Effects of stressful life events on bowel symptoms: subjects with irritable bowel syndrome compared with subjects without bowel dysfunction.
Open accessAbstract
A standardised inventory of stressful life events and a bowel symptom questionnaire were administered at three month intervals for one year to 383 women who were unselected with respect to bowel symptoms. A NEO Personality Inventory was given initially to assess neuroticism. Subjects who satisfied restrictive diagnostic criteria for irritable bowel syndrome were compared with those who complained of abdominal pain plus altered bowel habits but who did not meet restrictive diagnostic criteria (functional bowel disorder) and with controls without bowel dysfunction. The irritable bowel group showed significantly higher levels of stress than the other two groups even when the confounding effects of neuroticism were statistically controlled for. Time lagged correlations showed that stress in one three month interval was significantly correlated with bowel symptoms in the subsequent three month interval for all groups. The slope of the regression line relating stress to bowel symptoms was significantly steeper for the irritable bowel group than for the other two groups at three and six months, suggesting that subjects with irritable bowel syndrome show a greater reactivity to stress. Stress scores were also significantly correlated with the number of disability days and the number of medical clinic visits for bowel symptoms.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Recent investigations have found that mindfulness meditation induces changes in neural circuits implicated in interoception and emotion regulation, while improving attentional control.
“Recent investigations have found that mindfulness meditation induces changes in the activation of neural circuits implicated in interoception (awareness of stimuli originating inside the body (21)) and emotion regulation (22,23), while improving attentional control (24–27).”
From Mindfulness training reduces the severity of irritable bowel syndrome in women: Results of a randomized controlled trial (2011) · cites this paper as [26]
Citation (21) is attached specifically to the definition of interoception as awareness of stimuli originating inside the body, not to the sentence’s other claims about meditation. The Abstract and Discussion examine stressful life events and bowel symptoms; searches for interoception and awareness of internal bodily stimuli found no passage defining the term. (LLM, conf=0.76)
Experimental — accuracy not yet measuredEarly life experiences, adult stressors, lack of social support, and other social learning experiences can affect physiological and psychological responses and may precipitate abdominal distress and psychiatric disorders.
“Early life experiences (e.g., abuse), adult stressors (e.g., divorce or bereavement), lack of social support, and other social learning experiences can affect both an individual’s physiological and psychological responses, and may precipitate abdominal distress, as well as psychiatric disorders (4,7–11).”
From Psychosocial Distress and Somatic Symptoms in Community Subjects With Irritable Bowel Syndrome: A Psychological Component Is the Rule (2009) · cites this paper as [10]
Different types of psychological stressors, including early-life stress and sustained stress, have been recognized as risk factors or promoters of events that result in disease exacerbation in patients with ulcerative colitis and IBS.
“Although different types of psychological stressors, including early-life stress and sustained stress, have been recognized as risk factors or promoters of events that result in disease exacerbation in patients with ulcerative colitis2 and IBS,3”
From Principles and clinical implications of the brain-gut-enteric microbiota axis (2009) · cites this paper as [3]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The social readjustment rating scale
Holmes, T. H., & Rahe, R. H. (1967) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(67)90010-4 · Cited by 11,174 · see citing works
Assessing the impact of life changes: Development of the Life Experiences Survey.
Sarason, I. G., Johnson, J. H., & Siegel, J. M. (1978) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.46.5.932 · Cited by 2,788 · see citing works
Towards positive diagnosis of the irritable bowel.
