Pancreatic cancer
Open accessAbstract
Pancreatic cancer is a major cause of cancer-associated mortality, with a dismal overall prognosis that has remained virtually unchanged for many decades. Currently, prevention or early diagnosis at a curable stage is exceedingly difficult; patients rarely exhibit symptoms and tumours do not display sensitive and specific markers to aid detection. Pancreatic cancers also have few prevalent genetic mutations; the most commonly mutated genes are KRAS, CDKN2A (encoding p16), TP53 and SMAD4 - none of which are currently druggable. Indeed, therapeutic options are limited and progress in drug development is impeded because most pancreatic cancers are complex at the genomic, epigenetic and metabolic levels, with multiple activated pathways and crosstalk evident. Furthermore, the multilayered interplay between neoplastic and stromal cells in the tumour microenvironment challenges medical treatment. Fewer than 20% of patients have surgically resectable disease; however, neoadjuvant therapies might shift tumours towards resectability. Although newer drug combinations and multimodal regimens in this setting, as well as the adjuvant setting, appreciably extend survival, ∼80% of patients will relapse after surgery and ultimately die of their disease. Thus, consideration of quality of life and overall survival is important. In this Primer, we summarize the current understanding of the salient pathophysiological, molecular, translational and clinical aspects of this disease. In addition, we present an outline of potential future directions for pancreatic cancer research and patient management.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The focus of treatment in the majority of pancreatic cancer patients has been about achieving a balance between palliative chemotherapy and maintaining quality-of-life.
“Hence, the focus of treatment in the majority of the patients has been about achieving a balance between palliative chemotherapy and maintaining quality-of-life [4].”
From Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer (2023) · cites this paper as [4]
Pancreatic ductal adenocarcinoma (PDAC) lines were chosen because cancers of the pancreas are characterized by rapid progression, invasiveness, and elevated fermentative metabolism.
“Pancreatic ductal adenocarcinoma (PDAC) lines were chosen for our study because cancers of the pancreas are characterized by rapid progression,9,10 invasiveness,11,12 and elevated fermentative metabolism.13,14,15,16”
From Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cells (2024) · cites this paper as [11]
A central reason PDAC is lethal is that it is usually detected late, often after distant metastasis has occurred.
“The factors driving the lethality of PDAC are numerous, centered on an inability to detect the disease until late in progression, often after distant metastasis3.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [3]
Only 15-20% of PDAC patients are eligible for surgery at diagnosis.
“only 15–20% of patients are eligible for surgery at diagnosis3.”
From Pancreatic cancer: Advances and challenges (2023) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Dindo, D., Demartines, N., & Clavien, P.-A. (2004) · Annals of Surgery · doi:10.1097/01.sla.0000133083.54934.ae · Cited by 31,378 · see citing works
The National Comprehensive Cancer Network
McGivney, W. T. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980515)82:10+ · Cited by 16,760 · see citing works
Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., Filiberti, A., Flechtner, H., Fleishman, S. B., Haes, J. C. J. M. D., et al. (1993) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/85.5.365 · Cited by 16,005 · see citing works
Siegel, R. L., Miller, K. D., & Jemal, A. (2015) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21254 · Cited by 11,854 · see citing works
Signatures of mutational processes in human cancer
Initiative, A. P. C. G., Alexandrov, L. B., ICGC Breast Cancer Consortium, ICGC MMML-Seq Consortium, PedBrain, I., Nik-Zainal, S., Wedge, D. C., Aparicio, S. A. J. R., Behjati, S., Biankin, A. V., et al. (2013) · Nature · doi:10.1038/nature12477 · Cited by 9,660 · see citing works
Self-citationPD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Le, D. T., Uram, J. N., Wang, H., Bartlett, B. R., Kemberling, H., Eyring, A. D., Skora, A. D., Luber, B. S., Azad, N. S., Laheru, D., et al. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1500596 · Cited by 9,377 · see citing works
Self-citationRahib, L., Smith, B. D., Aizenberg, R., Rosenzweig, A. B., Fleshman, J. M., & Matrisian, L. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0155 · Cited by 7,094 · see citing works
Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine
Von Hoff, D. D., Ervin, T., Arena, F. P., Chiorean, E. G., Infante, J., Moore, M., Seay, T., Tjulandin, S. A., Ma, W. W., Saleh, M. N., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1304369 · Cited by 6,712 · see citing works
The functional assessment of cancer therapy scale: development and validation of the general measure
Cella, D. F., Tulsky, D. S., Gray, G., Sarafian, B., Linn, E., Bonomi, A., Silberman, M., Yellen, S. B., Winicour, P., & Brannon, J. (1993) · Journal of Clinical Oncology · doi:10.1200/jco.1993.11.3.570 · Cited by 6,020 · see citing works
Burris, H. A., Moore, M. J., Andersen, J., Green, M. R., Rothenberg, M. L., Modiano, M., Cripps, M. C., Portenoy, R. K., Storniolo, A. M., Tarassoff, P. G., et al. (1997) · Journal of Clinical Oncology · doi:10.1200/jco.1997.15.6.2403 · Cited by 5,895 · see citing works
Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies
Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3007094 · Cited by 5,067 · see citing works
Self-citationPostoperative pancreatic fistula: An international study group (ISGPF) definition
Bassi, C., Dervenis, C., Butturini, G., Fingerhut, A. L., Yeo, C. J., Izbicki, J. R., Neoptolemos, J. P., Sarr, M. G., Traverso, W. L., & Büchler, M. W. (2005) · Surgery · doi:10.1016/j.surg.2005.05.001 · Cited by 4,280 · see citing works
Self-citationCore Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Jones, S., Zhang, X., Parsons, D. W., Lin, J. C.-H., Leary, R. J., Angenendt, P., Mankoo, P., Carter, H., Kamiyama, H., Jimeno, A., et al. (2008) · Science · doi:10.1126/science.1164368 · Cited by 3,969 · see citing works
Self-citationMoore, M. J., Goldstein, D., Hamm, J., Figer, A., Hecht, J. R., Gallinger, S., Au, H. J., Murawa, P., Walde, D., Wolff, R. A., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2006.07.9525 · Cited by 3,848 · see citing works
Genomic analyses identify molecular subtypes of pancreatic cancer
Bailey, P., Chang, D. K., Nones, K., Johns, A. L., Patch, A.-M., Gingras, M.-C., Miller, D. K., Christ, A. N., Bruxner, T. J. C., Quinn, M. C., et al. (2016) · Nature · doi:10.1038/nature16965 · Cited by 3,621 · see citing works
Self-citationOlive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170 · see citing works
Self-citationWente, M. N., Bassi, C., Dervenis, C., Fingerhut, A. L., Gouma, D. J., Izbicki, J. R., Neoptolemos, J. P., Padbury, R. T. A., Sarr, M. G., Traverso, L. W., et al. (2007) · Surgery · doi:10.1016/j.surg.2007.05.005 · Cited by 3,065 · see citing works
Self-citationGlypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works
International Agency for Research on Cancer (IARC)
(2018) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-94186-5_629 · Cited by 2,796 · see citing works
A Randomized Trial of Chemoradiotherapy and Chemotherapy after Resection of Pancreatic Cancer
Neoptolemos, J. P., Stocken, D. D., Friess, H., Bassi, C., Dunn, J., Hickey, H., Beger, H. G., Fernández‐Cruz, L., Dervenis, C., LACAINE, F., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032295 · Cited by 2,709 · see citing works
