The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives
Open accessAbstract
Cyclooxygenase (COX), the key enzyme for synthesis of prostaglandins, exists in two isoforms (COX-1 and COX-2). COX-1 is constitutively expressed in the gastrointestinal tract in large quantities and has been suggested to maintain mucosal integrity through continuous generation of prostaglandins. COX-2 is induced predominantly during inflammation. On this premise selective COX-2 inhibitors not affecting COX-1 in the gastrointestinal tract mucosa have been developed as gastrointestinal sparing anti-inflammatory drugs. They appear to be well tolerated by experimental animals and humans following acute and chronic (three or more months) administration. However, there is increasing evidence that COX-2 has a greater physiological role than merely mediating pain and inflammation. Thus gastric and intestinal lesions do not develop when COX-1 is inhibited but only when the activity of both COX-1 and COX-2 is suppressed. Selective COX-2 inhibitors delay the healing of experimental gastric ulcers to the same extent as non-COX-2 specific non-steroidal anti-inflammatory drugs (NSAIDs). Moreover, when given chronically to experimental animals, they can activate experimental colitis and cause intestinal perforation. The direct involvement of COX-2 in ulcer healing has been supported by observations that expression of COX-2 mRNA and protein is upregulated at the ulcer margin in a temporal and spatial relation to enhanced epithelial cell proliferation and increased expression of growth factors. Moreover, there is increasing evidence that upregulation of COX-2 mRNA and protein occurs during exposure of the gastric mucosa to noxious agents or to ischaemia-reperfusion. These observations support the concept that COX-2 represents (in addition to COX-1) a further line of defence for the gastrointestinal mucosa necessary for maintenance of mucosal integrity and ulcer healing.
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Cites
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Sohail, R., Mathew, M., Patel, K. K., Reddy, S. A., Haider, Z., Naria, M., Habib, A., Abdin, Z. U., Razzaq Chaudhry, W., & Akbar, A. (2023) · Cureus · doi:10.7759/cureus.37080 · Cited by 239
Gwee, K.-A., Goh, V., Lima, G., & Setia, S. (2018) · Journal of Pain Research · doi:10.2147/jpr.s156938 · Cited by 117
Banerjee, D., Hassarajani, S. A., Maity, B., Narayan, G., Bandyopadhyay, S. K., & Chattopadhyay, S. (2010) · Food & Function · doi:10.1039/c0fo00025f · Cited by 82
Natural Products with Antiplatelet Action
Hirsch, G. E., Nazario Viecili, P. R., de Almeida, A. S., Nascimento, S., Porto, F. G., Otero, J., Schmidt, A., da Silva, B., Parisi, M. M., & Klafke, J. Z. (2017) · Current Pharmaceutical Design · doi:10.2174/1381612823666161123151611 · Cited by 57
Metadata
- Authors
- HALTER, F., TARNAWSKI, A. S., SCHMASSMANN, A., & PESKAR, B. M.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2001-09-01
- Volume
- 49
- Issue
- 3
- Pages
- 443-453
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2122283496
- Cited by
- 285
- References
- 107
- FWCI
- 8.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- HALTER, F., TARNAWSKI, A. S., SCHMASSMANN, A., & PESKAR, B. M. (2001). Cyclooxygenase 2—implications on maintenance of gastric mucosal integrity and ulcer healing: controversial issues and perspectives. Gut. https://doi.org/10.1136/gut.49.3.443
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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