Cited by 540Gastrointestinal motility and disordersGut microbiota and healthInflammatory Bowel Disease

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Open access

Piche, T, Barbara, G, Aubert, P, Bruley des Varannes, S, Dainese, R, Nano, J L, Cremon, C, Stanghellini, V, De Giorgio, R, Galmiche, J P, Neunlist, M·2009·Gut

DOI 10.1136/gut.2007.140806

Open this paper in CoChat — free account Open PDF

Abstract

Background: Growing evidence suggests that patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. We aimed to investigate (1) paracellular permeability in colonic biopsies of patients with IBS; and (2) the ability of soluble factors from colonic biopsies to reproduce these alterations in vitro. Methods: Paracellular permeability in colonic biopsies of healthy subjects and patients with IBS was measured by mounting the biopsies in Ussing chambers. Cleared supernatant (SUP) of the culture from colonic biopsies was collected and applied to Caco-2 cells for 48 h. Paracellular permeability and transepithelial resistance (TER) were evaluated. mRNA expression of the tight junction proteins, zonula occludens (ZO)-1 and occludin, was assessed in colonic biopsies. Abdominal pain was assessed using a validated questionnaire. Results: Permeability of colonic biopsies was significantly higher in patients with IBS compared to healthy subjects. These changes were associated with significantly lower expression of ZO-1 mRNA in biopsies of IBS as compared to healthy subjects. Compared to healthy subjects, SUP of IBS markedly reduced TER and significantly increased permeability in Caco-2 cells. SUP of IBS patients induced a significant decrease of ZO-1 mRNA in Caco-2 as compared to healthy subjects. SUP-induced increased paracellular permeability correlated with the severity of abdominal pain. Conclusions: Our study shows that colonic soluble mediators are able to reproduce functional (permeability) and molecular (ZO-1 mRNA expression) alterations observed in IBS patients. These findings might pave the way both to identify novel biomarkers as well as new therapeutic targets in IBS.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/gut.2007.140806

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Functional bowel disorders and functional abdominal pain
Thompson, W. G., Longstreth, G. F., Drossman, D. A., Heaton, K. W., Irvine, E. J., & Müller-Lissner, S. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii43 · Cited by 2,440
Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome
Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G. S., Santini, D., Pasquinelli, G., Morselli-Labate, A. M., Grady, E. F., Bunnett, N. W., et al. (2004) · Gastroenterology · doi:10.1053/j.gastro.2003.11.055 · Cited by 1,475
Self-citation
Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome
Spiller, R. C., Jenkins, D., Thornley, J. P., Hebden, J. M., Wright, T., Skinner, M., & Neal, K. R. (2000) · Gut · doi:10.1136/gut.47.6.804 · Cited by 1,155
Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome
Barbara, G., Wang, B., Stanghellini, V., de Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2006.11.039 · Cited by 783
Self-citation
Role for protease activity in visceral pain in irritable bowel syndrome
Cenac, N., Andrews, C. N., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N. W., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29255 · Cited by 591 · cited 3×
“Previous studies (10, 11) have shown that candidates such as protease and histamine are involved in the effects of SUP of IBS upon the neuronal excitability.”
Self-citation
Neutrophil Transmigration in Inflammatory Bowel Disease Is Associated with Differential Expression of Epithelial Intercellular Junction Proteins
Kucharzik, T. F., Walsh, S. V., Chen, J. Z., Parkos, C. A., & Nusrat, A. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63051-9 · Cited by 523
IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells
Nusrat, A., Turner, J. R., & Madara, J. (2000) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.2000.279.5.g851 · Cited by 499
Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes
Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476
Enteric Glia Regulate Intestinal Barrier Function and Inflammation Via Release of S-Nitrosoglutathione
Savidge, T., Newman, P., Pothoulakis, C., Rühl, A., Neunlist, M., Bourreille, A., Hurst, R. D., & Sofroniew, M. V. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.01.051 · Cited by 435
Self-citation

