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Clinical, microbiological, and immunological effects of fructo-oligosaccharide in patients with Crohn's disease
Open accessAbstract
BACKGROUND AND AIMS: The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease. PATIENTS AND METHODS: Ten patients with active ileocolonic Crohn's disease received 15 g of FOS for three weeks. Disease activity was measured using the Harvey Bradshaw index. Faecal and mucosal bifidobacteria were quantified by fluorescence in situ hybridisation, and mucosal dendritic cell IL-10 and Toll-like receptor (TLR) expression were assessed by flow cytometry of dissociated rectal biopsies. RESULTS: FOS induced a significant reduction in the Harvey Bradshaw index from 9.8 (SD 3.1) to 6.9 (3.4) (p<0.01). There was a significant increase in faecal bifidobacteria concentration from 8.8 (0.9) log(10) to 9.4 (0.9) log(10) cells/g dry faeces (p<0.001). The percentage of IL-10 positive dendritic cells increased from 30 (12)% to 53 (10)% (p=0.06). Finally, the percentage of dendritic cells expressing TLR2 and TLR4 increased from 1.7 (1.7)% to 36.8 (15.9)% (p=0.08) and from 3.6 (3.6)% to 75.4 (3.4)% (p<0.001), respectively. CONCLUSIONS: FOS supplementation increases faecal bifidobacteria concentrations and modifies mucosal dendritic cell function. This novel therapeutic strategy appears to decrease Crohn's disease activity in a small open label trial and therefore warrants further investigation.
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“an open label trial of fructo-oligosaccharide in CD showed promise,79”
From The gut microbiota and host health: a new clinical frontier (2016) · cites this paper as [79]
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“Additionally, prebiotic use has been shown to improve mucosal dendritic cell function associated with TLR2 activity [62], and increase the expression of glucagon-like peptide 2, associated with GI barrier regulation [59].”
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Cites
Recognition of Commensal Microflora by Toll-Like Receptors Is Required for Intestinal Homeostasis
Rakoff-Nahoum, S., Paglino, J., Eslami-Varzaneh, F., Edberg, S., & Medzhitov, R. (2004) · Cell · doi:10.1016/j.cell.2004.07.002 · Cited by 4,251
Amann, R., Binder, B. J., Olson, R. J., Chisholm, S. W., Devereux, R., & Stahl, D. A. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.6.1919-1925.1990 · Cited by 4,049
A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY
Harvey, R. F., & Bradshaw, J. M. (1980) · The Lancet · doi:10.1016/s0140-6736(80)92767-1 · Cited by 2,974
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
Kadowaki, N., Ho, S., Antonenko, S., de Waal Malefyt, R., Kastelein, R. A., Bazan, F., & Liu, Y.-J. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.863 · Cited by 1,964
Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria
Macpherson, A. J., & Uhr, T. (2004) · Science · doi:10.1126/science.1091334 · Cited by 1,584
Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin
Gibson, G. R., Beatty, E. R., Wang, X., & Cummings, J. H. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90192-2 · Cited by 1,529
Sellon, R. K., Tonkonogy, S., Schultz, M., Dieleman, L. A., Grenther, W., Balish, E., Rennick, D. M., & Sartor, R. B. (1998) · Infection and Immunity · doi:10.1128/iai.66.11.5224-5231.1998 · Cited by 1,483
Mucosal flora in inflammatory bowel disease
Swidsinski, A. V., Ladhoff, A., Pernthaler, A., Swidsinski, S., Loening-Baucke, V. A., Ortner, M., Weber, J., Hoffmann, U., Schreiber, S., Dietel, M., et al. (2002) · Gastroenterology · doi:10.1053/gast.2002.30294 · Cited by 1,344
Manz, W., Amann, R., Ludwig, W., Vancanneyt, M., & SCHLEIFER, K. H. (1996) · Microbiology · doi:10.1099/13500872-142-5-1097 · Cited by 1,176
Research works printed but not linked: 1
- Stagg AJ, Kamm MA, Knight SC. Intestinal dendritic cells increase T cell expression of alpha4 beta7 integrin. Eur J Immunol 2002;32:1445-54.