Self-citationÖzdemir, B. C., Pentcheva-Hoang, T., Carstens, J. L., Zheng, X., Wu, C.-C., Simpson, T. R., Laklai, H., Sugimoto, H., Kahlert, C., Novitskiy, S. V., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.005 · Cited by 2,681 · see citing works
Whole genomes redefine the mutational landscape of pancreatic cancer
Initiative, A. P. C. G., Waddell, N., Pajic, M., Patch, A.-M., Chang, D. K., Kassahn, K. S., Bailey, P., Johns, A. L., Miller, D., Nones, K., et al. (2015) · Nature · doi:10.1038/nature14169 · Cited by 2,642 · see citing works
Self-citationWente, M. N., Veit, J. A., Bassi, C., Dervenis, C., Fingerhut, A. L., Gouma, D. J., Izbicki, J. R., Neoptolemos, J. P., Padbury, R. T. A., Sarr, M. G., et al. (2007) · Surgery · doi:10.1016/j.surg.2007.02.001 · Cited by 2,630 · see citing works
Self-citationHingorani, S. R., Wang, L., Multani, A. S., Combs, C., Deramaudt, T. B., Hruban, R. H., Rustgi, A. K., Chang, S., & Tuveson, D. A. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.04.023 · Cited by 2,609 · see citing works
Self-citationDistant metastasis occurs late during the genetic evolution of pancreatic cancer
Yachida, S., Jones, S., Bozic, I., Antal, T., Leary, R., Fu, B., Kamiyama, M., Hruban, R. H., Eshleman, J. R., Nowak, M. A., et al. (2010) · Nature · doi:10.1038/nature09515 · Cited by 2,502 · see citing works
Self-citationPreinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Hingorani, S. R., Petricoin, E. F., Maitra, A., Rajapakse, V., King, C., Jacobetz, M. A., Ross, S., Conrads, T. P., Veenstra, T. D., Hitt, B. A., et al. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00309-x · Cited by 2,471 · see citing works
Self-citationInternational consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
Tanaka, M., Fernández-del Castillo, C., Adsay, V., Chari, S., Falconi, M., Jang, J.-Y., Kimura, W., Levy, P., Pitman, M. B., Schmidt, C. M., et al. (2012) · Pancreatology · doi:10.1016/j.pan.2012.04.004 · Cited by 2,354 · see citing works
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works
Self-citationProvenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195 · see citing works
Moffitt, R. A., Marayati, R., Flate, E. L., Volmar, K. E., Loeza, S. G. H., Hoadley, K. A., Rashid, N. U., Williams, L. A., Eaton, S. C., Chung, A. H., et al. (2015) · Nature Genetics · doi:10.1038/ng.3398 · Cited by 2,194 · see citing works
Organoid models of human and mouse ductal pancreatic cancer
Boj, S. F., Hwang, C.-I., Baker, L. A., Chio, I. I. C., Engle, D. D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M. S., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.021 · Cited by 2,150 · see citing works
Self-citationFeig, C., Jones, J. O., Kraman, M., Wells, R. J. B., Deonarine, A., Chan, D. S., Connell, C. M., Roberts, E. W., Zhao, Q., Caballero, O. L., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1320318110 · Cited by 2,100 · see citing works
Self-citationStromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
Rhim, A. D., Oberstein, P. E., Thomas, D. H., Mirek, E. T., Palermo, C. F., Sastra, S. A., Dekleva, E. N., Saunders, T., Becerra, C. P., Tattersall, I. W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.021 · Cited by 2,085 · see citing works
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058 · see citing works
Self-citationOncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
Ying, H., Kimmelman, A. C., Lyssiotis, C. A., Hua, S., Chu, G. C., Fletcher-Sananikone, E., Locasale, J. W., Son, J., Zhang, H., Coloff, J. L., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.058 · Cited by 2,043 · see citing works
Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
Son, J., Lyssiotis, C. A., Ying, H., Wang, X., Hua, S., Ligorio, M., Perera, R. M., Ferrone, C. R., Mullarky, E., Shyh-Chang, N., et al. (2013) · Nature · doi:10.1038/nature12040 · Cited by 1,990 · see citing works
Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy
Collisson, E. A., Sadanandam, A., Olson, P., Gibb, W. J., Truitt, M., Gu, S., Cooc, J., Weinkle, J., Kim, G. E., Jakkula, L., et al. (2011) · Nature Medicine · doi:10.1038/nm.2344 · Cited by 1,967 · see citing works
Self-citationOettle, H., Neuhaus, P., Hochhaus, A., Hartmann, J. T., Gellert, K., Ridwelski, K., Niedergethmann, M., Zülke, C., Fahlke, J., Arning, M., et al. (2013) · JAMA · doi:10.1001/jama.2013.279201 · Cited by 1,799 · see citing works
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
Commisso, C., Davidson, S. M., Soydaner-Azeloglu, R. G., Parker, S. J., Kamphorst, J. J., Hackett, S., Grabocka, E., Nofal, M., Drebin, J. A., Thompson, C. B., et al. (2013) · Nature · doi:10.1038/nature12138 · Cited by 1,683 · see citing works
CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans
Beatty, G. L., Chiorean, E. G., Fishman, M. P., Saboury, B., Teitelbaum, U. R., Sun, W., Huhn, R. D., Song, W., Li, D., Sharp, L. L., et al. (2011) · Science · doi:10.1126/science.1198443 · Cited by 1,678 · see citing works
Genetics and biology of pancreatic ductal adenocarcinomaPreprint
Hezel, A. F., Kimmelman, A. C., Stanger, B. Z., Bardeesy, N. M., & DePinho, R. A. (2006) · Genes & Development · doi:10.1101/gad.1415606 · Cited by 1,570 · see citing works
Gillen, S., Schuster, T., Büschenfelde, C. M. Z., Frieß, H., & Kleeff, J. H. (2010) · PLoS Medicine · doi:10.1371/journal.pmed.1000267 · Cited by 1,554 · see citing works
Self-citationPancreatic cancers require autophagy for tumor growth
Yang, S., Wang, X., Contino, G., Liesa, M., Sahin, E., Ying, H., Bause, A., Li, Y., Stommel, J. M., Dell'Antonio, G., et al. (2011) · Genes & Development · doi:10.1101/gad.2016111 · Cited by 1,498 · see citing works
Very high risk of cancer in familial Peutz–Jeghers syndrome
Giardiello, F. M., Brensinger, J. D., Tersmette, A. C., Goodman, S. N., Petersen, G. M., Booker, S. V., Cruz–Correa, M., & Offerhaus, G. J. A. (2000) · Gastroenterology · doi:10.1053/gast.2000.20228 · Cited by 1,435 · see citing works
Cancer risks in BRCA2 mutation carriers.
Olsson, H. (1999) · Journal of the National Cancer Institute · doi:10.1093/jnci/91.15.1310 · Cited by 1,404 · see citing works
Neoptolemos, J. P., Stocken, D. D., Bassi, C., Ghaneh, P., Cunningham, D., Goldstein, D., Padbury, R., Moore, M. J., Gallinger, S., Mariette, C., et al. (2010) · JAMA · doi:10.1001/jama.2010.1275 · Cited by 1,395 · see citing works
Self-citationOne Thousand Consecutive Pancreaticoduodenectomies
Cameron, J. L., Riall, T. S., Coleman, J., & Belcher, K. A. (2006) · Annals of Surgery · doi:10.1097/01.sla.0000217673.04165.ea · Cited by 1,279 · see citing works
Guerra, C., Schuhmacher, A. J., Cañamero, M., Grippo, P. J., Verdaguer, L., Pérez-Gallego, L., Dubus, P., Sandgren, E. P., & Barbacid, M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.012 · Cited by 1,224 · see citing works
Wang-Gillam, A., Li, C.-P., Bodoky, G., Dean, A., Shan, Y.-S., Jameson, G., Macarulla, T., Lee, K.-H., Cunningham, D., Blanc, J. F., et al. (2016) · The Lancet · doi:10.1016/s0140-6736(15)00986-1 · Cited by 1,222 · see citing works
Targeting lactate metabolism for cancer therapeutics
Doherty, J. R., & Cleveland, J. L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69741 · Cited by 1,173 · see citing works
Sherman, M. H., Yu, R. T., Engle, D. D., Ding, N., Atkins, A. R., Tiriac, H., Collisson, E. A., Connor, F., Van Dyke, T., Kozlov, S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.007 · Cited by 1,158 · see citing works
Self-citationCaldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132 · see citing works
Self-citationHyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer
Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302529 · Cited by 1,120 · see citing works
