The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis.
Open accessAbstract
Familial adenomatous polyposis has been associated with several extraintestinal cancers, but the relative and absolute risks of these malignancies have not been determined. Extraintestinal cancers reportedly associated with adenomatous polyposis (thyroid gland, adrenal gland, pancreas, and biliary tract) were identified in polyposis patients and their at risk relatives in The Johns Hopkins Registry. The incidence rates of identified tumours were then compared with the general population through person year analysis with adjustment for population. For comparison, the incidence rates of the two most common cancers not associated with polyposis (breast cancer in women and lung cancer) were also calculated. There was an increased relative risk of thyroid cancer (relative risk 7.6; 95% confidence limits (CL) 2.5-17.7) and pancreatic adenocarcinoma (relative risk 4.46; 95% CL 1.2-11.4) in polyposis patients and at risk relatives. The absolute risk was 26.8 and 21.4 cases/100,000 person years, respectively. No cases of adrenal or biliary cancer were found in this cohort. There was no increased relative risk of lung cancer (95% CL 0.04-1.4) or breast cancer (95% CL 0.04-1.4) over the general population. The relative risks of thyroid and pancreatic cancer are increased in familial adenomatous polyposis, but the absolute lifetime risk is low. Screening for pancreatic cancer may not be worthwhile with currently available methods, but careful physical examination of the thyroid gland is warranted along with consideration for ultrasonography.
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Cites
Gardner's syndrome with adrenal carcinoma
MARSHALL, W. H., MARTIN, F. I. R., & MACKAY, I. R. (1967) · Australasian Annals of Medicine · doi:10.1111/imj.1967.16.3.242 · Cited by 61
Cited by
Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.22 · Cited by 1,982
Syngal, S., Brand, R. E., Church, J. M., Giardiello, F. M., Hampel, H. L., & Burt, R. W. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.435 · Cited by 1,662
Self-citationFamilial adenomatous polyposis
Galiatsatos, P., & Foulkes, W. D. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00375.x · Cited by 757
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer
Roberts, N. J., Norris, A. L., Petersen, G. M., Bondy, M. L., Brand, R., Gallinger, S., Kurtz, R. C., Olson, S. H., Rustgi, A. K., Schwartz, A. G., et al. (2016) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0402 · Cited by 361
Pathogenesis, diagnosis and management of thyroid nodules in children
Niedziela, M. (2006) · Endocrine-Related Cancer · doi:10.1677/erc.1.00882 · Cited by 343
Metadata
- Authors
- Giardiello, F. M., Offerhaus, G. J., Lee, D. H., Krush, A. J., Tersmette, A. C., Booker, S. V., Kelley, N. C., & Hamilton, S. R.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1993-10
- Volume
- 34
- Issue
- 10
- Pages
- 1394-1396
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2048341930
- Cited by
- 363
- References
- 1
- FWCI
- 4.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Giardiello, F. M., Offerhaus, G. J., Lee, D. H., Krush, A. J., Tersmette, A. C., Booker, S. V., Kelley, N. C., & Hamilton, S. R. (1993). Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis. Gut. https://doi.org/10.1136/gut.34.10.1394
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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