The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Hepatocellular carcinoma: clinical frontiers and perspectives
Open accessAbstract
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and alcohol-induced liver disease. The molecular pathogenesis is extremely complex and heterogeneous. To date the molecular information has not impacted on treatment decisions. Periodic surveillance imaging of patients with cirrhosis is widely practiced, especially because diagnostic, radiographic criteria for early-stage HCC have been defined (including nodules between 1 and 2 cm) and effective treatment is available for tumours detected at an early stage. Worldwide the approach to resection versus transplantation varies depending upon local resources, expertise and donor availability. The criteria for transplantation are discussed, and the controversial areas highlighted with evidence-based recommendations provided. Several approaches are available for intermediate stage disease, including radiofrequency ablation, transarterial chemoembolisation and radioembolisation; the rationale for these therapies is buttressed by appropriate outcome-based studies. For advanced disease, systemic therapy with sorafenib remains the option best supported by current data. Thus, while several trials have failed to improve the benefits of established therapies, studies assessing the sequential or combined application of those already known to be beneficial are needed. Also, new concepts are provided in regards to selecting and stratifying patients for second-line studies, which may help explain the failure of prior studies.
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Cited by
EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma
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Self-citationCircRNA: a novel type of biomarker for cancer
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Metadata
- Authors
- Bruix, J., Gores, G. J., & Mazzaferro, V.
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2014-02-14
- Volume
- 63
- Issue
- 5
- Pages
- 844-855
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2151305493
- Cited by
- 1,364
- References
- 11
- FWCI
- 69.24
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bruix, J., Gores, G. J., & Mazzaferro, V. (2014). Hepatocellular carcinoma: clinical frontiers and perspectives. Gut. https://doi.org/10.1136/gutjnl-2013-306627
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
