The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression
Open accessAbstract
We read with interest the recent work by Uhde et al ,1 which demonstrated that physically asymptomatic non-coeliac gluten/wheat sensitivity involves compromised intestinal epithelium barrier dysfunction in conjunction with systemic immune activation events. We also read with interest the recent work by Marchesi et al ,2 which comprehensively reviewed the role of microbiota in physical disorders of the gut and extra-gut organs. But common to these Gut papers was the lack of accounting for anxiety and depression, comorbidities often experienced in gastroenterology clinics. Patients who are otherwise physically asymptomatic often do not explicitly divulge these mental disorders, or the disorders are unintentionally overlooked, yet they report ‘diminished quality of life’. In response to this gap, we explored roles of dysbiosis and gut barrier integrity in individuals physically asymptomatic for gastrointestinal distress, yet nonetheless experiencing mental distress. We hypothesised that anxiety and depressive disorders are linked to human gut dysbiosis with microbiota that secrete lipopolysaccharide (LPS) endotoxin into plasma, which in conjunction with compromised gut barrier integrity has systemic manifestations including the brain. We further hypothesised that this correlates with altered intestinal epithelium paracellular integrity molecules discharged …
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This may contribute to the MDD-associated elevations in circulating bacteria-derived compounds (such as lipopolysaccharide (LPS)108), which is recognized by toll-like receptor 4 (TLR4) on peripheral blood mononuclear cells (PBMCs) that trigger pro-inflammatory cytokine production109.”
From Central regulation of stress-evoked peripheral immune responses (2023) · cites this paper as [108]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“plasma biomarkers of increased gut permeability, including LPS and zonulin, have been found in greater abundance in people with depressive disorders compared to healthy controls238.”
From Comorbidity between major depressive disorder and physical diseases: a comprehensive review of epidemiology, mechanisms and management (2023) · cites this paper as [238]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The gut microbiota and host health: a new clinical frontier
Marchesi, J. R., Adams, D. H., Fava, F., Hermes, G. D. A., Hirschfield, G. M., Hold, G., Quraishi, M. N., Kinross, J., Smidt, H., Tuohy, K. M., et al. (2016) · Gut · doi:10.1136/gutjnl-2015-309990 · Cited by 2,302
The microbiome and host behavior
Vuong, H. E., Yano, J. M., Fung, T. C., & Hsiao, E. Y. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031347 · Cited by 537
Sturgeon, C., & Fasano, A. (2016) · Tissue Barriers · doi:10.1080/21688370.2016.1251384 · Cited by 497
Dose-dependent effects of endotoxin on neurobehavioral functions in humans
Grigoleit, J.-S., Kullmann, J. S., Wolf, O. T., Hammes, F., Wegner, A., Jablonowski, S., Engler, H., Gizewski, E., Oberbeck, R., & Schedlowski, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028330 · Cited by 241
Uhde, M., Ajamian, M., Caio, G., GIORGIO, R. D., Indart, A. C., Green, P. H., Verna, E. C., Volta, U., & Alaedini, A. (2016) · Gut · doi:10.1136/gutjnl-2016-311964 · Cited by 232
Guerrant, R. L., Leite, Á. M., Pinkerton, R., de Medeiros, P. H. Q. S., Cavalcante, P. A., DeBoer, M. D., Kosek, M. N., Duggan, C., Gewirtz, A. T., Kagan, J. C., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158772 · Cited by 216
Lasselin, J., Elsenbruch, S., Lekander, M., Axelsson, J., Karshikoff, B., Grigoleit, J., Engler, H., Schedlowski, M., & Benson, S. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.01.003 · Cited by 106
Cited by
Sorted by citations
Leaky gut: mechanisms, measurement and clinical implications in humans
Camilleri, M. (2019) · Gut · doi:10.1136/gutjnl-2019-318427 · Cited by 1,081
Perturbations in Gut Microbiota Composition in Psychiatric Disorders
Nikolova, V. L., Smith, M. R. B., Hall, L. J., Cleare, A. J., Stone, J. M., & Young, A. H. (2021) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2021.2573 · Cited by 777
