Cytokines in inflammatory bowel disease
Abstract
Cytokines have a crucial role in the pathogenesis of inflammatory bowel diseases (IBDs), such as Crohn's disease and ulcerative colitis, where they control multiple aspects of the inflammatory response. In particular, the imbalance between pro-inflammatory and anti-inflammatory cytokines that occurs in IBD impedes the resolution of inflammation and instead leads to disease perpetuation and tissue destruction. Recent studies suggest the existence of a network of regulatory cytokines that has important implications for disease progression. In this Review, we discuss the role of cytokines produced by innate and adaptive immune cells, as well as their relevance to the future therapy of IBD.
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IL-6 production may enhance mucosal inflammation via T cell activation.
“Moreover, IL-6 production may enhance mucosal inflammation via T cell activation,6,35,36 providing a link between inflammation and tumour growth.”
From PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells (2022) · cites this paper as [6]
IFNa may deplete clonal stem cells via induction of HSCs into cell cycle entry and exhaustion.
“IFNa remains a highly effective therapy for MPN, frequently resulting in the normalization of the patients' blood counts and even molecular response (i.e. reduction in variant allele frequencies), with evidence suggesting that IFNa may deplete clonal stem cells via induction of HSCs into cell cycle entry and exhaustion 12,18 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [18]
IFNa remains a highly effective therapy for MPN, frequently resulting in normalization of patients' blood counts and even molecular response.
“IFNa remains a highly effective therapy for MPN, frequently resulting in the normalization of the patients' blood counts and even molecular response (i.e. reduction in variant allele frequencies), with evidence suggesting that IFNa may deplete clonal stem cells via induction of HSCs into cell cycle entry and exhaustion 12,18 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [18]
MPNs are often driven by a single somatic mutation in CALR, JAK2 or MPL, and thus provide an informative model of an early clonal process within the hematopoietic system.
“MPNs are often driven by a single somatic mutation in CALR , JAK2 or MPL , and thus provide an informative model of an early clonal process within the hematopoietic system 18 .”
From Type 1 interferon perturbates clonal competition by reshaping human blood development (2026) · cites this paper as [18]
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- Authors
- Neurath, M. F.
- Affiliations
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Corresponding author
- Neurath, Markus F.
- ORCID
- Neurath, Markus F.
- Venue
- Nature Reviews Immunology
- Published
- 2014-04-22
- Volume
- 14
- Issue
- 5
- Pages
- 329-342
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2024346860
- Cited by
- 2,706
- References
- 10
- Citations by year
- 2026: 212 · 2025: 269 · 2024: 272 · 2023: 273 · 2022: 280 · 2021: 270 · 2020: 250 · 2019: 215 · 2018: 198 · 2017: 173 · 2016: 162 · 2015: 101 · 2014: 25 · 2013: 4 · 2012: 2
- FWCI
- 20.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- cytokines, inflammatory bowel disease, Crohn's disease, ulcerative colitis, inflammatory cytokines, anti-inflammatory cytokines, regulatory cytokines, cytokine imbalance, innate immune cells, adaptive immune cells, cytokine-targeted therapy, IBD pathogenesis, inflammation resolution
- MeSH terms
- Animals, Humans, Immunity, Innate, Inflammatory Bowel Diseases, Cytokines, Adaptive Immunity
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