The gut microbial influence on cholestatic liver disease

Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity

Markle, J. G. M., Frank, D. N., Mortin-Toth, S., Robertson, C. E., Feazel, L. M., Rolle-Kampczyk, U., von Bergen, M., McCoy, K. D., Macpherson, A. J., & Danska, J. S. (2013) · Science · doi:10.1126/science.1233521 · Cited by 2,025 · see citing works

Carbohydrate quality and human health: a series of systematic reviews and meta-analyses

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Gut microbiome–mediated bile acid metabolism regulates liver cancer via NKT cells

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The gut microbiota at the intersection of diet and human health

Gentile, C. L., & Weir, T. L. (2018) · Science · doi:10.1126/science.aau5812 · Cited by 1,049 · see citing works

Gut microbiota and intestinal FXR mediate the clinical benefits of metformin

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Patient age, sex, and inflammatory bowel disease phenotype associate with course of primary sclerosing cholangitis

Weismüller, T. J., Trivedi, P. J., Bergquist, A., Imam, M., Lenzen, H., Ponsioen, C. Y., Holm, K., Gotthardt, D., Färkkilä, M. A., Marschall, H.-U., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.02.038 · Cited by 533 · see citing works

Dysregulated Microbial Fermentation of Soluble Fiber Induces Cholestatic Liver Cancer

Singh, V., Yeoh, B. S., Chassaing, B., Xiao, X., Saha, P., Aguilera Olvera, R., Lapek, J. D., Zhang, L., Wang, W.-B., Hao, S., et al. (2018) · Cell · doi:10.1016/j.cell.2018.09.004 · Cited by 532 · see citing works

The gut microbiota influences anticancer immunosurveillance and general health

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Gut microbiota composition and activity in relation to host metabolic phenotype and disease risk

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The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota

Balmer, M. L., Slack, E., de Gottardi, A., Lawson, M. A. E., Hapfelmeier, S., Miele, L., Grieco, A., Van Vlierberghe, H., Fahrner, R., Patuto, N., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008618 · Cited by 470 · see citing works

Gut microbial profile is altered in primary biliary cholangitis and partially restored after UDCA therapy

Tang, R., Wei, Y., Li, Y., Chen, W., Chen, H., Wang, Q., Yang, F., Miao, Q., Xiao, X., Zhang, H., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313332 · Cited by 434 · see citing works

The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls

Kummen, M., Holm, K., Anmarkrud, J. A., Nygård, S., Vesterhus, M., Høivik, M. L., Trøseid, M., Marschall, H.-U., Schrumpf, E., Moum, B., et al. (2017) · Gut · doi:10.1136/gutjnl-2015-310500 · Cited by 426 · see citing works

Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis

Nakamoto, N., Sasaki, N., Aoki, R., Miyamoto, K., Suda, W., Teratani, T., Suzuki, T., Koda, Y., Chu, P.-S., Taniki, N., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-018-0333-1 · Cited by 425 · see citing works

Primary sclerosing cholangitis is characterised by intestinal dysbiosis independent from IBD

Sabino, J., Vieira-Silva, S., Machiels, K., Joossens, M., Falony, G., Ballet, V., Ferrante, M., Van Assche, G., Van der Merwe, S., Vermeire, S., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-311004 · Cited by 413 · see citing works

Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis

Bajer, L., Kverka, M., Kostovčík, M., Mačinga, P., Dvořák, J., Stehlíková, Z., Březina, J., Wohl, P., Špičák, J., & Drastich, P. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i25.4548 · Cited by 360 · see citing works

Bile acids and intestinal microbiota in autoimmune cholestatic liver diseases

Li, Y., Tang, R., Leung, P. S. C., Gershwin, M. E., & Ma, X. (2017) · Autoimmunity Reviews · doi:10.1016/j.autrev.2017.07.002 · Cited by 247 · see citing works

Alterations and correlations of the gut microbiome, metabolism and immunity in patients with primary biliary cirrhosis

Lv, L., Fang, D., Shi, D., Chen, D., Yan, R., Zhu, Y., Chen, Y., Shao, L., Guo, F., Wu, W., et al. (2016) · Environmental Microbiology · doi:10.1111/1462-2920.13401 · Cited by 245 · see citing works

Fecal microbiota transplantation in patients with primary sclerosing cholangitis: a pilot clinical trial

Allegretti, J. R., Kassam, Z., Carrellas, M., Mullish, B. H., Marchesi, J. R., Pechlivanis, A., Smith, M., Gerardin, Y., Timberlake, S., Pratt, D. S., et al. (2019) · American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000115 · Cited by 234 · see citing works

Absence of the intestinal microbiota exacerbates hepatobiliary disease in a murine model of primary sclerosing cholangitis

Tabibian, J. H., O'Hara, S. P., Trussoni, C. E., Tietz, P. S., Splinter, P. L., Mounajjed, T., Hagey, L. R., & LaRusso, N. F. (2016) · Hepatology · doi:10.1002/hep.27927 · Cited by 223 · see citing works

