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Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity.
Open accessAbstract
In a series of 59 experiments in nine duodenal ulcer patients, 24 hour intragastric acidity was measured before, during, and after treatment with daily oral omeprazole. Omeprazole 10, 20, and 30 mg/day for one week caused a 37, 90, and 97% decrease of 24 hour intragastric acidity, respectively. No further decrease of acidity was observed when the dose of omeprazole was doubled to 60 mg/day, or after a second week of treatment with 30 mg/day. One week after stopping treatment with omeprazole (14 doses) there was a significant 26% decrease of 24 hour intragastric acidity, with full recovery seven weeks later. Fasting plasma gastrin concentration was significantly raised during treatment with all doses of omeprazole. Omeprazole 30 mg/day is the optimal dose for a maximal decrease of 24 hour intragastric acidity in duodenal ulcer patients.
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Cited by
Is there an optimal degree of acid suppression for healing of duodenal ulcers?
Burget, D. W., Chiverton, S. G., & Hunt, R. H. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)91015-x · Cited by 340
Klinkenberg-Knol, E. C., Festen, H. P. M., Jansen, J. M. B. J., Meuwissen, S. G. M., & Lamers, C. B. H. W. (1987) · The Lancet · doi:10.1016/s0140-6736(87)91726-0 · Cited by 276
Marked increase in gastric acid secretory capacity after omeprazole treatment.
Waldum, H. L., Arnestad, J. S., Brenna, E., Eide, I., Syversen, U., & Sandvik, A. K. (1996) · Gut · doi:10.1136/gut.39.5.649 · Cited by 243
Proton Pump Inhibitor Use and Risk of Colorectal Cancer: A Population-Based, Case–Control Study
Robertson, D. J., Larsson, H., Friis, S., Pedersen, L., Baron, J. A., & Sørensen, H. T. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.06.014 · Cited by 139
Giusti, M., Sidoti, M., Augeri, C., Rabitti, C., & Minuto, F. (2004) · European Journal of Endocrinology · doi:10.1530/eje.0.1500299 · Cited by 111
Metadata
- Authors
- Sharma, B. K., Walt, R. P., Pounder, R. E., Gomes, M. D., Wood, E. C., & Logan, L. H.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1984-09
- Volume
- 25
- Issue
- 9
- Pages
- 957-964
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W1971221969
- Cited by
- 240
- References
- 0
- FWCI
- 18.21
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Sharma, B. K., Walt, R. P., Pounder, R. E., Gomes, M. D., Wood, E. C., & Logan, L. H. (1984). Optimal dose of oral omeprazole for maximal 24 hour decrease of intragastric acidity. Gut. https://doi.org/10.1136/gut.25.9.957
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