Manning, A. P., Thompson, W., Heaton, K. W., & Morris, A. F. (1978) · BMJ · doi:10.1136/bmj.2.6138.653 · Cited by 1,404 · see citing works
Psychosocial Factors in the Irritable Bowel Syndrome
Drossman, D. A., McKee, D. C., Sandler, R. S., Mitchell, C. M., Cramer, E. M., Lowman, B. C., & Burger, A. L. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80017-9 · Cited by 757 · see citing works
Paykel, E. S. (1971) · Archives of General Psychiatry · doi:10.1001/archpsyc.1971.01750160052010 · Cited by 736 · see citing works
Bowel Patterns Among Subjects Not Seeking g Health Care
Drossman, D. A., Sandler, R. S., McKee, D. C., & Lovitz, A. J. (1982) · Gastroenterology · doi:10.1016/s0016-5085(82)80186-8 · Cited by 711 · see citing works
Tolerance for Rectosigmoid Distention in Irritable Bowel Syndrome
Whitehead, W. E., Holtkötter, B., Enck, P., Hoelzl, R., Holmes, K. D., Anthony, J. C., Shabsin, H. S., & Schuster, M. M. (1990) · Gastroenterology · doi:10.1016/0016-5085(90)90332-u · Cited by 592 · see citing works
Self-citationChaudhary, N. A., & Truelove, S. C. (1962) · QJM · doi:10.1093/oxfordjournals.qjmed.a066971 · Cited by 498 · see citing works
Symptoms of Psychologic Distress Associated With Irritable Bowel Syndrome
Whitehead, W. E., Bosmajian, L., Zonderman, A. B., Costa Jr., P. T., & Schuster, M. M. (1988) · Gastroenterology · doi:10.1016/s0016-5085(88)80018-0 · Cited by 480 · see citing works
Self-citationSocial Psychologic Factors Affecting the Presentation of Bodily Complaints
Mechanic, D. (1972) · New England Journal of Medicine · doi:10.1056/nejm197205252862105 · Cited by 468 · see citing works
Whitehead, W. E., Engel, B. T., & Schuster, M. M. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01395503 · Cited by 462 · see citing works
Self-citationMethodological aspects of life events research
Paykel, E. S. (1983) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(83)90065-x · Cited by 412 · see citing works
Jenkins, C. D. (1979) · Archives of General Psychiatry · doi:10.1001/archpsyc.1979.01780040021001 · Cited by 252 · see citing works
Psychological significance of the irritable colon syndrome
Hislop, I. G. (1971) · Gut · doi:10.1136/gut.12.6.452 · Cited by 246 · see citing works
Effect of anger on colon motor and myoelectric activity in irritable bowel syndrome
Welgan, P. R., Meshkinpour, H., & Beeler, M. (1988) · Gastroenterology · doi:10.1016/0016-5085(88)90006-6 · Cited by 227 · see citing works
Illness Experience and Life Stresses in Patients with Irritable Colon and with Ulcerative Colitis
Mendeloff, A. I., Monk, M., Siegel, C. I., & Lilienfeld, A. M. (1970) · New England Journal of Medicine · doi:10.1056/nejm197001012820104 · Cited by 172 · see citing works
Life events, psychiatric illness and the irritable bowel syndrome.
Ford, M. J., Miller, P. M., Eastwood, J., & Eastwood, M. A. (1987) · Gut · doi:10.1136/gut.28.2.160 · Cited by 150 · see citing works
Tp, A., & Tulin, M. (1947) · PubMed · Cited by 146 · see citing works
Haderstorfer, B., Psycholgin, D., Whitehead, W. E., & Schuster, M. M. (1989) · PubMed · Cited by 69 · see citing works
Self-citationLarge Bowel Disorders. I. Illness Configuration and Life Events
Fava, G. A., & Pavan, L. (2010) · Psychotherapy and Psychosomatics · doi:10.1159/000287001 · Cited by 69 · see citing works
Laird, S. M., & Sage, M. (1972) · BMJ · doi:10.1136/bmj.2.5814.653 · Cited by 45 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The functional gastrointestinal disorders and the Rome III process
Drossman, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.03.008 · Cited by 2,416 · see citing works
AGA technical review on irritable bowel syndrome.
Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works
Self-citationPrinciples and clinical implications of the brain-gut-enteric microbiota axis
Rhee, S. H., Pothoulakis, C., & Mayer, E. A. (2009) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2009.35 · Cited by 1,342 · see citing works
Messaoudi, M., Lalonde, R., Violle, N., Javelot, H., Desor, D., Nejdi, A., Bisson, J.-F., Rougeot, C., Pichelin, M., Cazaubiel, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114510004319 · Cited by 1,324 · see citing works
Whitehead, W. E., Palsson, O., & Jones, K. R. (2002) · Gastroenterology · doi:10.1053/gast.2002.32392 · Cited by 1,116 · see citing works
Self-citationO'Mahony, S. M., Marchesi, J. R., Scully, P., Codling, C., Ceolho, A.-M., Quigley, E. M. M., Cryan, J. F., & Dinan, T. G. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.026 · Cited by 1,069 · see citing works
Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M. D., Schemann, M., et al. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.14 · Cited by 1,057 · see citing works
Guidelines on the irritable bowel syndrome: mechanisms and practical management
Spiller, R., Aziz, Q., Creed, F., Emmanuel, A., Houghton, L., Hungin, P., Jones, R., Kumar, D., Rubin, G., Trudgill, N., et al. (2007) · Gut · doi:10.1136/gut.2007.119446 · Cited by 818 · see citing works
Psychosocial Aspects of the Functional Gastrointestinal Disorders
Levy, R. L., Olden, K. W., Naliboff, B. D., Bradley, L. A., Francisconi, C., Drossman, D. A., & Creed, F. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.057 · Cited by 776 · see citing works
Pimentel, M., Chow, E. J., & Lin, H. C. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07234.x · Cited by 670 · see citing works
The neurobiology of stress and gastrointestinal disease
MAYER, E. A. (2000) · Gut · doi:10.1136/gut.47.6.861 · Cited by 666 · see citing works
Vanuytsel, T., van Wanrooy, S., Vanheel, H., Vanormelingen, C., Verschueren, S., Houben, E., Salim Rasoel, S., Tόth, J., Holvoet, L., Farré, R., et al. (2014) · Gut · doi:10.1136/gutjnl-2013-305690 · Cited by 615 · see citing works
Koloski, N. A., Jones, M., Kalantar, J., Weltman, M., Zaguirre, J., & Talley, N. J. (2012) · Gut · doi:10.1136/gutjnl-2011-300474 · Cited by 611 · see citing works
Gut microbiota and the neuroendocrine system
Farzi, A., Fröhlich, E. E., & Holzer, P. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0600-5 · Cited by 478 · see citing works
Labus, J. S., Bolus, R., Chang, L., Wiklund, I., Naesdal, J., Mayer, E. A., & Naliboff, B. D. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02007.x · Cited by 475 · see citing works
Increased mast cells in the irritable bowel syndrome
O’Sullivan, Clayton, Breslin, Harman, Bountra, Mclaren, & O’Morain (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00221.x · Cited by 480 · see citing works
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome
Bennett, E. J., Tennant, C. C., Piesse, C., Badcock, C.-A., & Kellow, J. E. (1998) · Gut · doi:10.1136/gut.43.2.256 · Cited by 405 · see citing works
Chang, L., Toner, B. B., Fukudo, S., Guthrie, E., Locke, G. R., Norton, N. J., & Sperber, A. D. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.09.071 · Cited by 374 · see citing works
Management of the irritable bowel syndrome
Camilleri, M. (2001) · Gastroenterology · doi:10.1053/gast.2001.21908 · Cited by 344 · see citing works
Evolving pathophysiologic models of functional gastrointestinal disorders
Mayer, E. A., & Collins, S. M. (2002) · Gastroenterology · doi:10.1053/gast.2002.33584 · Cited by 326 · see citing works
WHITEHEAD, W., & PALSSON, O. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70099-x · Cited by 314 · see citing works
Self-citationThe functional gastrointestinal disorders and the Rome II process
Drossman, D. A. (1999) · Gut · doi:10.1136/gut.45.2008.ii1 · Cited by 313 · see citing works
Irritable bowel syndrome: a little understood organic bowel disease?
Talley, N. J., & Spiller, R. E. (2002) · The Lancet · doi:10.1016/s0140-6736(02)09712-x · Cited by 304 · see citing works
Biopsychosocial Model of Irritable Bowel Syndrome
Tanaka, Y., Kanazawa, M., Fukudo, S., & Drossman, D. A. (2011) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm.2011.17.2.131 · Cited by 305 · see citing works
Posserud, I., Agerforz, P., Ekman, R., Björnsson, E. S., Abrahamsson, H., & Simrén, M. (2004) · Gut · doi:10.1136/gut.2003.017962 · Cited by 292 · see citing works
Irritable bowel syndrome: a gut microbiota-related disorder?
