Cited by 199Gastrointestinal motility and disordersGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studies

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Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population

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Kennedy, T M, Jones, R H, Hungin, A P S, O’Flanagan, H, Kelly, P·1998·Gut

DOI 10.1136/gut.43.6.770PMC PMC1727355

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Abstract

Background —Associations have been shown between irritable bowel syndrome (IBS) and gastro-oesophageal reflux, between gastro-oesophageal reflux and asthma, and more recently between IBS and bronchial hyper-responsiveness (BHR). Aims —To explore the inter-relations between these conditions. Subjects —A randomly selected community sample of 4432 adults. Methods —A validated postal symptom questionnaire investigating the associations between IBS, gastro-oesophageal reflux symptoms, and symptomatic BHR. Results —3169 questionnaires (71.7% response) returned by 1451 men and 1718 women were analysed. One year prevalences, in men and women respectively, of IBS were 10.5% and 22.9%, of dyspepsia 26.3% and 25.25%, of gastro-oesophageal reflux symptoms 29.4% and 28.2%, of BHR 13.2% and 14.6%, and of chronic bronchitis 8.3% and 4.9%. Logistic regression showed independent associations between IBS and BHR, gastro-oesophageal reflux symptoms, and dyspepsia. There was no significant independent association between IBS and chronic bronchitis. In men and women the odds ratio with 95% confidence interval (CI) for IBS and gastro-oesophageal reflux symptoms was 2.6 (2.1–3.1; p<0.001) and for IBS and BHR 2.1 (1.7–2.7; p<0.001). These associations held on stratifying for sex and consultation behaviour. IBS, gastro-oesophageal reflux symptoms, and bronchial hyper-responsiveness occurred more frequently together than expected, 2.5% (95% CI 2.41–2.57) of the sample having all three conditions compared with an expected prevalence of 0.7% (95% CI 0.66–0.71). The conditions were independently associated with each other. Conclusions —These observations may indicate the presence of an underlying disorder producing symptoms in gastrointestinal and respiratory systems.

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Authors: Kennedy, T. M., Jones, R. H., Hungin, A. P. S., O’Flanagan, H., & Kelly, P.
Affiliations: St Thomas' Hospital (GB)
aDepartment of General Practice, UMDS (Guy’s and St Thomas’s Medical School), London, bNorthern Region Research Network, Stockton-on-Tees, cCentre for Health Services and Medical Research, University of Teesside, Stockton-on-Tees, Cleveland
Corresponding author: Kennedy, T M
ORCID: Kennedy, T M
Jones, R H
Hungin, A P S
Venue: Gut
Publisher: BMJ
Published: 1998-12-01
Volume: 43
Issue: 6
Pages: 770-774
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gut.43.6.770
PMC: PMC1727355
OpenAlex: W2107657525
Cited by: 199
References: 28
Citations by year: 2026: 1 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 15 · 2013: 9 · 2012: 11
FWCI: 5.63
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Gut (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Health Sciences › Medicine › Gastroenterology › Gastroesophageal reflux and treatments
Health Sciences › Medicine › Gastroenterology › Helicobacter pylori-related gastroenterology studies
Keywords: irritable bowel syndrome, gastroesophageal reflux, airway hyperresponsiveness, dyspepsia, chronic bronchitis, asthma, comorbidities, prevalence, sex differences, consultation behaviour
MeSH terms: Adult, Colonic Diseases, Functional, Female, Gastroesophageal Reflux, United Kingdom, Health Surveys, Humans, Male, Middle Aged, Prevalence, Bronchial Hyperreactivity

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Irritable bowel syndrome, gastro-oesophageal reflux, and bronchial hyper-responsiveness in the general population

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