Cited by
Sorted by citations
Items 201–300 of 469
Ryz, N. R., Meddings, J. B., & Taylor, C. G. (2008) · British Journal Of Nutrition · doi:10.1017/s000711450812342x · Cited by 32
do Nascimento, R. D. P., Moya, A. M. T. M., Machado, A. P. D. F., Geraldi, M. V., Diez‐Echave, P., Vezza, T., Gálvez, J., Cazarin, C. B. B., & Maróstica, M. R. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109796 · Cited by 32
Plant-Derived Prebiotics and Its Health Benefits
Althubiani, A. S., Alghamdi, S., Samreen, S., Qais, F. A., Khan, M. S., Ahmad, I., & Malak, H. A. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814619-4.00004-5 · Cited by 32
Probiotic Ameliorating Effects of Altered GABA/Glutamate Signaling in a Rodent Model of Autism
Bin-Khattaf, R. M., Alonazi, M. A., Al-Dbass, A. M., Almnaizel, A. T., Aloudah, H. S., Soliman, D. A., & El-Ansary, A. K. (2022) · Metabolites · doi:10.3390/metabo12080720 · Cited by 30
High-Fiber Diet and Crohn’s Disease: Systematic Review and Meta-Analysis
Serrano-Fernandez, V., Palomino, M. S., Laredo‐Aguilera, J. A., Pozuelo‐Carrascosa, D. P., & Carmona‐Torres, J. M. (2023) · Nutrients · doi:10.3390/nu15143114 · Cited by 32
Vitetta, L., Briskey, D. R., Hayes, E., Shing, C. M., & Peake, J. M. (2012) · Inflammopharmacology · doi:10.1007/s10787-012-0126-8 · Cited by 29
From Gut to Eye: Exploring the Role of Microbiome Imbalance in Ocular Diseases
Tîrziu, A.-T., Șușan, M. M., Șușan, R. M., Sonia, T., Harich, O. O., Tudora, A. G., Varga, N.-I., Dragomir, T. L., Avram, C. R., Boru, C., et al. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13185611 · Cited by 33
Papalois, A. E., Gioxari, A., Kaliora, A. C., Lymperopoulou, A., Agrogiannis, G. D., Papada, E., & Andrikopoulos, N. K. (2012) · Journal of Medicinal Food · doi:10.1089/jmf.2012.0018 · Cited by 28
Park, S., Kang, Y., Koh, H., & Kim, S. (2020) · Korean Journal of Pediatrics · doi:10.3345/cep.2019.00500 · Cited by 28
The effects and cell barrier mechanism of main dietary nutrients on intestinal barrier
Fan, J., Yang, Y., Ma, C., Liu, X., Wang, Y., Chen, F., Wang, B., Bian, X., Yang, C., & Zhang, N. (2022) · Current Opinion in Food Science · doi:10.1016/j.cofs.2022.100942 · Cited by 28
Crouch, L. I., Rodrigues, C. S., Bakshani, C. R., Tavares-Gomes, L., Gaifem, J., & Pinho, S. S. (2024) · Seminars in Immunology · doi:10.1016/j.smim.2024.101891 · Cited by 29
Metabolomic analysis of amino acid metabolism in colitic rats supplemented with lactosucrose
Ruan, Z., Lv, Y., Fu, X., He, Q., Deng, Z., Liu, W., Yu, Y., Wu, X., Wu, G., Wu, X., et al. (2013) · Amino Acids · doi:10.1007/s00726-013-1535-8 · Cited by 27
Paraclostridium bifermentans exacerbates pathosis in a mouse model of ulcerative colitis
Kutsuna, R., Tomida, J., Morita, Y., & Kawamura, Y. (2018) · PLoS ONE · doi:10.1371/journal.pone.0197668 · Cited by 27
Hufnagel, B., Müllner, V., Hlatky, K., Tallian, C., Vielnascher, R., Guebitz, G. M., Wirth, M., & Gabor, F. (2020) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117091 · Cited by 30
Gut Microbiota Modulation in IBD: From the Old Paradigm to Revolutionary Tools
Murgiano, M., Bartocci, B., Puca, P., Vincenzo, F. D., GAUDIO, A. D., Papa, A., Cammarota, G., Gasbarrini, A., Scaldaferri, F., & Lopetuso, L. R. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073059 · Cited by 30
Joo, E., Yamane, S., Hamasaki, A., Harada, N., Matsunaga, T., Muraoka, A., Suzuki, K., Nasteska, D., Fukushima, T., Hayashi, T., et al. (2012) · Nutrition · doi:10.1016/j.nut.2012.09.007 · Cited by 26
Nutraceuticals in rodent models as potential treatments for human Inflammatory Bowel Disease
Ghattamaneni, N. K. R., Panchal, S. K., & Brown, L. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.04.015 · Cited by 26