Bhattarai, Y., Muniz Pedrogo, D. A., & Kashyap, P. C. (2017) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00338.2016 · Cited by 294 · see citing works
Impact of irritable bowel syndrome on quality of life
Whitehead, W. E., Burnett, C. K., Cook, E. W., & Taub, E. (1996) · Digestive Diseases and Sciences · doi:10.1007/bf02071408 · Cited by 290 · see citing works
Self-citationReview article: irritable bowel syndrome
Camilleri, M., & Choi, M. (1997) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1997.84256000.x · Cited by 287 · see citing works
Gaylord, S. A., Palsson, O. S., Garland, E. L., Faurot, K. R., Coble, R. S., Mann, D. J., Frey, W., Leniek, K., & Whitehead, W. E. (2011) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.184 · Cited by 281 · see citing works
“28 ) that is correlated with selective attention to gastrointestinal sensations and anxiety about the significance of these sensations (”
BackgroundSelf-citationThe interview for recent life events
PAYKEL, E. S. (1997) · Psychological Medicine · doi:10.1017/s0033291796004424 · Cited by 275 · see citing works
The Role of Stress on Physiologic Responses and Clinical Symptoms in Irritable Bowel Syndrome
Chang, L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.01.032 · Cited by 268 · see citing works
Celiac disease–like abnormalities in a subgroup of patients with irritable bowel syndrome
Wahnschaffe, U., Ullrich, R., Riecken, E. O., & Schulzke, J. D. (2001) · Gastroenterology · doi:10.1053/gast.2001.29572 · Cited by 280 · see citing works
Sikandar, S., & Dickenson, A. H. (2012) · Current Opinion in Supportive and Palliative Care · doi:10.1097/spc.0b013e32834f6ec9 · Cited by 254 · see citing works
OʼSullivan, M. (2000) · Digestive and Liver Disease · doi:10.1016/s1590-8658(00)80021-3 · Cited by 245 · see citing works
Minderhoud, I. M., Oldenburg, B., Wismeijer, J. A., Henegouwen, G. P. V. B., & Smout, A. J. P. M. (2004) · Digestive Diseases and Sciences · doi:10.1023/b:ddas.0000020506.84248.f9 · Cited by 243 · see citing works
Mechanisms and efficacy of dietary FODMAP restriction in IBS
Staudacher, H. M., Irving, P. M., Lomer, M. C. E., & Whelan, K. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.259 · Cited by 243 · see citing works
Schumann, D., Klose, P., Lauche, R., Dobos, G., Langhorst, J., & Cramer, H. (2017) · Nutrition · doi:10.1016/j.nut.2017.07.004 · Cited by 224 · see citing works
Meta‐analysis: the treatment of irritable bowel syndrome
Pantoflickova, D., Michetti, P., Fried, M., Beglinger, C., & Blum, A. L. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02267.x · Cited by 222 · see citing works
New pathophysiological mechanisms in irritable bowel syndrome
Barbara, G., GIORGIO, R. D., Stanghellini, V., Cremon, C., Salvioli, B., & Corinaldesi, R. (2004) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2004.02036.x · Cited by 221 · see citing works
Altered Rectal Perception in Irritable Bowel Syndrome Is Associated With Symptom Severity
Posserud, I., Syrous, A., Lindström, L., Tack, J., Abrahamsson, H., & Simrén, M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.07.024 · Cited by 248 · see citing works
Intergenerational Transmission of Gastrointestinal Illness Behavior
Levy, R. L., Whitehead, W. E., Korff, M. R. V., & Feld, A. D. (2000) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(99)00825-4 · Cited by 219 · see citing works
Self-citationAre Anxiety and Depression Related to Gastrointestinal Symptoms in the General Population?