Fungi participate in the dysbiosis of gut microbiota in patients with primary sclerosing cholangitis

Lemoinne, S., Kemgang, A., Belkacem, K. B., Straube, M., Jégou, S., Corpechot, C., Saint-Antoine IBD Network, Chazouillères, O., Housset, C., & Sokol, H. (2019) · Gut · doi:10.1136/gutjnl-2018-317791 · Cited by 215 · see citing works

Hepatic inflammation in rats with experimental small intestinal bacterial overgrowth

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Review: Mechanisms of How the Intestinal Microbiota Alters the Effects of Drugs and Bile Acids

Klaassen, C. D., & Cui, J. Y. (2015) · Drug Metabolism and Disposition · doi:10.1124/dmd.115.065698 · Cited by 208 · see citing works

Enterobacteriaceae are essential for the modulation of colitis severity by fungi

Sovran, B., Planchais, J., Jégou, S., Straube, M., Lamas, B., Natividad, J. M., Agus, A., Dupraz, L., Glodt, J., Costa, G. D., et al. (2018) · Microbiome · doi:10.1186/s40168-018-0538-9 · Cited by 181 · see citing works

The gut-adherent microbiota of PSC–IBD is distinct to that of IBD

Quraishi, M. N., Sergeant, M., Kay, G., Iqbal, T., Chan, J., Constantinidou, C., Trivedi, P., Ferguson, J., Adams, D. H., Pallen, M., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-311915 · Cited by 179 · see citing works

Intestinal dysbiosis augments liver disease progression via NLRP3 in a murine model of primary sclerosing cholangitis

Liao, L., Schneider, K. M., Gálvez, E. J. C., Frissen, M., Marschall, H., Su, H., Hatting, M., Wahlstrom, A. M., Haybaeck, J., Puchas, P., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316670 · Cited by 175 · see citing works

Role of the intestinal microbiome in liver disease

Henao‐Mejia, J., Elinav, E., Thaiss, C. A., Licona-Limón, P., & Flavell, R. A. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2013.07.001 · Cited by 167 · see citing works

p-ANCAs in autoimmune liver disorders recognise human β-tubulin isotype 5 and cross-react with microbial protein FtsZ

Terjung, B., Söhne, J., Lechtenberg, B., Gottwein, J. M., Muennich, M., Herzog, V., Mähler, M., Sauerbruch, T., & Spengler, U. (2009) · Gut · doi:10.1136/gut.2008.157818 · Cited by 153 · see citing works

The features of mucosa‐associated microbiota in primary sclerosing cholangitis

Torres, J., Bao, X., Goel, A., Colombel, J. ‐., Pekow, J., Jabri, B., Williams, K. M., Castillo, A., Odin, J. A., Meckel, K., et al. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13552 · Cited by 149 · see citing works

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease

Tedesco, D., Thapa, M., Chin, C. Y., Ge, Y., Gong, M., Li, J., Gumber, S., Speck, P., Elrod, E. J., Burd, E. M., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.02.019 · Cited by 137 · see citing works

Loss of CFTR Affects Biliary Epithelium Innate Immunity and Causes TLR4–NF-κB—Mediated Inflammatory Response in Mice

Fiorotto, R., Scirpo, R., Trauner, M. A., Fabris, L., Hoque, R., Spirlı̀, C., & Strazzabosco, M. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.06.052 · Cited by 136 · see citing works

The Mucosa-associated Microbiota of PSC Patients is Characterized by Low Diversity and Low Abundance of Uncultured Clostridiales II

Rossen, N. G., Fuentes, S., Boonstra, K., D’Haens, G. R., Heilig, H. G., Zoetendal, E. G., de Vos, W. M., & Ponsioen, C. Y. (2015) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jju023 · Cited by 129 · see citing works

The gut microbiota, bile acids and their correlation in primary sclerosing cholangitis associated with inflammatory bowel disease

Torres, J., Palmela, C., Brito, H., Bao, X., Ruiqi, H., Moura-Santos, P., da Silva, J. P., Oliveira, A. A. S., Vieira, C. L., Pérez, K., et al. (2017) · United European Gastroenterology Journal · doi:10.1177/2050640617708953 · Cited by 121 · see citing works

Probiotics in primary sclerosing cholangitis: a randomized placebo-controlled crossover pilot study

Vleggaar, F. P., Monkelbaan, J. F., & van Erpecum, K. J. (2008) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e3282f5197e · Cited by 110 · see citing works

Dysbiosis of oral microbiota and its association with salivary immunological biomarkers in autoimmune liver disease

Abe, K., Takahashi, A., Fujita, M., Imaizumi, H., Hayashi, M., Okai, K., & Ohira, H. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198757 · Cited by 109 · see citing works

Primary sclerosing cholangitis and the microbiota: current knowledge and perspectives on etiopathogenesis and emerging therapies

Tabibian, J. H., O’Hara, S. P., & Lindor, K. D. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.913189 · Cited by 93 · see citing works

