Cited by 510Gut microbiota and healthGastrointestinal motility and disordersInflammatory Bowel Disease

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression

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Abstract

We read with interest the recent work by Uhde et al ,1 which demonstrated that physically asymptomatic non-coeliac gluten/wheat sensitivity involves compromised intestinal epithelium barrier dysfunction in conjunction with systemic immune activation events. We also read with interest the recent work by Marchesi et al ,2 which comprehensively reviewed the role of microbiota in physical disorders of the gut and extra-gut organs. But common to these Gut papers was the lack of accounting for anxiety and depression, comorbidities often experienced in gastroenterology clinics. Patients who are otherwise physically asymptomatic often do not explicitly divulge these mental disorders, or the disorders are unintentionally overlooked, yet they report ‘diminished quality of life’. In response to this gap, we explored roles of dysbiosis and gut barrier integrity in individuals physically asymptomatic for gastrointestinal distress, yet nonetheless experiencing mental distress. We hypothesised that anxiety and depressive disorders are linked to human gut dysbiosis with microbiota that secrete lipopolysaccharide (LPS) endotoxin into plasma, which in conjunction with compromised gut barrier integrity has systemic manifestations including the brain. We further hypothesised that this correlates with altered intestinal epithelium paracellular integrity molecules discharged …

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Crossref · 10.1136/gutjnl-2017-314759

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Metadata

Authors
Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K.
Affiliations
University of Florida Health (US)
Corresponding author
Stevens, Bruce R
Venue
Gut
Publisher
BMJ
Published
2017-08-16
Volume
67
Issue
8
Pages
1555.2-1557
ISSN
  • 0017-5749 (ISSN-L)
  • 1468-3288
OpenAlex
W2745400272
Cited by
508
References
7
Citations by year
2026: 37 · 2025: 66 · 2024: 70 · 2023: 72 · 2022: 65 · 2021: 70 · 2020: 66 · 2019: 37 · 2018: 19 · 2017: 4
FWCI
14.00
Type
journal article
Language
en
Open access
Locations
  • Gut (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • HighWire Press Open Archive (submittedVersion)
Funders
  • PCORI-OneFlorida Clinical Research Consortium
  • National Institutes of Health
  • Gatorade Trust through funds distributed by the University of Florida, Department of Medicine
  • University of Florida Department of Physiology and Functional Genomics
  • University of Florida Clinical and Translational Science Institute grant from the National Center For Advancing Translational Sciences of the National Institutes of Health
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
Keywords
intestinal permeability, zonulin, FABP2, lipopolysaccharide, gut dysbiosis, gut microbiota, anxiety, depression, non-celiac gluten sensitivity, wheat sensitivity, plasma biomarkers, endotoxin
MeSH terms
Gastrointestinal Microbiome, Anxiety, Cholera Toxin, Depression, Haptoglobins, Humans, Intestines, Permeability, Protein Precursors, Biomarkers, Fatty Acid-Binding Proteins

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