Gut microbiome and aging: physiological and mechanistic insights
Nagpal, R., Mainali, R., Ahmadi, S., Wang, S., Singh, R., Kavanagh, K., Kitzman, D. W., Kushugulova, A., Marotta, F., & Yadav, H. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170030 · Cited by 670
Kim, S., Goel, R., Kumar, A., Qi, Y., Lobaton, G. O., Hosaka, K., Mohammed, M., Handberg, E. M., Richards, E. M., Pepine, C. J., et al. (2018) · Clinical Science · doi:10.1042/cs20180087 · Cited by 559
Self-citationMailing, L. J., Allen, J. M., Buford, T. W., Fields, C. J., & Woods, J. A. (2019) · Exercise and Sport Sciences Reviews · doi:10.1249/jes.0000000000000183 · Cited by 521
Tang, J., Xu, L., Zeng, Y., & Gong, F. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107272 · Cited by 517
Fasano, A. (2020) · F1000Research · doi:10.12688/f1000research.20510.1 · Cited by 496
Biological, Psychological, and Social Determinants of Depression: A Review of Recent Literature
Remes, O., Mendes, J. F., & Templeton, P. (2021) · Brain Sciences · doi:10.3390/brainsci11121633 · Cited by 482
Altered gut microbiota profile in patients with generalized anxiety disorder
Jiang, H., Zhang, X., Yu, Z., Zhang, Z., Deng, M., Zhao, J., & Ruan, B. (2018) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2018.07.007 · Cited by 430
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361
RetractedBao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
The gut microbiome’s role in the development, maintenance, and outcomes of sepsis
Adelman, M. W., Woodworth, M. H., Langelier, C., Busch, L. M., Kempker, J. A., Kraft, C. S., & Martin, G. S. (2020) · Critical Care · doi:10.1186/s13054-020-02989-1 · Cited by 342
The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
Doifode, T., Giridharan, V. V., Generoso, J. S., Bhatti, G., Collodel, A., Schulz, P. E., Forlenza, O. V., & Barichello, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2020.105314 · Cited by 347
Tulkens, J., Vergauwen, G., Deun, J. V., Geeurickx, E., Dhondt, B., Lippens, L., Scheerder, M. D., Miinalainen, I., Rappu, P., Geest, B. G. D., et al. (2018) · Gut · doi:10.1136/gutjnl-2018-317726 · Cited by 354
Berk, M., Köhler‐Forsberg, O., Turner, M., Penninx, B. W. J. H., Wrobel, A., Firth, J., Loughman, A., Reavley, N. J., McGrath, J. J., Momen, N. C., et al. (2023) · World Psychiatry · doi:10.1002/wps.21110 · Cited by 336
Faecal short chain fatty acids profile is changed in Polish depressive women
Skonieczna-Żydecka, K., Grochans, E., Maciejewska, D., Szkup, M., Schneider-Matyka, D., Jurczak, A., Łoniewski, I., Kaczmarczyk, M., Marlicz, W., Czerwińska-Rogowska, M., et al. (2018) · Nutrients · doi:10.3390/nu10121939 · Cited by 284
Sun, H., Chen, N., Yang, X., Xia, Y., & Wu, D. (2021) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2021.112340 · Cited by 285
D’Amato, A., Di Cesare Mannelli, L., Lucarini, E., Man, A. L., Le Gall, G., Branca, J. J. V., Ghelardini, C., Amedei, A., Bertelli, E., Regoli, M., et al. (2020) · Microbiome · doi:10.1186/s40168-020-00914-w · Cited by 269
Sang, T., Guo, C., Guo, D., Wu, J., Wang, Y., Wang, Y., Chen, J., Chen, C., Wu, K., Na, K., et al. (2021) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2020.117594 · Cited by 268
Immunoregulatory role of the gut microbiota in inflammatory depression
Liu, P., Liu, Z., Wang, J., Wang, J., Gao, M., Zhang, Y., Yang, C., Zhang, A., Li, G., Li, X., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47273-w · Cited by 268
Zhou, M., Fan, Y., Xu, L., Yu, Z., Wang, S., Xu, H., Zhang, J., Zhang, L., Liu, W., Wu, L., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01589-9 · Cited by 262
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
Campbell, C., Kandalgaonkar, M. R., Golonka, R. M., Yeoh, B. S., Vijay–Kumar, M., & Saha, P. (2023) · Biomedicines · doi:10.3390/biomedicines11020294 · Cited by 270
Prevotella copri increases fat accumulation in pigs fed with formula diets
Chen, C., Fang, S., Hong Kui, W. E. I., He, M., Fu, H., Xiong, X., Zhou, Y., Wu, J., Gao, J., Yang, H., et al. (2021) · Microbiome · doi:10.1186/s40168-021-01110-0 · Cited by 250
Salvia miltiorrhiza and ischemic diseases.