Self-citationWhole-exome sequencing of pancreatic cancer defines genetic diversity and therapeutic targets
Witkiewicz, A. K., McMillan, E. A., Balaji, U., Baek, G., Lin, W.-C., Mansour, J., Mollaee, M., Wagner, K.-U., Koduru, P., Yopp, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7744 · Cited by 1,115 · see citing works
Aguirre, A. J., Bardeesy, N., Sinha, M., Lopez, L., Tuveson, D. A., Horner, J., Redston, M. S., & DePinho, R. A. (2003) · Genes & Development · doi:10.1101/gad.1158703 · Cited by 1,033 · see citing works
Self-citationDynamics of the immune reaction to pancreatic cancer from inception to invasion
Clark, C. E., Hingorani, S. R., Mick, R., Combs, C., Tuveson, D. A., & Vonderheide, R. H. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0175 · Cited by 990 · see citing works
Self-citationHereditary Pancreatitis and the Risk of Pancreatic Cancer
Lowenfels, A. B., Maisonneuve, P., DiMagno, E. P., Elitsur, Y., Gates, L. K., Perrault, J., Whitcomb, D. C., & International Hereditary Pancreatitis Study Group (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.6.442 · Cited by 988 · see citing works
Wise, D. R., Ward, P. S., Shay, J. E. S., Cross, J. R., Gruber, J. J., Sachdeva, U. M., Platt, J. M., DeMatteo, R. G., Simon, M. C., & Thompson, C. B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117773108 · Cited by 975 · see citing works
Bockhorn, M., Uzunoglu, F. G., Adham, M., IMRIE, C. W., Milićević, M., Sandberg, A. A., Asbun, H. J., Bassi, C., Büchler, M. W., Charnley, R., et al. (2014) · Surgery · doi:10.1016/j.surg.2014.02.001 · Cited by 967 · see citing works
Self-citationBayne, L. J., Beatty, G. L., Jhala, N., Clark, C. E., Rhim, A. D., Stanger, B. Z., & Vonderheide, R. H. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.025 · Cited by 947 · see citing works
Recent progress in pancreatic cancer
Wolfgang, C. L., Herman, J. M., Laheru, D. A., Klein, A. P., Erdek, M. A., Fishman, E. K., & Hruban, R. H. (2013) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21190 · Cited by 918 · see citing works
Self-citationKamphorst, J. J., Nofal, M., Commisso, C., Hackett, S. R., Lu, W., Grabocka, E., Vander Heiden, M. G., Miller, G., Drebin, J. A., Bar-Sagi, D., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-2211 · Cited by 893 · see citing works
Basturk, O., Hong, S.-M., Wood, L. D., Adsay, N. V., Albores-Saavedra, J., Biankin, A. V., Brosens, L. A. A., Fukushima, N., Goggins, M., Hruban, R. H., et al. (2015) · American Journal of Surgical Pathology · doi:10.1097/pas.0000000000000533 · Cited by 864 · see citing works
Self-citationFerrone, C. R., Marchegiani, G., Hong, T. S., Ryan, D. P., Deshpande, V., McDonnell, E., Sabbatino, F., Santos, D., Allen, J. N., Blaszkowsky, L. S., et al. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000867 · Cited by 841 · see citing works
Cunningham, D., Chau, I., Stocken, D. D., Valle, J. W., Smith, D. B., Steward, W. P., Harper, P., Dunn, J., Smith, C. T., West, J., et al. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2009.24.2446 · Cited by 822 · see citing works
Self-citationTranscriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature · doi:10.1038/nature14587 · Cited by 799 · see citing works
Canto, M. I., Harinck, F., Hruban, R. H., Offerhaus, G. J., Poley, J.-W., Kamel, I., Nio, Y., Schulick, R. S., Bassi, C., Kluijt, I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303108 · Cited by 784 · see citing works
Self-citationOncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
Collins, M. A., Bednar, F., Zhang, Y., Brisset, J.-C., Galbán, S., Galbán, C. J., Rakshit, S., Flannagan, K. S., Adsay, N. V., & Pasca di Magliano, M. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59227 · Cited by 770 · see citing works
Huang, L., Holtzinger, A., Jagan, I., BeGora, M. D., Lohse, I., Ngai, N., Nostro, M. C., Wang, R., Muthuswamy, L. B., Crawford, H. C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3973 · Cited by 745 · see citing works
Oncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasia
Pylayeva-Gupta, Y., Lee, K. E., Hajdu, C. H., Miller, G., & Bar-Sagi, D. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.024 · Cited by 721 · see citing works
p53 status determines the role of autophagy in pancreatic tumour development
Rosenfeldt, M. T., O’Prey, J., Morton, J. P., Nixon, C., MacKay, G., Mrowinska, A., Au, A., Rai, T. S., Zheng, L., Ridgway, R., et al. (2013) · Nature · doi:10.1038/nature12865 · Cited by 713 · see citing works
Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
Huch, M., Bonfanti, P., Boj, S., Sato, T., Loomans, C. J. M., van de Wetering, M., Sojoodi, M., Li, V. S. W., Schuijers, J., Gračanin, A., et al. (2013) · EMBO Journal · doi:10.1038/emboj.2013.204 · Cited by 710 · see citing works
Kopp, J. L., von Figura, G., Mayes, E., Liu, F.-F., Dubois, C. L., Morris, J. P., Pan, F. C., Akiyama, H., Wright, C. V. E., Jensen, K., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.10.025 · Cited by 697 · see citing works
Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds
Klein, A. P., Brune, K. A., Petersen, G. M., Goggins, M., Tersmette, A. C., Offerhaus, G. J. A., Griffin, C., Cameron, J. L., Yeo, C. J., Kern, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3823 · Cited by 678 · see citing works
Self-citationTol, J. A. M. G., Gouma, D. J., Bassi, C., Dervenis, C., Montorsi, M., Adham, M., Andrén‐Sandberg, Å., Asbun, H. J., Bockhorn, M., Büchler, M. W., et al. (2014) · Surgery · doi:10.1016/j.surg.2014.06.016 · Cited by 677 · see citing works
Self-citationBardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674 · see citing works
Mayers, J. R., Wu, C. H., Clish, C. B., Kraft, P., Torrence, M. E., Fiske, B. P., Yuan, C., Bao, Y., Townsend, M. K., Tworoger, S. S., et al. (2014) · Nature Medicine · doi:10.1038/nm.3686 · Cited by 652 · see citing works
Most Pancreatic Cancer Resections are R1 Resections
Esposito, I., Kleeff, J. H., Bergmann, F., Reiser, C., Herpel, E., Frieß, H., Schirmacher, P., & Büchler, M. W. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9839-8 · Cited by 643 · see citing works
Self-citationBoffetta, P., Hecht, S. S., Gray, N. J., Gupta, P. C., & Straíf, K. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70173-6 · Cited by 634 · see citing works
Increased Risk of Pancreatic Cancer in Melanoma-Prone Kindreds withp16INK4Mutations
Goldstein, A. M., Fraser, M. C., Struewing, J. P., Hussussian, C. J., Ranade, K., Zametkin, D. P., Fontaine, L. S., Organic, S. M., Dracopoli, N. C., Clark, W. H., et al. (1995) · New England Journal of Medicine · doi:10.1056/nejm199510123331504 · Cited by 620 · see citing works
Clinical and genetic characteristics of hereditary pancreatitis in Europe
Howes, N., Lerch, M. M., Greenhalf, W., Stocken, D. D., Ellis, I., Simon, P., Truninger, K., Ammann, R. W., Cavallini, G., Charnley, R., et al. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00013-8 · Cited by 612 · see citing works
Self-citationLe, D. T., Wang-Gillam, A., Picozzi, V., Greten, T. F., Crocenzi, T., Springett, G., Morse, M., Zeh, H., Cohen, D., Fine, R. L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2014.57.4244 · Cited by 611 · see citing works
Ene–Obong, A., Clear, A. J., Watt, J., Wang, J., Fatah, R., Riches, J. C., Marshall, J. F., Chin–Aleong, J., Chelala, C., Gribben, J. G., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.07.025 · Cited by 579 · see citing works
Catenacci, D. V. T., Junttila, M. R., Karrison, T., Bahary, N., Horiba, M. N., Nattam, S. R., Marsh, R., Wallace, J., Kozloff, M., Rajdev, L., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.62.8719 · Cited by 561 · see citing works
National Failure to Operate on Early Stage Pancreatic Cancer
