The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
Open accessAbstract
OBJECTIVE: Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome. DESIGN: We used molecular pathological epidemiology database of 1069 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, and measured F. nucleatum DNA in carcinoma tissue. Cox proportional hazards model was used to compute hazard ratio (HR), controlling for potential confounders, including microsatellite instability (MSI, mismatch repair deficiency), CpG island methylator phenotype (CIMP), KRAS, BRAF, and PIK3CA mutations, and LINE-1 hypomethylation (low-level methylation). RESULTS: Compared with F. nucleatum-negative cases, multivariable HRs (95% CI) for colorectal cancer-specific mortality in F. nucleatum-low cases and F. nucleatum-high cases were 1.25 (0.82 to 1.92) and 1.58 (1.04 to 2.39), respectively, (p for trend=0.020). The amount of F. nucleatum was associated with MSI-high (multivariable odd ratio (OR), 5.22; 95% CI 2.86 to 9.55) independent of CIMP and BRAF mutation status, whereas CIMP and BRAF mutation were associated with F. nucleatum only in univariate analyses (p<0.001) but not in multivariate analysis that adjusted for MSI status. CONCLUSIONS: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker. Our data may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Numerous studies, of multiple cohorts, of patients with CRC worldwide have found similar associations.23–27”
From Influence of the Gut Microbiome, Diet, and Environment on Risk of Colorectal Cancer (2020) · cites this paper as [26]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The gut microbiota, bacterial metabolites and colorectal cancer
Louis, P., Hold, G. L., & Flint, H. J. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3344 · Cited by 2,925
Kostic, A. D., Chun, E., Robertson, L., Glickman, J. N., Gallini, C. A., Michaud, M., Clancy, T. E., Chung, D. C., Lochhead, P., Hold, G. L., et al. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.007 · Cited by 2,718
Self-citationRubinstein, M. R., Wang, X., Liu, W., Hao, Y., Cai, G., & Han, Y. W. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.07.012 · Cited by 2,476
Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
Castellarin, M., Warren, R. L., Freeman, J. D., Dreolini, L., Krzywinski, M., Strauss, J., Barnes, R., Watson, P., Allen-Vercoe, E., Moore, R. A., et al. (2012) · Genome Research · doi:10.1101/gr.126516.111 · Cited by 2,043
Genomic analysis identifies association of Fusobacterium with colorectal carcinoma
Kostic, A. D., Gevers, D., Pedamallu, C. S., Michaud, M., Duke, F., Earl, A. M., Ojesina, A. I., Jung, J., Bass, A. J., Tabernero, J., et al. (2012) · Genome Research · doi:10.1101/gr.126573.111 · Cited by 1,960
Self-citationGur, C., Ibrahim, Y., Isaacson, B., Yamin, R., Abed, J., Gamliel, M., Enk, J., Bar-On, Y., Stanietsky-Kaynan, N., Coppenhagen-Glazer, S., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.010 · Cited by 1,490
Self-citationLong-term colorectal-cancer incidence and mortality after lower endoscopy
Nishihara, R., Wu, K., Lochhead, P., Morikawa, T., Liao, X., Qian, Z. R., Inamura, K., Kim, S. A., Kuchiba, A., Yamauchi, M., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1301969 · Cited by 1,483