Ji, X., Tan, B. K., & Zhu, Y. Z. (2000) · PubMed · Cited by 242
The intestinal barrier in disorders of the central nervous system
Pellegrini, C., Fornai, M., D'Antongiovanni, V., Antonioli, L., Bernardini, N., & Derkinderen, P. (2023) · The Lancet Gastroenterology & Hepatology · doi:10.1016/s2468-1253(22)00241-2 · Cited by 239
Microbiota alterations in proline metabolism impact depression
Mayneris‐Perxachs, J., Castells‐Nobau, A., Arnoriaga‐Rodríguez, M., Martín, M., de la Vega-Correa, L., Zapata, C., Burokas, A., Blasco, G., Coll, C., Escrichs, A., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.04.001 · Cited by 232
Chen, Y.-H., Bai, J., Wu, D., Yu, S.-F., Qiang, X.-L., Bai, H., Wang, H., & Peng, Z. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.08.014 · Cited by 231
Qiao, J., Chen, R., Wang, M., Bai, R., Cui, X., Liu, Y., Wu, C., & Chen, C. (2021) · Nanoscale · doi:10.1039/d1nr00038a · Cited by 224
Sasso, J. M., Ammar, R. M., Tenchov, R., Lemmel, S. A., Kelber, O., Grieswelle, M., & Zhou, Q. A. (2023) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00127 · Cited by 229
Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential
Yong, S. J., Tong, T., Chew, J., & Lim, W. L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01361 · Cited by 222
Central regulation of stress-evoked peripheral immune responses
Chan, K. L., Poller, W. C., Swirski, F. K., & Russo, S. J. (2023) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00729-2 · Cited by 207
Protective Effects of Natural Polysaccharides on Intestinal Barrier Injury: A Review
Huo, J., Wu, Z., Sun, W., Wang, Z., Wu, J., Huang, M., Wang, B., & Sun, B. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.1c05966 · Cited by 197
Intestinal Barrier Dysfunction in Irritable Bowel Syndrome: A Systematic Review
Hanning, N., Edwinson, A. L., Ceuleers, H., Peters, S. A., De Man, J. G., Hassett, L. C., De Winter, B. Y., & Grover, M. (2021) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756284821993586 · Cited by 197
Leaky gut biomarkers in depression and suicidal behavior
Ohlsson, L., Gustafsson, A., Lavant, E. H., Suneson, K., Brundin, L., Westrin, Å., Ljunggren, L., & Lindqvist, D. (2018) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.12978 · Cited by 186
Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
Opazo, M. C., Ortega-Rocha, E. M., Coronado-Arrázola, I., Bonifaz, L. C., Boudin, H., Neunlist, M., Bueno, S. M., Kalergis, A. M., & Riedel, C. A. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00432 · Cited by 179
Gut Microbial Signatures Can Discriminate Unipolar from Bipolar Depression
Zheng, P., Yang, J., Li, Y., Wu, J., Liang, W., Yin, B., Tan, X., Huang, Y., Chai, T., Zhang, H., et al. (2020) · Advanced Science · doi:10.1002/advs.201902862 · Cited by 177
The microbiome and HLA-B27-associated acute anterior uveitis
Rosenbaum, J. T., & Asquith, M. J. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0097-2 · Cited by 169
Feng, D., Zhang, H., Jiang, X., Zou, J., Li, Q., Mai, H., Su, D., Ling, W., & Feng, X. (2020) · Environmental Pollution · doi:10.1016/j.envpol.2020.114880 · Cited by 165
Intestinal epithelial barrier functions in ageing
Branca, J. J. V., Gulisano, M., & Nicoletti, C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100938 · Cited by 165
Gut-Muscle Axis Exists and May Affect Skeletal Muscle Adaptation to Training
