Cited by 1,080Gut microbiota and healthGenetic factors in colorectal cancerOral microbiology and periodontitis research

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Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis

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Mima, Kosuke, Nishihara, Reiko, Qian, Zhi Rong, Cao, Yin, Sukawa, Yasutaka, Nowak, Jonathan A, Yang, Juhong, Dou, Ruoxu, Masugi, Yohei, Song, Mingyang, Kostic, Aleksandar D, Giannakis, Marios, Bullman, Susan, Milner, Danny A, Baba, Hideo, Giovannucci, Edward L, Garraway, Levi A, Freeman, Gordon J, Dranoff, Glenn, Garrett, Wendy S, Huttenhower, Curtis, Meyerson, Matthew, Meyerhardt, Jeffrey A, Chan, Andrew T, Fuchs, Charles S, Ogino, Shuji·2016·Gut

DOI 10.1136/gutjnl-2015-310101PMC PMC4769120

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Abstract

OBJECTIVE: Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome. DESIGN: We used molecular pathological epidemiology database of 1069 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, and measured F. nucleatum DNA in carcinoma tissue. Cox proportional hazards model was used to compute hazard ratio (HR), controlling for potential confounders, including microsatellite instability (MSI, mismatch repair deficiency), CpG island methylator phenotype (CIMP), KRAS, BRAF, and PIK3CA mutations, and LINE-1 hypomethylation (low-level methylation). RESULTS: Compared with F. nucleatum-negative cases, multivariable HRs (95% CI) for colorectal cancer-specific mortality in F. nucleatum-low cases and F. nucleatum-high cases were 1.25 (0.82 to 1.92) and 1.58 (1.04 to 2.39), respectively, (p for trend=0.020). The amount of F. nucleatum was associated with MSI-high (multivariable odd ratio (OR), 5.22; 95% CI 2.86 to 9.55) independent of CIMP and BRAF mutation status, whereas CIMP and BRAF mutation were associated with F. nucleatum only in univariate analyses (p<0.001) but not in multivariate analysis that adjusted for MSI status. CONCLUSIONS: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker. Our data may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.

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Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
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Rubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
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Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960
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Self-citation
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Nishihara, R., Wu, K., Lochhead, P., Morikawa, T., Liao, X., Qian, Z. R., Inamura, K., Kim, S. A., Kuchiba, A., Yamauchi, M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301969 · Cited by 1,483
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Systemic Therapy for Colorectal Cancer
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Systemic Therapy for Colorectal Cancer
Varghese, A. M. (2019) · DeckerMed CGSO Case-Based Reviews · doi:10.2310/cgso.16189 · Cited by 883

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Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242046
Additional file 18 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242052
Additional file 15 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242037
Additional file 1 of Detection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer: a systematic review and meta-analysis
Janati, A. I., Karp, I., Laprise, C., Sabri, H., & Emami, E. (2020) · Figshare · doi:10.6084/m9.figshare.13331949
Additional file 7 of Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26617432
Additional file 14 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrázek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242031
Additional file 6 of Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26617429
Additional file 3 of Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Benedetti, F., Mongodin, E. F., Badger, J. H., Munawwar, A., Cellini, A., Yuan, W., Silvestri, G., Kraus, C. N., Marini, S., Rathinam, C. V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26692294
Additional file 4 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242124
Additional file 1 of Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Benedetti, F., Mongodin, E. F., Badger, J. H., Munawwar, A., Cellini, A., Yuan, W., Silvestri, G., Kraus, C. N., Marini, S., Rathinam, C. V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.25397511
Additional file 1 of Location and condition based reconstruction of colon cancer microbiome from human RNA sequencing data
Sambruni, G., Macandog, A. D. G., Wirbel, J., Cagnina, D., Catozzi, C., Dallavilla, T., Borgo, F., Fazio, N., Romario, U. F., Petz, W. L., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22735449
Additional file 13 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242028
Additional file 1 of Multi-omic profiling reveals associations between the gut mucosal microbiome, the metabolome, and host DNA methylation associated gene expression in patients with colorectal cancer
Wang, Q., Ye, J., Fang, D., Lv, L., Wu, W., Shi, D., Li, Y., Yang, L., Bian, X., Wu, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.12177459
Additional file 1 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242064
Additional file 3 of Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26617420
Additional file 7 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242142
Additional file 8 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242145
Additional file 1 of Nutrition-wide association study of microbiome diversity and composition in colorectal cancer patients
Hoang, T., Kim, M. J., Park, J. W., Jeong, S.-Y., Lee, J., & Shin, A. (2022) · Figshare · doi:10.6084/m9.figshare.20070837
Additional file 5 of Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26617426
Additional file 1 of Fusobacterium nucleatum predicts a high risk of metastasis for esophageal squamous cell carcinoma
Li, Z., Shi, C., Zheng, J., Guo, Y., Fan, T., Zhao, H., Jian, D., Cheng, X., Tang, H., & Ma, J. (2021) · Figshare · doi:10.6084/m9.figshare.16909587
Additional file 2 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrazek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242112
Additional file 4 of Comparative genomic analysis of Fusobacterium nucleatum reveals high intra-species diversity and cgmlst marker construction
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2024) · Figshare · doi:10.6084/m9.figshare.26617423
Additional file 1 of Potential of fecal microbiota for detection and postoperative surveillance of colorectal cancer
Yao, Q., Tang, M., Zeng, L., Chu, Z., Sheng, H., Zhang, Y., Zhou, Y., Zhang, H., Jiang, H., & Ye, M. (2021) · Figshare · doi:10.6084/m9.figshare.14691964
Additional file 1 of Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085
Hui, B., Zhou, C., Xu, Y., Wang, R., Dong, Y., Zhou, Y., Ding, J., Zhang, X., Xu, J., & Gu, Y. (2024) · Figshare · doi:10.6084/m9.figshare.25231238
Additional file 10 of Dysbiosis of skin microbiome and gut microbiome in melanoma progression
Mekadim, C., Skalníková, H. K., Cizkova, J., Cizkova, V., Palanová, A., Horák, V., & Mrázek, J. (2022) · Figshare · doi:10.6084/m9.figshare.19242013
Additional file 5 of Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Benedetti, F., Mongodin, E. F., Badger, J. H., Munawwar, A., Cellini, A., Yuan, W., Silvestri, G., Kraus, C. N., Marini, S., Rathinam, C. V., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26692300