Flagged first, then by citations

Show all 33 references

Research works printed but not linked: 2

10.1111/j.1572-0241.2006.00667.x · DOI
10.1136/gut.47.6.804 · DOI · Paper page

Sorted by citations

Items 301–400 of 540

Intestinal dysbiosis in irritable bowel syndrome: etiological factor or epiphenomenon?
Cremon, C., Carini, G., GIORGIO, R. D., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2010) · Expert Review of Molecular Diagnostics · doi:10.1586/erm.10.33 · Cited by 19
Self-citation
Brain-Derived Neurotrophic Factor Modulates Intestinal Barrier by Inhibiting Intestinal Epithelial Cells Apoptosis in Mice
ZHAO, D.-Y., ZHANG, W.-X., Qi, Q. ‐., LONG, X., LI, X., Yu, Y.-B., & Zuo, X. (2018) · Physiological Research · doi:10.33549/physiolres.933641 · Cited by 19
The Serum Metabolite Response to Diet Intervention with Probiotic Acidified Milk in Irritable Bowel Syndrome Patients Is Indistinguishable from that of Non-Probiotic Acidified Milk by 1H NMR-Based Metabonomic Analysis
Pedersen, S. M. M., Nielsen, N. C., Andersen, H. J., Olsson, J., Simrén, M., Öhman, L., Svensson, U., Malmendal, A., & Bertram, H. C. (2010) · Nutrients · doi:10.3390/nu2111141 · Cited by 19
RETRACTED ARTICLE: Gut microbiota and related diseases: clinical features
Stanghellini, V., Barbara, G., Cremon, C., Cogliandro, R. F., Antonucci, A., Gabusi, V., Frisoni, C., GIORGIO, R. D., Grasso, V., Serra, M., et al. (2010) · Internal and Emergency Medicine · doi:10.1007/s11739-010-0451-0 · Cited by 18
Self-citation
Retracted
Peripheral apelin mediates visceral hypersensitivity and impaired gut barrier in a rat irritable bowel syndrome model
Nozu, T., Miyagishi, S., Ishioh, M., Takakusaki, K., & Okumura, T. (2022) · Neuropeptides · doi:10.1016/j.npep.2022.102248 · Cited by 18
Functional Gastrointestinal Disorders.
Duffy, M., Boggiano, V. L., Ganesh, R., & Mueller, M. (2023) · Primary Care · doi:10.1016/j.pop.2023.03.006 · Cited by 13
Global research progress of visceral hypersensitivity and irritable bowel syndrome: bibliometrics and visualized analysis
Tian, S., Zhang, H., Chen, S., Wu, P.-N., & Chen, M. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1175057 · Cited by 16
Recent advances in the diagnosis of irritable bowel syndrome
El‐Salhy, M. (2015) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2015.1067138 · Cited by 18
Faecal biomarker patterns in patients with symptoms of irritable bowel syndrome
Emmanuel, A. V., Landis, D. L., Peucker, M., & Hungin, A. P. S. (2016) · Frontline Gastroenterology · doi:10.1136/flgastro-2015-100651 · Cited by 18
Mindful Eating: A Review Of How The Stress-Digestion-Mindfulness Triad May Modulate And Improve Gastrointestinal And Digestive Function.
Cherpak-Castagna, C. E. (2019) · PubMed Central · Cited by 18
Impact of the ileal microbiota on colon cancer
Roberti, M. P., Rauber, C., Kroemer, G., & Zitvogel, L. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.09.016 · Cited by 18
Egg white ovomucin hydrolysate inhibits intestinal integrity damage in LPS-treated Caco-2 cells
Bao, X., & Wu, J. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104822 · Cited by 18
ACF7 regulates colonic permeability
Liang, Y., Shi, C., Yang, J., Chen, H., Xia, Y., Zhang, P., Wang, F., Han, H., & Qin, H. (2013) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2013.1284 · Cited by 17
Zbtb20 identifies and controls a thymus-derived population of regulatory T cells that play a role in intestinal homeostasis
Krzyzanowska, A. K., Haynes, R. A. H., Kovalovsky, D., Lin, H., Osorio, L., Edelblum, K. L., Corcoran, L. M., Rabson, A. B., Denzin, L. K., & Sant’Angelo, D. B. (2022) · Science Immunology · doi:10.1126/sciimmunol.abf3717 · Cited by 16
Ameliorating effects of electroacupuncture on the low‐grade intestinal inflammation in rat model of diarrhea‐predominant irritable bowel syndrome
Li, X., Ren, K., Hong, X., Guo, S., Yu, S., & Yang, S. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15981 · Cited by 17
Polymeric microspheres redefining the landscape of colon-targeted delivery: A contemporary update
Shendge, R. S., Zalte, T. S., & Khade, S. B. (2024) · European Journal of Medicinal Chemistry Reports · doi:10.1016/j.ejmcr.2024.100156 · Cited by 18
Soluble Mediators Released from PI-IBS Patients’ Colon Induced Alteration of Mast Cell: Involvement of Reactive Oxygen Species
Han, W., Lu, X., Jia, X., Zhou, T., & Guo, C. (2011) · Digestive Diseases and Sciences · doi:10.1007/s10620-011-1897-2 · Cited by 17