A pilot study of fecal bile acid and microbiota profiles in inflammatory bowel disease and primary sclerosing cholangitis

Vaughn, B. P., Kaiser, T., Staley, C. M., Hamilton, M. J., Reich, J., Graiziger, C. T., Singroy, S., Kabage, A. J., Sadowsky, M. J., & Khoruts, A. (2019) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s186097 · Cited by 92 · see citing works

Role of the Microbiota and Antibiotics in Primary Sclerosing Cholangitis

Tabibian, J. H., Talwalkar, J. A., & Lindor, K. D. (2013) · BioMed Research International · doi:10.1155/2013/389537 · Cited by 91 · see citing works

Characterization of Intestinal Microbiota in Ulcerative Colitis Patients with and without Primary Sclerosing Cholangitis

Kevans, D., Tyler, A. D., Holm, K., Jørgensen, K. K., Vatn, M. H., Karlsen, T. H., Kaplan, G. G., Eksteen, B., Gevers, D., Hov, J. R., et al. (2015) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjv204 · Cited by 88 · see citing works

Cholestatic liver diseases: new targets, new therapies

Santiago, P., Scheinberg, A. R., & Levy, C. (2018) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284818787400 · Cited by 83 · see citing works

Faecal microbiota profiles as diagnostic biomarkers in primary sclerosing cholangitis

Rühlemann, M. C., Heinsen, F., Zenouzi, R., Lieb, W., Franke, A., & Schramm, C. (2016) · Gut · doi:10.1136/gutjnl-2016-312180 · Cited by 81 · see citing works

The gut microbiota contributes to a mouse model of spontaneous bile duct inflammation

Schrumpf, E., Kummen, M., Valestrand, L., Greiner, T. U., Holm, K., Arulampalam, V., Reims, H. M., Baines, J. F., Bäckhed, F., Karlsen, T. H., et al. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.09.020 · Cited by 78 · see citing works

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis

Dhillon, A. K., Kummen, M., Trøseid, M., Åkra, S., Liaskou, E., Moum, B. A., Vesterhus, M., Karlsen, T. H., Seljeflot, I., & Hov, J. R. (2018) · Liver International · doi:10.1111/liv.13979 · Cited by 73 · see citing works

Characterisation of the faecal microbiota in Japanese patients with paediatric-onset primary sclerosing cholangitis

Iwasawa, K., Suda, W., Tsunoda, T., Oikawa‐Kawamoto, M., Umetsu, S., Inui, A., Fujisawa, T., Morita, H., Sogo, T., & Hattori, M. (2016) · Gut · doi:10.1136/gutjnl-2016-312533 · Cited by 66 · see citing works

The Microbiome in Primary Sclerosing Cholangitis: Current Evidence and Potential Concepts

Hov, J., & Karlsen, T. (2017) · Seminars in Liver Disease · doi:10.1055/s-0037-1608801 · Cited by 65 · see citing works

Dysbiosis of the salivary microbiota in pediatric-onset primary sclerosing cholangitis and its potential as a biomarker

Iwasawa, K., Suda, W., Tsunoda, T., Oikawa‐Kawamoto, M., Umetsu, S., Takayasu, L., Inui, A., Fujisawa, T., Morita, H., Sogo, T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-23870-w · Cited by 60 · see citing works

The immunobiology of female predominance in primary biliary cholangitis

Gerussi, A., Cristoferi, L., Carbone, M., Asselta, R., & Invernizzi, P. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.10.015 · Cited by 41 · see citing works

Diet‐Induced Dysbiosis and Genetic Background Synergize With Cystic Fibrosis Transmembrane Conductance Regulator Deficiency to Promote Cholangiopathy in Mice

Debray, D., Mourabit, H. E., Merabtene, F., Brot, L., Ulveling, D., Chrétien, Y., Rainteau, D. P., Moszer, I., Wendum, D., Sokol, H., et al. (2018) · Hepatology Communications · doi:10.1002/hep4.1266 · Cited by 36 · see citing works

Elevated trimethylamine‐N ‐oxide (TMAO) is associated with poor prognosis in primary sclerosing cholangitis patients with normal liver function

Kummen, M., Vesterhus, M. N., Trøseid, M., Moum, B. A., Svardal, A. M., Boberg, K. M., Aukrust, P., Karlsen, T. H., Berge, R. K., & Hov, J. R. (2016) · United European Gastroenterology Journal · doi:10.1177/2050640616663453 · Cited by 32 · see citing works

Association between serum soluble CD 14 and IL ‐8 levels and clinical outcome in primary biliary cholangitis

Umemura, T., Sekiguchi, T., Joshita, S., Yamazaki, T., Fujimori, N., Shibata, S., Ichikawa, Y., Komatsu, M., Matsumoto, A., Shums, Z., et al. (2016) · Liver International · doi:10.1111/liv.13316 · Cited by 28 · see citing works