Self-citationGarrett, W. S. (2015) · Science · doi:10.1126/science.aaa4972 · Cited by 1,404
Self-citationSystemic Therapy for Colorectal Cancer
Meyerhardt, J. A., & Mayer, R. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra040958 · Cited by 1,080
Self-citationSystemic Therapy for Colorectal Cancer
Varghese, A. M. (2019) · DeckerMed CGSO Case-Based Reviews · doi:10.2310/cgso.16189 · Cited by 883
Cited by
Sorted by citations
Items 701–800 of 1,000
Zhang, H., Zuo, L., Li, J., Geng, Z., Ge, S., Song, X., Wang, Y., Zhang, X., Wang, L. Y., Zhao, T., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1126217 · Cited by 8
A Bioinformatics Tool for Identifying Intratumoral Microbes from the ORIEN Dataset
Wang, C., Ma, A., Li, Y., McNutt, M. E., Zhang, S., Zhu, J., Hoyd, R., Wheeler, C. E., Robinson, L. A., Chan, C. H. F., et al. (2024) · Cancer Research Communications · doi:10.1158/2767-9764.crc-23-0213 · Cited by 7
Predictive Values of Colon Microbiota in the Treatment Response to Colorectal Cancer
Ros, J. G., Ramos-Arenas, V., & Conesa‐Zamora, P. (2020) · Pharmacogenomics · doi:10.2217/pgs-2020-0044 · Cited by 9
Malik, S., Zhu, C., Li, J., LaComb, J. F., Denoya, P. I., Kravets, I., Miller, J. D., Yang, J., Kramer, M., McCombie, W. R., et al. (2021) · World Journal of Gastroenterology · doi:10.3748/wjg.v27.i14.1465 · Cited by 8
Self-citationMicrobiome and Colorectal Cancer
Ahmed, I., & Umar, S. (2018) · Current Colorectal Cancer Reports · doi:10.1007/s11888-018-0416-7 · Cited by 8
The Anti- and Pro-Tumorigenic Role of Microbiota and Its Role in Anticancer Therapeutic Strategies
Greco, G., Zeppa, S. D., Agostini, D., Attisani, G., Stefanelli, C., Ferrini, F., Sestili, P., & Fimognari, C. (2022) · Cancers · doi:10.3390/cancers15010190 · Cited by 8
Kim, B., Lee, J., Jung, E. S., Lee, S., Suh, D. H., Park, Y. J., Kim, J., Kwak, J., & Lee, S. H. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1282932 · Cited by 7
Emerging roles of intratumoral microbiota: a key to novel cancer therapies
Fang, P., Yang, H. J., Zhang, H., Shuai, D., Li, M., Chen, L., & Liu, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1506577 · Cited by 7
Oral microbiota and biliary tract cancers: unveiling hidden mechanistic links
Zhang, Y., & Zhang, S. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1585923 · Cited by 8
Fan, Q., Shang, F., Chen, C., Zhou, H., Fan, J., Yang, M., Nie, X., Liu, L., Cai, K., & Liu, H. (2021) · Cancer Management and Research · doi:10.2147/cmar.s294936 · Cited by 10
Koliarakis, I., Lagkouvardos, I., Vogiatzoglou, K., Tsamandouras, I., Intze, E., Messaritakis, I., Souglakos, J., & Tsiaoussis, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25169025 · Cited by 7
Wang, Y., Ma, H., Li, H., Huang, Y., Tang, Y., Tang, X., Sun, P., Tan, Z., Pang, H., & Yang, F. (2025) · Probiotics and Antimicrobial Proteins · doi:10.1007/s12602-025-10459-9 · Cited by 7
Han-feng, X., Jiang, W. G., Zhu, F., Zhu, C., Wei, J., & Wang, J. (2016) · Apmis · doi:10.1111/apm.12534 · Cited by 7
Sakamoto, R., Kajihara, I., Myangat, T. M., Otsuka-Maeda, S., Sawamura, S., Nishimura, Y., Kanemaru, H., Kanazawa-Yamada, S., Nakamura, K., Honda, N., et al. (2021) · European Journal of Dermatology · doi:10.1684/ejd.2021.3972 · Cited by 7
The Crosstalk between Microbiome and Immunotherapeutics: Myth or Reality
