Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression

Frolkis, Alexandra D; Vallerand, Isabelle A; Shaheen, Abdel-Aziz; Lowerison, Mark W; Swain, Mark G; Barnabe, Cheryl; Patten, Scott B; Kaplan, Gilaad G

doi:10.1136/gutjnl-2018-317182

Depression increases the risk of inflammatory bowel disease, which may be mitigated by the use of antidepressants in the treatment of depression

Objective Depression is associated with IBD, but the effect of antidepressants on IBD has been sparsely studied. We assessed the impact of depression and antidepressant therapies on the development of IBD. Design The Health Improvement Network (THIN) was used to identify a cohort of patients with…