Role of microRNA in IBS with increased gut permeability
Vicario, M., Martínez, C., & Santos, J. (2010) · Gut · doi:10.1136/gut.2009.203695 · Cited by 17
Serotonin disrupts esophageal mucosal integrity: an investigation using a stratified squamous epithelial model
Wu, L., Oshima, T., Tomita, T., Ohda, Y., Fukui, H., Watari, J., & Miwa, H. (2016) · Journal of Gastroenterology · doi:10.1007/s00535-016-1195-z · Cited by 17
S3-Leitlinie Reizdarmsyndrom: Definition, Pathophysiologie, Diagnostik und Therapie. Gemeinsame Leitlinie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselkrankheiten (DGVS) und der Deutschen Gesellschaft für Neurogastroenterologie und Motilität (DGNM) 1 AWMF-Registriernummer: 021/016 Irritable Bowel Syndrome: German Consensus Guidelines on Definition, Pathophysiology and Management. German Society of Digestive and Metabolic Diseases (DGVS) and German Society of Neurogastroenterology …
Andresen, V., Pehl, C., Allescher, H. ‐., Bischoff, S. C., Enck, P., Frieling, T., Haag, S., Holtmann, G., Karaus, M., Keller, J., et al. (2011) · Cited by 17
The role of gut microbiota in the treatment of irritable bowel syndrome
Leylabadlo, H. E., Heravi, F. S., Soltani, E., Abbasi, A., Kafil, H. S., Parsaei, M., Sanaie, S., Ahmadian, Z., & Ghotaslou, R. (2021) · Reviews in Medical Microbiology · doi:10.1097/mrm.0000000000000284 · Cited by 16
Mucosal Plasma Cell Activation and Proximity to Nerve Fibres Are Associated with Glycocalyx Reduction in Diarrhoea-Predominant Irritable Bowel Syndrome: Jejunal Barrier Alterations Underlying Clinical Manifestations
Pardo‐Camacho, C., Mall, J. G., Martínez, C., Pigrau, M., Expósito, E., Albert-Bayo, M., Melón-Ardanaz, E., Nieto, A., Rodiño‐Janeiro, B. K., Fortea, M., et al. (2022) · Cells · doi:10.3390/cells11132046 · Cited by 16
Gut Non-Bacterial Microbiota: Emerging Link to Irritable Bowel Syndrome
Liu, A., Gao, W., Zhu, Y., Hou, X., & Chu, H. (2022) · Toxins · doi:10.3390/toxins14090596 · Cited by 18
Sodium butyrate administration improves intestinal development of suckling lambs
Sun, M., Ji, W., Ye, H., Cai, Y., Yun, Y., Wei, X., Wang, C., & Mao, H. (2024) · Journal of Animal Science · doi:10.1093/jas/skae028 · Cited by 16
Butyrate promotes visceral hypersensitivity in IBS model via mast cell-derived DRG neuron lincRNA-01028-PKC-TRPV1 pathway
Li, Y., Li, J., & Dai, C. (2024) · mBio · doi:10.1128/mbio.01533-24 · Cited by 23
Integrated 16S rRNA Gene Sequencing and Metabolomics Analysis to Investigate the Important Role of Osthole on Gut Microbiota and Serum Metabolites in Neuropathic Pain Mice
Li, R., Wang, F., Dang, S.-J., Yao, M., Zhang, W., & Wang, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.813626 · Cited by 17
HClO‐Activated Near‐Infrared Fluorogenic Aza‐BODIPY‐Bisferrocene Triad with High Turn‐on Ratio for In Vivo Biosensing
Yin, D., Yao, C., Chen, Y., He, Z., Yu, P., Sun, X., Wang, S., & Zhang, F. (2022) · Advanced Healthcare Materials · doi:10.1002/adhm.202201139 · Cited by 16
Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?
Heuston, S., & Hyland, N. P. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02055.x · Cited by 16
In VivoandIn VitroAntinociceptive Effect ofFagopyrum cymosum(Trev.) Meisn Extracts: A Possible Action by Recovering Intestinal Barrier Dysfunction
Liu, L., Cai, X., Yan, J., Luo, Y., Shao, M., Lu, Y., Sun, Z., & Cao, P. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/983801 · Cited by 16
The rapid rise of ultra-processed foods brings up human health concerns
Zhang, L., Jiang, L., Liu, C., Wu, J., Li, Z., & Wang, J. (2025) · Journal of Future Foods · doi:10.1016/j.jfutfo.2025.08.013 · Cited by 19
The Role of Bovine Kappa-Casein Glycomacropeptide in Modulating the Microbiome and Inflammatory Responses of Irritable Bowel Syndrome
Qu, Y., Park, S. H., & Dallas, D. C. (2023) · Nutrients · doi:10.3390/nu15183991 · Cited by 15
Homocysteine-mediated intestinal epithelial barrier dysfunction in the rat model of irritable bowel syndrome caused by maternal separation
Zhao, Y., & Qian, L. (2014) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmu076 · Cited by 15
Supernatants of irritable bowel syndrome mucosal biopsies impair human colonic smooth muscle contractility
Guarino, M. P. L., Barbara, G., Cicenia, A., Altomare, A., Barbaro, M. R., Cocca, S., Scirocco, A., Cremon, C., Emerenziani, S., Stanghellini, V., et al. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12928 · Cited by 15
Self-citation