Tojjari, A., Abushukair, H. M., & Saeed, A. (2022) · Cancers · doi:10.3390/cancers14194641 · Cited by 9
Interaction of microbiome and immunity in tumorigenesis and clinical treatment
Yu, Y., & Zhong, W. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113894 · Cited by 7
Burns, M. B., Montassier, E., Abrahante, J., Priya, S., Niccum, D. E., Khoruts, A., Starr, T. K., Knights, D., & Blekhman, R. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/090795 · Cited by 7
González, A., Fullaondo, A., Navarro, D., Rodríguez, J., Tîrnȃucȃ, C., & Odriozola, A. (2024) · Cancers · doi:10.3390/cancers16234008 · Cited by 6
Greco, L., Rubbino, F., Ferrari, C., Cameletti, M., Grizzi, F., Bonelli, F., Malesci, A., Mazzone, M., Ricciardiello, L., & Laghi, L. (2025) · Gut Microbiome · doi:10.1017/gmb.2025.3 · Cited by 7
Pai, Y.-C., Huang, C., Lin, L.-Y., Li, Y.-H., & Yu, L. C. (2025) · Journal of physiological investigation. · doi:10.4103/ejpi.ejpi-d-25-00045 · Cited by 6
Primary tumor microbiomes predict distant metastasis of colorectal cancer
Parajuli, B., Midya, V., Kiddle, R., Jager, N. D., Eggers, S. I., Spakowicz, D. J., Hoyd, R., Salhia, B., Chan, C. H. F., Churchman, M. L., et al. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-01188-x · Cited by 7
Yang, X., Ning, T., Zhang, W., Hou, S., Su, J., Li, W., & Wu, J. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02561-w · Cited by 6
Wang, J.-Y., Lu, Y.-Q., Tan, X.-R., Ma, S., Dai, J.-H., Feng, S.-Y., Duan, Y.-F., Bai, J., Li, Y.-Q., Gong, S., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-026-02581-1 · Cited by 6
FXR agonists for colorectal and liver cancers, as a stand-alone or in combination therapy
Yu, D., Lu, Z., Wang, R., Xiang, Y., Li, H., Lu, J., Zhang, L., Chen, H., Li, W., Luan, X., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115570 · Cited by 7
Su, S., Bu, Q., Bai, X., Huang, Y., Wang, F., Hong, J., Fang, J., Wu, S., & Sheng, C. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106586 · Cited by 6
Modarres, M. P., Habibi, M. A., Pashaei, M. R., Mohammadpour, Y., Jazi, K., & Ahmadpour, S. (2024) · Current Cancer Therapy Reviews · doi:10.2174/0115733947270529231116114913 · Cited by 6
Bacterial DnaK reduces the activity of anti-cancer drugs cisplatin and 5FU
Benedetti, F., Mongodin, E. F., Badger, J. H., Munawwar, A., Cellini, A., Yuan, W., Silvestri, G., Kraus, C. N., Marini, S., Rathinam, C. V., et al. (2024) · Journal of Translational Medicine · doi:10.1186/s12967-024-05078-x · Cited by 6
Immunomodulation aspects of gut microbiome-related interventional strategies in colorectal cancer
Cheraghpour, M., Fatemi, N., Shadnoush, M., Talebi, G., Tierling, S., & Bermúdez‐Humarán, L. G. (2024) · Medical Oncology · doi:10.1007/s12032-024-02480-9 · Cited by 6
Ilozumba, M. N., Lin, T., Hardikar, S. S., Byrd, D. A., Round, J. L., Stephens, W. Z., Holowatyj, A. N., Warby, C. A., Damerell, V., Li, C. I., et al. (2024) · Cancer Medicine · doi:10.1002/cam4.70431 · Cited by 6
Ohsawa, M., Nishi, H., Emi, M., Yoshikawa, T., Hamai, Y., Ibuki, Y., Kurokawa, T., Hirohata, R., Kitasaki, N., Kawada‐Matsuo, M., et al. (2024) · Journal of Radiation Research · doi:10.1093/jrr/rrae061 · Cited by 6
Dysbiosis Patterns in Glottic and Laryngeal Cancers: A Systematic Review of Microbiome Alterations