Przewłócka, K., Folwarski, M., Kaźmierczak-Siedlecka, K., Skonieczna‐Żydecka, K., & Kaczor, J. J. (2020) · Nutrients · doi:10.3390/nu12051451 · Cited by 166
PROVIT: Supplementary Probiotic Treatment and Vitamin B7 in Depression—A Randomized Controlled Trial
Reininghaus, E. Z., Platzer, M., Kohlhammer-Dohr, A., Hamm, C., Mörkl, S., Bengesser, S., Fellendorf, F. T., Lahousen-Luxenberger, T., Leitner-Afschar, B., Schöggl, H., et al. (2020) · Nutrients · doi:10.3390/nu12113422 · Cited by 172
Hao, W., Ma, Q., Wang, L., Yuan, N., Gan, H. T., He, L., Li, X., Huang, J., & Chen, J. (2024) · Microbiome · doi:10.1186/s40168-024-01756-6 · Cited by 163
Lai, W., Deng, W.-F., Xu, S., Zhao, J., Xu, D., Liu, Y., Guo, Y., Wang, M., He, F.-S., Ye, S.-W., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719003027 · Cited by 143
Xia, W.-J., Xu, M., Yu, X., Du, M., Li, X., Yang, T., Lu, L., Li, Y., Kang, K. B., Su, Q., et al. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1854642 · Cited by 146
Microalgae‐Based Hydrogel for Inflammatory Bowel Disease and Its Associated Anxiety and Depression
Zhong, D., Jin, K., Wang, R., Chen, B., Zhang, J., Ren, C., Chen, X. S., Lu, J., & Zhou, M. (2024) · Advanced Materials · doi:10.1002/adma.202312275 · Cited by 148
Dickerson, F., Adamos, M. B., Katsafanas, E., Khushalani, S., Origoni, A. E., Savage, C. L. G., Schweinfurth, L. A. B., Stallings, C. R., Sweeney, K., Goga, J. K., et al. (2018) · Bipolar Disorders · doi:10.1111/bdi.12652 · Cited by 138
The Microbiota-Inflammasome Hypothesis of Major Depression
Inserra, A., Rogers, G. B., Licinio, J., & Wong, M. (2018) · BioEssays · doi:10.1002/bies.201800027 · Cited by 134
Sun, L., Ma, L., Zhang, H., Cao, Y., Wang, C., Hou, N., Huang, N., von Deneen, K. M., Zhao, C., Shi, Y., et al. (2019) · Theranostics · doi:10.7150/thno.31562 · Cited by 139
Role of the gut microbiome in three major psychiatric disorders
Borkent, J., Ioannou, M., Laman, J. D., Haarman, B. C. M., & Sommer, I. E. (2022) · Psychological Medicine · doi:10.1017/s0033291722000897 · Cited by 139
Ortega, M. A., Álvarez-Mon, M. Á., Montero, C. G., Fraile‐Μartinez, O., Monserrat, J., Martinez-Rozas, L., Rodríguez–Jiménez, R., Álvarez‐Mon, M., & Lahera, G. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01964-w · Cited by 137
Inflammation‐driven brain and gut barrier dysfunction in stress and mood disorders
Doney, E., Cadoret, A., Dion‐Albert, L., Lebel, M., & Ménard, C. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15239 · Cited by 134
Spichak, S., Bastiaanssen, T. F. S., Berding, K., Vlckova, K., Clarke, G., Dinan, T. G., & Cryan, J. F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.02.044 · Cited by 127
Liu, Z., Li, L., Ma, S., Jin, Y., Zhang, H., Li, Y., Sair, A. T., Pan, J., Liu, X., Li, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c04290 · Cited by 129
Gut microbes in neurocognitive and mental health disorders
Halverson, T., & Alagiakrishnan, K. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1808239 · Cited by 125
Age-related changes in intestinal immunity and the microbiome
Walrath, T., Dyamenahalli, K. U., Hulsebus, H. J., McCullough, R. L., Idrovo, J., Boe, D. M., McMahan, R. H., & Kovacs, E. J. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0620-405rr · Cited by 129
Safadi, J. M., Quinton, A. M. G., Lennox, B., Burnet, P. W. J., & Minichino, A. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01032-1 · Cited by 125