Intestinal microbiota in primary sclerosing cholangitis

Hov, J. R., & Kummen, M. (2016) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000334 · Cited by 27 · see citing works

The Microbiome and Primary Sclerosing Cholangitis

Ali, A. H., Carey, E. J., & Lindor, K. M. (2016) · Seminars in Liver Disease · doi:10.1055/s-0036-1594007 · Cited by 19 · see citing works

Recent advances in clinical practice: Epidemiology of autoimmune liver diseases

Trivedi, P. J., & Hirschfield, G. M. (2021) · Gut · doi:10.1136/gutjnl-2020-322362 · Cited by 244 · see citing works

Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility

Fossmark, R., Martinsen, T. C., & Waldum, H. L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20205203 · Cited by 160 · see citing works

Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis

Kummen, M., Thingholm, L. B., Rühlemann, M. C., Holm, K., Hansen, S. H., Moitinho-Silva, L., Liwinski, T., Zenouzi, R., Storm-Larsen, C., Midttun, Ø., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.058 · Cited by 129 · see citing works

Gut microbiome in primary sclerosing cholangitis: A review

Little, R., Wine, E., Kamath, B. M., Griffiths, A. M., & Ricciuto, A. (2020) · World Journal of Gastroenterology · doi:10.3748/wjg.v26.i21.2768 · Cited by 125 · see citing works

Gut Microbiota in Intestinal and Liver Disease

Jones, R. M., & Neish, A. S. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030320-095722 · Cited by 117 · see citing works

Inflammatory bowel disease and primary sclerosing cholangitis: One disease or two?

van Munster, K. N., Bergquist, A. M., & Ponsioen, C. Y. (2023) · Journal of Hepatology · doi:10.1016/j.jhep.2023.09.031 · Cited by 115 · see citing works

The Gut-Liver Axis in Cholestatic Liver Diseases

Blesl, A., & Stadlbauer, V. (2021) · Nutrients · doi:10.3390/nu13031018 · Cited by 99 · see citing works

A Current Understanding of Bile Acids in Chronic Liver Disease

Farooqui, N., Elhence, A., & Shalimar, S. (2021) · Journal of Clinical and Experimental Hepatology · doi:10.1016/j.jceh.2021.08.017 · Cited by 91 · see citing works

TREM-2 plays a protective role in cholestasis by acting as a negative regulator of inflammation

Labiano, I., Agirre-Lizaso, A., Olaizola, P., Echebarria, A., Huici-Izagirre, M., Olaizola, I., Esparza-Baquer, A., Sharif, O., Hijona, E., Milkiewicz, P., et al. (2022) · Journal of Hepatology · doi:10.1016/j.jhep.2022.05.044 · Cited by 78 · see citing works

Lactobacillus acidophilus ameliorates cholestatic liver injury through inhibiting bile acid synthesis and promoting bile acid excretion

Wu, L., Zhou, J., Zhou, A., Lei, Y., Tang, L., Hu, S., Wang, S., Xu, X., Chen, Q., Tu, D., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2390176 · Cited by 78 · see citing works

Promising traditional Chinese medicine for the treatment of cholestatic liver disease process (cholestasis, hepatitis, liver fibrosis, liver cirrhosis)

Wei, C., Qiu, J. Y., Wu, Y., Chen, K., Yu, Z., Huang, Z., Yang, K., Hu, H., & Liu, F. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115550 · Cited by 73 · see citing works

Pilot Multi-Omic Analysis of Human Bile from Benign and Malignant Biliary Strictures: A Machine-Learning Approach

Urmán, J., Herranz, J. M., Uriarte, I., Rullán, M., Oyón, D., González, B., Fernández-Urién, I., Carrascosa, J., Bolado, F., Zabalza, L., et al. (2020) · Cancers · doi:10.3390/cancers12061644 · Cited by 70 · see citing works

Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling

Meadows, V., Kennedy, L., Ekser, B., Kyritsi, K., Kundu, D., Zhou, T.-H., Chen, L.-X., Pham, L., Wu, N., Demieville, J., et al. (2021) · Hepatology · doi:10.1002/hep.32028 · Cited by 55 · see citing works

Gut Microbiota in Liver Disease: What Do We Know and What Do We Not Know?

Jiang, L., & Schnabl, B. (2020) · Physiology · doi:10.1152/physiol.00005.2020 · Cited by 64 · see citing works

Cholestasis: exploring the triangular relationship of gut microbiota-bile acid-cholestasis and the potential probiotic strategies

Yu, L., Liu, Y., Wang, S., Zhang, Q., Zhao, J., Zhang, H., Narbad, A., Tian, F., Zhai, Q., & Chen, W. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2181930 · Cited by 68 · see citing works

Osteopontin characterizes bile duct–associated macrophages and correlates with liver fibrosis severity in primary sclerosing cholangitis

De Muynck, K., Heyerick, L., De Ponti, F. F., Vanderborght, B., Meese, T., Van Campenhout, S., Baudonck, L., Gijbels, E., Rodrigues, P. M., Banales, J. M., et al. (2024) · Hepatology · doi:10.1097/hep.0000000000000557 · Cited by 64 · see citing works

Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice

Cabrera-Rubio, R., Patterson, A. M., Cotter, P. D., & Beraza, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-48784-z · Cited by 61 · see citing works

Oleanolic acid alleviates ANIT-induced cholestatic liver injury by activating Fxr and Nrf2 pathways to ameliorate disordered bile acids homeostasis

Liu, J., Liu, J., Meng, C., Huang, C., Liu, F., & Xia, C. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154173 · Cited by 50 · see citing works

The gut microbiota-bile acid axis in cholestatic liver disease

Sun, D.-Y., Xie, C., Zhao, Y., Liao, J.-M., Li, S.-S., Zhang, Y.-N., Wang, D.-D., Hua, K., Gu, Y.-C., Du, J.-B., et al. (2024) · Molecular Medicine · doi:10.1186/s10020-024-00830-x · Cited by 53 · see citing works

Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis

Lapidot, Y., Amir, A., Ben-Simon, S., Veitsman, E., Cohen‐Ezra, O., Davidov, Y., Weiss, P., Bradichevski, T., Segev, S., Koren, O., et al. (2020) · Hepatology International · doi:10.1007/s12072-020-10089-z · Cited by 42 · see citing works

A Review of Metabolomic Profiling in Rheumatoid Arthritis: Bringing New Insights in Disease Pathogenesis, Treatment and Comorbidities

Bartikoski, B. J., de Oliveira, M. S., Santo, R. C. D. E., dos Santos, L. P., dos Santos, N. G., & Xavier, R. M. (2022) · Metabolites · doi:10.3390/metabo12050394 · Cited by 37 · see citing works

The Gut Microbiota-Derived Immune Response in Chronic Liver Disease

Won, S., Park, E., Jeong, J., Ganesan, R., Gupta, H., Gebru, Y. A., Sharma, S., Kim, D. J., & Suk, K. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158309 · Cited by 31 · see citing works

Mechanism of Paeoniflorin on ANIT-Induced Cholestatic Liver Injury Using Integrated Metabolomics and Network Pharmacology

Chen, L., Zhao, X., Wei, S., Ma, X., Liu, H., Li, J., Jing, M., Wang, M., & Zhao, Y. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.737630 · Cited by 29 · see citing works

Mechanism-based target therapy in primary biliary cholangitis: opportunities before liver cirrhosis?

Yang, Y., He, X.-S., Rojas, M., Leung, P. S. C., & Gao, L. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1184252 · Cited by 29 · see citing works

The Microbiome in Autoimmune Liver Diseases: Metagenomic and Metabolomic Changes

Zheng, Y., Ran, Y., Zhang, H., Wang, B., & Zhou, L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.715852 · Cited by 28 · see citing works

Hepatic Autophagy Deficiency Remodels Gut Microbiota for Adaptive Protection via FGF15-FGFR4 Signaling

Yan, S., Khambu, B., Chen, X., Dong, Z., Guo, G. L., & Yin, X. (2020) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2020.10.011 · Cited by 26 · see citing works

A prospective pilot study of a gluten‐free diet for primary sclerosing cholangitis and associated colitis

Liwinski, T., Hübener, S., Henze, L., Hübener, P., Heinemann, M., Tetzlaff, M., Hiller, M. I., Jagemann, B., Surabattula, R., Leeming, D. J., et al. (2022) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.17256 · Cited by 26 · see citing works

Targeting Gut Microbiota for the Treatment of Primary Biliary Cholangitis: From Bench to Bedside

Zhang, L., Yang, L., & Chu, H. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00408 · Cited by 24 · see citing works

Role of intestinal flora in primary sclerosing cholangitis and its potential therapeutic value

Li, Z.-J., Gou, H.-Z., Zhang, Y., Song, X., & Zhang, L. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i44.6213 · Cited by 23 · see citing works

Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice

Hasan, M. N., Chen, J., Matye, D. J., Wang, H., Luo, W., Gu, L., Clayton, Y. D., Du, Y., & Li, T. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100340 · Cited by 18 · see citing works

Phosphatidylcholine in bile‐derived small extracellular vesicles as a novel biomarker of cholangiocarcinoma

Muraki, R., Morita, Y., Ida, S., Kitajima, R., Furuhashi, S., Takeda, M., Kikuchi, H., Hiramatsu, Y., Takanashi, Y., Hamaya, Y., et al. (2023) · Cancer Medicine · doi:10.1002/cam4.5973 · Cited by 18 · see citing works

New insights into the interplay between intestinal flora and bile acids in inflammatory bowel disease

Zheng, L. (2022) · World Journal of Clinical Cases · doi:10.12998/wjcc.v10.i30.10823 · Cited by 17 · see citing works

Emodin alleviates cholestatic liver injury by modulating Sirt1/Fxr signaling pathways