Lechien, J. R. (2025) · Journal of Voice · doi:10.1016/j.jvoice.2025.02.036 · Cited by 6
Highly Sensitive DNA Testing of Fusobacterium nucleatum in Colorectal Tumors
Hullar, M. A. J., Kahsai, O. J., Hill, C. M., Levy, L., Malen, R. C., Curtis, K. R., Ammar, H., Sillah, A., Reedy, A. M., Lampe, J. W., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1020 · Cited by 8
Self-citationDarbyshire, A. L., Mothersole, R. G., & Wolthers, K. R. (2021) · Biochemistry · doi:10.1021/acs.biochem.0c00902 · Cited by 6
Esophageal microbiota composition and outcome of esophageal cancer treatment: a systematic review
Plat, V. D., van Rossen, T. M., Daams, F. D., de Boer, N. K. H., de Meij, T. G. J., Budding, A. E., Vandenbroucke‐Grauls, C. M. J. E., & van der Peet, D. L. (2021) · Diseases of the Esophagus · doi:10.1093/dote/doab076 · Cited by 6
Jampílek, J., Kráľová, K., & Bella, V. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823733-5.00009-x · Cited by 7
Bugs as Drugs: Understanding the Linkage between Gut Microbiota and Cancer Treatment
Rana, D., Salave, S., Perla, A., Nadkarni, A., Kolhe, S., Jindal, A. B., Mandoli, A., Dwivedi, P., & Benival, D. M. (2022) · Current Drug Targets · doi:10.2174/1389450123666220309101345 · Cited by 6
Liu, J., Jiang, J., Lan, Y., Li, C., Han, R., Wang, J., Wang, T., Zhao, Z., Fan, Z., He, L., et al. (2023) · American Journal of Orthodontics and Dentofacial Orthopedics · doi:10.1016/j.ajodo.2023.07.019 · Cited by 7
Villar-Ortega, P., Ruíz, M. E., Gutiérrez-Soto, M., Jiménez, M. R.-C., Navarro‐Marí, J. M., & Fernández, J. G. (2021) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/j.eimc.2021.01.005 · Cited by 6
Nishimura, H., Fukui, H., Wang, X., Ebisutani, N., Nakanishi, T., Tomita, T., Oshima, T., Hirota, S., & Miwa, H. (2021) · Pathogens · doi:10.3390/pathogens10040434 · Cited by 6
Microbial profiling identifies potential key drivers in gastric cancer patients
Li, Y., Wang, J., Wang, M., Gao, Y., Jin, C.-Y., Shi, X., Ji, B., Wei, Y., & Liu, H. (2021) · Biotechnology & Biotechnological Equipment · doi:10.1080/13102818.2021.1896384 · Cited by 6
Mikrobielle Biomarker zur Krebsfrüherkennung
Voigt, A. Y., Zeller, G., & Bork, P. (2017) · DMW - Deutsche Medizinische Wochenschrift · doi:10.1055/s-0042-110193 · Cited by 6
A resource for the comparison and integration of heterogeneous microbiome networksPreprint
Hu, Z., Kishore, D., Wang, Y., Bîrzu, G., DeLisi, C., Korolev, K. S., & Segrè, D. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.07.503059 · Cited by 6
Tumor microbiome analysis provides prognostic value for patients with stage III colorectal cancer
Kim, J. H., Yu, J., Kim, D.-K., Lee, S., Lee, S. H., Ahn, B. K., Kim, T. I., & Park, S. J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1212812 · Cited by 4
Oral microbiota in colorectal cancer: Unraveling mechanisms and application potential
Zhang, X., Chen, Y., Xia, Y., Lin, S., Zhou, X., Pang, X., Yu, J., & Sun, L. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123462 · Cited by 5
Sherry, C., Dadgar, N., Park, H., Knotts, C. M., Grayhack, E. E., Blodgett, R. J., Xiao, K., Omstead, A. N., Donnenberg, A. D., Bartlett, D. L., et al. (2025) · Microorganisms · doi:10.3390/microorganisms13071644 · Cited by 5
