The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors
Abstract
[Extract] The emergence of autoimmunity, including Crohn’s disease (CD) where the immune relationship with commensal bacteria is corrupted, has been linked to hygiene.1 2 A gradual decline in endoparasites is but one argument that might explain this phenomenon.3 Weinstock and colleagues have successfully tested the pig whipworm, Trichuris suis, in patients with inflammatory bowel disease (IBD).4 5 However, repeated inoculation was required and concern has been raised that aberrant migration could occur.6 The haematophagous hookworm, Necator americanus (NA), is proposed as an alternative. We have tested if CD patients tolerate hookworm infection, and the practical issues associated with establishing reservoir donors (RDs).
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“Patients with Crohn disease were infected with N americanus, with the majority showing improvements in symptom scores.87”
From Global issues in allergy and immunology: Parasitic infections and allergy (2017) · cites this paper as [87]
Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Lee, W. M. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021844 · Cited by 1,594
Research works printed but not linked: 10
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- 10.1056/NEJMra020831 · DOI
- 10.1067/mlc.2002.124343 · DOI
- 10.1053/j.gastro.2005.01.005 · DOI · Paper page
- 10.1136/gut.2004.041749 · DOI · Paper page
- 10.1097/01.MIB.0000160369.47671.a2 · DOI
- 10.1056/NEJMra032492 · DOI
- 1976, Gastroenteroogy, 70, 439, 10.1016/S0016-5085(76)80163-1 · DOI
- 1989, Gastroenterology, 96, 804, 10.1016/S0016-5085(89)80080-0 · DOI
- 10.1053/j.gastro.2004.03.015 · DOI
Cited by
Sorted by citations
Vemuri, R., Shankar, E. M., Chieppa, M., Eri, R., & Kavanagh, K. (2020) · Microorganisms · doi:10.3390/microorganisms8040483 · Cited by 162
Hookworm recombinant protein promotes regulatory T cell responses that suppress experimental asthma
Navarro, S., Pickering, D. A., Ferreira, I. B., Jones, L., Ryan, S., Troy, S., Leech, A., Hotez, P. J., Zhan, B., Laha, T., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf8807 · Cited by 139
Self-citationGlobal issues in allergy and immunology: Parasitic infections and allergy
Cruz, A. A., Cooper, P. J., Figueiredo, C. A., Alcantara-Neves, N. M., Rodrigues, L. C., & Barreto, M. L. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.09.005 · Cited by 82
Metadata
- Authors
- Croese, J., O’Neil, J., Masson, J., Cooke, S., Melrose, W., Pritchard, D., & Speare, R.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2005-12-12
- Volume
- 55
- Issue
- 1
- Pages
- 136-137
- ISSN
- 0017-5749
- 1468-3288
- Cited by
- 216
- References
- 2
- Language
- en
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