Association Between Irritable Bowel Syndrome and Restless Legs Syndrome: A Comparative Study With Control Group
Borji, R., Fereshtehnejad, S., Vakili, S. T. T., Daryani, N. E., & Ajdarkosh, H. (2012) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2012.18.4.426 · Cited by 15
Soluble mediators in plasma from irritable bowel syndrome patients excite rat submucosal neurons
O’Malley, D., Buckley, M. M., McKernan, D. P., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.08.005 · Cited by 15
Shuganyin decoction improves the intestinal barrier function in a rat model of irritable bowel syndrome induced by water-avoidance stress
Lu, L., Yan, L., Yuan, J., Ye, Q., & Lin, J. (2018) · Chinese Medicine · doi:10.1186/s13020-017-0161-x · Cited by 15
Acid-functionalized single-walled carbon nanotubes alter epithelial tight junctions and enhance paracellular permeability
Singh, A. P., Mia, M. B., & Saxena, R. K. (2020) · Journal of Biosciences · doi:10.1007/s12038-020-9989-9 · Cited by 15
Open‐label pilot study of ethosuximide as adjunctive therapy for relieving abdominal pain related to Irritable Bowel Syndrome
El-Haggar, S. M., Hegazy, S. K., Abd-Elsalam, S. M., & Bahaa, M. M. (2021) · Journal of Clinical Pharmacy and Therapeutics · doi:10.1111/jcpt.13556 · Cited by 14
The gut microbiome and the brain
Rykalo, N. A., Riehl, L., & Kress, M. (2024) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0000000000000717 · Cited by 16
Modulation of VIP ergic phenotype of enteric neurons by colonic biopsy supernatants from patients with inflammatory bowel diseases: Involvement of IL ‐6 in Crohn's disease
Soufflet, F., Biraud, M., Rolli‐Derkinderen, M., Lardeux, B. R., Trang, C., Coron, E., Varannes, S. B. D., Bourreille, A., & Neunlist, M. (2017) · Neurogastroenterology & Motility · doi:10.1111/nmo.13198 · Cited by 14
Self-citation
Elevated serum neopterin levels in children with functional constipation: association with systemic proinflammatory cytokines
Çıralı, C., Ulusoy, E., Küme, T., & Arslan, N. (2018) · World Journal of Pediatrics · doi:10.1007/s12519-018-0144-8 · Cited by 14
The Effect of Prim-O-Glucosylcimifugin on Tryptase-Induced Intestinal Barrier Dysfunction in Caco-2 Cells
Xu, L., Cai, J., Tian, A., Qian, K., Qin, R., Qi, S., Tan, X., Qiu, Y., Gong, M., Han, B., et al. (2018) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b18-00059 · Cited by 14
Colonic hypersensitivity and low‐grade inflammation in a spontaneous animal model for functional gastrointestinal disorders
Méleine, M., Accarie, A., Wauters, L. I., Tóth, J. G., Gourcerol, G., Tack, J. F., Farré, R., & Vanuytsel, T. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13614 · Cited by 14
Impaired gastric mucosal integrity identified by confocal endomicroscopy in Helicobacter pylori‐negative functional dyspepsia
Ji, R., Wang, P., Kou, G., Zuo, X., Wang, X., & Li, Y. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13719 · Cited by 14
Síndrome de intestino irritable en la enfermedad inflamatoria intestinal. ¿Sinergia en las alteraciones del eje cerebro-intestino?
de Arce, E. P., Quera, R., Beltrán, C. J., Madrid, A. M., & Nos, P. (2021) · Gastroenterología y Hepatología · doi:10.1016/j.gastrohep.2021.02.022 · Cited by 14
Factors related to irritable bowel syndrome and differences among subtypes: A cross-sectional study in the UK Biobank
Wang, K., Liu, H., Liu, J., Han, L., Zheng, K., Liang, L., Jiang, S., Meng, N., Chen, P., Qiao, X., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.905564 · Cited by 17
Alanyl-glutamine restores maternal deprivation-induced TLR4 levels in a rat neonatal model
Mbodji, K., Torre, S., Haas, V. K., Déchelotte, P., & Marion‐Letellier, R. (2011) · Clinical Nutrition · doi:10.1016/j.clnu.2011.04.002 · Cited by 14
Drug Delivery to the Colon
Basit, A. W., & McConnell, E. L. (2011) · Springer eBooks · doi:10.1007/978-1-4614-1004-1_18 · Cited by 14
Potential Regulatory Effects of Corticotropin-Releasing Factor on Tight Junction-Related Intestinal Epithelial Permeability are Partially Mediated by CK8 Upregulation
Hu, Y., Bin, L., Chaoying, C., Meng, Z., Meng, L. Y., & Wang, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485420 · Cited by 14
Non-pharmacologic strategies for the management of intestinal inflammation
Maioli, T. U., Trindade, L. M., Souza, A., Torres, L., Andrade, M. E. R., Cardoso, V. N., & Generoso, S. D. V. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112414 · Cited by 17
Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20In VitroandIn Vivo
Yang, Z., Grinchuk, V., Ip, S., Che, C., Fong, H. H. S., Lao, L., Wu, J. C. Y., Sung, J. J. �., Berman, B., Shea‐Donohue, T., et al. (2012) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/491496 · Cited by 14
Fecal luminal factors from patients with irritable bowel syndrome induce distinct gene expression of colonoids
Iribarren, C., Nordlander, S., Sundin, J., Isaksson, S., Savolainen, O. I., Törnblom, H., Magnusson, M. K., Simrén, M., & Öhman, L. (2022) · Neurogastroenterology & Motility · doi:10.1111/nmo.14390 · Cited by 13
Microbiota-Accessible Boron-Containing Compounds in Complex Regional Pain Syndrome
Biță, C. E., Scorei, I. R., Vreju, F. A., Mușetescu, A. E., Mogoşanu, G. D., Biţă, A., Dinescu, V. C., Dinescu, Ș. C., Criveanu, C., Bărbulescu, A. L., et al. (2023) · Medicina · doi:10.3390/medicina59111965 · Cited by 15
Tranilast alleviates visceral hypersensitivity and colonic hyperpermeability by suppressing NLRP3 inflammasome activation in irritable bowel syndrome rat models
Nozu, T., Arie, H., Miyagishi, S., Ishioh, M., Takakusaki, K., & Okumura, T. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112099 · Cited by 13
Ochratoxin A challenges the intestinal epithelial cell integrity: results obtained in model experiments with Caco-2 cells
Alizadeh, A., Akbari, P., Varasteh, S., Braber, S., Malekinejad, H., & Fink‐Gremmels, J. (2019) · World Mycotoxin Journal · doi:10.3920/wmj2019.2451 · Cited by 13
Acute psychological stress increases paracellular permeability and modulates immune activity in rectal mucosa of healthy volunteers
Gerdin, L., González-Castro, A. M., Ericson, A., Persborn, M., Santos, J., Walter, S. A., Keita, Å. V., Vicario, M., & Söderholm, J. D. (2022) · United European Gastroenterology Journal · doi:10.1002/ueg2.12329 · Cited by 13
Nanomaterials disrupting cell-cell junctions towards various diseases
Xu, S., Pang, X., Zhang, X., Lv, Q., Zhang, M., Wang, J., Ni, N., & Sun, X. J. (2023) · Nano Research · doi:10.1007/s12274-023-5455-y · Cited by 13
Effect of beta-glucan, inositol and digestive enzymes in GI symptoms of patients with IBS.
Ciacci, C., Franceschi, F., Purchiaroni, F., Capone, P., Buccelletti, F., Iacomini, P., Ranaudo, A., Andreozzi, P., Tondi, P., Silveri, N. G., et al. (2011) · PubMed · Cited by 13
Use of GELSECTAN® in Patients with Irritable Bowel Syndrome (IBS): an Italian Experience
Bellini, M., Berti, G., Bonfrate, L., Ciranni, F., Ciaula, A. D., Ruscio, M. D., Dell’Era, A., Lambiase, C., Noto, A., Pancetti, A., et al. (2021) · Patient Preference and Adherence · doi:10.2147/ppa.s318859 · Cited by 12
Probiotic Yeast from Miso Ameliorates Stress-Induced Visceral Hypersensitivity by Modulating the Gut Microbiota in a Rat Model of Irritable Bowel Syndrome
Sugihara, N., Okada, Y., Tomioka, A., Ito, S., Tanemoto, R., Nishii, S., Mizoguchi, A., Inaba, K., Hanawa, Y., Horiuchi, K., et al. (2023) · Gut and Liver · doi:10.5009/gnl220100 · Cited by 12
Maturation Phenotype of Peripheral Blood Monocyte/Macrophage After Stimulation with Lipopolysaccharides in Irritable Bowel Syndrome
Rodríguez, Ó., Hernández-Ruiz, J., López‐Vidal, Y., Charúa-Guindic, L., Escobedo, G., & Schmulson, M. J. (2017) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16137 · Cited by 12
Nodular lymphoid hyperplasia: A marker of low-grade inflammation in irritable bowel syndrome?
Piscaglia, A. C., Laterza, L., Cesario, V., Gerardi, V., Landi, R., Lopetuso, L. R., Calò, G., Fabbretti, G., Brisigotti, M., Stefanelli, M. L., et al. (2016) · World Journal of Gastroenterology · doi:10.3748/wjg.v22.i46.10198 · Cited by 12
Impact of shift work on irritable bowel syndrome and functional dyspepsia
Wang, N., Liu, X., Ye, W., Shi, Z., & Bai, T. (2022) · Medicine · doi:10.1097/md.0000000000029211 · Cited by 12
An Overview of the Effects of Tenapanor on Visceral Hypersensitivity in the Treatment of Irritable Bowel Syndrome with Constipation
Singh, P., Sayuk, G. S., Rosenbaum, D. P., Edelstein, S. A., Kozuka, K., & Chang, L. (2024) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s454526 · Cited by 11
A Systematic Review: Fecal Bacterial Profile in Patients with Irritable Bowel Syndrome Analyzed with the GA-Map Dysbiosis Test Based on the 16S rRNA Gene of Bacterial Species or Groups
Teige, E. S., Sortvik, U., & Lied, G. A. (2024) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s451675 · Cited by 12
Ultrastructure of intestinal mucosa in diarrhea-predominant irritable bowel syndrome
