CoChat
Sign Up
Cited by 83

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Central adiposity, regional fat distribution, and the risk of cholecystectomy in women

Tsai, C-J, Leitzmann, M F, Willett, W C, Giovannucci, E L·2006·Gut
DOI 10.1136/gut.2005.076133
Open this paper in CoChat — free account

Abstract

Purpose: Whether central adiposity contributes independently of total adiposity to the risk for gall stones is inconclusive. We examined prospectively indicators of central adiposity in relation to the occurrence of gall stone disease. Methods: We evaluated the relationship between abdominal circumference and waist to hip ratio and risk of cholecystectomy in a cohort of women who had no history of gall stone disease. As part of the Nurses’ Health Study, the women reported on questionnaires their weights, heights, and waist and hip circumferences, and the occurrence of cholecystectomy. A total of 42 312 women, aged 39–66 years in 1986, who were free of prior gall stone disease, provided complete waist and hip circumference measurements in 1986. Results: We documented 3197 cases of cholecystectomy during 514 283 person years of follow up. After adjusting simultaneously for regional (waist circumference or waist to hip ratio) and total adiposity (body mass index) measures as well as for other risk factors of gall stone disease, women with a height adjusted waist circumference of 36 inches or larger had a relative risk (RR) of 1.96 (95% confidence interval (CI) 1.53–2.51; p trend <0.0001) compared with women with a height adjusted waist circumference of less than 26 inches. Waist to hip ratio was directly associated with the risk, with an RR of 1.39 (95% CI 1.16–1.66; p trend <0.0001) for women with a waist to hip ratio of 0.86 or higher compared with women with a waist to hip ratio of less than 0.70. Conclusion: Abdominal circumference and waist to hip ratio were associated with an increased risk of cholecystectomy, independently of body mass index in women.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/gut.2005.076133

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Both obesity and abdominal obesity increase the risk of stone formation and of requiring cholecystectomy because of higher likelihood of symptomatic stones.

    “Both obesity and abdominal obesity increase the risk not only of stone formation but also of requiring surgical treatment (cholecystectomy) because of the higher likelihood of presenting with symptomatic stones [10,12,13].”

    From Excess Body Weight and Gallstone Disease (2021) · cites this paper as [10]

    The Results and Conclusion (pages unavailable) associate abdominal adiposity with increased cholecystectomy risk in women, independently of BMI. The Methods say symptomatic gallstones are the main indication for surgery, but the Discussion says the study did not screen for gallstones. It therefore does not establish that obesity increases stone formation or that a greater likelihood of stones becoming symptomatic explains the surgical risk. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Increased risk associated with abdominal adiposity can occur independently of BMI.

    “The increased risk associated with abdominal adiposity can occur independently of BMI, as illustrated in 2 cohorts from the USA [10,11].”

    From Excess Body Weight and Gallstone Disease (2021) · cites this paper as [10]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Flagged first, then by citations

Research works printed but not linked: 29

  1. 10.1136/bmj.322.7278.91 · DOI
  2. 10.1046/j.1365-2036.2003.01439.x · DOI
  3. Cohen DE. Pathogenesis of gallstones. In: Zakim D, Boyer TD, eds. Hepatology: a textbook of liver disease, 4th Edn. Philadelphia: WB Saunders 2002:1713–43.
  4. 10.1002/hep.510310238 · DOI
  5. 10.1161/01.ATV.10.4.497 · DOI · Paper page
  6. 10.1210/jcem-54-2-254 · DOI · Paper page
  7. 1991, Eur J Gastroenterol Hepatol, 3, 745
  8. 10.1016/S0168-8278(01)00180-5 · DOI
  9. 1989, Am J Epidemiol, 129, 587, 10.1093/oxfordjournals.aje.a115171 · DOI · Paper page
  10. 10.1053/jhep.2002.33336 · DOI
  11. 1995, Scand J Gastroenteol, 30, 372, 10.3109/00365529509093293 · DOI
  12. 1997, Arch Med Res, 28, 543
  13. Sleisenger MH, Fordtran JS, eds. Gastrointestinal and liver disease: pathophysiology, diagnosis, management. Philadelphia: WB Saunders, 2002.
  14. 1992, Am J Clin Nutr, 55, 1033, 10.1093/ajcn/55.6.1033 · DOI
  15. 10.1097/00001648-199011000-00009 · DOI · Paper page
  16. Rothman KJ, Greenland S. Modern epidemiology. Philadelphia: Lippincott Williams & Wilkins, 1998.
  17. 1990, J Am Diet Assoc, 90, 1697, 10.1016/S0002-8223(21)01878-2 · DOI
  18. 10.1016/0026-0495(70)90062-4 · DOI · Paper page
  19. 1986, Am J Clin Nutr, 44, 739, 10.1093/ajcn/44.6.739 · DOI · Paper page
  20. 10.1172/JCI111040 · DOI
  21. 1994, Am J Epidemiol, 140, 989, 10.1093/oxfordjournals.aje.a117206 · DOI
  22. Willett WC. Nutritional epidemiology, 2nd Edn. New York: Oxford University Press 1998. · DOI · Paper page
  23. 2001, Hepatology, 34, 877, 10.1053/jhep.2001.29005 · DOI
  24. 10.3109/07853890108995963 · DOI
  25. 10.1385/ENDO:13:2:155 · DOI
  26. 10.1210/edrv-14-1-72 · DOI
  27. 10.1016/0003-9861(74)90412-3 · DOI
  28. 10.1016/S0168-8278(98)80282-1 · DOI
  29. 1998, Int J Obes Relat Metab Disord, 22, 294, 10.1038/sj.ijo.0800583 · DOI

Cited by

Sorted by citations

Metadata

Authors
Tsai, C.-J., Leitzmann, M. F., Willett, W. C., & Giovannucci, E. L.
Venue
Gut
Publisher
BMJ
Published
2006-02-14
Volume
55
Issue
5
Pages
708-714
ISSN
  • 0017-5749
  • 1468-3288
DOI
10.1136/gut.2005.076133
Cited by
83
References
1
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review