The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal cancer tissue
Abstract
Background: The antitumoral immune response is one determinant of colorectal cancer (CRC) outcome. Recent work suggests that Foxp3 + CD25 + CD4 + regulatory T cells (T4reg) might hamper effective immunosurveillance of emerging cancer cells and impede effective immune responses to established tumours. In this descriptive study, we analysed blood and tissue regulatory T cell populations in patients with CRC. Methods: Blood and tissue regulatory Foxp3 + T cells from 40 patients with CRC were compared to regulatory Foxp3 + T cells from normal colonic tissue and from blood of 26 healthy volunteers. Flow cytometry was used to quantify and phenotype all Foxp3 + T cell populations. Correlations were sought with the tumour stage and with micro-invasive status. The suppressive capacity of regulatory Foxp3 + T cells was assessed by their effect on CD4 + CD25 − T cell proliferation in vitro and by their capacity to inhibit cytokine production by conventional T cells. Results: We found a significant increase of CD8 + CD25 + Foxp3 + cells (T8reg) in blood and CRC tissue; their phenotype was close to that of T4reg. T8reg cells infiltrating CRC were activated, as suggested by increased cytoxic T lymphocyte-associated antigen-4, glucocorticoid-induced tumour necrosis factor-related protein, and transforming growth factor (TGF)β1 expression compared to T8reg from normal autologous colonic tissue. Moreover, T8reg were able to suppress CD4 + CD25 − T cell proliferation and Th1 cytokine production ex vivo, demonstrating that tumour-infiltrating T8reg have strong suppressive capacities. T8reg numbers correlated with the tumour stage and with micro-invasive status. Finally, interleukin 6 and TGFβ1 synergistically induced the generation of CD8 + CD25 + Foxp3 + T cells ex vivo. Conclusions: We have identified a new regulatory T cell population (CD8 + Foxp3 + ) in colorectal tumours. After isolation from cancer tissue these CD8 + Foxp3 + cells demonstrated strong immunosuppressive properties in vitro. These data suggest that these cells may contribute to tumoral immune escape and disease progression.
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Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing
Zheng, C., Zheng, L., Yoo, J.-K., Guo, H., Zhang, Y., Guo, X., Kang, B., Hu, R., Huang, J. Y., Zhang, Q., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.035 · Cited by 2,152
The polarization of immune cells in the tumour environment by TGFβ
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Metadata
- Authors
- Chaput, N., Louafi, S., Bardier, A., Charlotte, F., Vaillant, J.-C., Ménégaux, F., Rosenzwajg, M., Lemoine, F., Klatzmann, D., & Taieb, J.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2008-11-20
- Volume
- 58
- Issue
- 4
- Pages
- 520-529
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2135917116
- Cited by
- 264
- References
- 48
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chaput, N., Louafi, S., Bardier, A., Charlotte, F., Vaillant, J.-C., Ménégaux, F., Rosenzwajg, M., Lemoine, F., Klatzmann, D., & Taieb, J. (2009). Identification of CD8 + CD25 + Foxp3 + suppressive T cells in colorectal cancer tissue. Gut. https://doi.org/10.1136/gut.2008.158824
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