The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Open accessAbstract
Background—Life stress contributes to symptom onset and exacerbation in the majority of patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD); research evidence is conflicting, however, as to the strength of these effects. Aims—To test prospectively the relation of chronic life stress threat to subsequent symptom intensity over time. Patients—One hundred and seventeen consecutive outpatients satisfying the modified Rome criteria for IBS (66% with one or more concurrent FD syndromes) participated. Methods—The life stress and symptom intensity measures were determined from interview data collected independently at entry, and at six and 16 months; these measures assessed the potency of chronic life stress threat during the prior six months or more, and the severity and frequency of IBS and FD symptoms during the following two weeks. Results—Chronic life stress threat was a powerful predictor of subsequent symptom intensity, explaining 97% of the variance on this measure over 16 months. No patient exposed to even one chronic highly threatening stressor improved clinically (by 50%) over the 16 months; all patients who improved did so in the absence of such a stressor. Conclusion—The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Early life experiences (e.g., abuse), adult stressors (e.g., divorce or bereavement), lack of social support, and other social learning experiences can affect both an individual’s physiological and psychological responses, and may precipitate abdominal distress, as well as psychiatric disorders (4,7–11).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [11]
In the citing paper
“a critical event in the onset of clinical symptoms of GI disorders including irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD) [7], [8], [9], [10]”
From CRF induces intestinal epithelial barrier injury via the release of mast cell proteases and TNF-α (2012) · cites this paper as [8]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
(1970) · Cited by 24,983
Social Origins of Depression: A Study of Psychiatric Disorder in Women.
Schnitzer, P. K., Brown, G. W., & Harris, T. (1980) · Contemporary Sociology A Journal of Reviews · doi:10.2307/2065631 · Cited by 3,053
Social Origins of Depression: A Study of Psychiatric Disorder in Women
McDaniel, E. G. (1980) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-198009000-00013 · Cited by 1,894
Assessment of Anger: The State-Trait Anger Scale
Butcher, J. N., & Spielberger, C. D. (2013) · Medical Entomology and Zoology · doi:10.4324/9781315825656-12 · Cited by 1,239
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757
Agréus, L., Svärdsudd, K., Nyrén, O., & Tibblin, G. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90373-9 · Cited by 686
Chaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498
Onset and Disappearance of Gastrointestinal Symptoms and Functional Gastrointestinal Disorders
Talley, N. J., Weaver, A. L., Zinsmeister, A. R., & Melton, L. J. (1992) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a116483 · Cited by 471
A controlled trial of psychological treatment for the irritable bowel syndrome
Guthrie, E., Creed, F. H., Dawson, D., & Tomenson, B. (1991) · Gastroenterology · doi:10.1016/0016-5085(91)90215-7 · Cited by 461
Cited by
Sorted by citations
Intestinal barrier function: molecular regulation and disease pathogenesis
Groschwitz, K. R., & Hogan, S. P. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.05.038 · Cited by 1,775
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324
“Indeed, several studies have indicated that stressful events are associated with the onset of chronic GI disturbances (5) , functional ones (6–8) , inflammatory bowel disease (9–12) or peptic ulcers (13–16) , as well as anxiety and depression depending on the genetic background (17–19) .”
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,102
Postinfectious Irritable Bowel Syndrome
Spiller, R., & Garsed, K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.02.074 · Cited by 1,024
Metadata
- Authors
- Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E.
- Affiliations
- Royal North Shore Hospital (AU)
- Corresponding author
- Kellow, J E
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1998-08-01
- Volume
- 43
- Issue
- 2
- Pages
- 256-261
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727204
- OpenAlex
- W2101601471
- Cited by
- 405
- References
- 35
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 6 · 2022: 5 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 9 · 2017: 10 · 2016: 11 · 2015: 7 · 2014: 23 · 2013: 20 · 2012: 21
- FWCI
- 13.71
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Infant Health and Development
- Keywords
- irritable bowel syndrome, functional dyspepsia, symptom intensity, clinical outcomes, symptom exacerbation
- MeSH terms
- Adult, Chronic Disease, Colonic Diseases, Functional, Emotions, Female, Humans, Male, Personality, Prognosis, Prospective Studies, Stress, Psychological, Time Factors, Age Distribution, Sex Distribution
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