Hu, Z., Cheng, X., Cai, J., Huang, C., Hu, J., & Liu, J. (2024) · Scientific Reports · doi:10.1038/s41598-024-67882-1 · Cited by 16 · see citing works

Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy

Li, X., Xie, H., Chao, J., Jia, Y.-H., Zuo, J., An, Y., Bao, Y., Jiang, X. W., & Ying, H. (2023) · BMC Microbiology · doi:10.1186/s12866-023-02983-x · Cited by 16 · see citing works

Unveiling the interplay between NSAID-induced dysbiosis and autoimmune liver disease in children: insights into the hidden gateway to autism spectrum disorders. Evidence from ex vivo, in vivo, and clinical studies

Mohamed, D. I., Nahas, H. H. A., Elshaer, A. M., El-Waseef, D. A. E.-D. A., El-Kharashi, O. A., Mohamed, S. M. Y., Sabry, Y. G., Almaimani, R. A., Almasmoum, H. A., Altamimi, A. S. A., et al. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1268126 · Cited by 16 · see citing works

Gut microbiome in liver pathophysiology and cholestatic liver disease

Yan, S., & Yin, X. (2021) · Liver Research · doi:10.1016/j.livres.2021.08.001 · Cited by 16 · see citing works

The HSP90 inhibitor 17‐DMAG alleviates primary biliary cholangitis via cholangiocyte necroptosis prevention

Chen, L., Fan, H., Chu, H., Du, F., Chen, Y., Hu, L., Li, Z., Wang, W., Hou, X., & Yang, L. (2022) · Journal of Cellular Biochemistry · doi:10.1002/jcb.30321 · Cited by 15 · see citing works

Gut microbiome and bile acid metabolism in liver disease: Mechanisms, clinical implications, and therapeutic opportunities

Zhou, H., Huang, Y., Chen, C., Song, M., & Hylemon, P. B. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100120 · Cited by 15 · see citing works

Alterations in gut microbiota and metabolite profiles in patients with infantile cholestasis

Jin, M., Cui, J., Ning, H.-J., Wang, M., Liu, W., Yao, K., Yuan, J., & Zhong, X. (2023) · BMC Microbiology · doi:10.1186/s12866-023-03115-1 · Cited by 12 · see citing works

Caffeoylquinic acids from Silphium perfoliatum L. show hepatoprotective effects on cholestatic mice by regulating enterohepatic circulation of bile acids

Zhang, G., Jia, W., Liu, L., Wang, L., Xu, J., Tao, J., Xu, M., Yue, M., Luo, H., Hai, P., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118870 · Cited by 10 · see citing works

Bile Acids in Control of the Gut-Liver-Axis

Hild, B., Heinzow, H. S., Schmidt, H., & Maschmeier, M. (2021) · Zeitschrift für Gastroenterologie · doi:10.1055/a-1330-9644 · Cited by 10 · see citing works

Human Blood Bacteriome: Eubiotic and Dysbiotic States in Health and Diseases

Suparan, K., Sriwichaiin, S., Chattipakorn, N., & Chattipakorn, S. C. (2022) · Cells · doi:10.3390/cells11132015 · Cited by 9 · see citing works

Intestinal Microbiome in Dogs with Chronic Hepatobiliary Disease: Can We Talk about the Gut–Liver Axis?

Habermaass, V., Olivero, D., Gori, E., Mariti, C., Longhi, E., & Marchetti, V. (2023) · Animals · doi:10.3390/ani13203174 · Cited by 9 · see citing works

Bidirectional Mendelian randomization links gut microbiota to primary biliary cholangitis

Zhou, Z., Li, W., Wu, Y., Wang, T., Zhang, J., You, L., Li, H., Zheng, C., Gao, Y., & Sun, X. (2024) · Scientific Reports · doi:10.1038/s41598-024-79227-z · Cited by 8 · see citing works

NMR-based metabolomic signature: An important tool for the diagnosis and study of pathogenesis of autoimmune hepatitis

Dimou, A. D., Zachou, K., Kostara, C. E., Azariadis, K., Giannoulis, G., Lyberopoulou, A., Bairaktari, E. T., & Dalekos, G. Ν. (2024) · Hepatology · doi:10.1097/hep.0000000000000767 · Cited by 8 · see citing works

Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression

Moreno‐Gonzalez, M., Hampton, K., Ruiz, P. S. B., Beasy, G., Nagies, F. S. P., Parker, A., Lazenby, J., Bone, C., Alava-Arteaga, A., Patel, M. P., et al. (2024) · JHEP Reports · doi:10.1016/j.jhepr.2024.101159 · Cited by 7 · see citing works

Bibliometric analysis of research on intestinal flora and primary biliary cholangitis published between 2004 and 2024 using VOSviewer and CiteSpace visualization

Li, T., & Jing, W. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1565778 · Cited by 6 · see citing works

The Role of the Gut Microbiome in the Development and Progression of Type 2 Diabetes and Liver Disease