Bilimoria, K. Y., Bentrem, D. J., Ko, C. Y., Stewart, A. K., Winchester, D. P., & Talamonti, M. (2007) · Annals of Surgery · doi:10.1097/sla.0b013e3180691579 · Cited by 554 · see citing works
Immunotherapy Converts Nonimmunogenic Pancreatic Tumors into Immunogenic Foci of Immune Regulation
Lutz, E. R., Wu, A. A., Bigelow, E. O., Sharma, R. B., Mo, G., Soares, K. C., Solt, S., Dorman, A., Wamwea, A., Yager, A., et al. (2014) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-14-0027 · Cited by 551 · see citing works
Self-citationRisk of Pancreatic Cancer in Families With Lynch Syndrome
Kastrinos, F. (2009) · JAMA · doi:10.1001/jama.2009.1529 · Cited by 544 · see citing works
Tempero, M. A., Plunkett, W. K., van Haperen, V. W. T. R., Hainsworth, J. D., Höchster, H. S., Lenzi, R., & Abbruzzese, J. L. (2003) · Journal of Clinical Oncology · doi:10.1200/jco.2003.09.140 · Cited by 519 · see citing works
Self-citationChari, S. T., Leibson, C. L., Rabe, K. G., Timmons, L. J., Ransom, J. E., de Andrade, M., & Petersen, G. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.10.040 · Cited by 519 · see citing works
Stromal response to Hedgehog signaling restrains pancreatic cancer progression
Lee, J. J., Perera, R. M., Wang, H., Wu, D.-C., Liu, X. S., Han, S., Fitamant, J., Jones, P. D., Ghanta, K. S., Kawano, S., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1411679111 · Cited by 502 · see citing works
Mucinous Cystic Neoplasm of the Pancreas is Not an Aggressive Entity
Crippa, S., Salvia, R., Warshaw, A. L., Domínguez, I., Bassi, C., Falconi, M., Thayer, S. P., Zamboni, G., Lauwers, G. Y., Mino-Kenudson, M. A., et al. (2008) · Annals of Surgery · doi:10.1097/sla.0b013e31811f4449 · Cited by 488 · see citing works
Autophagy is critical for pancreatic tumor growth and progression in tumors with p53 alterations
Yang, A., Rajeshkumar, N. V., Wang, X., Yabuuchi, S., Alexander, B. M., Chu, G. C., Von Hoff, D. D., Maitra, A., & Kimmelman, A. C. (2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-0362 · Cited by 486 · see citing works
Sausen, M., Phallen, J., Adleff, V., Jones, S., Leary, R. J., Barrett, M. T., Anagnostou, V., Parpart-Li, S., Murphy, D., Kay Li, Q., et al. (2015) · Nature Communications · doi:10.1038/ncomms8686 · Cited by 484 · see citing works
Self-citationBramhall, S. R., Allum, W. H., Jones, A., et al. (1995) · British journal of surgery · doi:10.1002/bjs.1800820137 · Cited by 483 · see citing works
Pancreatic Adenocarcinoma, Version 2.2014
Tempero, M. A., Malafa, M. P., Behrman, S. W., Benson, A. B., Casper, E. S., Chiorean, E. G., Chung, V. M., Cohen, S. J., Czito, B. G., Engebretson, A., et al. (2014) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2014.0106 · Cited by 464 · see citing works
Self-citationCoffee and Cancer of the Pancreas
MacMahon, B., Yen, S., Trichopoulos, D., Warren, K. W., & Nardi, G. L. (1981) · New England Journal of Medicine · doi:10.1056/nejm198103123041102 · Cited by 452 · see citing works
A Starring Role for Stellate Cells in the Pancreatic Cancer Microenvironment
Apte, M. V., Wilson, J. S., Lugea, A., & Pandol, S. J. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.11.037 · Cited by 449 · see citing works
Self-citationArterial Resection During Pancreatectomy for Pancreatic Cancer
Mollberg, N. M., Rahbari, N. N., Koch, M., et al. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e31823ac299 · Cited by 446 · see citing works
Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers
Golan, T., Kanji, Z. S., Epelbaum, R., Devaud, N., Dagan, E., Holter, S., Aderka, D., Paluch–Shimon, S., Kaufman, B., Gershoni‐Baruch, R., et al. (2014) · British Journal of Cancer · doi:10.1038/bjc.2014.418 · Cited by 437 · see citing works
Erkan, M., Michalski, C. W., Rieder, S., Reiser–Erkan, C., Abiatari, I., Kolb, A., Giese, N. A., Esposito, I., Frieß, H., & Kleeff, J. H. (2008) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2008.05.006 · Cited by 426 · see citing works
Self-citationBosetti, C., Lucenteforte, E., Silverman, D. T., Petersen, G. M., Bracci, P. M., Ji, B.-T., Negri, E., Li, D., Risch, H. A., Olson, S. H., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr541 · Cited by 415 · see citing works
Pancreatic Cancer Surgery in the New Millennium
Hartwig, W., Hackert, T., Hinz, U., Gluth, A., Bergmann, F., Strobel, O., Büchler, M. W., & Werner, J. (2011) · Annals of Surgery · doi:10.1097/sla.0b013e31821fd334 · Cited by 412 · see citing works
Hruban, R., Adsay, N., Albores-saavedra, J., Anver, M., Biankin, A., Boivin, G. P., Furth, E., Furukawa, T., Klein, A., Klimstra, D., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2168 · Cited by 411 · see citing works
Self-citationHabbe, N., Shi, G., Meguid, R. A., Fendrich, V., Esni, F., Chen, H., Feldmann, G., Stoffers, D. A., Konieczny, S. F., Leach, S. D., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810097105 · Cited by 410 · see citing works
Imaging diagnosis of pancreatic cancer: A state-of-the-art review
Lee, E. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i24.7864 · Cited by 401 · see citing works
Daemen, A., Peterson, D., Sahu, N., McCord, R., Du, X., Liu, B., Kowanetz, K., Hong, R., Moffat, J., Gao, M., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1501605112 · Cited by 398 · see citing works
The EGF receptor family: spearheading a merger of signaling and therapeutics
Bublil, E. M., & Yarden, Y. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.02.008 · Cited by 398 · see citing works
Soares, K. C., Rucki, A. A., Wu, A. A., Olino, K. L., Xiao, Q., Chai, Y., Wamwea, A., Bigelow, E. O., Lutz, E. R., Liu, L. L., et al. (2014) · Journal of Immunotherapy · doi:10.1097/cji.0000000000000062 · Cited by 398 · see citing works
The Clinical Utility of CA 19-9 in Pancreatic Adenocarcinoma: Diagnostic and Prognostic Updates
Poruk, K. E., Gay, D., Brown, K. S., Mulvihill, J. D., Boucher, K. M., Scaife, C. L., Firpo, M. A., & Mulvihill, S. J. (2013) · Current Molecular Medicine · doi:10.2174/1566524011313030003 · Cited by 396 · see citing works
EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
Navas, C., Hernández-Porras, I., Schuhmacher, A. J., Sibilia, M., Guerra, C., & Barbacid, M. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.001 · Cited by 391 · see citing works
250 Robotic Pancreatic Resections
Zureikat, A. H., Moser, A. J., Boone, B. A., et al. (2013) · Annals of Surgery · doi:10.1097/sla.0b013e3182a4e87c · Cited by 390 · see citing works
Izeradjene, K., Combs, C., Best, M., Gopinathan, A., Wagner, A., Grady, W. M., Deng, C.-X., Hruban, R. H., Adsay, N. V., Tuveson, D. A., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.017 · Cited by 379 · see citing works
Self-citationIjichi, H., Chytil, A., Gorska, A. E., Aakre, M. E., Fujitani, Y., Fujitani, S., Wright, C. V. E., & Moses, H. L. (2006) · Genes & Development · doi:10.1101/gad.1475506 · Cited by 379 · see citing works
Hospital Volume and Mortality After Pancreatic Resection
van Heek, N. T., Kuhlmann, K. F. D., Scholten, R. J. P. M., de Castro, S. M. M., Busch, O. R., van Gulik, T. M., Obertop, H., & Gouma, D. J. (2005) · Annals of Surgery · doi:10.1097/01.sla.0000188462.00249.36 · Cited by 374 · see citing works
Hruban, R. H., Pitman, M. B., & Klimstra, D. S. (2007) · American Registry of PathologyWashington, DC eBooks · doi:10.55418/9781933477022 · Cited by 371 · see citing works
Self-citationKleeff, J. H., Ishiwata, T., Kumbasar, A., Friess, H., Büchler, M. W., Lander, A. D., & Korc, M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci4105 · Cited by 369 · see citing works
Self-citationXiao, Y., & Freeman, G. J. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1397 · Cited by 368 · see citing works
Increased risk of thyroid and pancreatic carcinoma in familial adenomatous polyposis.
