragalus polysaccharides in cyclophosphamide-induced immunosuppressed mice by regulating gut microbiota.
Li, Y., Zheng, J.-P., Wang, Y., Yang, H.-B., Cao, L.-C., Gan, S.-Y., Ma, J., & Liu, H. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.124789 · Cited by 75
Updates on treatment of irritable bowel syndrome
Hammerle, C. W., & Surawicz, C. M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.2639 · Cited by 65
Probiotic Properties of Lactic Acid Bacteria Isolated from Water-Buffalo Mozzarella Cheese
Jeronymo-Ceneviva, A. B., de Paula, A. T., Silva, L. F., Todorov, S. D., Franco, B. D. G. D. M., & Penna, A. L. B. (2014) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-014-9166-2 · Cited by 63
Clinical and symptom scores are significantly correlated with fecal microbiota features in patients with symptomatic uncomplicated diverticular disease: a pilot study
Kvasnovsky, C., Leong, L. E. X., Choo, J. M., Abell, G. C. J., Papagrigoriadis, S., Bruce, K. D., & Rogers, G. B. (2017) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000000995 · Cited by 66
Myocardial infarction and gut microbiota: An incidental connection
Vahed, S. Z., Barzegari, A., Tamayo, M. Z., Letourneur, D., & Pavon‐Djavid, G. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.11.008 · Cited by 65
Lactobacillus rhamnosus GGandStreptococcus thermophilusinduce suppressor of cytokine signalling 3 (SOCS3) gene expression directly and indirectly via interleukin-10 in human primary macrophages
Latvala, S., Miettinen, M., Kekkonen, R. A., Korpela, R., & Julkunen, I. (2011) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2011.04408.x · Cited by 61
Mechanisms and effectiveness of prebiotics in modifying the gastrointestinal microbiota for the management of digestive disorders
Whelan, K. (2013) · Proceedings of The Nutrition Society · doi:10.1017/s0029665113001262 · Cited by 61
Probiotic Bio-Three induces Th1 and anti-inflammatory effects in PBMC and dendritic cells
Hua, M. C. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i28.3529 · Cited by 61
Effects of bifidobacterial cytoplasm, cell wall and exopolysaccharide on mouse lymphocyte proliferation and cytokine production
Amrouche, T., Boutin, Y., Prioult, G., & Fliss, I. (2005) · International Dairy Journal · doi:10.1016/j.idairyj.2005.01.008 · Cited by 61
Perioperative Synbiotics Decrease Postoperative Complications in Periampullary Neoplasms: A Randomized, Double-Blind Clinical Trial
Sommacal, H. M., Bersch, V. P., Vitola, S. P., & Osvaldt, A. B. (2015) · Nutrition and Cancer · doi:10.1080/01635581.2015.1004734 · Cited by 60
Oral administration of Enterococcus faecalis FK-23 suppresses Th17 cell development and attenuates allergic airway responses in mice
Zhang, B., An, J., Shimada, T., Liu, S., & Maeyama, K. (2012) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2012.1010 · Cited by 62
Probiotics in dermatologic practice
Fuchs‐Tarlovsky, V., Marquez-Barba, M. F., & Sriram, K. (2015) · Nutrition · doi:10.1016/j.nut.2015.09.001 · Cited by 60
Differential immune-stimulatory effects of LTAs from different lactic acid bacteria via MAPK signaling pathway in RAW 264.7 cells
Jeong, J. H., Jang, S., Jung, B. J., Jang, K.-S., Kim, B., Chung, D. K., & Kim, H. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.11.002 · Cited by 59
Fermentation products: immunological effects on human and animal models
Granier, A., Goulet, O., & Hoarau, C. (2013) · Pediatric Research · doi:10.1038/pr.2013.76 · Cited by 61
Adenylate cycalse toxin ofBordetella pertussisinhibits TLR-induced IRF-1 and IRF-8 activation and IL-12 production and enhances IL-10 through MAPK activation in dendritic cells
Hickey, F. B., Brereton, C. F., & Mills, K. H. G. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208113 · Cited by 58
Plasmacytoid dendritic cells (PDC) are the major DC subset innately producing cytokines in human lymph nodes
Cox, K., North, M. E., Burke, M., Singhal, H., Renton, S. C., Aqel, N. M., Islam, S., & Knight, S. C. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1103532 · Cited by 58
Self-citation
Differential inflammatory mediator response in vitro from murine macrophages to lactobacilli and pathogenic intestinal bacteria
Marcinkiewicz, J., Ciszek‐Lenda, M., Bobek, M., Strus, M., Heczko, P., Kurnyta, M., Biedroń, R., & Chmielarczyk, A. (2007) · International Journal of Experimental Pathology · doi:10.1111/j.1365-2613.2007.00530.x · Cited by 57
Isolation of adhesive strains and evaluation of the colonization and immune response by Lactobacillus plantarum L2 in the rat gastrointestinal tract
Wang, B., Li, J., Li, Q., Zhang, H., & Li, N. (2009) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2009.03.016 · Cited by 56
Nutrition Modulation of Gastrointestinal Toxicity Related to Cancer Chemotherapy
Xue, H., Sawyer, M. B., Wischmeyer, P. E., & Baracos, V. E. (2011) · Journal of Parenteral and Enteral Nutrition · doi:10.1177/0148607110377338 · Cited by 56
Inhibitory Effects of Fermented Brown Rice on Induction of Acute Colitis by Dextran Sulfate Sodium in Rats
Kataoka, K., Ogasa, S., Kuwahara, T., Bando, Y., Hagiwara, M., Arimochi, H., Nakanishi, S., Iwasaki, T., & Ohnishi, Y. (2007) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-0063-3 · Cited by 56

Authors: Hart, A. L., Lammers, K., Brigidi, P., Vitali, B., Rizzello, F., Gionchetti, P., Campieri, M., Kamm, M. A., Knight, S. C., & Stagg, A. J.
Affiliations: Imperial College London (GB)
University of Bologna (IT)
St Mark's Hospital (GB)
Corresponding author: Stagg, A J
ORCID: Hart, A L
Brigidi, P
Rizzello, F
Gionchetti, P
Campieri, M
Kamm, M A
Knight, S C
Venue: Gut
Publisher: BMJ
Published: 2004-10-11
Volume: 53
Issue: 11
Pages: 1602-1609
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2003.037325
PMC: PMC1774301
OpenAlex: W1968082302
Cited by: 555
References: 41
Citations by year: 2026: 5 · 2025: 6 · 2024: 14 · 2023: 9 · 2022: 14 · 2021: 13 · 2020: 17 · 2019: 20 · 2018: 13 · 2017: 19 · 2016: 22 · 2015: 31 · 2014: 41 · 2013: 35 · 2012: 36
FWCI: 50.89
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: probiotic bacteria, dendritic cells, VSL#3, Bifidobacterium, lactobacilli, IL-10, dendritic cell maturation, interferon-gamma, IL-12, lipopolysaccharide, immunomodulation, inflammatory bowel disease, intestinal lamina propria
MeSH terms: Cell Differentiation, Cells, Cultured, Colon, Dendritic Cells, Humans, Interferon-gamma, Intestinal Mucosa, Phenotype, Up-Regulation, Immunophenotyping, Interleukin-10, Antigen Presentation, Th1 Cells, Interleukin-12, Probiotics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Modulation of human dendritic cell phenotype and function by probiotic bacteria

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks