Impairment of gut microbial biotin metabolism and host biotin status in severe obesity: effect of biotin and prebiotic supplementation on improved metabolism
Open accessAbstract
Objectives: Gut microbiota is a key component in obesity and type 2 diabetes, yet mechanisms and metabolites central to this interaction remain unclear. We examined the human gut microbiome’s functional composition in healthy metabolic state and the most severe states of obesity and type 2 diabetes within the MetaCardis cohort. We focused on the role of B vitamins and B7/B8 biotin for regulation of host metabolic state, as these vitamins influence both microbial function and host metabolism and inflammation. Design: We performed metagenomic analyses in 1545 subjects from the MetaCardis cohorts and different murine experiments, including germ-free and antibiotic treated animals, faecal microbiota transfer, bariatric surgery and supplementation with biotin and prebiotics in mice. Results: Severe obesity is associated with an absolute deficiency in bacterial biotin producers and transporters, whose abundances correlate with host metabolic and inflammatory phenotypes. We found suboptimal circulating biotin levels in severe obesity and altered expression of biotin-associated genes in human adipose tissue. In mice, the absence or depletion of gut microbiota by antibiotics confirmed the microbial contribution to host biotin levels. Bariatric surgery, which improves metabolism and inflammation, associates with increased bacterial biotin producers and improved host systemic biotin in humans and mice. Finally, supplementing high-fat diet-fed mice with fructo-oligosaccharides and biotin improves not only the microbiome diversity, but also the potential of bacterial production of biotin and B vitamins, while limiting weight gain and glycaemic deterioration. Conclusion: Strategies combining biotin and prebiotic supplementation could help prevent the deterioration of metabolic states in severe obesity. Trial registration number: NCT02059538 .
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Multi-faceted studies using different methods and research platforms can enable more mechanistic understandings of associations between microbes and host phenotypes.
“An additional advantage of multi-faceted studies using different methods and research platforms is that they can enable more mechanistic understandings of associations between microbes and host phenotypes 37-39 .”
From Human microbiome myths and misconceptions (2023) · cites this paper as [39]
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Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849 · see citing works
Health effects of overweight and obesity in 195 countries over 25 years
Collaborators, T. G. 2. O. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1614362 · Cited by 7,918 · see citing works
Enterotypes of the human gut microbiome
MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works
Self-citationRichness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Self-citationSokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
An integrated catalog of reference genes in the human gut microbiome
MetaHIT Consortium, Li, J., Jia, H., Cai, X., Zhong, H., Feng, Q., Sunagawa, S., Arumugam, M., Kultima, J. R., Prifti, E., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2942 · Cited by 2,164 · see citing works
Self-citationDietary intervention impact on gut microbial gene richness
Cotillard, A., Kennedy, S. P., Kong, L. C., Prifti, E., Pons, N., Le Chatelier, E., Almeida, M., Quinquis, B., Levenez, F., Galleron, N., et al. (2013) · Nature · doi:10.1038/nature12480 · Cited by 1,832 · see citing works
Self-citationCani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,770 · see citing works
Gut microbiota-derived metabolites as central regulators in metabolic disorders
Agus, A., Clément, K., & Sokol, H. (2021) · Gut · doi:10.1136/gutjnl-2020-323071 · Cited by 1,347 · see citing works
Self-citationQuantitative microbiome profiling links gut community variation to microbial load
Vandeputte, D., Kathagen, G., D’hoe, K., Vieira-Silva, S., Valles-Colomer, M., Sabino, J., Wang, J., Tito, R. Y., De Commer, L., Darzi, Y., et al. (2017) · Nature · doi:10.1038/nature24460 · Cited by 1,218 · see citing works
Self-citationSystematic genome assessment of B-vitamin biosynthesis suggests co-operation among gut microbes
Magnúsdóttir, S., Ravcheev, D., de Crécy-Lagard, V., & Thiele, I. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00148 · Cited by 876 · see citing works
PICRUSt2: An improved and customizable approach for metagenome inferencePreprint
Douglas, G. M., Maffei, V. J., Zaneveld, J., Yurgel, S. N., Brown, J. R., Taylor, C. M., Huttenhower, C., & Langille, M. G. I. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/672295 · Cited by 812 · see citing works
Metabolism of Dietary and Microbial Vitamin B Family in the Regulation of Host Immunity
Yoshii, K., Hosomi, K., Sawane, K., & Kunisawa, J. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00048 · Cited by 586 · see citing works
Intestinal flora and endogenous vitamin synthesis
Hill, M. J. (1997) · European Journal of Cancer Prevention · doi:10.1097/00008469-199703001-00009 · Cited by 551 · cited 1× · see citing works
“Finally, supplementing high-fat diet-fed mice with fructo-oligosaccharides and biotin improves not only the microbiome diversity, but also the potential of bacterial production of biotin and B vitamins, while limiting weight gain and glycaemic deterioration.”
BackgroundThe Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study
Wu, H., Tremaroli, V., Schmidt, C., Lundqvist, A., Olsson, L. M., Kramer, M. M., Gummesson, A., Perkins, R., Bergström, G. M. L., & Bäckhed, F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.011 · Cited by 528 · see citing works
Self-citationStatin therapy is associated with lower prevalence of gut microbiota dysbiosis
Vieira‐Silva, S., Falony, G., Belda, E., Nielsen, T., Aron‐Wisnewsky, J., Chakaroun, R., Forslund, S. K., Assmann, K. E., Valles‐Colomer, M., Nguyen, T. T. D., et al. (2020) · Nature · doi:10.1038/s41586-020-2269-x · Cited by 492 · see citing works
Self-citationStructure and function of biotin-dependent carboxylases
Tong, L. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1096-0 · Cited by 473 · see citing works
Henegar, C., Tordjman, J., Achard, V., Lacasa, D., Cremer, I., Guerre-Millo, M., Poitou, C., Basdevant, A., Stich, V., Viguerie, N., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-1-r14 · Cited by 471 · see citing works
Self-citationBariatric surgery and long-term nutritional issues
Lupoli, R., Lembo, E., Saldalamacchia, G., Avola, C. K., Angrisani, L., & Capaldo, B. (2017) · World Journal of Diabetes · doi:10.4239/wjd.v8.i11.464 · Cited by 433 · see citing works
Major microbiota dysbiosis in severe obesity: fate after bariatric surgery
Aron-Wisnewsky, J., Prifti, E., Belda, E., Ichou, F., Kayser, B. D., Dao, M. C., Verger, E. O., Hedjazi, L., Bouillot, J.-L., Chevallier, J.-M., et al. (2019) · Gut · doi:10.1136/gutjnl-2018-316103 · Cited by 418 · see citing works
Self-citationIntestinal absorption of water-soluble vitamins in health and disease
Said, H. M. (2011) · Biochemical Journal · doi:10.1042/bj20110326 · Cited by 416 · see citing works
Meta-Analysis Reveals Reproducible Gut Microbiome Alterations in Response to a High-Fat Diet
Bisanz, J. E., Upadhyay, V., Turnbaugh, J. A., Ly, K., & Turnbaugh, P. J. (2019) · Cell Host & Microbe · doi:10.1016/j.chom.2019.06.013 · Cited by 333 · see citing works
Prest, E. I., Hammes, F., Kötzsch, S., van Loosdrecht, M. C. M., & Vrouwenvelder, J. S. (2013) · Water Research · doi:10.1016/j.watres.2013.07.051 · Cited by 308 · see citing works
Troy, S., Soty, M., Ribeiro‐Parenti, L., Laval, L., Migrenne, S., Fioramonti, X., Pillot, B., Fauveau, V., Aubert, R., Viollet, B., et al. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.008 · Cited by 302 · see citing works
Scientific Opinion on Dietary Reference Values for chromium
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3845 · Cited by 266 · see citing works
Besson, H., Brage, S., Jakes, R. W., Ekelund, U., & Wareham, N. J. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28432 · Cited by 263 · see citing works
Micronutrient Requirements and Sharing Capabilities of the Human Gut Microbiome
Rodionov, D. A., Arzamasov, A. A., Khoroshkin, M., Iablokov, S. N., Leyn, S. A., Peterson, S. N., Novichkov, P. S., & Osterman, A. L. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01316 · Cited by 177 · see citing works
Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling
Monteiro-Sepulveda, M., Touch, S., Mendes-Sá, C., André, S., Poitou, C., Allatif, O., Cotillard, A., Fohrer-Ting, H., Hubert, E.-L., Remark, R., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.020 · Cited by 170 · see citing works
Self-citationClosing in on complete pathways of biotin biosynthesis
Lin, S., & Cronan, J. E. (2011) · Molecular BioSystems · doi:10.1039/c1mb05022b · Cited by 158 · see citing works
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery
Debédat, J., Clément, K., & Aron‐Wisnewsky, J. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00351-3 · Cited by 156 · see citing works
Self-citationHebbeln, P., Rodionov, D. A., Alfandega, A., & Eitinger, T. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609905104 · Cited by 149 · see citing works
Roy, T. L., Debédat, J., Marquet, F., Da-Cunha, C., Ichou, F., Guerre-Millo, M., Kapel, N., Aron‐Wisnewsky, J., & Clément, K. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03289 · Cited by 143 · see citing works
Self-citationRomine, M. F., Rodionov, D. A., Maezato, Y., Osterman, A. L., & Nelson, W. C. (2017) · The ISME Journal · doi:10.1038/ismej.2017.2 · Cited by 133 · see citing works
Hayashi, A., Mikami, Y., Miyamoto, K., Kamada, N., Sato, T., Mizuno, S., Naganuma, M., Teratani, T., Aoki, R., Fukuda, S., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.07.057 · Cited by 133 · see citing works
Albarracín, C., Fuqua, B. C., Evans, J. L., & Goldfine, I. D. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.755 · Cited by 128 · see citing works
Serum biotin levels in women complaining of hair loss
Trüeb, R. (2016) · International Journal of Trichology · doi:10.4103/0974-7753.188040 · Cited by 121 · see citing works
Respondek, F., Gérard, P., Bossis, M., Boschat, L., Bruneau, A., Rabot, S., Wagner, A., & Martin, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071026 · Cited by 115 · see citing works
Delmée, E., Cani, P. D., Gual, G., Knauf, C., Burcelin, R., Maton, N., & Delzenne, N. M. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.05.013 · Cited by 111 · see citing works
Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding
Staggs, C. G., Sealey, W. M., McCabe, B. J., Teague, A. M., & Mock, D. M. (2004) · Journal of Food Composition and Analysis · doi:10.1016/j.jfca.2003.09.015 · Cited by 105 · see citing works
Pharmacological effects of biotin
Fernández‐Mejía, C. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.03.018 · Cited by 100 · see citing works
Mock, D. M., Henrich, C. L., Carnell, N. S., & Mock, N. I. (2002) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.5.1061 · Cited by 75 · see citing works
Lazo-de-la-Vega-Monroy, M.-L., Larrieta, E., German, M. S., Báez‐Saldaña, A., & Fernández‐Mejía, C. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.03.020 · Cited by 69 · see citing works
Singer, G. M., & Geohas, J. (2006) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2006.8.636 · Cited by 66 · see citing works
Aguilera‐Méndez, A., & Fernández‐Mejía, C. (2012) · BioFactors · doi:10.1002/biof.1034 · Cited by 48 · see citing works
Verger, E. O., Armstrong, P., Nielsen, T., Chakaroun, R., Aron‐Wisnewsky, J., Gøbel, R. J., Schütz, T., Delaere, F., Gausserès, N., Clément, K., et al. (2016) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2016.10.030 · Cited by 39 · see citing works
Self-citationScientific Opinion on Dietary Reference Values for biotin
EFSA Panel on Dietetic Products, N. A. A. (. (2014) · EFSA Journal · doi:10.2903/j.efsa.2014.3580 · Cited by 36 · see citing works
Orhan, C., Küçük, O., Tuzcu, M., Şahin, N., Komorowski, J. R., & Şahin, K. (2018) · Food Science & Nutrition · doi:10.1002/fsn3.851 · Cited by 28 · see citing works
Biotin-dependent functions in adiposity: a study of monozygotic twin pairs
Järvinen, E., Ismail, K., Muniandy, M., Bogl, L. H., Heinonen, S., Tummers, M., Miettinen, S., Kaprio, J. A., Rissanen, A., Ollikainen, M., et al. (2015) · International Journal of Obesity · doi:10.1038/ijo.2015.237 · Cited by 27 · see citing works
Lakhan, R., & Said, H. M. (2017) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00300.2016 · Cited by 17 · see citing works
Salmonellainfection inhibits intestinal biotin transport: cellular and molecular mechanisms
Ghosal, A., Jellbauer, S., Kapadia, R., Raffatellu, M., & Said, H. M. (2015) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00112.2015 · Cited by 13 · see citing works
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Hul, M. V., & Cani, P. D. (2023) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00794-0 · Cited by 335 · see citing works
Intermediate role of gut microbiota in vitamin B nutrition and its influences on human health
Wan, Z., Zheng, J., Zhu, Z., Sang, L., Zhu, J., Luo, S., Zhao, Y., Wang, R., Zhang, Y., Hao, K., et al. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1031502 · Cited by 201 · see citing works
Dynamics of the normal gut microbiota: A longitudinal one-year population study in Sweden
Olsson, L. M., Boulund, F., Nilsson, S., Khan, M. T., Gummesson, A., Fagerberg, L., Engstrand, L. G., Perkins, R., Uhlén, M., Bergström, G. M. L., et al. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.03.002 · Cited by 189 · see citing works
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Walker, A. W., & Hoyles, L. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01426-7 · Cited by 163 · see citing works
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The role of the gut microbiota in health and cardiovascular diseases
Wang, L., Wang, S., Zhang, Q., He, C., Fu, C., & Wei, Q. (2022) · Molecular Biomedicine · doi:10.1186/s43556-022-00091-2 · Cited by 124 · see citing works
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Chakaroun, R., Olsson, L. M., & Bäckhed, F. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00771-0 · Cited by 122 · see citing works
Self-citationAndrikopoulos, P., Aron‐Wisnewsky, J., Chakaroun, R., Myridakis, A., Forslund, S. K., Nielsen, T., Adriouch, S., Holmes, B., Chilloux, J., Vieira‐Silva, S., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-39824-4 · Cited by 86 · see citing works
Self-citationBalzer, A. H. A., & Whitehurst, C. B. (2023) · Current Issues in Molecular Biology · doi:10.3390/cimb45110549 · Cited by 69 · see citing works
Agius, R., Pace, N. P., & Fava, S. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3725 · Cited by 62 · see citing works
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Karachaliou, C., & Livaniou, E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126578 · Cited by 58 · see citing works
Bermúdez‐Humarán, L. G., Chassaing, B., & Langella, P. (2024) · Microbial Cell Factories · doi:10.1186/s12934-024-02449-3 · Cited by 59 · see citing works
Deng, L., Wojciech, Ł., Png, C. W., Kioh, D. Y. Q., Gu, Y., Aung, T. T., Malleret, B., Chan, E. C. Y., Peng, G., Zhang, Y., et al. (2023) · Theranostics · doi:10.7150/thno.81583 · Cited by 53 · see citing works
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Feng, J., Ma, H., Huang, Y., Li, J., & Li, W. (2022) · Biomedicines · doi:10.3390/biomedicines10123272 · Cited by 50 · see citing works
Deng, L., Wojciech, Ł., Png, C. W., Kioh, D. Y. Q., Ng, G. C., Chan, E. C. Y., Zhang, Y., Gascoigne, N. R. J., & Tan, K. S. W. (2023) · npj Biofilms and Microbiomes · doi:10.1038/s41522-023-00389-1 · Cited by 47 · see citing works
Thouvenot, K., Turpin, T., Taïlé, J., Clément, K., Meilhac, O., & Gonthier, M. (2022) · Biomolecules · doi:10.3390/biom12030378 · Cited by 46 · see citing works
Self-citationNavigating the B vitamins: Dietary diversity, microbial synthesis, and human health
Yang, Y., Ke, Y., Liu, X., Zhang, Z., Zhang, R., Tian, F., Zhi, L., Zhao, G., Lv, B., Hua, S., et al. (2024) · Cell Host & Microbe · doi:10.1016/j.chom.2023.12.004 · Cited by 45 · see citing works
Sun, X., Huang, H., Wang, X., Wei, R.-Q., Niu, H.-Y., Chen, H. Y., Luo, M., Abdugheni, R., Wang, Y., Liu, F.-L., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2347725 · Cited by 41 · see citing works
Byndloss, M. X., Devkota, S., Duca, F. A., Niess, J. H., Nieuwdorp, M., Orho‐Melander, M., Sanz, Y., Tremaroli, V., & Zhao, L. (2024) · Diabetologia · doi:10.1007/s00125-024-06198-1 · Cited by 45 · see citing works
Self-citationDietary fibers boost gut microbiota-produced B vitamin pool and alter host immune landscape
Grant, E. T., Parrish, A., Boudaud, M., Hunewald, O. E., Hirayama, A., Ollert, M. W., Fukuda, S., & Desai, M. S. (2024) · Microbiome · doi:10.1186/s40168-024-01898-7 · Cited by 42 · see citing works
Muratore, E., Leardini, D., Baccelli, F., Venturelli, F., Prete, A., & Masetti, R. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.993668 · Cited by 40 · see citing works
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Shi, Y., Cao, Q., Sun, J., Hu, X., Su, Z. G., Xu, Y., Zhang, H., Lan, L., & Feng, Y. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011110 · Cited by 38 · see citing works
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Zhang, W.-W., Thakur, K., Zhang, J., & Wei, Z. (2024) · Food & Function · doi:10.1039/d4fo00835a · Cited by 32 · see citing works
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Self-citationBajaj, J. S., Reddy, K. R., Tandon, P., García–Tsao, G., Kamath, P. S., O’Leary, J. G., Wong, F. S.-H., Lai, J. C., Vargas, H. E., Thuluvath, P. J., et al. (2022) · Liver Transplantation · doi:10.1002/lt.26552 · Cited by 23 · see citing works
Statistical modeling of gut microbiota for personalized health status monitoring
Zhu, J., Xie, H., Yang, Z., Chen, J., Yin, J., Tian, P., Wang, H., Zhao, J., Zhang, H., Lu, W., et al. (2023) · Microbiome · doi:10.1186/s40168-023-01614-x · Cited by 23 · see citing works
Dietary Impacts on Gestational Diabetes: Connection between Gut Microbiome and Epigenetic Mechanisms
Bankole, T., Winn, H. N., & Li, Y. (2022) · Nutrients · doi:10.3390/nu14245269 · Cited by 22 · see citing works
Zhi, S., Zhang, W., Shi, Y., Cui, T., Xu, Y., Yang, R., Huang, M., Zhou, C., Zhang, H., Lu, T., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp3954 · Cited by 20 · see citing works
Lai, Y., Reina-Gonzalez, P., Maor, G., Miller, G. W., & Sarkar, S. (2025) · Science Signaling · doi:10.1126/scisignal.adn9868 · Cited by 20 · see citing works
Gut microbiome and obesity care: Bridging dietary, surgical, and pharmacological interventions
Masi, D., Watanabe, M., & Clément, K. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102573 · Cited by 20 · see citing works
Self-citationMuratore, E., Leardini, D., Baccelli, F., Venturelli, F., Cerasi, S., Zanaroli, A., Lanari, M., Prete, A., Masetti, R., & Zama, D. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1075778 · Cited by 22 · see citing works
Licorice-regulated gut–joint axis for alleviating collagen-induced rheumatoid arthritis
Yang, D., Lv, G., Wu, Y., Guo, W., Wang, Y., Hu, J., Li, N., Zheng, F. Y., Dai, Y., Pi, Z., et al. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156203 · Cited by 19 · see citing works
The Trajectory of Successful Aging: Insights from Metagenome and Cytokine Profiling
Chulenbayeva, L., Ganzhula, Y., Kozhakhmetov, S., Jarmukhanov, Z., Nurgaziyev, M., Nurgozhina, A., Mukhanbetzhanov, N., Sergazy, S., Zhetkenev, S., Borykbay, Z., et al. (2024) · Gerontology · doi:10.1159/000536082 · Cited by 21 · see citing works
Li, Z., Zhang, S., Xiao, Q., Shui, S., Dong, P., Jiang, Y., Chen, Y., Lan, F., Peng, Y., Ying, B., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c14656 · Cited by 18 · see citing works
Microbial vitamin production mediates dietary effects on diabetic risk
Wang, D., Pham, V. T., Steinert, R. E., Zhernakova, A., & Fu, J. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2154550 · Cited by 18 · see citing works
Guan, H., Zhao, S., Li, J., Wang, Y., Niu, P., Zhang, Y., Zhang, Y., Fang, X., Miao, R., & Tian, J. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1363877 · Cited by 17 · see citing works
Zheng, M., Chao, X., Zheng, Y., Hong, T., Wu, W., Zhu, Y., Ni, H., & Jiang, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137545 · Cited by 17 · see citing works
Han, L., Liu, X., Lan, Y., Hua, Y., Fan, Z.-X., & Li, Y.-F. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1416185 · Cited by 19 · see citing works
Vogt, S. L., Serapio-Palacios, A., Woodward, S. E., Santos, A. S., de Vries, S. P. W., Daigneault, M. C., Brandmeier, L. V., Grant, A. J., Maskell, D. J., Allen‐Vercoe, E., et al. (2023) · Gut Microbes · doi:10.1080/19490976.2023.2190303 · Cited by 15 · see citing works
Celano, G., Calabrese, F. M., Riezzo, G., D’Attoma, B., Ignazzi, A., Chito, M. D., Sila, A., Nucci, S. D., Rinaldi, R., Linsalata, M., et al. (2024) · Nutrients · doi:10.3390/nu16132079 · Cited by 14 · see citing works
Mao, X., Paerhati, G., Wu, Y., & Cheng, L. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1499142 · Cited by 14 · see citing works
Łoniewski, I., Szulińska, M., Kaczmarczyk, M., Podsiadło, K., Styburski, D., Skonieczna‐Żydecka, K., & Bogdański, P. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03801-0 · Cited by 15 · see citing works
Riggen-Bueno, V., del Toro‐Arreola, S., Baltazar-Díaz, T. A., Vega‐Magaña, N., Rodríguez, M. P., Castaño-Jiménez, P. A., Sánchez-Orozco, L. V., Vera-Cruz, J. M., & Bueno‐Topete, M. R. (2024) · Metabolites · doi:10.3390/metabo14020121 · Cited by 13 · see citing works
Chen, Q., Wang, X., Zhang, P., & Li, B. (2025) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.70147 · Cited by 14 · see citing works
Wen, L., Yang, K., Wang, J., Zhou, H., & Ding, W. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1574887 · Cited by 14 · see citing works
Xu, L., Yan, J., Yin, T., Pan, Y., Chen, M., Wang, X., Wu, L., & Ding, H. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00742-6 · Cited by 12 · see citing works
Role of Vitamins in Cardiovascular Health: Know Your Facts - Part 1
Manolis, A. S., Manolis, T. A., Melita, H., & Manolis, A. S. (2023) · Current Vascular Pharmacology · doi:10.2174/1570161121666230912155548 · Cited by 12 · see citing works
Lai, Y., Tang, W., Luo, X., Zheng, H., Zhang, Y., Wang, M., Yu, G., & Yang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1369116 · Cited by 12 · see citing works
Qian, S., Bao, Y., Li, X., Dong, Y., Zhang, X., & Wu, Z. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04271-9 · Cited by 12 · see citing works
Preclinical Studies of Natural Products Targeting the Gut Microbiota: Beneficial Effects on Diabetes
Jiang, X., Sun, B., & Zhou, Z. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c02960 · Cited by 12 · see citing works
Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease
Guiducci, L., Nicolini, G., & Forini, F. (2023) · Metabolites · doi:10.3390/metabo13060760 · Cited by 13 · see citing works
Zhang, S., Kang, T., Malacrinò, A., Zhang, Z., Zhang, Z., Lin, W., & Wu, H. (2024) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.13453 · Cited by 10 · see citing works
Yin, J., Peng, X., Yang, A., Lin, M., Ji, K., Dai, X., Huang, J., Li, L., & Feng, L. (2024) · International Journal of Food Science & Technology · doi:10.1111/ijfs.17328 · Cited by 10 · see citing works
Multi-omics analyses reveal altered gut microbial thiamine production in obesity
Xia, Y., Lu, L., Wang, L., Qiu, Y., Liu, X., & Ge, W. (2025) · Frontiers in Microbiology · doi:10.3389/fmicb.2025.1516393 · Cited by 10 · see citing works
The influence of early life exposures on the infant gut virome
Zhang, Y., Castro-Mejía, J. L., Deng, L., Shah, S. A., Thorsen, J., Rodríguez, C. L., Jessen, L. E., Dion, M. B., Chawes, B., Bønnelykke, K., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2501194 · Cited by 9 · see citing works
Xia, Y., Ji, C., Li, M., Zhang, W., Cheng, X., Qiu, Y., & Ge, W. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115784 · Cited by 9 · see citing works
Zhao, L., Zhou, T., Chen, J., Cai, W., Shi, R., Duan, Y., Yuan, L., & Xing, C. (2022) · Drug Delivery · doi:10.1080/10717544.2022.2108163 · Cited by 9 · see citing works
Li, Y., Liu, M., Kong, B., Zhang, G., & Zhang, Q. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1439652 · Cited by 8 · see citing works
Tissue pleiotropic effect of biotin and prebiotic supplementation in established obesity
Voland, L., Yuan, M., Lecoutre, S., Debédat, J., Pelloux, V., Pradeau, M., Coles, E., Merabtene, F., Zhang, C., Mardinoğlu, A., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00295.2022 · Cited by 7 · see citing works
Self-citationAssociation of tumor microbiome with survival in resected early-stage PDAC
Meng, Y., Wang, C., Usyk, M., Kwak, S., Peng, C., Hu, K. S., Oberstein, P. E., Krogsgaard, M., Li, H., Hayes, R. B., et al. (2025) · mSystems · doi:10.1128/msystems.01229-24 · Cited by 7 · see citing works
Understanding the Effect of B Vitamins on Gut Microbiota: A Comprehensive Review
Karademir, E., Gedik, B. A., Bostan, Z. Z., & Karadağ, M. G. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf236 · Cited by 7 · see citing works
Xia, Y., Wang, L., Qiu, Y., & Ge, W. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1532581 · Cited by 7 · see citing works
Understanding HCC sex disparities
Kotsiliti, E. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00588-9 · Cited by 7 · see citing works
Toubon, G., Butel, M., Rozé, J., Delannoy, J., Ancel, P., Aires, J., & Charles, M.-A. A. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01442-x · Cited by 7 · see citing works
Abavisani, M., Sajjadi, S. M., Ebadpour, N., Karav, S., & Sahebkar, A. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01051-7 · Cited by 7 · see citing works
Connan, C., Fromentin, S., Benallaoua, M., Alvarez, A., Pons, N., Quinquis, B., Morabito, C., Nazare, J., Borezée‐Durant, E., Haimet, F., et al. (2025) · JMIR Research Protocols · doi:10.2196/64894 · Cited by 6 · see citing works
Self-citationFate of riboflavin in human gut and its fostering role in butyrate metabolism
Zhang, W.-W., Zhang, J., Hu, F., & Thakur, K. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.104356 · Cited by 6 · see citing works
Zhang, R., Wang, Y., Wang, H., Ke, Y.-Q., Shen, X., Huang, L., Lin, J.-J., He, W., Chen, Z., Li, Z., et al. (2024) · Insights into Imaging · doi:10.1186/s13244-024-01859-6 · Cited by 5 · see citing works
B vitamins as adjunct therapies for depressive disorder.
Zheng, Z.-Q., Shen, L., Zhao, L.-M., & Ji, H.-F. (2025) · Trends in endocrinology and metabolism · doi:10.1016/j.tem.2025.04.007 · Cited by 5 · see citing works
Khassenbekova, Z., Makangali, K., Shoman, A., Sagandyk, A., Mukhanbetzhanov, N., Tarikhov, F., Fazylov, T., Аннаоразов, Ы. А., Vinogradova, E. B., Kozhakhmetov, S., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157186 · Cited by 5 · see citing works
Wang, Y., Wang, X., Niu, X., Han, K., Ru, N., Xiang, J., & Linghu, E. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176881 · Cited by 5 · see citing works
Belda, E., Capeau, J., Zucker, J., Chatelier, E. L., Pons, N., Oñate, F. P., Quinquis, B., Alili, R., Fellahi, S., Katlama, C., et al. (2024) · BMC Medical Genomics · doi:10.1186/s12920-024-01978-5 · Cited by 5 · see citing works
Self-citationProcházková, N., Laursen, M. F., Barbera, G. L., Tsekitsidi, E., Jørgensen, M. S., Rasmussen, M. A., Raes, J., Licht, T. R., Dragsted, L. O., & Roager, H. M. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.23.574598 · Cited by 5 · see citing works
Self-citationIntegrative multi-omics analysis reveals oral microbiome-metabolome signatures of obesity
Shibl, A. A., Denekew, T. W., Ahmad, A. R., Abdelrazig, S., Leonor, C., Utenova, L., Zhang, G., AbdelBaqi, M., Malla, Y., Arshad, M., et al. (2026) · Cell Reports · doi:10.1016/j.celrep.2025.116819 · Cited by 7 · see citing works
Biotin rescues manganese-induced Parkinson’s disease phenotypes and neurotoxicityPreprint
Lai, Y., Reina-Gonzalez, P., Maor, G., Miller, G. W., & Sarkar, S. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.21.568033 · Cited by 4 · see citing works
Pinto-Cardoso, S. M., Aguilar‐Vargas, A., López-Filloy, M., Chávez-Torres, M., Murakami-Osawara, A., Briceño, O., Romero-Mora, K. A., Rodríguez‐Moguel, N. C., de Oca, G. S. M., Ávila‐Ríos, S., et al. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04313-9 · Cited by 3 · see citing works
Tiny contributors to severe obesity inside the gut
Sanz, Y., & Olivares, M. (2022) · Gut · doi:10.1136/gutjnl-2021-326781 · Cited by 3 · see citing works
Masi, D., Massicard, M., & Clément, K. (2023) · Nutrition Clinique et Métabolisme · doi:10.1016/s0985-0562(24)00006-2 · Cited by 2 · see citing works
Self-citationMoosavi, D., Curtis, K. R., Randolph, T. W., Kahsai, O. J., Ammar, H., Lim, U., Cheng, I. C., Wilkens, L. R., Marchand, L. L., Lampe, J. W., et al. (2025) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-24-1770 · Cited by 2 · see citing works
Prominent mediatory role of gut microbiome in the effect of lifestyle on host metabolic phenotypes
Adriouch, S., Belda, E., Swartz, T. D., Forslund, S. K., Prifti, E., Aron‐Wisnewsky, J., Chakaroun, R., Nielsen, T., Poitou, C., Lassen, P. B., et al. (2025) · Gut Microbes · doi:10.1080/19490976.2025.2599565 · Cited by 4 · see citing works
Self-citationEffects of gut microbiota on the susceptibility of ischemic stroke in mice
Wu, G., Wang, H., Zhou, Q., Fu, J., Zhang, F., Duan, Z., Wang, S., Huang, J., Zhou, H., Ma, Z., et al. (2026) · mSystems · doi:10.1128/msystems.00149-26 · Cited by 2 · see citing works
Hu, Y., Liang, Y., Lv, Y., Mu, P., Wang, Y., Huang, D., & Liu, D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1632406 · Cited by 2 · see citing works
Wang, S., Dai, W., Liu, Y., Zou, X., Pan, M., & Chu, X. (2026) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70891 · Cited by 1 · see citing works
Kahraman, E. K., Donma, O., Donma, M. M., Yılmaz, A., & Güzel, S. (2025) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.70079 · Cited by 1 · see citing works
Yang, Y., Jiang, W., Wu, P., Liu, Y., Ma, Y.-B., Kuang, S., Li, S., Tang, L., Zhong, C.-B., Feng, L., et al. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107461 · Cited by 1 · see citing works
Kpodo, K. R., Schreier, L. L., Miska, K. B., & Proszkowiec‐Weglarz, M. (2026) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-026-01360-8 · Cited by 2 · see citing works
Shigetomi, S., Fujimoto, N., Hirano, K., Matsuda, T., Kato, C., Nishimura, N., & Hino, S. (2026) · Journal of Nutrition · doi:10.1016/j.tjnut.2026.101469 · Cited by 1 · see citing works
Shi, J., Abdel-Ghany, S. E., Abdelfattah, M. M., Hu, X., Wadan, A. S., & Sabit, H. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02820-3 · Cited by 2 · see citing works
- Authors
- Belda, E., Voland, L., Tremaroli, V., Falony, G., Adriouch, S., Assmann, K. E., Prifti, E., Aron-Wisnewsky, J., Debédat, J., Le Roy, T., Nielsen, T., Amouyal, C., André, S., Andreelli, F., Blüher, M., Chakaroun, R., Chilloux, J., Coelho, L. P., Dao, M. C., Das, P., Fellahi, S., Forslund, S., Galleron, N., Hansen, T. H., Holmes, B., Ji, B., Krogh Pedersen, H., Le, P., Le Chatelier, E., Lewinter, C., Mannerås-Holm, L., Marquet, F., Myridakis, A., Pelloux, V., Pons, N., Quinquis, B., Rouault, C., Roume, H., Salem, J.-E., Sokolovska, N., Søndertoft, N. B., Touch, S., Vieira-Silva, S., The MetaCardis Consortium, Galan, P., Holst, J., Gøtze, J. P., Køber, L., Vestergaard, H., Hansen, T., Hercberg, S., Oppert, J.-M., Nielsen, J., Letunic, I., Dumas, M.-E., Stumvoll, M., Pedersen, O. B., Bork, P., Ehrlich, S. D., Zucker, J.-D., Bäckhed, F., Raes, J., & Clément, K.
- Affiliations
- Inserm (FR)
- University of Gothenburg (SE)
- Vlaams Instituut voor Biotechnologie (BE)
- Sorbonne Université (FR)
- Nutrition and Obesities: Systemic Approaches, NutriOmics, Research Unit, Sorbonne Université, INSERM, Paris, France
- University of Copenhagen (DK)
- Leipzig University (DE)
- Imperial College London (GB)
- European Molecular Biology Laboratory (DE)
- Chalmers University of Technology (SE)
- Max Delbrück Center (DE)
- Université Paris-Saclay (FR)
- Danone (France) (FR)
- Center for Basic Metabolic Research, Novo Nordisk Foundation, University of Copenhagen, Kobenhavn, Denmark
- MetaGenoPolis, Université Paris-Saclay, INRAE, Jouy-en-Josas, France
- Rigshospitalet (DK)
- Assistance Publique – Hôpitaux de Paris (FR)
- Center for Microbiology, VIB, Leuven, Belgium
- Conservatoire National des Arts et Métiers (FR)
- Nutritional Epidemiology Unit, INSERM, INRAE, CNAM, Paris 13 University, Bobigny, France
- Biobyte Solution, GmbH, Heidelberg, Germany
- Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München, University of Leipzig Faculty of Medicine, Leipzig, Germany
- Structural and Computational Biology, European Molecular Biology Laboratory, Heidelberg, Germany
- King's College London (GB)
- Corresponding author
- Clément, Karine
- ORCID
- Belda, Eugeni
- Voland, Lise
- Tremaroli, Valentina
- Falony, Gwen
- Adriouch, Solia
- Assmann, Karen E
- Prifti, Edi
- Debédat, Jean
- Le Roy, Tiphaine
- Nielsen, Trine
- Amouyal, Chloé
- André, Sébastien
- Blüher, Matthias
- Chakaroun, Rima
- Chilloux, Julien
- Coelho, Luis Pedro
- Dao, Maria Carlota
- Das, Promi
- Fellahi, Soraya
- Forslund, Sofia
- Galleron, Nathalie
- Hansen, Tue H
- Holmes, Bridget
- Ji, Boyang
- Le, Phuong
- Mannerås-Holm, Louise
- Myridakis, Antonis
- Pons, Nicolas
- Roume, Hugo
- Salem, Joe-Elie
- Sokolovska, Nataliya
- Søndertoft, Nadja B
- Touch, Sothea
- Galan, Pilar
- Holst, Jens
- Køber, Lars
- Vestergaard, Henrik
- Hansen, Torben
- Oppert, Jean-Michel
- Nielsen, Jens
- Dumas, Marc-Emmanuel
- Pedersen, Oluf Borbye
- Ehrlich, Stanislav Dusko
- Zucker, Jean-Daniel
- Bäckhed, Fredrik
- Raes, Jeroen
- Clément, Karine
- Venue
- Gut
- Publisher
- BMJ
- Published
- 2022-01-11
- Volume
- 71
- Issue
- 12
- Pages
- 2463-2480
- ISSN
- 0017-5749 (ISSN-L)
- 1468-3288
- PMC
- PMC9664128
- OpenAlex
- W4206679594
- Cited by
- 140
- References
- 50
- Citations by year
- 2026: 24 · 2025: 28 · 2024: 36 · 2023: 34 · 2022: 18
- FWCI
- 9.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Gut (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by-nc)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- Socio-Environmental Systems Modeling (acceptedVersion, cc-by-nc)
- Lirias (KU Leuven) (acceptedVersion, cc-by-nc)
- HAL (submittedVersion, other-oa)
- Chalmers Research (Chalmers University of Technology) (submittedVersion, other-oa)
- HAL (submittedVersion)
- Brunel University Research Archive (BURA) (Brunel University London) (submittedVersion, cc-by-nc)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (submittedVersion)
- Qucosa (Saxon State and University Library Dresden) (submittedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (submittedVersion, cc-by-nc)
- Spiral (Imperial College London) (submittedVersion, cc-by-nc)
- Funders
- Fondation pour la Recherche Médicale (FDT201904008276, FDT202106012793)
- Deutsche Forschungsgemeinschaft (SFB 1052)
- Seventh Framework Program (HEALTH-F4-2012-305312)
- Leducq Foundation (17CVD01)
- Sorbonne University (French National Agency of Research (ANR-Captor and deepIntegromics))
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Biotin and Related Studies
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- morbid obesity, gut microbiota, biotin metabolism, type 2 diabetes, prebiotic supplementation, fructooligosaccharides, biotin supplementation, bariatric surgery, antibiotic depletion, germ-free mice, adipose tissue, B vitamins, gut microbiota diversity
- MeSH terms
- Gastrointestinal Microbiome, Animals, Biotin, Diabetes Mellitus, Type 2, Humans, Inflammation, Mice, Inbred C57BL, Obesity, Obesity, Morbid, Vitamin B Complex, Mice, Prebiotics
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