Guraka, A., Sreedharan, S., Arasaradnam, R. P., Tripathi, G., & Kermanizadeh, A. (2024) · Nutrition Reviews · doi:10.1093/nutrit/nuae172 · Cited by 5 · see citing works

Integrating Network Analysis and Metabolomics to Reveal Mechanism of Huaganjian Decoction in Treatment of Cholestatic Hepatic Injury

Dong, Q., Chen, J., Jiang, Y., Zhu, Z., Zheng, Y., Zhang, J., Zhang, Z., Chen, W., Sun, S., Pang, L., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.773957 · Cited by 5 · see citing works

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Kasztelan‐Szczerbińska, B., Rycyk, A., Szczerbińska, A., & Cichoż‐Lach, H. (2023) · Nutrients · doi:10.3390/nu15030760 · Cited by 6 · see citing works

Research on gut microbiota characteristics of PBC patients at different ALBI grades based on machine learning

Shi, H., Wang, Q., Xu, B., Liu, Y., Zhao, J., Xue, Y., Huang, C., & Jin, R. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1495170 · Cited by 4 · see citing works

Melatonin alleviates cholestatic liver injury through modulating gut microbiota and activating the NRF2/HO-1 antioxidant pathway

Dong, S., Liu, J., Xuan, C., Zhou, S., Han, Z., Zhu, C., Chen, N., Liu, R., Wang, W., Chu, H., et al. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103131 · Cited by 3 · see citing works

Biliary Microbiota in Health and Disease: Clinical Implications in Lithiasis, Infection, and Antimicrobial Resistance

Marinaccio, C., Giovanetti, M., Neri, B., Biasutto, D., D’Amico, A., Altomare, A., Branda, F., Restaneo, L., Ciccozzi, M., Cicala, M., et al. (2026) · Antibiotics · doi:10.3390/antibiotics15050445 · Cited by 3 · see citing works

Lactobacillus plantarum ameliorates intrahepatic cholestasis by modulating the gut microbiota and tryptophan metabolism

Dong, S., Guo, L., Xuan, C., Zhu, C., Han, Z., Chen, N., Wang, X., Shen, M., Wei, X., Yang, H., et al. (2026) · Food Research International · doi:10.1016/j.foodres.2026.118719 · Cited by 2 · see citing works

Bile Duct Diseases

Zen, Y., Hübscher, S. G., & Nakanuma, Y. (2023) · Elsevier eBooks · doi:10.1016/b978-0-7020-8228-3.00009-0 · Cited by 2 · see citing works

Gut microbiota in chronic liver diseases in children

Васильевна, В. Г., Nikitin, A. V., Андреевна, С. Т., Потапов, А. С., Валерьевна, Д. В., & Danilov, L. G. (2023) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2023-68-2-69-73 · Cited by 2 · see citing works

INTESTINAL MICROBIOME AND BILE ACIDS METABOLISMIN PATIENTS WITH PRIMARY BILIARY CHOLANGITISUSING MARE’S MILK

Zhumabayeva, M. S., Dossatayeva, G. S., Shaimardanova, G., Kozina, L., & Алексеевич, Т. В. (2019) · Ġylym men densaulyķ saķtau. · doi:10.34689/sh.2019.5.53876 · Cited by 1 · see citing works

Integration bile acid metabolomics and gut microbiome to study the anti-liver fibrosis effects of total alkaloids of Corydalis saxicola Bunting

Wang, Q., Zhang, M., Meng, M., Luo, Z., Pan, Z., Deng, L., Qin, J., Guo, B., Zhu, D., Zhang, Y., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01158-2 · Cited by 1 · see citing works

Natural Killer T cells promote cholestatic liver disease independent of antigen presentation by cholangiocytes

Valestrand, L., Nordhus, K. S., Claudel, T., Øgaard, J., Frank, A., Amundsen-Isaksen, E., Fuchs, C., Berntsen, N. L., Chung, B., Jiang, X.-J., et al. (2026) · Hepatology Communications · doi:10.1097/hc9.0000000000000862 · Cited by 1 · see citing works

Knowledge mapping of cholestatic liver disease and TGR5 research: A bibliometric study of trends and frontiers

Tang, Y., Qi, F., Yu, Y., Fu, Y., & Zhu, P. (2026) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2026.109158 · Cited by 1 · see citing works

Bacteria as key players in primary sclerosing cholangitis?