Intratumoral core microbiota predicts prognosis and therapeutic response in gastrointestinal cancers
Liu, J., Wei, D., Chen, Y., & Liu, X. (2025) · Microbiology Spectrum · doi:10.1128/spectrum.00390-25 · Cited by 5
Epigenetic Modulation, Intratumoral Microbiome, and Immunity in Early-Onset Colorectal Cancer
Jin, N. Y., Hoyd, R., Yilmaz, A. S., Zhu, J., Liu, Y., Singh, M. S. J., Grencewicz, D. J., Mo, X. M., Kalady, M. F., Rosenberg, D. W., et al. (2025) · Cancer Research Communications · doi:10.1158/2767-9764.crc-25-0177 · Cited by 7
Advancements in Understanding and Preventing Obesity-Related Colon Cancer
Shieh, C., Thompson, H. J., McLaughlin, E. M., Chiang, C., & Hussan, H. (2024) · The Cancer Journal · doi:10.1097/ppo.0000000000000744 · Cited by 5
Zhang, L., Duan, X., Zhao, Y., Zhang, D., & Zhang, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1526589 · Cited by 5
Wang, H., Baba, Y., Hara, Y., Toihata, T., Kosumi, K., Harada, K., Iwatsuki, M., Miyamoto, Y., & Baba, H. (2025) · Annals of Surgical Oncology · doi:10.1245/s10434-024-16288-4 · Cited by 5
Self-citationOmran, T. A., Camacho, J. L. S., Senthakumaran, T., Gundersen, G., Alte, A. K., Randen, U., Tunsjø, H. S., Saether, P. C., & Bemanian, V. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1601423 · Cited by 5
Wen, X., Ye, X., Yang, X., RuJin, J., Qian, C., & Wang, X. (2022) · Clinical & Translational Oncology · doi:10.1007/s12094-022-02995-5 · Cited by 5
Intestinal Microbiomics in Physiological and Pathological Conditions
Ionescu, R. F., Cozma, E. C., Enache, R. M., Creţoiu, S. M., Iancu, M., Mandea, M., Profir, M., Roşu, O. A., & Gașpar, B. S. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.110642 · Cited by 5
Whittling down the bacterial subspecies that might drive colon cancer
Sears, C. L., & Queen, J. (2024) · Nature · doi:10.1038/d41586-024-00662-z · Cited by 5
Chen, S., Chang, W.-H., Zhang, J., Liu, X.-Y., Gao, T., Qi, X., Cai, D., Mao, Y., & Lu, T. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s489432 · Cited by 5
Oral Bacteria and Bowel Diseases – Mini Review
Yoneda, M., & Suzuki, N. (2016) · Journal of Gastrointestinal & Digestive System · doi:10.4172/2161-069x.1000404 · Cited by 5
[Relationship between oral and gut microbes].
Xingqun, C., Xu, X., & Zhou, X. (2017) · PubMed Central · doi:10.7518/hxkq.2017.03.017 · Cited by 5
Fusobacterium nucleatum, rectal cancer and radiotherapy
Mann, E. H., & Maughan, T. (2020) · Annals of Oncology · doi:10.1016/j.annonc.2020.06.019 · Cited by 5
Personalized nutrition for colorectal cancer
Wang, K., & Song, M. (2021) · Advances in cancer research · doi:10.1016/bs.acr.2021.02.004 · Cited by 5
Self-citationThe Microbiome: the Link to Colorectal Cancer and Research Opportunities
Cass, S. H., Ajami, N. J., & White, M. G. (2022) · Current Treatment Options in Oncology · doi:10.1007/s11864-022-00960-6 · Cited by 5
Shimizu, M., Miyanaga, A., Seike, M., Matsuda, K., Matsumoto, M., Noro, R., Fujita, K., Mano, Y., Furuya, N., Kubota, K., et al. (2022) · Thoracic Cancer · doi:10.1111/1759-7714.14463 · Cited by 5
Zhu, Q., Dovletgeldiyev, A., Shen, C., Li, K., Hu, S., & He, Z. (2023) · Gut Pathogens · doi:10.1186/s13099-023-00570-z · Cited by 5
Microbiome and Diseases: Colorectal Cancer