Zhao, D.-Y., Qi, Q. ‐., Long, X., Li, X., Chen, F.-X., Yu, Y.-B., & Zuo, X.-L. (2019) · Physiology International · doi:10.1556/2060.106.2019.20 · Cited by 14
Dietary monosodium glutamate increases visceral hypersensitivity in a mouse model of visceral pain
Brant, B. J., Yu, Y., Omar, A. A., Polanco, J. O. J., Lopez, C. D. L., Jiménez-Vargas, N. N., Tsang, Q. K., McDonell, A., Takami, K., Reed, D. E., et al. (2023) · Neurogastroenterology & Motility · doi:10.1111/nmo.14596 · Cited by 11
Duodenal epithelial transport in functional dyspepsia: Role of serotonin.
Witte, A., D'Amato, M., Poulsen, S., Laurent, A., Knuhtsen, S., Bindslev, N., Hansen, M., & Schmidt, P. T. (2013) · World Journal of Gastrointestinal Pathophysiology · doi:10.4291/wjgp.v4.i2.28 · Cited by 9
Les dosages d’IgG anti-aliments : méthodes et pertinence clinique des résultats. Position du groupe de travail de biologie de la Société française d’allergologie
Chabane, H., Doyen, V., Bienvenu, F., Adel‐Patient, K., Vitte, J., Mariotte, D., & Bienvenu, J. (2018) · Revue française d'allergologie · doi:10.1016/j.reval.2018.01.007 · Cited by 11
Toll-Like Receptor Expression in Irritable Bowel Syndrome: On the Alert for a Microbial Threat?
Barbara, G. (2011) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.440 · Cited by 10
Self-citation
Antiflagellin antibodies suggest infective participation in irritable bowel syndrome pathogenesis
Cremon, C., Pallotti, F., Bacchilega, M., Stanghellini, V., Corinaldesi, R., & Barbara, G. (2008) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/17474124.2.6.735 · Cited by 10
Self-citation
Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa
Rodiño‐Janeiro, B. K., Pardo‐Camacho, C., Santos, J., & Martínez, C. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00186.2018 · Cited by 10
Lactiplantibacillus plantarum (CECT7484 and CECT7485) and Pedioccoccus acidilactici (CECT7483) enhance actin cytoskeleton and CYP1A1 expression restoring epithelial permeability alterations induced by irritable bowel syndrome mediators
Barbaro, M. R., Bianco, F., Cremon, C., Marasco, G., Bonomini, F., Palombo, M., Delprete, C., Pérez, M., Espadaler, J., Stanghellini, V., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2452235 · Cited by 9
Self-citation
Regulation of Intestinal Permeability in Health and Disease: Possible Therapeutic Applications
Güemes-González, A. M., Arriaga‐Pizano, L., Chacón‐Salinas, R., Wong‐Baeza, I., & Ferat-Osorio, E. A. (2025) · Archives of Medical Research · doi:10.1016/j.arcmed.2025.103321 · Cited by 13
Altered epithelial barrier functions in the colon of patients with spina bifida
Brochard, C., Bouguen, G., Olivier, R., Durand, T., Henno, S., Peyronnet, B., Pagenault, M., Lefevre, C., Boudry, G., Croyal, M., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-11289-3 · Cited by 9
Self-citation
Hylocereus undatus flower suppresses DSS-induced colitis in mice by reducing intestinal inflammation, repairing the intestinal physical barrier, and modulating gut and lung microbiota
Liao, W., Wu, H., Pang, L., He, B., Tong, J., Qin, J., Li, L., Liu, W. Y., Zhou, X., Huang, S., et al. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105820 · Cited by 10
A breach in the intestinal permeability as a factor of etiopathogenesis of functional gastrointestinal diseases
Андреев, Д. Н., & Dicheva, D. T. (2020) · Meditsinskiy sovet = Medical Council · doi:10.21518/2079-701x-2020-5-87-95 · Cited by 11
Differential mRNA expression in ileal and colonic biopsies in irritable bowel syndrome with diarrhea or constipation
Camilleri, M., Magnus, Y., Carlson, P., Wang, X., Chedid, V. G., Maselli, D. B., Taylor, A. L., McKinzie, S., Nagaraj, N. K., Busciglio, I. A., et al. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00063.2022 · Cited by 9
Effects of Stress on Intestinal Mucosal Functions
Söderholm, J. D. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00074-9 · Cited by 10
Proteases in intestinal health and disease
Deraison, C., & Vergnolle, N. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01129-w · Cited by 9
Modulating the gut microenvironment as a treatment strategy for irritable bowel syndrome: a narrative review
Iribarren, C., Maasfeh, L., Öhman, L., & Simrén, M. (2022) · Gut Microbiome · doi:10.1017/gmb.2022.6 · Cited by 9
Endoscopic laser endomicroscopy and “leaky gut” in patients with functional gastrointestinal symptoms and food intolerance
