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Cited by 156Probiotics and Fermented FoodsGastrointestinal motility and disordersGut microbiota and health

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

A prospective randomised study of the probiotic Lactobacillus plantarum 299V on indices of gut barrier function in elective surgical patients

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McNaught, C E, Woodcock, N P, MacFie, J, Mitchell, C J·2002·Gut
DOI 10.1136/gut.51.6.827PMC PMC1773461
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Abstract

Background: Bacterial translocation occurs in surgical patients and may predispose to postoperative septic morbidity. Many factors are thought to influence the prevalence of bacterial translocation, one of which is the composition of the gut microflora. The aim of this prospective and randomised study was to assess the effect of the probiotic Lactobacillus plantarum 299v on the incidence of bacterial translocation, gastric colonisation, and septic complications in elective surgical patients. Methods: Patients undergoing elective major abdominal surgery were randomised to either a treatment or control group. The treatment group received an oral preparation containing Lactobacillus plantarum 299v ( Proviva ) for at least one week preoperatively and also in the postoperative period. Bacterial translocation was determined by culture of a mesenteric lymph node and serosal scraping obtained at laparotomy. Gastric colonisation was assessed by microbiological culture of nasogastric aspirates. All postoperative septic complications were recorded. Results: A total of 129 patients completed the study (probiotic group n=64). There was no significant difference between the two groups in terms of bacterial translocation (12% v 12%; p=0.82), gastric colonisation with enteric organisms (11% v 17%; p=0.42), or septic morbidity (13% v 15%; p=0.74). Conclusions: Administration of Lactobacillus plantarum 299v in elective surgical patients does not influence the rate of bacterial translocation, gastric colonisation, or incidence of postoperative septic morbidity.

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  1. 1991, Br J Surg, 78, 356
  2. 1999, Am J Physiol, 276, G941
  3. 10.1002/bjs.1800841005 · DOI
  4. 2000, Care Crit Ill, 16, 6

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Metadata

Authors
McNaught, C. E., Woodcock, N. P., MacFie, J., & Mitchell, C. J.
Affiliations
Scarborough General Hospital (GB)
Corresponding author
MacFie, J
ORCID
Venue
Gut
Publisher
BMJ
Published
2002-12
Volume
51
Issue
6
Pages
827-831
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
DOI
10.1136/gut.51.6.827
PMC
PMC1773461
OpenAlex
W2156266318
Cited by
156
References
30
Citations by year
2026: 3 · 2025: 1 · 2024: 3 · 2023: 5 · 2022: 1 · 2021: 7 · 2020: 4 · 2019: 7 · 2018: 5 · 2017: 6 · 2016: 4 · 2015: 10 · 2014: 4 · 2013: 11 · 2012: 8
FWCI
13.01
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords
Lactobacillus plantarum 299v, probiotics, bacterial translocation, intestinal barrier, postoperative sepsis, elective abdominal surgery, mesenteric lymph nodes, gut microbiota
MeSH terms
Adult, Aged, Bacterial Infections, C-Reactive Protein, Female, Gastric Mucosa, Humans, Intestinal Mucosa, Lactobacillus, Lymph Nodes, Male, Middle Aged, Postoperative Complications, Preoperative Care, Prospective Studies, Chi-Square Distribution, Statistics, Nonparametric, Bacterial Translocation, Probiotics

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