Iftekhar, A., Sperlich, A., Janssen, K., & Sigal, M. J. (2018) · Springer eBooks · doi:10.1007/978-3-319-90545-7_15 · Cited by 5
Mechanistic and Therapeutic Advances in Colon Cancer: A Systematic Review
Xiu-jun, L., Han, Y., Zhang, A., Miao, J., Sun, H., Ge, Y., Wu, F., & Wang, X. (2019) · Open Journal of Proteomics and Genomics · doi:10.17352/ojpg.000008 · Cited by 5
Microbiota, mucosal immunity, and Colon cancer
Drewes, J. L., Domingue, J. C., & Housseau, F. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-819672-4.00008-8 · Cited by 5
Patients with Colorectal Cancer
Kenupp, M. G., Vianna, A., Uyeda, M., & Maluf, G. (2024) · International Healthcare Review (online) · doi:10.56226/83 · Cited by 5
Robinson, A. V., Vancuren, S. J., Marcone, M. F., & Allen‐Vercoe, E. (2025) · mSphere · doi:10.1128/msphere.00789-24 · Cited by 4
Burke, C., Glynn, T. J., Jahangir, C. A., Murphy, C. L., Buckley, N. E., Tangney, M., Rahman, A., & Gallagher, W. M. (2025) · Expert Review of Molecular Diagnostics · doi:10.1080/14737159.2025.2465743 · Cited by 4
Khoshbayan, A., Narimisa, N., Razavi, S., Shariati, A., Tavakoli‐Yaraki, M., Darban‐Sarokhalil, D., & Razavi, À. E. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10926-0 · Cited by 5
Haque, S., Bantun, F., Jalal, N. A., Faidah, H. S., Babalghith, A. O., Alobaidy, M. A., Aldairi, A. F., & Ahmad, F. (2025) · Gut Pathogens · doi:10.1186/s13099-025-00712-5 · Cited by 4
Jiang, Q. (2025) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2025.110235 · Cited by 4
Shen, W., Wang, H., Wang, J., Yuan, Y., Luo, Y., Chen, X. G., Li, J., Liu, Y., Yin, Y., Wang, M., et al. (2026) · Cell Host & Microbe · doi:10.1016/j.chom.2026.02.004 · Cited by 5
Self-citationAntibiotics, the microbiome and gastrointestinal cancers: A causal interference?
Ramai, D., Salati, M., Pomati, G., Amoroso, C., Facciorusso, A., Botticelli, A., & Ghidini, M. (2022) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2022.102315 · Cited by 4
Parhi, L., Shhadeh, A., Maalouf, N., Alon‐Maimon, T., Scaiewicz, V., & Bachrach, G. (2023) · BIO-PROTOCOL · doi:10.21769/bioprotoc.4635 · Cited by 4
Li, J., Wu, G., Yang, J., Yan, J., Li, D., Wang, Q., Xia, Y., Zhu, J., Guo, B., Cheng, F., et al. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1163359 · Cited by 4
Self-citationInfluence of the Oral Health Assessment Tool Score on Survival of Patients With Esophageal Cancer
Tamagawa, H., TAMAGAWA, A., Aoyama, T., HASHIMOTO, I., Maezawa, Y., Hara, K., Kato, A., KAMIYA, N., OTANI, K., Numata, M., et al. (2023) · In Vivo · doi:10.21873/invivo.13327 · Cited by 5
Microbiological links between periodontitis and systemic diseases: a brief review
Lee, S.-W. (2023) · Oral Biology Research · doi:10.21851/obr.47.03.202309.81 · Cited by 4
Kaliamoorthy, S., Sayeeram, S. P., SundarRaj, S., Balakrishnan, J., Nagarajan, M., & Samidorai, A. (2023) · Cureus · doi:10.7759/cureus.47238 · Cited by 4
Personalised medicine based on host genetics and microbiota applied to colorectal cancer
González, A., Badiola, I., Fullaondo, A., Rodríguez, J., & Odriozola, A. (2024) · Advances in genetics · doi:10.1016/bs.adgen.2024.08.004 · Cited by 4
Establishment and improvement of genetic manipulation tools for Fusobacterium nucleatum
Guan, Z., Wang, H., & Feng, Q. (2025) · Engineering Microbiology · doi:10.1016/j.engmic.2025.100192 · Cited by 4