Haug, T. T., Mykletun, A., & Dahl, A. A. (2002) · Scandinavian Journal of Gastroenterology · doi:10.1080/003655202317284192 · Cited by 218 · see citing works
Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress
Dickhaus, B., Mayer, E. A., Firooz, N., Stains, J., Conde, F. A., Olivas, T. I., Fass, R., Chang, L., Mayer, M., & Naliboff, B. D. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07156.x · Cited by 204 · see citing works
A Double-Blind Placebo-Controlled Trial with Loperamide in Irritable Bowel Syndrome
Efskind, P., Bernklev, T., & Vatn, M. H. (1996) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529609006766 · Cited by 206 · see citing works
Evidence-based clinical practice guidelines for irritable bowel syndrome
Fukudo, S., Kaneko, H., Akiho, H., Inamori, M., Endo, Y., Okumura, T., Kanazawa, M., Kamiya, T., Sato, K., Chiba, T., et al. (2014) · Journal of Gastroenterology · doi:10.1007/s00535-014-1017-0 · Cited by 207 · see citing works
Symptoms and Visceral Perception in Patients With Pain-Predominant Irritable Bowel Syndrome
Lembo, T., Naliboff, B., Munakata, J., Fullerton, S., Saba, L., Tung, S., Schmulson, M., & Mayer, E. A. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01009.x · Cited by 202 · see citing works
Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198 · see citing works
Psychosocial aspects of the functional gastrointestinal disorders
Drossman, D. A. (1996) · De Gruyter eBooks · doi:10.1515/9783110815542-005 · Cited by 194 · see citing works
Evidence-based clinical practice guidelines for irritable bowel syndrome 2020
Fukudo, S., Okumura, T., Inamori, M., Okuyama, Y., Kanazawa, M., Kamiya, T., Sato, K., Shiotani, A., Naito, Y., Fujikawa, Y., et al. (2021) · Journal of Gastroenterology · doi:10.1007/s00535-020-01746-z · Cited by 195 · see citing works
Talley, N. J., Dennis, E. H., Schettler-Duncan, V. A., Lacy, B. E., Olden, K. W., & Crowell, M. D. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07699.x · Cited by 239 · see citing works
Self-citationMurray, C. D. R., Flynn, J., Ratcliffe, L., Jacyna, M. R., Kamm, M. A., & Emmanuel, A. V. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.08.057 · Cited by 185 · see citing works
Zernicke, K. A., Campbell, T. S., Blustein, P. K., Fung, T. S., Johnson, J. A., Bacon, S. L., & Carlson, L. E. (2013) · International Journal of Behavioral Medicine · doi:10.1007/s12529-012-9241-6 · Cited by 178 · see citing works
The Effect of Emotional Stress and Depression on the Prevalence of Digestive Diseases
Lee, S. P., Sung, I., Kim, J. H., Lee, S., Park, H. S., & Shim, C. S. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm14116 · Cited by 180 · see citing works
Corticotropin‐Releasing Factor and the Brain‐Gut Motor Response to Stress
Taché, Y., Martı́nez, V., Million, M., & Rivier, J. (1999) · Canadian Journal of Gastroenterology and Hepatology · doi:10.1155/1999/375916 · Cited by 177 · see citing works
Antibiotics increase functional abdominal symptoms
Maxwell, P., Rink, E., Kumar, D., & Mendall, M. A. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05428.x · Cited by 176 · see citing works
Asian consensus on irritable bowel syndrome
Gwee, K., Bak, Y., Ghoshal, U. C., Gonlachanvit, S., Lee, O. Y., Fock, K. M., Chua, A. S. B., Lu, C., Goh, K., Kositchaiwat, C., et al. (2010) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2010.06353.x · Cited by 172 · see citing works
DuPont, H. L. (2014) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12728 · Cited by 171 · see citing works
Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?
Drossman, D. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00081-9 · Cited by 168 · see citing works
The role of stress in symptom exacerbation among IBS patients
Blanchard, E. B., Lackner, J. M., Jaccard, J. J., Rowell, D., Carosella, A. M., Powell, C., Sanders, K. A., Krasner, S. S., & Kuhn, E. R. (2008) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.10.010 · Cited by 167 · see citing works
Pace, F., Molteni, P., Bollani, S., Sarzi‐Puttini, P., Stockbrügger, R., Porro, G. B., & Drossman, D. A. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310004524 · Cited by 157 · see citing works
PSYCHOSOCIAL ASPECTS OF FUNCTIONAL GASTROINTESTINAL DISORDERS
Whitehead, W. E. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70363-0 · Cited by 158 · see citing works
Self-citationTargownik, L. E., Sexton, K. A., Bernstein, M. T., Beatie, B., Sargent, M., Walker, J. R., & Graff, L. A. (2015) · American Journal of Gastroenterology · doi:10.1038/ajg.2015.147 · Cited by 157 · see citing works
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158 · see citing works