Basak, S., Hridayanka, K. S. N., & Duttaroy, A. K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1323233 · Cited by 29
Ariaee, A., Koentgen, S., Wardill, H. R., Hold, G. L., Prestidge, C. A., Armstrong, H., & Joyce, P. (2024) · eGastroenterology · doi:10.1136/egastro-2023-100055 · Cited by 27
Zhang, Z., Hyun, J. E., Thiesen, A., Park, H., Hotte, N., Watanabe, H., Higashiyama, T., & Madsen, K. L. (2020) · Nutrients · doi:10.3390/nu12072088 · Cited by 26
Gut Microbiota: A Promising Milestone in Enhancing the Efficacy of PD1/PD-L1 Blockade Therapy
Zhou, Y., Liu, Z., & Chen, T. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.847350 · Cited by 25
Prebiotic inulin‐type fructans: nutritional benefits beyond dietary fibre source
Alexiou, H., & Franck, A. (2008) · Nutrition Bulletin · doi:10.1111/j.1467-3010.2008.00710.x · Cited by 25
Dendritic cells: the yin and yang in disease progression
Jiménez‐Cortegana, C., Palomares, F., Álba, G., Santa‐María, C., de la Cruz‐Merino, L., Sánchez‐Margalet, V., & López-Enríquez, S. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1321051 · Cited by 24
Lee, J., Kim, K. S., Koh, H., Lee, D.-W., & Kang, N. J. (2022) · Current Developments in Nutrition · doi:10.1093/cdn/nzac110 · Cited by 26
Arabinoxylan and Pectin Metabolism in Crohn’s Disease Microbiota: An In Silico Study
Sabater, C., Calvete‐Torre, I., Ruíz, L., & Margollés, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137093 · Cited by 24
Gut microbiome–based therapeutics in inflammatory bowel disease
Hu, K. A., & Gubatan, J. M. B. (2023) · Clinical and Translational Discovery · doi:10.1002/ctd2.182 · Cited by 25
Prebiotics, Probiotics and Helminths: The ‘Natural’ Solution?
Guarner, F. (2009) · Digestive Diseases · doi:10.1159/000228582 · Cited by 23
Crohn’s disease as an immunodeficiency
Hayee, B., Rahman, F. Z., Sewell, G. W., Smith, A. M., & Segal, A. W. (2010) · Expert Review of Clinical Immunology · doi:10.1586/eci.10.32 · Cited by 23
Magri, A., de Oliveira, M. R., Baldo, C., Tischer, C. A., Sartori, D., Mantovani, M. S., & Celligoi, M. A. P. C. (2019) · Journal of Applied Microbiology · doi:10.1111/jam.14569 · Cited by 22
Schölmerich, J. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1326.026 · Cited by 23
Prebiotics: types, selectivity and utilization by gut microbes
Yalçıntaş, Y. M., Bolino, M. J., Duman, H., Sarıtaş, S., Pekdemir, B., Kalkan, A. E., Canbolat, A. A., Bolat, E., Eker, F., Rocha, J. M., et al. (2025) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2025.2582557 · Cited by 24
Fujiwara, H. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.703298 · Cited by 22
Fiorindi, C., Russo, E., Balocchini, L., Amedei, A., & Giudici, F. (2022) · Nutrients · doi:10.3390/nu14194117 · Cited by 23
Hartzell, A. L., Maldonado-Gómez, M. X., Yang, J., Hutkins, R. W., & Rose, D. J. (2013) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2013.08.001 · Cited by 21
Gibson, G. R., & Delzenne, N. M. (2008) · Nutrition Today · doi:10.1097/01.nt.0000303311.36663.39 · Cited by 21
Gut microflora: a new target for therapeutic approaches in inflammatory bowel disease
Mitsuyama, K., & Sata, M. (2008) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.12.3.301 · Cited by 22
Bahadorı, F., Akinan, B. S., Akyıl, S., & Eroğlu, M. S. (2019) · Organic Communications · doi:10.25135/acg.oc.63.19.07.1336 · Cited by 20
Isidori, M., Corbee, R. J., & Trabalza‐Marinucci, M. (2022) · Veterinary Sciences · doi:10.3390/vetsci9020037 · Cited by 24
Components of the Fiber Diet in the Prevention and Treatment of IBD—An Update
Ferenc, K., Jarmakiewicz-Czaja, S., & Filip, R. (2022) · Nutrients · doi:10.3390/nu15010162 · Cited by 21
The gut mucin-microbiota interactions: a missing key to optimizing endurance performance
Clark, A. P., & Mach, N. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1284423 · Cited by 22