Kolour, H. R., Eshaghi, H., Shams, E., Sanjabi, F., Nobili, S., Raeisi, H., Sadeghi, A., Mojarad, E. N., & Fatemi, N. (2025) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-025-04457-w · Cited by 4
Tackling immunomonitoring in gastrointestinal cancer
Anciaux, M., Vandeputte, C., & Hendlisz, A. (2017) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000383 · Cited by 4
Cellular Reprogramming Technology for Dissecting Cancer Epigenome in Vivo
Ito, K., & Yamada, Y. (2017) · Epigenomics · doi:10.2217/epi-2017-0018 · Cited by 4
Racial disparity in survival of patients diagnosed with early-onset colorectal cancer
Wallace, K., Li, H., Paulos, C. M., Lewin, D., & Alekseyenko, A. V. (2020) · Colorectal Cancer · doi:10.2217/crc-2020-0015 · Cited by 4
Cell-Based Immunotherapy Approaches for Colorectal Cancer: Main Achievements and Challenges
Shahnazari, M., Samadi, P., Pourjafar, M., & Jalali, A. (2021) · Future Oncology · doi:10.2217/fon-2020-1218 · Cited by 4
Smorodin, E. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222111608 · Cited by 4
The Need for Oral Hygiene Care and Periodontal Status among Hospitalized Gastric Cancer Patients
Nicolae, F. M., Bennardo, F., Barone, S., Șurlin, P., Gheorghe, D. N., Burtea, D. E., Pătrașcu, Ș., Râmboiu, S., Radu, P. A., Ungureanu, B. S., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12050684 · Cited by 4
Influence of pathogens on host genome and epigenome in development of head and neck cancer
Desai, S. (2023) · Cancer Reports · doi:10.1002/cnr2.1846 · Cited by 4
Symbiotic symphony: Understanding host-microbiota dialogues in a spatial context
Chatterjee, S., Leach, S. T., Lui, K., & Mishra, A. (2024) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2024.03.001 · Cited by 4
Diet, microbes, and cancer across the tree of life: a systematic reviewPreprint
Kapsetaki, S. E., Alcaraz, G. M., Maley, C. C., Whisner, C. M., & Aktipis, A. (2021) · Research Square · doi:10.21203/rs.3.rs-1077771/v1 · Cited by 4
Zhao, B., Zhou, B., Li, Q., Su, C., Ma, J., & Yang, L. (2024) · MedComm – Future Medicine · doi:10.1002/mef2.70006 · Cited by 3
McGregor, A. K., Do, L. T. M., Gauvin, A., & Wolthers, K. R. (2025) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2025.110520 · Cited by 2
Colorectal cancer chemoprevention: Exploring the path from molecular mechanisms to available drugs
Ivy, D. M., Bordone, R., Magno, L. D., Coni, S., & Canettieri, G. (2025) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2025.189439 · Cited by 3
Gut microbiota and chemoradiotherapy response in rectal cancer: Biomarker opportunities
Taoum, C., Devaux, A., Rouanet, P., Colombo, P., Boucher, D., & Bonnet, M. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104974 · Cited by 3
Zhao, F., An, R., Yu, S., Ma, Y., Liu, W., 盛彩霞, Xie, X., & Zhang, J. (2026) · Clinical and Translational Medicine · doi:10.1002/ctm2.70704 · Cited by 3
Alexander, J. B., Mullish, B. H., Thomas, L., Weersma, R. K., Sokol, H., Roberts, L. A., Edwards, L. A., Emmanuel, A. V., Gerasimidis, K., Hall, L. J., et al. (2026) · Gut · doi:10.1136/gutjnl-2026-338252 · Cited by 5
Rethinking Colorectal Cancer Microbiome: From Universal Biomarkers to Patient-Stratified Signatures