Giardiello, F. M., Offerhaus, G. J. A., Lee, D. H., Krush, A. J., Tersmette, A. C., Booker, S. V., Kelley, N., & Hamilton, S. R. (1993) · Gut · doi:10.1136/gut.34.10.1394 · Cited by 359 · see citing works
Role of Pancreatic Stellate Cells in Pancreatic Cancer Metastasis
Xu, Z., Vonlaufen, A., Phillips, P. A., Fiala‐Beer, E., Zhang, X., Yang, L., Biankin, A. V., Goldstein, D., Pirola, R. C., Wilson, J. S., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090899 · Cited by 356 · see citing works
Self-citationBorg, A., Sandberg, T., Nilsson, K., Johannsson, O., Klinker, M., Masback, A., Westerdahl, J., Olsson, H., & Ingvar, C. (2000) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/92.15.1260 · Cited by 345 · see citing works
Context-Dependent Transformation of Adult Pancreatic Cells by Oncogenic K-Ras
Friedlander, S., Chu, G. C., Snyder, E. L., Girnius, N., Dibelius, G., Crowley, D. G., Vasile, E., DePinho, R. A., & Jacks, T. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.09.027 · Cited by 338 · see citing works
New insights into pancreatic cancer-induced paraneoplastic diabetes
Sah, R. P., Nagpal, S. J. S., Mukhopadhyay, D., & Chari, S. T. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.49 · Cited by 336 · see citing works
Impact of nationwide centralization of pancreaticoduodenectomy on hospital mortality
for the Dutch Pancreatic Cancer Group, de Wilde, R. F., Besselink, M. G., van der Tweel, I., de Hingh, I. H. J. T., van Eijck, C. H. J., Dejong, C. H. C., Porte, R. J., Gouma, D. J., Busch, O. R., et al. (2012) · British journal of surgery · doi:10.1002/bjs.8664 · Cited by 326 · see citing works
2564 resected periampullary adenocarcinomas at a single institution: trends over three decades
He, J. P., Ahuja, N., Makary, M. A., Cameron, J. L., Eckhäuser, F. E., Choti, M. A., Hruban, R. H., Pawlik, T. M., & Wolfgang, C. L. (2013) · HPB · doi:10.1111/hpb.12078 · Cited by 321 · see citing works
Self-citationDistal Pancreatectomy With En Bloc Celiac Axis Resection for Locally Advanced Pancreatic Body Cancer
Hirano, S., Kondo, S., Hara, T., et al. (2007) · Annals of Surgery · doi:10.1097/01.sla.0000258608.52615.5a · Cited by 317 · see citing works
The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma
Initiative, A. P. C. G., Pérez-Mancera, P. A., Rust, A. G., van der Weyden, L., Kristiansen, G., Li, A., Sarver, A. L., Silverstein, K. A. T., Grützmann, R., Aust, D., et al. (2012) · Nature · doi:10.1038/nature11114 · Cited by 316 · see citing works
Self-citationCarpelan-Holmström, M. A., Nordling, S., Pukkala, ., Sankila, R., Lüttges, J., Klöppel, G., & Haglund, C. (2005) · Gut · doi:10.1136/gut.2004.047191 · Cited by 313 · see citing works
Regine, W. F., Winter, K. A., Abrams, R. A., Safran, H. P., Hoffman, J. P., Konski, A. A., Benson, A. B., Macdonald, J. S., Rich, T. A., & Willett, C. G. (2011) · Annals of Surgical Oncology · doi:10.1245/s10434-011-1630-6 · Cited by 311 · see citing works
Kim, E. J.-H., Sahai, V., Abel, E. V., Griffith, K. A., Greenson, J. K., Takebe, N., Khan, G. N., Blau, J., Craig, R. A., Balis, U. J., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1269 · Cited by 306 · see citing works
Immunohistochemical Labeling for Dpc4 Mirrors Genetic Status in Pancreatic Adenocarcinomas
Wilentz, R. E., Su, G. H., Dai, J. L., Sparks, A. B., Argani, P., Sohn, T. A., Yeo, C. J., Kern, S. E., & Hruban, R. H. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64703-7 · Cited by 304 · see citing works
Self-citationMichalski, C. W., Kleeff, J. H., Wente, M. N., et al. (2007) · British journal of surgery · doi:10.1002/bjs.5716 · Cited by 304 · see citing works
Self-citationRuijs, M., Verhoef, S., Rookus, M. A., Pruntel, R., van der Hout, A. H., Hogervorst, F. B. L., Kluijt, I., Sijmons, R. H., Aalfs, C. M., Wagner, A., et al. (2010) · Journal of Medical Genetics · doi:10.1136/jmg.2009.073429 · Cited by 304 · see citing works
Quality of Life and Outcomes After Pancreaticoduodenectomy
Huang, J. J., Yeo, C. J., Sohn, T. A., et al. (2000) · Annals of Surgery · doi:10.1097/00000658-200006000-00014 · Cited by 300 · see citing works
Early Detection of Sporadic Pancreatic Cancer: Summative Review
Chari, S. T., Kelly, K., Hollingsworth, M. A., Thayer, S. P., Ahlquist, D. A., Andersen, D. K., Batra, S. K., Brentnall, T. A., Canto, M., Cleeter, D. F., et al. (2015) · Pancreas · doi:10.1097/mpa.0000000000000368 · Cited by 295 · see citing works
Beatty, G. L., Winograd, R., Evans, R. A., Long, K. B., Luque, S. L., Lee, J. W., Clendenin, C. J., Gladney, W. L., Knoblock, D. M., Guirnalda, P. D., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.010 · Cited by 293 · see citing works
Hurwitz, H. I., Uppal, N., Wagner, S. A., Bendell, J. C., Beck, J. T., Wade, S., Nemunaitis, J. J., Stella, P. J., Pipas, J. M., Wainberg, Z. A., et al. (2015) · Journal of Clinical Oncology · doi:10.1200/jco.2015.61.4578 · Cited by 293 · see citing works
Erkan, M., Reiser–Erkan, C., Michalski, C. W., Deucker, S., Sauliunaite, D., Streit, S., Esposito, I., Friess, H., & Kleeff, J. H. (2009) · Neoplasia · doi:10.1593/neo.81618 · Cited by 289 · see citing works
Self-citationMalvezzi, M., Bertuccio, P., Rosso, T., Rota, M., Levi, F., Vecchia, C. L., & Negri, E. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv001 · Cited by 289 · see citing works
Bosetti, C., Rosato, V., Li, D., Silverman, D. T., Petersen, G. M., Bracci, P. M., Neale, R. Ε., Muscat, J. E., Anderson, K. E., Gallinger, S., et al. (2014) · Annals of Oncology · doi:10.1093/annonc/mdu276 · Cited by 289 · see citing works
Self-citationFitzsimmons, D. F., Johnson, C. D., George, S., Payne, S. A., Sandberg, A. A., Bassi, C., Beger, H. G., Birk, D., Büchler, M. W., Dervenis, C., et al. (1999) · European Journal of Cancer · doi:10.1016/s0959-8049(99)00047-7 · Cited by 284 · see citing works
Self-citationPatient-centric trials for therapeutic development in precision oncology
Biankin, A. V., Piantadosi, S., & Hollingsworth, S. J. (2015) · Nature · doi:10.1038/nature15819 · Cited by 282 · see citing works
Self-citationLarsson, S. C., & Wolk, A. (2012) · British Journal of Cancer · doi:10.1038/bjc.2011.585 · Cited by 282 · see citing works
Pawlik, T. M., Laheru, D. A., Hruban, R. H., Coleman, J., Wolfgang, C. L., Campbell, K. A., Ali, S. Z., Fishman, E. K., Schulick, R. D., & Herman, J. M. (2008) · Annals of Surgical Oncology · doi:10.1245/s10434-008-9929-7 · Cited by 274 · see citing works
Self-citationWyse, J. M., Carone, M., Paquin, S. C., Usatii, M., & Sahai, A. V. (2011) · Journal of Clinical Oncology · doi:10.1200/jco.2010.32.2750 · Cited by 274 · see citing works
Mehrabi, A., Hafezi, M., Arvin, J., Esmaeilzadeh, M., Garoussi, C., Emami, G., Kössler‐Ebs, J., Müller-Stich, B. P., Büchler, M. W., Hackert, T., et al. (2014) · Surgery · doi:10.1016/j.surg.2014.06.081 · Cited by 271 · see citing works
Chiou, S., Winters, I. P., Wang, J., Naranjo, S., Dudgeon, C., Tamburini, F. B., Brady Jennifer, J., Yang, D., Grüner, B. M., Chuang, C.-H., et al. (2015) · Genes & Development · doi:10.1101/gad.264861.115 · Cited by 267 · see citing works
Lennon, A. M., Wolfgang, C. L., Canto, M. I., Klein, A. P., Herman, J. M., Goggins, M., Fishman, E. K., Kamel, I. R., Weiss, M. J., Diaz, L. A., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-0734 · Cited by 263 · see citing works
Self-citationCampbell, F., Smith, R. A., Whelan, P., et al. (2009) · Histopathology · doi:10.1111/j.1365-2559.2009.03376.x · Cited by 258 · see citing works
Ma, Z., Vocadlo, D. J., & Vosseller, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.470047 · Cited by 255 · see citing works
A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development
Faça, V. M., Song, K. S., Wang, H., Zhang, Q., Krasnoselsky, A. L., Newcomb, L. F., Plentz, R. R., Gurumurthy, S., Redston, M. S., Pitteri, S. J., et al. (2008) · PLoS Medicine · doi:10.1371/journal.pmed.0050123 · Cited by 255 · see citing works
The incidence of pancreatic cancer in BRCA1 and BRCA2 mutation carriers
T. H. B. C. S. G., Iqbal, J., Ragone, A., Lubinski, J., Lynch, H. T., Moller, P., Ghadirian, P., Foulkes, W. D., Armel, S., Eisen, A., et al. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.483 · Cited by 252 · see citing works
Minimally Invasive Versus Open Pancreaticoduodenectomy for Cancer
Adam, M. A., Choudhury, K. R., Dinan, M. A., Reed, S. D., Scheri, R. P., Blazer, D. G., Roman, S. A., & Sosa, J. A. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001055 · Cited by 248 · see citing works
Lucenteforte, E., Vecchia, C. L., Silverman, D. T., Petersen, G. M., Bracci, P. M., Ji, B.-T., Bosetti, C., Li, D., Gallinger, S., Miller, A. B., et al. (2011) · Annals of Oncology · doi:10.1093/annonc/mdr120 · Cited by 241 · see citing works
Common Activation of Canonical Wnt Signaling in Pancreatic Adenocarcinoma
di Magliano, M. P., Biankin, A. V., Heiser, P. W., Cano, D. A., Gutiérrez, P. J. A., Deramaudt, T. B., Segara, D., Dawson, A. C., Kench, J. G., Henshall, S. M., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001155 · Cited by 236 · see citing works
Self-citationAlcohol drinking and pancreatic cancer risk: a meta‐analysis of the dose‐risk relation
Tramacere, I., Scotti, L., Jenab, M., Bagnardi, V., Bellocco, R., Rota, M., Corrao, G., Bravi, F., Boffetta, P., & Vecchia, C. L. (2009) · International Journal of Cancer · doi:10.1002/ijc.24936 · Cited by 230 · see citing works
Nones, K., Waddell, N., Song, S., Patch, A., Miller, D. K., Johns, A. L., Wu, J., Kassahn, K. S., Wood, D., Bailey, P. J., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.28765 · Cited by 229 · see citing works
Self-citationKitano, M., Yamashita, Y., Tanaka, K., et al. (2013) · The American Journal of Gastroenterology · doi:10.1038/ajg.2013.305 · Cited by 228 · see citing works
Plectin-1 as a Novel Biomarker for Pancreatic Cancer
Bausch, D., Thomas, S., Mino-Kenudson, M. A., Fernández-del, C. C., Bauer, T. W., Williams, M., Warshaw, A. L., Thayer, S. P., & Kelly, K. A. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0999 · Cited by 226 · see citing works
Pancreatic cancer microenvironment
Kleeff, J. H., Beckhove, P., Esposito, I., Herzig, S., Huber, P. E., Löhr, M. J., & Friess, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.22871 · Cited by 222 · see citing works
Self-citationNeuroplastic Changes Occur Early in the Development of Pancreatic Ductal Adenocarcinoma
Stopczynski, R. E., Normolle, D. P., Hartman, D. J., Ying, H., DeBerry, J. J., Bielefeldt, K., Rhim, A. D., DePinho, R. A., Albers, K. M., & Davis, B. M. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2050 · Cited by 216 · see citing works
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma
Mann, K. M., Ward, J. M., Yew, C. C. K., Kovochich, A., Dawson, D. W., Black, M. A., Brett, B. T., Scheetz, T. E., Dupuy, A. J., Initiative, A. P. C. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202490109 · Cited by 210 · see citing works
Self-citationMultivisceral Resection for Pancreatic Malignancies
Hartwig, W., Hackert, T., Hinz, U., et al. (2009) · Annals of Surgery · doi:10.1097/sla.0b013e3181ad657b · Cited by 208 · see citing works
Zhou, Y., Zhang, Z., Liu, Y., et al. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1461-z · Cited by 208 · see citing works
Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer
Ma, Y., Hwang, R. F., Logsdon, C. D., & Ullrich, S. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4479 · Cited by 202 · see citing works
Hypoxia signaling pathways: modulators of oxygen-related organelles
Schönenberger, M. J. (2015) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2015.00042 · Cited by 199 · see citing works
2. Tobacco-attributable cancer burden in the UK in 2010
Parkin, D. M. (2011) · British Journal of Cancer · doi:10.1038/bjc.2011.475 · Cited by 198 · see citing works
International Agency for Research on Cancer
Wild, C. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-386454-3.00402-4 · Cited by 198 · see citing works
Motosugi, U., Ichikawa, T., Morisaka, H., et al. (2011) · Radiology · doi:10.1148/radiol.11103548 · Cited by 194 · see citing works
Pancreatic Cancer–Derived Exosomes Cause Paraneoplastic β-cell Dysfunction
Javeed, N., Sagar, G., Dutta, S. K., Smyrk, T. C., Lau, J. S., Bhattacharya, S., Truty, M. J., Petersen, G. M., Kaufman, R. J., Chari, S. T., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-2022 · Cited by 194 · see citing works
Giovinazzo, F., Turri, G., Katz, M. H. G., Heaton, N. D., & Ahmed, I. (2015) · British journal of surgery · doi:10.1002/bjs.9969 · Cited by 193 · see citing works
Meta-analysis of radical resection rates and margin assessment in pancreatic cancer
Chandrasegaram, M. D., Goldstein, D., Simes, J. R., et al. (2015) · British journal of surgery · doi:10.1002/bjs.9892 · Cited by 191 · see citing works
von Figura, G., Fukuda, A., Roy, N., Liku, M. E., Morris IV, J. P., Kim, G. E., Russ, H. A., Firpo, M. A., Mulvihill, S. J., Dawson, D. W., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb2916 · Cited by 190 · see citing works
Pancreatic Cancer Stroma: Friend or Foe?