Fickert, P. (2022) · Gut · doi:10.1136/gutjnl-2022-327876 · Cited by 1 · see citing works

Walnut kernel against liver damage induced by salt processed Psoraleae Fructus through regulating bile acid metabolism in ovariectomized rats

Zhu, X., Hua, Z., Hu, X., Xin, Y., Mei, C., Chen, F., Ding, H., Wu, Y. H., & Li, W. (2024) · Journal of Functional Foods · doi:10.1016/j.jff.2024.106412 · Cited by 1 · see citing works

The Microbiota-Gut-Liver Axis: Implications for the Pathophysiology of Liver Disease

Quigley, E. M. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-51709-0_8

Comparative assessment of intestinal microbiota in autoimmune and non-autoimmune liver diseases in children

Nikitin, A. V., Васильевна, В. Г., Потапов, А. С., Валерьевна, Д. В., & Danilov, L. G. (2024) · Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics) · doi:10.21508/1027-4065-2024-69-1-58-65

Gut microbiota in autoimmune and non-autoimmune liver diseases in children

Васильевна, В. Г., Nikitin, A. V., Андреевна, С. Т., Потапов, А. С., Валерьевна, Д. В., Danilov, L. G., & Спартаковна, К. В. (2024) · Экспериментальная и клиническая гастроэнтерология · doi:10.31146/1682-8658-ecg-215-7-25-33

The adhesion molecules β7 integrin and L-selectin contribute to cholestatic liver disease in male micePreprint

Seeger, A., Babbar, A., Eswaran, S., Adams, M., Muschaweck, M., Treichel, N. S., Clavel, T., Yin, G., Guillot, A., Scheuer, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.24.678237

Fatigue in Cholestatic Liver Disease: A Review of Mechanisms and Non-Pharmacological Management

Isley, S., Johnson, E., Swain, M. G., & Tandon, P. (2025) · Current Hepatology Reports · doi:10.1007/s11901-025-00706-6

Additional file 1 of Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy

Li, X., Xie, H., Chao, J.-J., Jia, Y., Zuo, J., An, Y.-P., Bao, Y.-R., Jiang, X., & Ying, H. (2023) · Figshare · doi:10.6084/m9.figshare.24234200

Additional file 2 of Profiles and integration of the gut microbiome and fecal metabolites in severe intrahepatic cholestasis of pregnancy

Li, X., Xie, H., Chao, J.-J., Jia, Y., Zuo, J., An, Y.-P., Bao, Y.-R., Jiang, X., & Ying, H. (2024) · Figshare · doi:10.6084/m9.figshare.24234340

Additional file 2 of Alterations in gut microbiota and metabolite profiles in patients with infantile cholestasis

Jin, M., Cui, J., 宁慧娟, Wang, M., Liu, W., Yao, K., Yuan, J., & Zhong, X. (2024) · Figshare · doi:10.6084/m9.figshare.26642311

Additional file 1 of Alterations in gut microbiota and metabolite profiles in patients with infantile cholestasis

Jin, M., Cui, J., 宁慧娟, Wang, M., Liu, W., Yao, K., Yuan, J., & Zhong, X. (2024) · Figshare · doi:10.6084/m9.figshare.26642308

Research trends on autoimmune liver diseases and gut microbiota (1989–2025): a bibliometric and visualization analysis based on the web of science core collection database

Wan, Y., Zheng, M., Fu, W., Zhu, H., Li, Y., Lin, H., Chen, J., Li, J., Mo, Q., Tai, W., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1785064

Microbiotic disorders in the oral cavity in patients with primary biliary cholangitis

Khokhlova, A. R., Robakidze, N. S., Raikhelson, K. L., Klur, M. V., & Davtyan, N. R. (2026) · Russian Family Doctor · doi:10.17816/rfd702048

Nadir Hastalıklarda Mikrobiyota: Moleküler Mekanizmalar ve Mikrobiyom Tabanlı Tedavi Potansiyelleri

GÖRGÜN, B. (2026) · Özgür Yayınları eBooks · doi:10.58830/ozgur.pub1358.c5472

Polysaccharides from the root tubers of Curcuma wenyujin ameliorate cholestatic liver injury associated with remodeling gut microbiota and restoring bile acid homeostasis

Zou, J., Kan, Y., Song, W., Song, S., Huang, D., Liu, J., & Guo, F. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1847544

Compositional and functional differences of gut microbiome and metabolome inform pathogenesis of cholestatic liver disease

Nikolaidis, M., Hu, C., Juran, B. D., McCauley, B. M., Schlicht, E. M., Bianchi, J. K., Ali, A. H., Tragaki, V., Atkinson, E. J., Johnson, S., et al. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2655793 · Cited by 3 · see citing works

The microbiota and the gut–liver axis in primary sclerosing cholangitis

Hov, J. R., & Karlsen, T. H. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00690-y · Cited by 121 · see citing works

Selected Aspects of the Intricate Background of Immune-Related Cholangiopathies—A Critical Overview

Kasztelan‐Szczerbińska, B., Rycyk, A., Szczerbińska, A., & Cichoż‐Lach, H. (2023) · Nutrients · doi:10.3390/nu15030760 · Cited by 6 · see citing works

Targeting the Gut Microbiome as a Treatment for Primary Sclerosing Cholangitis: A Conceptional Framework

Shah, A., Macdonald, G. A., Morrison, M., & Holtmann, G. (2020) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000604 · Cited by 77 · see citing works

Preface

Cappell, M. S. (2008) · Medical Clinics of North America · doi:10.1016/j.mcna.2008.01.008 · Cited by 1 · see citing works