Schena, C. A., Laterza, V., Covino, M., & Rosa, F. (2026) · Gastrointestinal Disorders · doi:10.3390/gidisord8020026 · Cited by 3
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
Chen, J., Bai, Y., Shen, L., Ying, J., Xu, J. Q., Tang, J., & Bao, Y.-J. (2026) · MedComm · doi:10.1002/mco2.70825 · Cited by 3
Microbiota dysfunction in patients with brain damage in chronic critical condition
Grechko, A. V., Buyakova, I. V., & Nv, B. (2022) · Russian neurological Journal · doi:10.30629/2658-7947-2022-27-1-94-104 · Cited by 3
Huang, R., Yao, Y., Tong, X., Wang, L., Qian, W., Lu, J., Zhang, W., Liu, Y., Wang, S., Xian, S., et al. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.00135-23 · Cited by 3
Metadata
- Authors
- Mima, K., Nishihara, R., Qian, Z. R., Cao, Y., Sukawa, Y., Nowak, J. A., Yang, J., Dou, R., Masugi, Y., Song, M., Kostic, A. D., Giannakis, M., Bullman, S., Milner, D. A., Baba, H., Giovannucci, E. L., Garraway, L. A., Freeman, G. J., Dranoff, G., Garrett, W. S., Huttenhower, C., Meyerson, M., Meyerhardt, J. A., Chan, A. T., Fuchs, C. S., & Ogino, S.
- Affiliations
- Harvard University (US)
- Brigham and Women's Hospital (US)
- Broad Institute (US)
- Kumamoto University (JP)
- Corresponding author
- Ogino, Shuji
- ORCID
- Mima, Kosuke
- Nishihara, Reiko
- Qian, Zhi Rong
- Cao, Yin
- Sukawa, Yasutaka
- Nowak, Jonathan A
- Yang, Juhong
- Dou, Ruoxu
- Masugi, Yohei
- Song, Mingyang
- Kostic, Aleksandar D
- Giannakis, Marios
- Bullman, Susan
- Milner, Danny A
- Baba, Hideo
- Giovannucci, Edward L
- Garraway, Levi A
- Freeman, Gordon J
- Dranoff, Glenn
- Garrett, Wendy S
- Huttenhower, Curtis
- Meyerson, Matthew
- Meyerhardt, Jeffrey A
- Chan, Andrew T
- Fuchs, Charles S
- Ogino, Shuji
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2015-08-26
- Volume
- 65
- Issue
- 12
- Pages
- 1973-1980
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC4769120
- OpenAlex
- W2199896469
- Cited by
- 1,080
- References
- 53
- Citations by year
- 2026: 108 · 2025: 116 · 2024: 131 · 2023: 119 · 2022: 141 · 2021: 140 · 2020: 105 · 2019: 71 · 2018: 64 · 2017: 47 · 2016: 34 · 2015: 4
- FWCI
- 21.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (KL2TR001100)
- National Cancer Institute (P50CA127003, R01CA151993, R01CA118553, R01CA137178, R35CA197735, P01CA087969, R01CA169141, K07CA122826, P01CA055075, UM1CA186107, UM1CA167552, K07CA190673, R01CA154426)
- National Institute of Diabetes and Digestive and Kidney Diseases (K24DK098311)
- National Center for Advancing Translational Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- Fusobacterium nucleatum, colorectal cancer, rectal cancer, colon cancer, prognosis, colorectal cancer-specific mortality, tumor microbiome, microsatellite instability, CpG island methylator phenotype, BRAF mutation, prognostic factors, gut microbiota, antitumor immunity
- MeSH terms
- Aged, Carcinoma, Female, Follow-Up Studies, Humans, Male, Middle Aged, Mutation, Neoplasm Staging, Phenotype, Prognosis, Prospective Studies, Research Design, Biomarkers, Tumor, Colorectal Neoplasms, Databases, Factual, Proto-Oncogene Proteins p21(ras), Fusobacterium nucleatum, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins B-raf, Kaplan-Meier Estimate, Microsatellite Instability, Class I Phosphatidylinositol 3-Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