Perreau, C., Thabuis, C., Verstrepen, L., Ghyselinck, J., & Marzorati, M. (2023) · Nutrients · doi:10.3390/nu15194229 · Cited by 20
Oral microbiome dysbiosis and gastrointestinal diseases: a narrative review
El-Ghannam, M., Hassanien, M. H., Ameen, Y. A., Turky, E. A., ELattar, G. M., Ray, A. A. E., & Eltalkawy, M. D. (2024) · Egyptian Liver Journal · doi:10.1186/s43066-024-00340-9 · Cited by 20
Nutrition and inflammatory bowel disease
Tighe, M. P., Cummings, F. J. R., & Afzal, N. A. (2011) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328349eb4d · Cited by 19
Haskey, N., Gold, S. L., Faith, J. J., & Raman, M. (2023) · Nutrients · doi:10.3390/nu15051080 · Cited by 19
Tuck, C. J., Caminero, A., Jiménez-Vargas, N. N., Soltys, C., Polanco, J. O. J., Lopez, C. D. L., Constante, M., Lourenssen, S. R., Verdu, E. F., Muir, J. G., et al. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13675 · Cited by 18
Role of the gut microbiome in psychological symptoms associated with inflammatory bowel diseases
Atanasova, K., Knödler, L.-L., Reindl, W., Ebert, M. P. A., & Thomann, A. (2025) · Seminars in Immunopathology · doi:10.1007/s00281-025-01036-x · Cited by 19
Xu, T., Sun, R., Zhang, Y., Zhang, C., Wang, Y., Wang, Z. A., & Du, Y. (2022) · Molecules · doi:10.3390/molecules27217622 · Cited by 18
Aldubayan, M. A., Mao, X., Laursen, M. F., Pigsborg, K., Christensen, L. H., Roager, H. M., Nielsen, D. S., Hjorth, M. F., & Magkos, F. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1108088 · Cited by 19
Islam, P., Ice, J. A., Alake, S. E., Adedigba, P. A., Hatter, B., Robinson, K., Clarke, S. L., Versypt, A. N. F., Ritchey, J. W., Lucas, E. A., et al. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziae021 · Cited by 17
Potential of prebiotics as functional foods – a review
Sarkar, S. (2007) · Nutrition & Food Science · doi:10.1108/00346650710749062 · Cited by 17
Integrative medicine and human health ‐ the role of pre‐, pro‐ and synbiotics
Bengmark, S. (2012) · Clinical and Translational Medicine · doi:10.1186/2001-1326-1-6 · Cited by 17
Intestinal barrier function in neonatal foals: Options for improvement
Vendrig, J. C., & Fink‐Gremmels, J. (2012) · The Veterinary Journal · doi:10.1016/j.tvjl.2012.01.032 · Cited by 17
Hepburn, N. J., Garaiová, I., Williams, E. A., Michael, D. R., & Plummer, S. (2013) · Beneficial Microbes · doi:10.3920/bm2013.0012 · Cited by 17
Eating away cancer: the potential of diet and the microbiome for shaping immunotherapy outcome
Nguyen, N.-T. A., Jiang, Y., & McQuade, J. L. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1409414 · Cited by 19
McKenzie, N. D., Hong, H. S., Ahmad, S., & Holloway, R. W. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103165 · Cited by 16
da Silva, B. P., Martino, H. S. D., & Tako, E. (2021) · Food & Function · doi:10.1039/d1fo01159f · Cited by 16
Clarke, S. T., Brooks, S. P. J., Inglis, G. D., Yanke, L. J., Green, J., Petronella, N., Ramdath, D. D., Berčík, P., Green-Johnson, J. M., & Kalmokoff, M. L. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517002318 · Cited by 16
Changes of intestinal microbiota and microbiota-based treatments in IBD
Li, Q., Zhou, S., Wang, Y., & Cong, J. (2022) · Archives of Microbiology · doi:10.1007/s00203-022-03069-4 · Cited by 16
Short fungal fractions of β-1,3 glucans affect platelet activation
Vancraeyneste, H., Charlet, R., Guérardel, Y., Choteau, L., Bauters, A., Tardivel, M., François, N., Dubuquoy, L., Soloviev, D. A., Poulain, D., et al. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00907.2015 · Cited by 15
Munsell, M. A., & Mullin, G. E. (2009) · CRC Press eBooks · doi:10.1201/9781420067637.ch14 · Cited by 15
Is the Gut Microbiota a Neglected Aspect of Gut and Brain Disorders?
