The DOI matches its Crossref record; 27 of the 28 references it cites were found in a registry or an index.
Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population
Open accessAbstract
Background —Associations have been shown between irritable bowel syndrome (IBS) and gastro-oesophageal reflux, between gastro-oesophageal reflux and asthma, and more recently between IBS and bronchial hyper-responsiveness (BHR). Aims —To explore the inter-relations between these conditions. Subjects —A randomly selected community sample of 4432 adults. Methods —A validated postal symptom questionnaire investigating the associations between IBS, gastro-oesophageal reflux symptoms, and symptomatic BHR. Results —3169 questionnaires (71.7% response) returned by 1451 men and 1718 women were analysed. One year prevalences, in men and women respectively, of IBS were 10.5% and 22.9%, of dyspepsia 26.3% and 25.25%, of gastro-oesophageal reflux symptoms 29.4% and 28.2%, of BHR 13.2% and 14.6%, and of chronic bronchitis 8.3% and 4.9%. Logistic regression showed independent associations between IBS and BHR, gastro-oesophageal reflux symptoms, and dyspepsia. There was no significant independent association between IBS and chronic bronchitis. In men and women the odds ratio with 95% confidence interval (CI) for IBS and gastro-oesophageal reflux symptoms was 2.6 (2.1–3.1; p<0.001) and for IBS and BHR 2.1 (1.7–2.7; p<0.001). These associations held on stratifying for sex and consultation behaviour. IBS, gastro-oesophageal reflux symptoms, and bronchial hyper-responsiveness occurred more frequently together than expected, 2.5% (95% CI 2.41–2.57) of the sample having all three conditions compared with an expected prevalence of 0.7% (95% CI 0.66–0.71). The conditions were independently associated with each other. Conclusions —These observations may indicate the presence of an underlying disorder producing symptoms in gastrointestinal and respiratory systems.
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“Two other population based studies in the United States and the United Kingdom reported 25% and 19% overlap between IBS and GERD, respectively.17,18”
From Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal Functional Syndromes (2010) · cites this paper as [18]
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Metadata
- Authors
- Kennedy, T. M., Jones, R. H., Hungin, A. P. S., O’Flanagan, H., & Kelly, P.
- Affiliations
- St Thomas' Hospital (GB)
- aDepartment of General Practice, UMDS (Guy’s and St Thomas’s Medical School), London, bNorthern Region Research Network, Stockton-on-Tees, cCentre for Health Services and Medical Research, University of Teesside, Stockton-on-Tees, Cleveland
- Corresponding author
- Kennedy, T M
- Venue
- Gut
- Publisher
- BMJ
- Published
- 1998-12-01
- Volume
- 43
- Issue
- 6
- Pages
- 770-774
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1727355
- OpenAlex
- W2107657525
- Cited by
- 199
- References
- 28
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 15 · 2013: 9 · 2012: 11
- FWCI
- 5.63
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
- Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
- Keywords
- irritable bowel syndrome, gastroesophageal reflux, airway hyperresponsiveness, dyspepsia, chronic bronchitis, asthma, comorbidities, prevalence, sex differences, consultation behaviour
- MeSH terms
- Adult, Colonic Diseases, Functional, Female, Gastroesophageal Reflux, United Kingdom, Health Surveys, Humans, Male, Middle Aged, Prevalence, Bronchial Hyperreactivity
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