The gut-adherent microbiota of PSC–IBD is distinct to that of IBD
Abstract
Primary sclerosing cholangitis–IBD (PSC–IBD) is an inflammatory autoimmune hepato–biliary–enteric disease in which it is predicted that gut microbiota have potential pathophysiological effects, relevant to disease initiation and outcome. The recent article by Kummen et al 1 who reported that the gut microbiota in PSC is distinct compared with those from healthy controls and patients with UC without liver disease, is therefore of interest. However, it remains unclear if these alterations in the gut microbiota are a cause or an effect of liver disease, and there remains a challenging task to link dysbiosis with disease pathogenesis, as well as clarify whether faecal microbiota are entirely representative of communities of mucosa-associated bacteria, which might uniquely interact with immune and epithelial cells. Nevertheless Kummen et al notably demonstrated that the Veillonella genus showed a marked increase in PSC–IBD, in comparison with both healthy controls and patients with UC alone. Given interest in the mechanism of lymphocyte tracking between the bowel and liver …
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Recent studies support an association between changes in the microbiome and the progression of cholestatic liver disease in patients.
“Recent studies have further supported the association between changes in the microbiome and the progression of cholestatic liver disease in patients9–14.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [10]
Recent studies described that cholestatic patients with PSC have an overall less diverse microbiome composition.
“Recent studies described that cholestatic patients with PSC have an overall less diverse microbiome composition.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [10]
Changes at genera level in cholestatic patients differ among studies and include enrichment in Veillonella, Akkermansia, Ruminococcaceae (undefined genus) and Clostridium and decrease in Prevotella.
“The changes described at genera level differ among studies9–12 and include the enrichment in Veillonella, Akkermansia, Ruminococcaceae (undefined genus) and Clostridium9 and the decrease in Prevotella10, overall supporting the association between changes in the microbiome and cholestatic disease.”
From Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice (2019) · cites this paper as [10]
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- Authors
- Quraishi, M. N., Sergeant, M., Kay, G., Iqbal, T., Chan, J., Constantinidou, C., Trivedi, P., Ferguson, J., Adams, D. H., Pallen, M., & Hirschfield, G. M.
- Affiliations
- National Institute for Health and Care Research (GB)
- University of Warwick (GB)
- Queen Elizabeth Hospital Birmingham (GB)
- Corresponding author
- Hirschfield, Gideon M
- ORCID
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2016-04-19
- Volume
- 66
- Issue
- 2
- Pages
- 386.1-388
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- OpenAlex
- W2336309303
- Cited by
- 179
- References
- 6
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 21 · 2023: 19 · 2022: 20 · 2021: 25 · 2020: 19 · 2019: 24 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion)
- UEA Digital Repository (University of East Anglia) (submittedVersion)
- Funders
- National Institute for Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- primary sclerosing cholangitis, inflammatory bowel disease, gut microbiota, mucosa-associated microbiota, dysbiosis, Veillonella, ulcerative colitis, liver disease, pathogenesis, lymphocyte migration
- MeSH terms
- Gastrointestinal Microbiome, Humans, Cholangitis, Sclerosing, Inflammatory Bowel Diseases
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