Authors: Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., Kostic, A. D., Giannakis, M., Bullman, S., Milner, D. A., Baba, H., Giovannucci, E. L., Garraway, L. A., Freeman, G. J., Dranoff, G., Garrett, W. S., Huttenhower, C., Meyerson, M., Meyerhardt, J. A., Chan, A. T., Fuchs, C. S., & Ogino, S.
Affiliations: Harvard University (US)
Brigham and Women's Hospital (US)
Broad Institute (US)
Kumamoto University (JP)
Corresponding author: Ogino, Shuji
ORCID: Mima, Kosuke
Nishihara, Reiko
Qian, Zhi Rong
Cao, Yin
Sukawa, Yasutaka
Nowak, Jonathan A
Yang, Juhong
Dou, Ruoxu
Masugi, Yohei
Song, Mingyang
Kostic, Aleksandar D
Giannakis, Marios
Bullman, Susan
Milner, Danny A
Baba, Hideo
Giovannucci, Edward L
Garraway, Levi A
Freeman, Gordon J
Dranoff, Glenn
Garrett, Wendy S
Huttenhower, Curtis
Meyerson, Matthew
Meyerhardt, Jeffrey A
Chan, Andrew T
Fuchs, Charles S
Ogino, Shuji
Venue: Gut
Publisher: BMJ
Published: 2015-08-26
Volume: 65
Issue: 12
Pages: 1973-1980
ISSN: 0017-5749 (ISSN-L)
1468-3288
DOI: 10.1136/gutjnl-2015-310101
PMC: PMC4769120
OpenAlex: W2199896469
Cited by: 1,080
References: 53
Citations by year: 2026: 108 · 2025: 116 · 2024: 131 · 2023: 119 · 2022: 141 · 2021: 140 · 2020: 105 · 2019: 71 · 2018: 64 · 2017: 47 · 2016: 34 · 2015: 4
FWCI: 21.44
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Gut (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institutes of Health (KL2TR001100)
National Cancer Institute (P50CA127003, R01CA151993, R01CA118553, R01CA137178, R35CA197735, P01CA087969, R01CA169141, K07CA122826, P01CA055075, UM1CA186107, UM1CA167552, K07CA190673, R01CA154426)
National Institute of Diabetes and Digestive and Kidney Diseases (K24DK098311)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords: Fusobacterium nucleatum, colorectal cancer, rectal cancer, colon cancer, prognosis, colorectal cancer-specific mortality, tumor microbiome, microsatellite instability, CpG island methylator phenotype, BRAF mutation, prognostic factors, gut microbiota, antitumor immunity
MeSH terms: Aged, Carcinoma, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mutation, Neoplasm Staging, Phenotype, Prognosis, Prospective Studies, Research Design, Biomarkers, Tumor, Colorectal Neoplasms, Databases, Factual, Proto-Oncogene Proteins p21(ras), Fusobacterium nucleatum, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate, Microsatellite Instability, Class I Phosphatidylinositol 3-Kinases

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