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension
Zubcevic, J. A., Richards, E. M., Yang, T., Kim, S., Sumners, C., Pepine, C. J., & Raizada, M. K. (2019) · Circulation Research · doi:10.1161/circresaha.119.313965 · Cited by 126
Self-citationRudzki, L., Stone, T. W., Maes, M. H. J., Misiak, B., Samochowiec, J., & Szulc, A. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110240 · Cited by 125
A peripheral signature of Alzheimer’s disease featuring microbiota-gut-brain axis markers
Marizzoni, M., Mirabelli, P., Mombelli, E., Coppola, L., Festari, C., Lopizzo, N., Luongo, D., Mazzelli, M., Naviglio, D., Blouin, J.-L., et al. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01218-5 · Cited by 121
The Microbiota-Gut-Immune-Glia (MGIG) Axis in Major Depression
Rudzki, L., & Maes, M. H. J. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01961-y · Cited by 115
Dietary lipids from body to brain
Custers, Emma, E. M., Kiliaan, & Amanda, J. K. (2021) · Progress in Lipid Research · doi:10.1016/j.plipres.2021.101144 · Cited by 119
Anderson, G., & Maes, M. H. J. (2020) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026620666200131094445 · Cited by 116
Zhang, Q., Cheng, L., Wang, J., Hao, M., & Che, H. (2021) · Nutrients · doi:10.3390/nu13103315 · Cited by 112
Depressive symptoms in inflammatory bowel disease: an extraintestinal manifestation of inflammation?
Moulton, C. D., Pavlidis, P., Norton, C. S., Norton, S., Pariante, C. M., Hayee, B., & Powell, N. (2019) · Clinical & Experimental Immunology · doi:10.1111/cei.13276 · Cited by 107
Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis
Tan, C., Yan, Q., Ma, Y., Fang, J., & Yang, Y. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.1015175 · Cited by 120
Ischemic stroke and intestinal flora: an insight into brain–gut axis
Hu, W., Kong, X., Wang, H., Li, Y., & Luo, Y. (2022) · European journal of medical research · doi:10.1186/s40001-022-00691-2 · Cited by 102
Sauer, A. K., Bockmann, J., Steinestel, K., Boeckers, T. M., & Grabrucker, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092134 · Cited by 99
Yang, T., Aquino, V. P., Lobaton, G. O., Li, H., Colón-Pérez, L. M., Goel, R., Qi, Y., Zubcevic, J. A., Febo, M., Richards, E. M., et al. (2019) · Journal of the American Heart Association · doi:10.1161/jaha.118.010721 · Cited by 95
Self-citationGut permeability, inflammation, and bone density across the menopause transition
Shieh, A., Epeldegui, M., Karlamangla, A. S., & Greendale, G. A. (2019) · JCI Insight · doi:10.1172/jci.insight.134092 · Cited by 105
Chen, Y., Liang, J., Ouyang, F., Chen, X., Lu, T., Jiang, Z., Li, J., Li, Y., & Zeng, J. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00661 · Cited by 94
Tomaz, V. D. S., Filho, A. J. M. C., Cordeiro, R. C., Jucá, P. M., Soares, M. V. R., Barroso, P. N., Cristino, L. M. F., Jiang, W., Teixeira, A. L., de Lucena, D. F., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.03.022 · Cited by 92
Navarro‐Tapia, E., Almeida-Toledano, L., Sebastiani, G., Serra-Delgado, M., García‐Algar, Ó., & Andreu-Férnández, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052351 · Cited by 96
Veres-Székely, A., Szász, C., Pap, D., Szebeni, B., Bokrossy, P., & Vannay, Á. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087548 · Cited by 88