Central Processing of Rectal Pain in Patients With Irritable Bowel Syndrome: An Fmri Study
Bonaz, B. L., Baciu, M., Papillon, E., Bost, R., Gueddah, N., Bas, J. F. L., Fournet, J., & Segebarth, C. M. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05545.x · Cited by 150 · see citing works
van Tilburg, M. A. L., Palsson, O. S., & Whitehead, W. E. (2013) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2013.03.004 · Cited by 151 · see citing works
Self-citationRole of corticotropin-releasing hormone in irritable bowel syndrome and intestinal inflammation
Fukudo, S. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1942-7 · Cited by 147 · see citing works
The Effect of Life Stress on Symptoms of Heartburn
Naliboff, B. D., Mayer, M., Fass, R., FitzGerald, L., Chang, L., Bolus, R. R., & Mayer, E. A. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000124756.37520.84 · Cited by 146 · see citing works
Definition and epidemiology of functional gastrointestinal disorders
Corazziari, E. S. (2004) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2004.04.012 · Cited by 145 · see citing works
Mechanisms Underlying Visceral Hypersensitivity in Irritable Bowel Syndrome
Barbara, G., Cremon, C., GIORGIO, R. D., Dothel, G., Zecchi, L., Bellacosa, L., Carini, G., Stanghellini, V., & Corinaldesi, R. (2011) · Current Gastroenterology Reports · doi:10.1007/s11894-011-0195-7 · Cited by 144 · see citing works
Pinto-Sánchez, M. I., Ford, A. C., Avila, C., Verdu, E. F., Collins, S. M., Morgan, D., Moayyedi, P., & Berčík, P. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.128 · Cited by 140 · see citing works
An Initial Report of Sleep Disturbance in Inactive Inflammatory Bowel Disease
Keefer, L., Stepanski, E. J., Ranjbaran, Z., Benson, L. M., & Keshavarzian, A. (2006) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26656 · Cited by 137 · see citing works
Ait-Belgnaoui, A., Payard, I., Rolland, C., Harkat, C., Braniste, V., Théodorou, V., & Tompkins, T. A. (2018) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm16167 · Cited by 139 · see citing works
Sleep Disturbance Influences Gastrointestinal Symptoms in Women with Irritable Bowel Syndrome
Jarrett, M. E., Heitkemper, M. M., Cain, K. C., Burr, R. L., & Hertig, V. L. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1005581226265 · Cited by 139 · see citing works
Lynn, R. B., & Friedman, L. S. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312233292608 · Cited by 139 · see citing works
Camilleri, M., Heading, R. C., & Thompson, W. (2002) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2002.01305.x · Cited by 134 · see citing works
Gender role and irritable bowel syndrome: literature review and hypothesis
Toner, B. B., & Akman, D. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.01698.x · Cited by 132 · see citing works
Review article: an integrated approach to the irritable bowel syndrome
Drossman, D. A. (1999) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.1999.0130s2003.x · Cited by 130 · see citing works
Levy, R. L., Cain, K. C., Jarrett, M. E., & Heitkemper, M. M. (1997) · Journal of Behavioral Medicine · doi:10.1023/a:1025582728271 · Cited by 131 · see citing works
Epidemiology of Irritable Bowel Syndrome
Müller-Lissner, S. A. (2013) · Wiley eBooks · doi:10.1002/9781118444689.ch2 · Cited by 133 · see citing works
Choung, R. S., Locke, G. R., Zinsmeister, A. R., Schleck, C. D., & Talley, N. J. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.239 · Cited by 129 · see citing works
Yang, J., Lee, H.-R., Low, K., Chatterjee, S., & Pimentel, M. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-007-9839-8 · Cited by 129 · see citing works
Stereotaxic delivery of corticosterone to the amygdala modulates colonic sensitivity in rats
Meerveld, B. G., Gibson, M. S., Gunter, W., Shepard, J. D., Foreman, R. D., & Myers, D. A. (2001) · Brain Research · doi:10.1016/s0006-8993(00)03305-9 · Cited by 125 · see citing works
Evidence for visceral hypersensitivity in high-anxiety rats
Gunter, W., Shepard, J. D., Foreman, R. D., Myers, D. A., & Beverley (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00254-1 · Cited by 121 · see citing works
Galley, J. D., Yu, Z., Kumar, P., Dowd, S. E., Lyte, M., & Bailey, M. T. (2014) · Gut Microbes · doi:10.4161/19490976.2014.972241 · Cited by 120 · see citing works
Slow transit constipation: a model of human gut dysmotility. Review of possible aetiologies
Knowles, C. H., & Martín, M. (2000) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2000.00198.x · Cited by 119 · see citing works
Fortnightly Review: Irritable bowel, irritable body, or irritable brain?