Balan, Y., Archana Gaur, T., Sakthivadivel, V., Kamble, B. D., & Sundaramurthy, R. (2021) · Cureus · doi:10.7759/cureus.19740 · Cited by 14
Functional foods for the gut: probiotics, prebiotics and synbiotics
Drakoularakou, A., Rastall, R. A., & Gibson, G. R. (2011) · Elsevier eBooks · doi:10.1533/9780857092557.3.449 · Cited by 14
Haag, L.-M., & Siegmund, B. (2014) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2014.04.001 · Cited by 14
Microbial Modulation in Inflammatory Bowel Diseases
Yu, J., & Cheon, J. H. (2022) · Immune Network · doi:10.4110/in.2022.22.e44 · Cited by 13
[Impact of nutritional treatment in the evolution of inflammatory bowel disease].
Ballesteros-Pomar, M. D., Casariego, A. V., Fernández, A. C., Gómez, J. J. L., Fondo, A. U., & Rodríguez, I. C. (2010) · PubMed · Cited by 13
Baldi, S., Sarikaya, D., Lotti, S., Cuffaro, F., Fink, D., Colombini, B., Sofi, F., & Amedei, A. (2025) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2025.05.012 · Cited by 13
The Gut Microbiota and Inflammatory Bowel Disease
Conrad, M. A., Wu, G. D., & Kelsen, J. R. (2017) · Springer eBooks · doi:10.1007/978-3-319-49215-5_4 · Cited by 12
Chicory Inulin: A Versatile Biopolymer with Nutritional and Therapeutic Properties
Malik, B., & Rehman, R. U. (2021) · Springer eBooks · doi:10.1007/978-3-030-58975-2_16 · Cited by 12
Parian, A. M., Mullin, G. E., Langhorst, J., & Brown, A. C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35868-2.00050-5 · Cited by 15
Conno, B. D., Pesce, M., Chiurazzi, M., Andreozzi, M., Rurgo, S., Corpetti, C., Seguella, L., Re, A., Palenca, I., Esposito, G., et al. (2022) · Foods · doi:10.3390/foods11071044 · Cited by 12
Prebiotics in Inflammatory Bowel Diseases
Guarner, F. (2008) · CRC Press eBooks · doi:10.1201/9780849381829.ch18 · Cited by 12
Potential of probiotics as pharmaceutical agent: a review
Sarkar, S. (2013) · British Food Journal · doi:10.1108/bfj-06-2011-0163 · Cited by 13
Crittenden, R. G., & PLAYNE, M. J. (2008) · Wiley eBooks · doi:10.1002/9780470432624.ch7 · Cited by 13
High-yield production and purification of prebiotic inulin-type fructooligosaccharides
Wienberg, F., Hövels, M., & Deppenmeier, U. (2022) · AMB Express · doi:10.1186/s13568-022-01485-9 · Cited by 11
Ribeiro, P. V. D. M., Veloso, T. G. R., de Oliveira, L. L., Mendes, N. P., & Alfenas, R. D. C. G. (2023) · Brazilian Journal of Microbiology · doi:10.1007/s42770-023-01140-w · Cited by 12
Pathophysiology of Inflammatory Bowel Diseases
Hoentjen, F., & Dieleman, L. A. (2008) · CRC Press eBooks · doi:10.1201/9780849381829.ch17 · Cited by 11
Kaliyamoorthy, V., Jacop, J. P., Thirugnanasambantham, K., Ibrahim, H.-I. M., & Kandhasamy, S. (2022) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-022-03424-z · Cited by 11
The Microbiome in Visceral Medicine: Inflammatory Bowel Disease, Obesity and Beyond