Álvarez-Mon, M. Á., Gomez-Lahoz, A. M., Orozco, A., Lahera, G., Sosa-Reina, M. D., Díaz, D., Aubá, E., Albillos, A., Monserrat, J., & Álvarez‐Mon, M. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00812 · Cited by 86
Serum zonulin and its diagnostic performance in non-coeliac gluten sensitivity
Barbaro, M. R., Cremon, C., Morselli‐Labate, A. M., Sabatino, A. D., Giuffrida, P., Corazza, G. R., Stefano, M. D., Caio, G., Latella, G., Ciacci, C., et al. (2020) · Gut · doi:10.1136/gutjnl-2019-319281 · Cited by 88
Chang, Z., Liu, H.-M., Leu, Y., Hsu, C.-H., & Lee, T.-Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052667 · Cited by 92
Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain Injury
Ma, Y., Liu, T., Fu, J., Fu, S.-L., Hu, C., Sun, B., Fan, X., & Zhu, J. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz105 · Cited by 86
Crosstalk between gut microbiota and host immune system and its response to traumatic injury
Ullah, H., Arbab, S., Tian, Y., Chen, Y., Liu, C., Li, Q., & Li, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1413485 · Cited by 99
Wang, K., Yang, X., Wu, Z.-J., Wang, H., Li, Q., Mei, H., You, R., & Zhang, Y. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00240 · Cited by 85
Gut Microbiota Metabolites Sensed by Host GPR41/43 Protect Against Hypertension
Muralitharan, R. R., Zheng, T., Dinakis, E., Xie, L., Barbaro-Wahl, A., Jama, H. A., Nakai, M. E., Patterson, M., Leung, K. C., McArdle, Z. M., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325770 · Cited by 92
Melatonin Alleviates Neuroinflammation and Metabolic Disorder in DSS-Induced Depression Rats
Lv, W., Liu, C., Yu, L., Zhou, J., Li, Y., Xiong, Y., Guo, A., Chao, L., Qu, Q., Guang-wei, W., et al. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/1241894 · Cited by 85
Sauer, A. K., & Grabrucker, A. M. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01295 · Cited by 87
Chen, Y.-H., Xue, F., Yu, S.-F., Li, X.-S., Liu, L., Jia, Y., Yan, W., Tan, Q.-R., Wang, H., & Peng, Z. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.12.143 · Cited by 83
Malan‐Müller, S., Valles‐Colomer, M., Foxx, C. L., Vieira‐Silva, S., van den Heuvel, L. L., Raes, J., Seedat, S., Lowry, C. A., & Hemmings, S. M. J. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.11.009 · Cited by 84
Plasma Microbiome in COVID-19 Subjects: An Indicator of Gut Barrier Defects and Dysbiosis
Prasad, R., Patton, M. J., Floyd, J. L., Vieira, C. P., Fortmann, S., DuPont, M., Harbour, A., Jeremy, C. S., Wright, J., Lamendella, R., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169141 · Cited by 79
Self-citationAudet, M. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100772 · Cited by 82
Serum zonulin and claudin-5 levels in patients with bipolar disorder
Kılıç, F., Işık, Ü., Demirdaş, A., Doğuç, D. K., & Bozkurt, M. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.117 · Cited by 77
Wu, H., Wang, J., Teng, T., Yin, B., He, Y., Jiang, Y., Liu, X., Yu, Y., Li, X., & Zhou, X. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.11.058 · Cited by 79
Chen, H., Kuo, P., Hsu, C., Chiu, Y.-H., Liu, Y.-W., Lu, M., & Chen, C.-H. (2021) · Nutrients · doi:10.3390/nu13113731 · Cited by 81
Zhou, B., Jin, G., Pang, X., Mo, Q., Bao, J., Liu, T., Wu, J., Xie, R., Liu, X., Liu, J., et al. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106090 · Cited by 85
