The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Colorectal cancer molecular biology moves into clinical practice
Open accessAbstract
The promise of personalised medicine is now a clinical reality, with colorectal cancer genetics at the forefront of this next major advance in clinical medicine. This is no more evident than in the recent advances in testing of colorectal cancers for specific molecular alterations in order to guide treatment with the monoclonal antibody therapies cetuximab and panitumumab, which target the epidermal growth factor receptor. In this review, genetic mechanisms of colorectal cancer and how these alterations relate to emerging biomarkers for early detection and risk stratification (diagnostic markers), prognosis (prognostic markers) and the prediction of treatment responses (predictive markers) are examined.
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Cetuximab and Chemotherapy as Initial Treatment for Metastatic Colorectal Cancer
Van Cutsem, E., Köhne, C.-H., Hitre, E., Zaluski, J., Chang Chien, C.-R., Makhson, A., D'Haens, G., Pintér, T., Lim, R., Bodoky, G., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0805019 · Cited by 3,877
Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
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Wild-Type BRAF Is Required for Response to Panitumumab or Cetuximab in Metastatic Colorectal Cancer
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RAF/RAS oncogenes and mismatch-repair status
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Cited by
Clinical validation of the detection of KRAS and BRAF mutations from circulating tumor DNA
Thierry, A. R., Mouliere, F., El Messaoudi, S., Mollevi, C., Lopez-Crapez, E., Rolet, F., Gillet, B., Gongora, C., Dechelotte, P., Robert, B., et al. (2014) · Nature Medicine · doi:10.1038/nm.3511 · Cited by 678
Kloth, M., Ruesseler, V., Engel, C., Koenig, K., Peifer, M., Mariotti, E., Kuenstlinger, H., Florin, A., Rommerscheidt-Fuss, U., Koitzsch, U., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-309026 · Cited by 73
Functions of Circular RNA in Human Diseases and Illnesses
Gu, A., Jaijyan, D. K., Yang, S., Zeng, M., Pei, S., & Zhu, H. (2023) · Non-Coding RNA · doi:10.3390/ncrna9040038 · Cited by 65
HypoxaMIRs: Key Regulators of Hallmarks of Colorectal Cancer
Coronel-Hernández, J., Delgado-Waldo, I., Cantú de León, D., López-Camarillo, C., Jacobo-Herrera, N., Ramos-Payán, R., & Pérez-Plasencia, C. (2022) · Cells · doi:10.3390/cells11121895 · Cited by 13
Loughrey, M. B. (2020) · Histopathology Reporting · doi:10.1007/978-3-030-27828-1_6 · Cited by 6
Metadata
- Authors
- Pritchard, C. C., & Grady, W. M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2010-10-04
- Volume
- 60
- Issue
- 1
- Pages
- 116-129
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2141285914
- Cited by
- 344
- References
- 17
- FWCI
- 13.68
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