Gore, J., & Korc, M. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.026 · Cited by 189 · see citing works
Self-citationHarinck, F., Konings, I. C. A. W., Kluijt, I., Poley, J. W., van Hooft, J. E., van Dullemen, H. M., Nio, C. Y., Krak, N. C., Hermans, J. J., Aalfs, C. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2014-308008 · Cited by 185 · see citing works
Gleisner, A., Assumpcao, L., Cameron, J. L., et al. (2007) · Cancer · doi:10.1002/cncr.23074 · Cited by 184 · see citing works
Mayo, S. C., Gilson, M. M., Herman, J. M., Cameron, J. L., Nathan, H., Edil, B. H., Choti, M. A., Schulick, R. D., Wolfgang, C. L., & Pawlik, T. M. (2011) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2011.09.022 · Cited by 176 · see citing works
Minimally-Invasive vs Open Pancreaticoduodenectomy: Systematic Review and Meta-Analysis
Correa‐Gallego, C., Dinkelspiel, H. E., Sulimanoff, I., Fisher, S. B., Viñuela, E., Kingham, T. P., Fong, Y., DeMatteo, R. P., D'Angelica, M. I., Jarnagin, W. R., et al. (2013) · Journal of the American College of Surgeons · doi:10.1016/j.jamcollsurg.2013.09.005 · Cited by 168 · see citing works
The needs of patients with advanced, incurable cancer
Rainbird, K., Perkins, J. J., Sanson‐Fisher, R., Rolfe, I. E., & Anseline, P. F. (2009) · British Journal of Cancer · doi:10.1038/sj.bjc.6605235 · Cited by 167 · see citing works
Li, X., Wang, Z., Ma, Q., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-3426 · Cited by 167 · see citing works
TLR9 ligation in pancreatic stellate cells promotes tumorigenesis
Zambirinis, C. P., Levie, E., Nguy, S., Avanzi, A., Barilla, R., Xu, Y., Seifert, L., Daley, D., Greco, S. H., Deutsch, M., et al. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20142162 · Cited by 164 · see citing works
Self-citationTrends in Hospital Volume and Failure to Rescue for Pancreatic Surgery
Amini, N., Spolverato, G., Kim, Y., et al. (2015) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-015-2800-9 · Cited by 164 · see citing works
Tang, D., Yuan, Z., Xue, X., Lu, Z., Zhang, Y., Wang, H., Chen, M., An, Y., Wei, J., Zhu, Y., et al. (2011) · International Journal of Cancer · doi:10.1002/ijc.26290 · Cited by 163 · see citing works
Arnaoutakis, G. J., Rangachari, D., Laheru, D. A., et al. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1605-8 · Cited by 160 · see citing works
Pancreatic stellate cells enhance stem cell-like phenotypes in pancreatic cancer cells
Hamada, S., Masamune, A., Takikawa, T., Suzuki, N., Kikuta, K., Hirota, M., Hamada, H., Kobune, M., Satoh, K., & Shimosegawa, T. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.04.014 · Cited by 160 · see citing works
Genkinger, J. M., Kitahara, C. M., Bernstein, L., Berrington de Gonzalez, A., Brotzman, M., Elena, J. W., Giles, G. G., Hartge, P., Singh, P. N., Stolzenberg-Solomon, R. Z., et al. (2015) · Annals of Oncology · doi:10.1093/annonc/mdv355 · Cited by 159 · see citing works
β1 integrin controls EGFR signaling and tumorigenic properties of lung cancer cells
Morello, V., Cabodi, S., Sigismund, S., Leal, M. D. P. C., Repetto, D., Volante, M., Papotti, M. G., Turco, E., & Defilippi, P. (2011) · Oncogene · doi:10.1038/onc.2011.107 · Cited by 155 · see citing works
Dawson, D. W., Hertzer, K. M., Moro, A., Donald, G. W., Chang, H.-H., Go, V. L. W., Pandol, S. J., Lugea, A., Gukovskaya, A. S., Li, G., et al. (2013) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-13-0065 · Cited by 155 · see citing works
p53 mutations cooperate with oncogenic Kras to promote adenocarcinoma from pancreatic ductal cells
Bailey, J. M., Hendley, A. M., Lafaro, K. J., Pruski, M. A., Jones, N. C., Alsina, J., Younes, M., Maitra, A., McAllister, F., Iacobuzio-Donahue, C. A., et al. (2016) · Oncogene · doi:10.1038/onc.2015.441 · Cited by 154 · see citing works
Screening for Pancreatic Cancer in a High-Risk Cohort: An Eight-Year Experience
Al-Sukhni, W., Borgida, A., Rothenmund, H., Holter, S., Semotiuk, K., Grant, R. C., Wilson, S. R., Moore, M. J., Narod, S. A., Jhaveri, K. S., et al. (2011) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-011-1781-6 · Cited by 150 · see citing works
Keenan, B. P., Saenger, Y. M., Kafrouni, M. I., Leubner, A., Lauer, P., Maitra, A., Rucki, A. A., Gunderson, A. J., Coussens, L. M., Brockstedt, D. G., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.055 · Cited by 148 · see citing works
Klein, A. P., Lindström, S., Mendelsohn, J. B., Steplowski, E., Arslan, A. A., Bueno-de-Mesquita, H. B., Fuchs, C. S., Gallinger, S., Gross, M., Helzlsouer, K., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072311 · Cited by 148 · see citing works
Total Pancreatectomy for Primary Pancreatic Neoplasms
Hartwig, W., Gluth, A., Hinz, U., Bergmann, F., Spronk, P. E. R., Hackert, T., Werner, J., & Büchler, M. W. (2014) · Annals of Surgery · doi:10.1097/sla.0000000000000791 · Cited by 147 · see citing works
Combined MEK and PI3K Inhibition in a Mouse Model of Pancreatic Cancer
Alagesan, B., Contino, G., Guimarães, A. R., Corcoran, R. B., Deshpande, V., Wojtkiewicz, G. R., Hezel, A. F., Wong, K., Loda, M. F., Weissleder, R., et al. (2014) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-14-1591 · Cited by 145 · see citing works
Walter, D., Boeckel, P. G. V., Groenen, M. J. M., Weusten, B. L. A. M., Witteman, B. J. M., Tan, G. N., Brink, M. A., Nicolai, J. J., Tan, A. C. I. T. L., Alderliesten, J., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.03.012 · Cited by 144 · see citing works
Matsushita, A., Götze, T., & Korc, M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-3256 · Cited by 143 · see citing works
Self-citationCoté, G. A., Gore, J., McElyea, S. D., et al. (2014) · The American Journal of Gastroenterology · doi:10.1038/ajg.2014.331 · Cited by 137 · see citing works
Complex role for the immune system in initiation and progression of pancreatic cancer
Inman, K. S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i32.11160 · Cited by 137 · see citing works
Cancer risk in heterozygotes for ataxia-telangiectasia
Geoffroy-Perez, B., Janin, N., Ossian, K., Laug�, A., Croquette, M.-F., Griscelli, C., Debr�, M., Paillerets, B. B., Aurias, A., Stoppa‐Lyonnet, D., et al. (2001) · International Journal of Cancer · doi:10.1002/ijc.1329 · Cited by 134 · see citing works
Genetic Mutations Associated with Cigarette Smoking in Pancreatic Cancer
Blackford, A. L., Parmigiani, G., Kensler, T. W., Wolfgang, C. L., Jones, S., Zhang, X., Parsons, D. W., Lin, J., Leary, R. J., Eshleman, J. R., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0015 · Cited by 134 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Global Burden of 5 Major Types of Gastrointestinal Cancer
Arnold, M., Abnet, C. C., Neale, R. E., Vignat, J., Giovannucci, E. L., McGlynn, K. A., & Bray, F. (2020) · Gastroenterology · doi:10.1053/j.gastro.2020.02.068 · Cited by 2,027 · see citing works
Self-citationPancreatic cancer: Advances and challenges
Halbrook, C. J., Lyssiotis, C. A., Pasca di Magliano, M., & Maitra, A. (2023) · Cell · doi:10.1016/j.cell.2023.02.014 · Cited by 1,321 · see citing works
The Frequency of Ras Mutations in Cancer
Prior, I. A., Hood, F. E., & Hartley, J. L. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3682 · Cited by 1,130 · see citing works
Optimizing the outcomes of pancreatic cancer surgery
Strobel, O., Neoptolemos, J., Jäger, D., & Büchler, M. W. (2019) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0112-1 · Cited by 943 · see citing works
Self-citationMolecular subtypes of pancreatic cancer
Collisson, E. A., Bailey, P., Chang, D. K., & Biankin, A. V. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0109-y · Cited by 892 · see citing works
Self-citationEarly Detection of Pancreatic Cancer: Opportunities and Challenges
Singhi, A. D., Koay, E. J., Chari, S. T., & Maitra, A. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.01.259 · Cited by 841 · see citing works
Emran, T. B., Shahriar, A., Mahmud, A. R., Rahman, T., Abir, M. H., Siddiquee, M. F. R., Ahmed, H., Rahman, N., Nainu, F., Wahyudin, E., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.891652 · Cited by 606 · see citing works
Van Cutsem, E., Tempero, M. A., Sigal, D., Oh, D.-Y., Fazio, N., Macarulla, T., Hitre, E., Hammel, P., Hendifar, A. E., Bates, S. E., et al. (2020) · Journal of Clinical Oncology · doi:10.1200/jco.20.00590 · Cited by 499 · see citing works
