Non‐alcoholic steatohepatitis (NASH): where are we now and where are we going?
Open accessAbstract
Although non-alcoholic steatohepatitis (NASH) was considered relatively uncommon prior to the middle of the last decade, over the past three years there has been an explosion of studies on various aspects of NASH with one study reporting that after hepatitis C, NASH was the most common diagnosis in patients presenting largely with persistent abnormalities of liver function tests. The field of NASH has come a long way in a relatively short space of time. This article considers advances in knowledge that have arisen as a result of these studies and highlights areas for further work.
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Steatosis is believed to sensitize the liver to metabolic injury, leading to inflammation, necrosis, and fibrosis.
“Steatosis is believed to sensitize the liver to metabolic injury, leading to inflammation, necrosis, and fibrosis.2,[5][6][7]”
From Leptin reverses nonalcoholic steatohepatitis in patients with severe lipodystrophy† (2005) · cites this paper as [6]
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- Authors
- Day, C. P.
- Affiliations
- Newcastle University (GB)
- Corresponding author
- Day, C P
- ORCID
- Day, C P
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2002-05
- Volume
- 50
- Issue
- 5
- Pages
- 585.1-588
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC1773193
- OpenAlex
- W2121285903
- Cited by
- 181
- References
- 42
- Citations by year
- 2024: 3 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 9 · 2016: 5 · 2015: 5 · 2014: 10 · 2013: 8 · 2012: 10
- FWCI
- 2.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Gut (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- nonalcoholic steatohepatitis, liver function tests, hepatitis C, liver disease diagnosis, future research directions
- MeSH terms
- Fatty Liver, Hepatitis C, Humans, Insulin Resistance, Liver Function Tests, Obesity, Risk Factors
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