Zeb, F., Osaili, T. M. I., Obaid, R. S., Naja, F., Radwan, H. M., Ismail, L. C., Hasan, H. A., Hashim, M. S., Alam, I., Sehar, B., et al. (2023) · Nutrients · doi:10.3390/nu15020259 · Cited by 74
Santabárbara, J., Lipnicki, D. M., Olaya, B., Villagrasa, B., Bueno‐Notivol, J., Nuez, L., López‐Antón, R., & Gracia‐García, P. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061791 · Cited by 81
The gut microbiota promotes the pathogenesis of schizophrenia via multiple pathways
Yuan, X., Kang, Y., Zhuo, C., Huang, X., & Song, X. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.02.152 · Cited by 77
Microbiota‐microglia connections in age‐related cognition decline
Zhou, R., Qian, S., Cho, W. C. S., Zhou, J., Jin, C., Zhong, Y., Wang, J., Zhang, X., Xu, Z., Tian, M., et al. (2022) · Aging Cell · doi:10.1111/acel.13599 · Cited by 71
Kouba, B. R., Camargo, A., Gil‐Mohapel, J., & Rodrigues, A. L. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137077 · Cited by 77
Stevens, B. R., Roesch, L. F. W., Dobbler, P. T., Russell, J. T., Pepine, C. J., Holbert, R. C., Raizada, M. K., & Triplett, E. W. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0652-5 · Cited by 69
Self-citationMir, H.-D., Milman, A., Monnoye, M., Douard, V., Philippe, C., Aubert, A., Castanon, N., Vancassel, S., Guérineau, N. C., Naudon, L., et al. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.104750 · Cited by 72
Gut microbiome and thyroid autoimmunity
Virili, C., Stramazzo, I., & Centanni, M. (2021) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2021.101506 · Cited by 69
Pirolli, N. H., Bentley, W. E., & Jay, S. M. (2021) · Advanced Biology · doi:10.1002/adbi.202000540 · Cited by 71
Metabolomic Biomarkers in Anxiety Disorders
Humer, E. C., Pieh, C., & Probst, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134784 · Cited by 77
Metadata
- Authors
- Stevens, B. R., Goel, R., Seungbum, K., Richards, E. M., Holbert, R. C., Pepine, C. J., & Raizada, M. K.
- Affiliations
- University of Florida Health (US)
- Corresponding author
- Stevens, Bruce R
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2017-08-16
- Volume
- 67
- Issue
- 8
- Pages
- 1555.2-1557
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC5851874
- OpenAlex
- W2745400272
- Cited by
- 508
- References
- 7
- Citations by year
- 2026: 37 · 2025: 66 · 2024: 70 · 2023: 72 · 2022: 65 · 2021: 70 · 2020: 66 · 2019: 37 · 2018: 19 · 2017: 4
- FWCI
- 14.00
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Gut (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- PCORI-OneFlorida Clinical Research Consortium
- National Institutes of Health
- Gatorade Trust through funds distributed by the University of Florida, Department of Medicine
- University of Florida Department of Physiology and Functional Genomics
- University of Florida Clinical and Translational Science Institute grant from the National Center For Advancing Translational Sciences of the National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Keywords
- intestinal permeability, zonulin, FABP2, lipopolysaccharide, gut dysbiosis, gut microbiota, anxiety, depression, non-celiac gluten sensitivity, wheat sensitivity, plasma biomarkers, endotoxin
- MeSH terms
- Gastrointestinal Microbiome, Anxiety, Cholera Toxin, Depression, Haptoglobins, Humans, Intestines, Permeability, Protein Precursors, Biomarkers, Fatty Acid-Binding Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
