Cited by 234Gut microbiota and healthEscherichia coli research studiesGastrointestinal motility and disorders

Comparison of Translocation Rates of Various Indigenous Bacteria from the Gastrointestinal Tract to the Mesenteric Lymph Node

Steffen, E. K., Berg, R. D., Deitch, E. A.·1988·Journal of Infectious Diseases

Abstract

Bacterial translocation is defined as the passage of indigenous bacteria from the gastrointestinal (GI) tract through the lamina propria to the mesenteric lymph nodes (MLN) and other organs. We compared the relative abilities of various aerobic, facultatively anaerobic, and obligately anaerobic bacteria to translocate from the GI tract to the MLN in gnotobiotic mice colonized with single strains of bacteria. Indigenous gram-negative enteric bacilli translocated in large numbers to the MLN, whereas gram-positive bacteria translocated at intermediate levels and obligately anaerobic bacteria at only very low levels. Our results suggest that enteric bacilli such as Escherichia coli, Proteus, and Enterobacter are associated with a higher incidence of bacteremia in debilitated patients, because these bacteria translocate more efficiently from the GI tract than do other bacteria, especially obligate anaerobes.

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Crossref · 10.1093/infdis/157.5.1032

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  • Gram-negative bacteria are the most adept at translocating to mesenteric lymph nodes and are the most frequent cause of spontaneous bacterial infections in cirrhosis patients.

    “Gram-negative bacteria have been found to be the most adept at translocating to the mesenteric lymph nodes and are the most frequent cause of spontaneous bacterial infections in patients with cirrhosis105–107.”

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Authors
Steffen, E. K., Berg, R. D., & Deitch, E. A.
Affiliations
Louisiana State University (US)
Corresponding author
Berg, R. D.
Venue
Journal of Infectious Diseases
Published
1988-05-01
Volume
157
Issue
5
Pages
1032-1038
ISSN
  • 0022-1899 (ISSN-L)
  • 1537-6613
OpenAlex
W2090721012
Cited by
234
References
30
Citations by year
2026: 1 · 2024: 1 · 2023: 4 · 2022: 1 · 2021: 5 · 2020: 9 · 2019: 8 · 2018: 1 · 2017: 6 · 2016: 9 · 2015: 10 · 2014: 8 · 2013: 7 · 2012: 10
FWCI
2.32
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Infectious Diseases (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of General Medical Sciences (GM36376)
  • National Institute of Allergy and Infectious Diseases (AI-15826)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
bacterial translocation, mesenteric lymph nodes, gram-negative enteric bacilli, Gram-positive bacteria, obligate anaerobes, Escherichia coli, Proteus, Enterobacter, gnotobiotic mice, bacteremia, lamina propria, intestinal colonization
MeSH terms
Animals, Bacteria, Aerobic, Bacteria, Anaerobic, Bacteroides fragilis, Cell Movement, Digestive System, Escherichia coli, Gram-Negative Bacteria, Gram-Positive Bacteria, Lymph Nodes, Mesentery, Mice, Inbred BALB C, Mice, Nude, Staphylococcus epidermidis, Bacterial Physiological Phenomena, Mice

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