Frieling, T., Gjini, B., Melchior, I., Euler, P., Kreysel, C., Kalde, S., Krummen, B., Kießlich, R., & Hemmerlein, B. (2022) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1959-3200 · Cited by 8
Eosinophil and mast cell‐derived exosomes promote integrity of intestinal mucosa via the NEAT1 / miR ‐211‐5p/ glial cell line‐derived neurotrophic factor axis in duodenum
Wang, J., Gu, S., & Qin, B. (2023) · Environmental Toxicology · doi:10.1002/tox.23895 · Cited by 8
Understanding the potential causes of gastrointestinal dysfunctions in multiple system atrophy
Craig, C. F., Finkelstein, D. I., McQuade, R. M., & Diwakarla, S. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106296 · Cited by 8
Investigation of the effect of military stress on the prevalence of functional bowel disorders
Yu, X.-Z. (2012) · World Journal of Gastroenterology · doi:10.3748/wjg.v18.i23.3004 · Cited by 8
Reizdarm und Reizmagen – Pathophysiologie und Biomarker
Schemann, M. (2017) · Die Gastroenterologie · doi:10.1007/s11377-017-0143-7 · Cited by 8
GI Motility Testing
Lee, A. A., Baker, J. R., & Hasler, W. L. (2019) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000001138 · Cited by 8
Preclinical models of irritable bowel syndrome
López‐Gómez, L., Bagüés, A., Uranga, J. A., & Abalo, R. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821324-7.00012-5 · Cited by 8
Alterations to microbial secretome by estrogen may contribute to sex bias in irritable bowel syndrome
Pretorius, L., Staden, A. D. P. V., der Merwe, J. J. V., Henning, N., & Smith, C. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00906-8 · Cited by 8
Correlation between anxiety and decreased quality of life in patients with non‐esophageal eosinophilic gastrointestinal diseases
Tanaka, F., Kanamori, A., Sawada, A., Ominami, M., Nadatani, Y., Fukunaga, S., Otani, K., Hosomi, S., Kamata, N., Nagami, Y., et al. (2023) · JGH Open · doi:10.1002/jgh3.13025 · Cited by 7
Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity
Kim, S. U., Choi, J. A., Han, M., Choi, J., Park, J., Kim, M. S., & Kwon, Y. H. (2024) · The Korean Journal of Internal Medicine · doi:10.3904/kjim.2024.097 · Cited by 9
Mucoprotectants and gut barrier: mechanisms of action and clinical applications in IBS. Is there a possible role?
Rettura, F., Lambiase, C., Tedeschi, R., Grosso, A., Cancelli, L., Ricchiuti, A., Bottari, A., Giacomelli, L., de Bortoli, N., & Bellini, M. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1538791 · Cited by 9
The effectiveness and safety of natural food and food-derived extract supplements for treating functional gastrointestinal disorders—current perspectives
Liu, T., Asif, I. M., Bai, C., Huang, Y., Li, B., & Wang, L. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae047 · Cited by 7
The effects of a 6-week intervention with Limosilactobacillus reuteri ATCC PTA 6475 alone and in combination with L. reuteri DSM 17938 on gut barrier function, immune markers, and symptoms in patients with IBS-D—An exploratory RCT
König, J., Rubio, M., Forsgård, R. A., Rode, J., Axelsson, J., Grompone, G., & Brummer, R. J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0312464 · Cited by 7
Sex-dependent alterations of colonic epithelial permeability: relevance to irritable bowel syndrome
Larauche, M., Mahurkar-Joshi, S., Biraud, M., Ju, T., Mayer, E., & Chang, L. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1509935 · Cited by 7
Contribution of MicroRNAs in the Development of Irritable Bowel Syndrome Symptoms
Dupont, P. T., Izaguirre-Hernández, I. Y., & Remes-Troche, J. M. (2023) · Journal of Gastrointestinal and Liver Diseases · doi:10.15403/jgld-4676 · Cited by 7
Irritable Bowel Syndrome: Peripheral Mechanisms and Therapeutic Implications
Crisan, I. M., & Dumitrascu, D. L. (2014) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-269 · Cited by 7
Advancements in drug development for diarrhea-predominant irritable bowel syndrome
Dothel, G., Barbaro, M. R., Raschi, E., Barbara, G., & Ponti, F. D. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1442434 · Cited by 7
Self-citation
Sexually Dimorphic Influence of Neonatal Antibiotics on Bone
Pusceddu, M. M., Stokes, P., Wong, A., Gareau, M. G., & Genetos, D. C. (2019) · Journal of Orthopaedic Research® · doi:10.1002/jor.24396 · Cited by 7
Anomalies pariétales et de la flore au cours du syndrome de l’intestin irritable
Piche, T. (2009) · Gastroentérologie Clinique et Biologique · doi:10.1016/s0399-8320(09)71524-6 · Cited by 1
Self-citation

