The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas
Open accessAbstract
Background and aims: Hepatitis B virus (HBV) DNA integration into or close to cellular genes is frequently detected in HBV positive hepatocellular carcinomas (HCC). We have previously shown that viral integration can lead to aberrant target gene transcription. In this study, we attempted to investigate common pathways to hepatocarcinogenesis. Methods: By using a modified Alu-polymerase chain reaction approach, we analysed 50 HCCs along with 10 previously published cases. Results: Sixty eight cellular flanking sequences (seven repetitive or unidentified sequences, 42 cellular genes, and 19 sequences potentially coding for unknown proteins) were obtained. Fifteen cancer related genes and 25 cellular genes were identified. HBV integration recurrently targeted the human telomerase reverse transcriptase gene (three cases) and genes belonging to distinct pathways: calcium signalling related genes, 60s ribosomal protein encoding genes, and platelet derived growth factor and mixed lineage leukaemia encoding genes. Two tumour suppressor genes and five genes involved in the control of apoptosis were also found at the integration site. The viral insertion site was distributed over all chromosomes except 13, X, and Y. Conclusions: In 61/68 (89.7%) cases, HBV DNA was integrated into cellular genes potentially providing cell growth advantage. Identification of recurrent viral integration sites into genes of the same family allows recognition of common cell signalling pathways activated in hepatocarcinogenesis.
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Seeger, C., & Mason, W. S. (2000) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.64.1.51-68.2000 · Cited by 1,451
Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
Wang, J., Chenivesse, X., Henglein, B., & Bréchot, C. (1990) · Nature · doi:10.1038/343555a0 · Cited by 671
Self-citationMultiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas
Payne, G. S., Bishop, J. M., & Varmus, H. E. (1982) · Nature · doi:10.1038/295209a0 · Cited by 611
Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18549 · Cited by 562
Günther, S., Li, B. C., Miska, S., Krüger, D. H., Meisel, H., & Will, H. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5437-5444.1995 · Cited by 499
Tbe complete nudeotide sequences of the cloned hepatitis B vims DNA; subtype adr and adw
Ono, Y., Onda, H., Sasada, R., Igarashi, K., Sugino, Y., & Nishioka, K. (1983) · Nucleic Acids Research · doi:10.1093/nar/11.6.1747 · Cited by 427
New genes involved in cancer identified by retroviral tagging
Suzuki, T., Shen, H., Akagi, K., Morse, H. C., Malley, J. D., Naiman, D. Q., Jenkins, N. A., & Copeland, N. G. (2002) · Nature Genetics · doi:10.1038/ng949 · Cited by 420
Paterlini-Bréchot, P., Saigo, K., Murakami, Y., Chami, M., Gozuacik, D., Mugnier, C., Lagorce, D., & Bréchot, C. (2003) · Oncogene · doi:10.1038/sj.onc.1206492 · Cited by 354
Self-citationMurine T lymphomas in which the cellular myc oncogene has been activated by retroviral insertion
Corcoran, L. M., Adams, J. M., Dunn, A. R., & Cory, S. (1984) · Cell · doi:10.1016/0092-8674(84)90306-4 · Cited by 345
Esteller, M., & Herman, J. G. (2004) · Oncogene · doi:10.1038/sj.onc.1207316 · Cited by 326
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Mechanisms of HBV-induced hepatocellular carcinoma
Levrero, M., & Zucman-Rossi, J. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.021 · Cited by 1,052
Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma
Sung, W.-K., Zheng, H., Li, S., Chen, R., Liu, X., Li, Y., Lee, N. P., Lee, W. H., Ariyaratne, P. N., Tennakoon, C., et al. (2012) · Nature Genetics · doi:10.1038/ng.2295 · Cited by 991
Pathogenesis of hepatitis B virus infection
Chisari, F. V., Isogawa, M., & Wieland., S. F. (2010) · Pathologie Biologie · doi:10.1016/j.patbio.2009.11.001 · Cited by 414
Mak, L.-Y., Wong, D. K.-H., Pollicino, T., Raimondo, G., Hollinger, F. B., & Yuen, M.-F. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.042 · Cited by 223
Guo, X., Nie, H., Zhang, W., Li, J., Ge, J., Xie, B., Hu, W., Zhu, Y., Zhong, N., Zhang, X., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.01.001 · Cited by 100
Metadata
- Authors
- Murakami, Y., Saigo, K., Takashima, H., Minami, M., Okanoue, T., Bréchot, C., & Paterlini-Bréchot, P.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-07-11
- Volume
- 54
- Issue
- 8
- Pages
- 1162-1168
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2120650696
- Cited by
- 331
- References
- 38
- FWCI
- 10.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Murakami, Y., Saigo, K., Takashima, H., Minami, M., Okanoue, T., Bréchot, C., & Paterlini-Bréchot, P. (2005). Large scaled analysis of hepatitis B virus (HBV) DNA integration in HBV related hepatocellular carcinomas. Gut. https://doi.org/10.1136/gut.2004.054452
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