Chiriac, M. T., Mahapatro, M., Neurath, M. F., & Becker, C. (2017) · Visceral Medicine · doi:10.1159/000470892 · Cited by 11
Yoo, Y., Kim, S., Lee, W., Kim, J., Son, B., Lee, K. J., & Shin, H. (2024) · mSystems · doi:10.1128/msystems.01189-24 · Cited by 10
Prebiotic Carbohydrates for Therapeutics
Basavaiah, R., & Gurudutt, P. S. (2020) · Endocrine Metabolic & Immune Disorders - Drug Targets · doi:10.2174/1871530320666200929140522 · Cited by 10
Fecal Microbiota Transplantation Combined with Prebiotics Ameliorates Ulcerative Colitis in Mice
Qian, X., Jiang, H., Yao, W., Shao, H., He, W., He, Y., Bao, X., He, L., Jia, Y., & Xu, Z. (2023) · Future Microbiology · doi:10.2217/fmb-2023-0001 · Cited by 11
CARACTERIZACIÓN FÍSICA, NUTRICIONAL Y NO NUTRICIONAL DE LAS SEMILLAS DE INGA PATERNO
Sánchez-Mendoza, N. A., Jiménez‐Martínez, C., Cardador‐Martínez, A., del Campo, S. T. M., & Dávila-Ortíz, G. (2016) · Revista chilena de nutrición · doi:10.4067/s0717-75182016000400010 · Cited by 10
Dietary Fiber and Gastrointestinal Disease: an Evolving Story
O’Grady, J., & Shanahan, F. (2018) · Current Gastroenterology Reports · doi:10.1007/s11894-018-0667-0 · Cited by 10
Costa, M. D. O., Fouhse, J. M., Silva, A. P. S. P., Willing, B. P., & Harding, J. C. S. (2020) · PLoS ONE · doi:10.1371/journal.pone.0231942 · Cited by 11
Loo, J. V., & Bosscher, D. (2014) · ASM Press eBooks · doi:10.1128/9781555815462.ch11 · Cited by 10
Novel therapeutic modalities in pediatric inflammatory bowel disease.
Shteyer, E., & Wilschanski, M. A. (2008) · PubMed · Cited by 10
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Brotherton, C., & Taylor, A. G. (2013) · Gastroenterology Nursing · doi:10.1097/sga.0b013e3182a67a9a · Cited by 10
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Metadata
- Authors
- Lindsay, J. O.
- Affiliations
- Royal London Hospital (GB)
- Corresponding author
- Lindsay, J O
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2006-03-01
- Volume
- 55
- Issue
- 3
- Pages
- 348-355
- ISSN
- 0017-5749 (ISSN-L)
- PMC
- PMC1856087
- OpenAlex
- W2164571061
- Cited by
- 471
- References
- 55
- Citations by year
- 2026: 9 · 2025: 19 · 2024: 33 · 2023: 19 · 2022: 35 · 2021: 26 · 2020: 32 · 2019: 20 · 2018: 21 · 2017: 18 · 2016: 21 · 2015: 18 · 2014: 26 · 2013: 21 · 2012: 22
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- fructooligosaccharides, Crohn's disease, Bifidobacterium, dendritic cells, IL-10, TLR2, TLR4, gut microbiota, mucosal immunity, disease activity, prebiotics, rectal mucosa
- MeSH terms
- Adult, Bifidobacterium, Crohn Disease, Dendritic Cells, Feces, Female, Humans, Intestinal Mucosa, Male, Middle Aged, Oligosaccharides, Patient Compliance, Severity of Illness Index, Immunity, Mucosal, Toll-Like Receptors
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