Self-citationWang, S., Zheng, Y., Yang, F., Zhu, L., Zhu, X.-Q., Wang, Z.-F., Wu, X.-L., Zhou, C.-H., Yan, J.-Y., Hu, B.-Y., et al. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00659-4 · Cited by 369 · see citing works
Hosein, A. N., Huang, H., Wang, Z., Parmar, K., Du, W., Huang, J., Maitra, A., Olson, E., Verma, U., & Brekken, R. A. (2019) · JCI Insight · doi:10.1172/jci.insight.129212 · Cited by 302 · see citing works
Lead-time trajectory of CA19-9 as an anchor marker for pancreatic cancer early detection
Fahrmann, J. F., Schmidt, C. M., Mao, X., Irajizad, E., Loftus, M., Zhang, J., Patel, N., Vykoukal, J., Dennison, J. B., Long, J. P., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.11.052 · Cited by 208 · see citing works
Deoxycytidine release from pancreatic stellate cells promotes gemcitabine resistance
Dalin, S., Sullivan, M. R., Lau, A. N., Grauman-Boss, B., Mueller, H. S., Kreidl, E., Fenoglio, S., Luengo, A., Lees, J. A., Vander Heiden, M. G., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-0960 · Cited by 156 · see citing works
Romero, J. M., Grünwald, B., Jang, G.-H., Bavi, P. P., Jhaveri, A., Masoomian, M., Fischer, S. E., Zhang, A., Denroche, R. E., Lungu, I. M., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2803 · Cited by 146 · see citing works
Pancreatic ductal adenocarcinoma progression is restrained by stromal matrix
Jiang, H., Torphy, R. J., Steiger, K., Hongo, H., Ritchie, A. J., Kriegsmann, M., Horst, D., Umetsu, S. E., Joseph, N. M., McGregor, K., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci136760 · Cited by 127 · see citing works
Self-citationLee, J. J., Bernard, V., Semaan, A., Monberg, M. E., Huang, J., Stephens, B. M., Lin, D., Rajapakshe, K. I., Weston, B. R., Bhutani, M. S., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3925 · Cited by 128 · see citing works
Precancerous neoplastic cells can move through the pancreatic ductal system
Makohon-Moore, A. P., Matsukuma, K., Zhang, M., Reiter, J. G., Gerold, J. M., Jiao, Y., Sikkema, L., Attiyeh, M. A., Yachida, S., Sandone, C., et al. (2018) · Nature · doi:10.1038/s41586-018-0481-8 · Cited by 120 · see citing works
Self-citationWhy is pancreatic cancer so deadly? The pathologist's view
Hruban, R. H., Gaida, M. M., Thompson, E., Hong, S., Noë, M., Brosens, L. A., Jongepier, M., Offerhaus, G. J. A., & Wood, L. D. (2019) · The Journal of Pathology · doi:10.1002/path.5260 · Cited by 115 · see citing works
Self-citationEpithelial and stromal co-evolution and complicity in pancreatic cancer
Hingorani, S. R. (2023) · Nature Reviews Cancer · doi:10.1038/s41568-022-00530-w · Cited by 108 · see citing works
Brown, W. S., McDonald, P. C., Nemirovsky, O., Awrey, S., Chafe, S. C., Schaeffer, D. F., Li, J., Renouf, D. J., Stanger, B. Z., & Dedhar, S. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2020.100131 · Cited by 111 · see citing works
Truong, L.-H., & Pauklin, S. (2021) · Cancers · doi:10.3390/cancers13195028 · Cited by 102 · see citing works
Chong, E., Crowe, L., Mentor, K., Pandanaboyana, S., & Sharp, L. (2023) · Supportive Care in Cancer · doi:10.1007/s00520-022-07468-7 · Cited by 86 · see citing works
“Hence, the focus of treatment in the majority of the patients has been about achieving a balance between palliative chemotherapy and maintaining qualityof-life [4].”
Schalck, A., Sakellariou-Thompson, D., Forget, M.-A., Sei, E., Hughes, T. G., Reuben, A., Bai, S., Hu, M., Kumar, T., Hurd, M. W., et al. (2022) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-1248 · Cited by 85 · see citing works
Qureshi, T. A., Gaddam, S., Wachsman, A. M., Wang, L., Azab, L., Asadpour, V., Chen, W., Xie, Y., Wu, B., Pandol, S. J., et al. (2022) · Cancer Biomarkers · doi:10.3233/cbm-210273 · Cited by 79 · see citing works
Jäkel, C., Bergmann, F., Toth, R., Assenov, Y., van der Duin, D., Strobel, O., Hank, T., Klöppel, G., Dorrell, C., Grompe, M., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01118-x · Cited by 69 · see citing works
Family history of cancer, Ashkenazi Jewish ancestry, and pancreatic cancer risk
Hamada, T., Yuan, C., Yurgelun, M. B., Perez, K., Khalaf, N., Morales-Oyarvide, V., Babic, A., Nowak, J. A., Rubinson, D. A., Giannakis, M., et al. (2019) · British Journal of Cancer · doi:10.1038/s41416-019-0426-5 · Cited by 61 · see citing works
Lee, Y. E., Go, G.-Y., Koh, E.-Y., Yoon, H.-N., Seo, M., Hong, S.-M., Jeong, J. H., Kim, J.-C., Cho, D., Kim, T. S., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006130 · Cited by 61 · see citing works
cGAS-STING signaling encourages immune cell overcoming of fibroblast barricades in pancreatic cancer
Kabashima, A., Matsuo, Y., Ito, S., Akiyama, Y., Ishii, T., Shimada, S., Masamune, A., Tanabe, M., & Tanaka, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-14297-5 · Cited by 55 · see citing works
Pre-clinical Models of Metastasis in Pancreatic Cancer
Miquel, M., Zhang, S., & Pilarsky, C. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.748631 · Cited by 53 · see citing works
A biomimetic tumor model of heterogeneous invasion in pancreatic ductal adenocarcinoma
Bradney, M. J., Venis, S. M., Yang, Y., Konieczny, S. F., & Han, B. (2020) · Small · doi:10.1002/smll.201905500 · Cited by 38 · see citing works
Gyoten, M., Luo, Y., Fujiwara-Tani, R., Mori, S., Ogata, R., Kishi, S., & Kuniyasu, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242316814 · Cited by 28 · see citing works
Liu, X., Gündel, B., Li, X., Liu, J., Wright, A., Löhr, M., Arvidsson, G., & Heuchel, R. (2021) · Translational Oncology · doi:10.1016/j.tranon.2021.101107 · Cited by 24 · see citing works
Zhang, F., Zhong, W., Li, H., Huang, K., Yu, M., & Liu, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.665265 · Cited by 13 · see citing works
Blaszczak, W., White, B., Monterisi, S., & Swietach, P. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113612 · Cited by 9 · see citing works
- Authors
- Kleeff, J., Korc, M., Apte, M., La Vecchia, C., Johnson, C. D., Biankin, A. V., Neale, R. E., Tempero, M., Tuveson, D. A., Hruban, R. H., & Neoptolemos, J. P.
- Affiliations
- University of Liverpool (GB)
- Indiana University Melvin and Bren Simon Comprehensive Cancer Center (US)
- UNSW Sydney (AU)
- University Hospital Southampton NHS Foundation Trust (GB)
- University of Glasgow (GB)
- University of California, San Francisco (US)
- Cold Spring Harbor Laboratory (US)
- Johns Hopkins University (US)
- Corresponding author
- Kleeff, Jorg
- ORCID
- Venue
- Nature Reviews Disease Primers
- Published
- 2016-04-21
- Volume
- 2
- Issue
- 1
- Pages
- 16022-16022
- ISSN
- 2056-676X (ISSN-L)
- OpenAlex
- W4211181525
- Cited by
- 1,982
- References
- 275
- Citations by year
- 2026: 155 · 2025: 243 · 2024: 234 · 2023: 232 · 2022: 257 · 2021: 301 · 2020: 231 · 2019: 154 · 2018: 95 · 2017: 58 · 2016: 16 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 10.83
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Nature Reviews Disease Primers (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- UNSWorks (University of New South Wales, Sydney, Australia) (submittedVersion, cc-by-nc-nd)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- U.S. Department of Defense (W81XWH‐13‐PRCRP‐IA, W81XWH, W81XWH-13)
- Pancreatic Cancer UK (FLF2015_04_GLASGOW)
- Cancer Research UK (17263, 15957, 22533)
- National Institute for Health and Care Research (PB-PG-0407-13363, NF-SI-0510-10126)
- National Institutes of Health (W81XWH, 5P30CA45508-26, 5P30CA45508, CA62924, 5U01CA168409-3)
- Medical Research Council (MR/N005813/1)
- National Health and Medical Research Council
- National Cancer Institute (P50CA101955, U10CA180944, CA075059, CA 62924, R01CA190092)
- DOD Peer Reviewed Cancer Research Program
- Topics
- Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
- Health Sciences › Medicine › Surgery › Pancreatitis Pathology and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- pancreatic cancer, KRAS mutation, CDKN2A, TP53, SMAD4, tumor microenvironment, stromal cells, neoadjuvant therapy, adjuvant therapy, drug resistance, epigenetics, cancer metabolism, prognosis, quality of life
- MeSH terms
- Animals, Diabetes Mellitus, Humans, Jaundice, Magnetic Resonance Imaging, Neoplasm Proteins, Pancreatic Neoplasms, Prognosis, Risk Factors, Tomography, X-Ray Computed, Biomarkers, Tumor, Weight Loss, Proto-Oncogene Proteins p21(ras), Models, Animal, Animals, Genetically Modified, Mice, Early Detection of Cancer
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