Farthing, M. J. G. (1995) · BMJ · doi:10.1136/bmj.310.6973.171 · Cited by 119 · see citing works
Ringel, Y., Sperber, A. D., & Drossman, D. A. (2001) · Annual Review of Medicine · doi:10.1146/annurev.med.52.1.319 · Cited by 117 · see citing works
Miwa, H. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01872.x · Cited by 113 · see citing works
Herschbach, P., Henrich, G., & von Rad, M. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199903000-00005 · Cited by 110 · see citing works
Sweetser, S. R., Camilleri, M., Nord, S. L., Burton, D. D., Castenada, L., Croop, R. S., Tong, G., Dockens, R. C., & Zinsmeister, A. R. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00011.2009 · Cited by 114 · see citing works
Corticosteroid receptor-mediated mechanisms in the amygdala regulate anxiety and colonic sensitivity
Myers, B., & Meerveld, B. G. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00080.2007 · Cited by 113 · see citing works
Second Asian Consensus on Irritable Bowel Syndrome
Gwee, K., Gonlachanvit, S., Ghoshal, U. C., Chua, A. S. B., Miwa, H., Wu, J. C. Y., Bak, Y., Lee, O. Y., Lu, C., Park, H., et al. (2019) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm19041 · Cited by 112 · see citing works
Koloski, N. A., Talley, N. J., & Boyce, P. M. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.07388.x · Cited by 111 · see citing works
Meerveld, B. G., Johnson, A. C., Cochrane, S. W., Schulkin, J. A., & Myers, D. A. (2005) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2005.00648.x · Cited by 111 · see citing works
Quality of Life in Irritable Bowel Syndrome
Lea, R., & Whorwell, P. J. (2001) · PharmacoEconomics · doi:10.2165/00019053-200119060-00003 · Cited by 106 · see citing works
Does endoscopy have a positive impact on quality of life in dyspepsia?
Wiklund, I. E., Glise, H., Jerndal, P., Carlsson, J., & Talley, N. J. (1998) · Gastrointestinal Endoscopy · doi:10.1016/s0016-5107(98)70243-3 · Cited by 104 · see citing works
Dehhaghi, M., Panahi, H. K. S., Heng, B., & Guillemin, G. J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.562812 · Cited by 101 · see citing works
Abnormal Propagation Pattern of Duodenal Pressure Waves in the Irritable Bowel Syndrome (IBS)
Simrén, M., Castedal, M., Svedlund, J., Abrahamsson, H., & Björnsson, E. S. (2000) · Digestive Diseases and Sciences · doi:10.1023/a:1010770302403 · Cited by 101 · see citing works
Palsson, O. S., & Drossman, D. A. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2005.02.004 · Cited by 99 · see citing works
Winston, J. H., Xu, G., & Sarna, S. K. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.09.054 · Cited by 100 · see citing works
- Authors
- Whitehead, W. E., Crowell, M. D., Robinson, J. C., Heller, B. R., & Schuster, M. M.
- Affiliations
- Johns Hopkins University (US)
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1992-06
- Volume
- 33
- Issue
- 6
- Pages
- 825-830
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1379344
- OpenAlex
- W2091075637
- Cited by
- 432
- References
- 21
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 7 · 2023: 7 · 2022: 9 · 2021: 9 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 7 · 2016: 16 · 2015: 18 · 2014: 12 · 2013: 14 · 2012: 17
- FWCI
- 6.72
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2k05mh000133-17, 5r01nr001369-03)
- National Institute of Mental Health (KO5 MH00133)
- National Institute of Nursing Research (R01 NR01369)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Health Sciences › Health Professions › Pharmacy › Infant Health and Development
- Keywords
- irritable bowel syndrome, life events, bowel symptoms, functional bowel disorders, stress reactivity, neuroticism, abdominal pain, altered bowel habits, disability days, women
- MeSH terms
- Adult, Colonic Diseases, Functional, Constipation, Diarrhea, Female, Humans, Life Change Events, Neurotic Disorders, Personality Inventory, Prospective Studies, Stress, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