Authors: Piche, T., Barbara, G., Aubert, P., Bruley des Varannes, S., Dainese, R., Nano, J. L., Cremon, C., Stanghellini, V, De Giorgio, R., Galmiche, J. P., & Neunlist, M.
Affiliations: Inserm (FR)
University of Bologna (IT)
Corresponding author: Neunlist, M
ORCID: Barbara, G
Aubert, P
Cremon, C
Stanghellini, V
Neunlist, M
Venue: Gut
Publisher: BMJ
Published: 2008-09-29
Volume: 58
Issue: 2
Pages: 196-201
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.2007.140806
OpenAlex: W2161238054
Cited by: 540
References: 33
Citations by year: 2026: 18 · 2025: 20 · 2024: 26 · 2023: 23 · 2022: 40 · 2021: 32 · 2020: 31 · 2019: 31 · 2018: 24 · 2017: 39 · 2016: 36 · 2015: 26 · 2014: 46 · 2013: 34 · 2012: 38
FWCI: 25.00
Type: journal article
Language: en
Open access: green
inserm.hal.science
Licence: other-oa
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion, other-oa)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Institutional Research Information System University of Ferrara (University of Ferrara) (submittedVersion)
Funders: Sanofi
Ministero dell’Istruzione, dell’Università e della Ricerca (2002052573)
Università di Bologna
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords: irritable bowel syndrome, intestinal permeability, paracellular permeability, intestinal barrier integrity, colonic mucosa, soluble mediators, ZO-1, occludin, tight junction proteins, transepithelial electrical resistance, abdominal pain, Caco-2 cells, biomarkers
MeSH terms: Adult, Aged, Analysis of Variance, Biopsy, Cell Membrane, Cell Membrane Permeability, Colon, Female, Humans, Intestinal Mucosa, Male, Membrane Proteins, Middle Aged, Phosphoproteins, RNA, Messenger, Case-Control Studies, Electric Impedance, Statistics, Nonparametric, Caco-2 Cells, Reverse Transcriptase Polymerase Chain Reaction, Irritable Bowel Syndrome, Young Adult, Occludin, Zonula Occludens-1 Protein

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks