The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.
Effects of isolated obesity on systolic and diastolic left ventricular function
Open accessAbstract
Background: Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. Objective: To determine the direct effect of different grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function. Methods: 48 obese and 25 normal weight women were studied. They had no other pathological conditions. Obesity was classed as slight (n = 17; body mass index (BMI) 25–29.9 kg/m 2), moderate (n = 20; BMI 30–34.9 kg/m 2), or severe (n = 11; BMI ⩾ 35 kg/m 2). Echocardiographic indices of systolic and diastolic function were obtained, and dysfunction was assumed when at least two values differed by ⩾ 2 SD from the normal weight group. Results: Ejection fraction (p < 0.05), fractional shortening (p < 0.05), and mean velocity of circumferential shortening (p < 0.05) were increased in slight and moderate obesity. Left ventricular dimensions were increased (p < 0.001) but relative wall thickness was unchanged. No obese patients met criteria for systolic dysfunction. In obese subjects, the mitral valve pressure half time (p < 0.01) and the left atrial diameter (p < 0.001) were increased and the deceleration slope was decreased (p < 0.01); all other diastolic variables were unchanged. No differences were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects (p = 0.002), being present in two with slight obesity (12%), seven with moderate obesity (35%), and five with severe obesity (45%). BMI correlated significantly with indices of left ventricular function. Conclusions: Subclinical left ventricular diastolic dysfunction is present in all grades of isolated obesity, correlates with BMI, and is associated with increased systolic function in the early stages of obesity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects (16, 17, 22, 140, 274, 371, 375).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
In the citing paper
“Similarly, E-wave deceleration times have been reported to be increased (274) or unchanged (279) in obese subjects.”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
In the citing paper
“Some studies have found reduced early diastolic (E-wave) velocities (155) while others have found them to be unchanged (242, 266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
In the citing paper
“More recently, however, several studies have found that LV ejection fraction is normal or even supranormal in the majority of obese subjects, even those with severe obesity (22, 28, 155, 191, 242, 274, 279, 375, 377).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
In the citing paper
“Lastly, late diastolic (A-wave) velocities have been reported to be increased (28, 155, 242) or unchanged (266, 274, 279, 314).”
From Cardiac remodeling in obesity (2008) · cites this paper as [274]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Nishimura, R. A., Abel, M., Hatle, L. K., & Tajik, A. J. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65673-0 · Cited by 752
Epstein, F. H., & Katz, A. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220206 · Cited by 563
Spirito, P., Maron, B. J., & Bonow, R. O. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80461-2 · Cited by 424
DIVITIIS, O. D., Fazio, S., Petitto, M., Maddalena, G., Contaldo, F., & Mancini, M. (1981) · Circulation · doi:10.1161/01.cir.64.3.477 · Cited by 394
MacMahon, S. W., Wilcken, D., & Macdonald, G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602063140602 · Cited by 362
Manyari, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012133232413 · Cited by 325
Cardiovascular Changes After Weight Reduction in Obesity Hypertension
Reisin, E., FROHLICH, E. D., Messerli, F. H., DRESLINSKI, G. R., DUNN, F. G., JONES, M. M., & BATSON, H. M. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-3-315 · Cited by 263
Effect of weight on cardiovascular disease
Kannel, W. B., D’Agostino, R. B., & Cobb, J. L. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.419 · Cited by 232
Alpert, M. A., Terry, B. E., & Kelly, D. L. (1985) · The American Journal of Cardiology · doi:10.1016/0002-9149(85)90156-0 · Cited by 210
Disparate cardiovascular effects of obesity and arterial hypertension
Messerli, F. H., Sundgaard-Riise, K., Reisin, E., Dreslinski, G. R., Dunn, F. G., & Frohlich, E. D. (1983) · The American Journal of Medicine · doi:10.1016/0002-9343(83)91071-9 · Cited by 197
The health consequences of moderate obesity.
Larsson, B., Björntorp, P. A., & Tibblin, G. (1981) · PubMed · Cited by 193
Cooper, R., Simmons, B. E., Castañer, A., Santhanam, V., Ghali, J. K., & Mar, M. (1990) · The American Journal of Cardiology · doi:10.1016/0002-9149(90)90807-d · Cited by 186
Cardiomyopathy of obesity: A clinicopathologic evaluation of 43 obese patients with heart failure
Kasper, E. K., Hruban, R. H., & Baughman, K. L. (1992) · The American Journal of Cardiology · doi:10.1016/0002-9149(92)90739-l · Cited by 175
Lauer, M. S., Anderson, K. M., & Levy, D. A. (1992) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(92)90063-s · Cited by 174
Cardiovascular Effects of Weight Reduction
Alexander, J. K., & Peterson, K. L. (1972) · Circulation · doi:10.1161/01.cir.45.2.310 · Cited by 158
Left ventricular filling abnormalities in asymptomatic morbid obesity
ZARICH, S. W., Kowalchuk, G. J., McGuire, M. P., Benotti, P. N., Mascioli, E. A., & Nesto, R. W. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90835-9 · Cited by 133
Assessment of cardiac function in patients who were morbidly obese.
Alaud-din, A., Meterissian, S. H., Lisbona, R., MacLean, L. D., & Forse, R. A. (1990) · PubMed · Cited by 131
Obesity and cardiovascular disease
Rexrode, K. M., Manson, J. E., & Hennekens, C. H. (1996) · Current Opinion in Cardiology · doi:10.1097/00001573-199609000-00007 · Cited by 119
Relation of Body Fat Distribution to Ischemic Heart Disease
Freedman, D. S., Williamson, D. F., Croft, J. B., Ballew, C., & Byers, T. (1995) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a117545 · Cited by 113
Abnormal left ventricular diastolic filling in eccentric left ventricular hypertrophy of obesity
Chakko, S. C., Mayor, M., Allison, M. D., Kessler, K. M., Materson, B. J., & Myerburg, R. J. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90718-z · Cited by 103
The influence of obesity on left ventricular filling and systolic function
Stoddard, M. F., Tseuda, K., Thomas, M., Dillon, S., & Kupersmith, J. (1992) · American Heart Journal · doi:10.1016/0002-8703(92)90280-9 · Cited by 96
Keogh, J. B., & Clifton, P. M. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.6.1602 · Cited by 86
Considerations in the use of echocardiography in epidemiology. The Framingham Study.
Savage, D. D., Garrison, R. J., Kannel, W. B., Anderson, S. J., Feinleib, M., & Castelli, W. P. (1987) · Hypertension · doi:10.1161/01.hyp.9.2_pt_2.ii40 · Cited by 78
Huang, B., Rodreiguez, B., Burchfield, C., Chyou, P. O.-H., Curb, J. D., & Sharp, D. S. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800410 · Cited by 45
Left ventricular filling in the systemic hypertension of obesity
Grossman, E., Oren, S., & Messerli, F. H. (1991) · The American Journal of Cardiology · doi:10.1016/0002-9149(91)90710-3 · Cited by 44
Jk, A. (1994) · PubMed · Cited by 42
Cardiomyopathy of overload: A major determinant of prognosis in congestive heart failure
(1990) · Journal of Cardiothoracic Anesthesia · doi:10.1016/0888-6296(90)90321-6 · Cited by 38
Obesity and Cardiovascular Disease
Shaper, A. G. (2007) · Novartis Foundation symposium · doi:10.1002/9780470514962.ch6 · Cited by 31
Kortelainen, M., & Särkioja, T. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.3.574 · Cited by 28
Hyperinsulinemia in patients with coronary heart disease in absence of overt risk factors.
Ariza, C., Frati, A., Gómez, G., & Almazán, A. (1997) · PubMed · Cited by 18
Dwyer, J. T. (1996) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/63.3.415 · Cited by 18
Cardiovascular changes in obese subjects on very low calorie diet.
Ramhamadany, E., Dasgupta, P., Brigden, G. S., Lahiri, A., Raftery, E. B., & Baird, I. M. (1989) · PubMed · Cited by 18
Disparate cardiovascular effects of obesity and arterial hypertension
Messerli, F. H. (1984) · The American Journal of Medicine · doi:10.1016/0002-9343(84)91016-7 · Cited by 12
[Effect of obesity on the morphology of the left ventricle].
Pascual Díaz, M., Fj, T. M., Martínez, H. A., Pomares, F., Vera, T. V., Arcos, F. S., Figal, D. P., & Valdés Chávarri, M. (1999) · PubMed · Cited by 6
Dwyer, J. T. (1996) · Preventive Medicine · doi:10.1006/pmed.1996.0011 · Cited by 5
[Waist/hip ratio. Obesity and cardiovascular risk].
Sanz, E. J. (1997) · PubMed · Cited by 5
Flagged first, then by citations
1 of the 40 references couldn’t be matched to a known paper.
Research works printed but not linked: 11
- 1996, Ciba Found Symp, 201, 90
- 1997, Ann Intern Med, 14, 3
- 1997, Arch Med Res, 28, 115
- 1933, Arch Intern Med, 52, 929
- 1990, Surgery, 108, 809
- 1993, Heart Dis Stroke, 2, 317
- 1999, Med Clin, 113, 721
- 1981, Int J Obes, 5, 97
- 1987, Hypertension, 2, 1140
- 1986, N Engl J Med, 302, 334
- 1989, Int J Obes, 13, 95
Cited by
Sorted by citations
Klein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y., & Eckel, R. H. (2004) · Circulation · doi:10.1161/01.cir.0000145546.97738.1e · Cited by 934
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Alterations of Left Ventricular Myocardial Characteristics Associated With Obesity
Wong, C. Y., O’Moore-Sullivan, T., Leano, R., Byrne, N., Beller, E., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147184.13872.0f · Cited by 713
An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases
Elagizi, A., Kachur, S. M., Lavie, C. J., Carbone, S., Pandey, A., Ortega, F. B., & Milani, R. V. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.003 · Cited by 718
Impact of Obesity and the Obesity Paradox on Prevalence and Prognosis in Heart Failure
Lavie, C. J., Alpert, M., Arena, R. A., Mehra, M. R., Milani, R. V., & Ventura, H. O. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2013.01.006 · Cited by 617
Metadata
- Authors
- Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernández, A. M., Tébar, F. J., & Valdés, M.
- Affiliations
- Hospital Universitario Virgen de la Arrixaca (ES)
- Corresponding author
- Valdés, M
- Venue
- Heart
- Publisher
- BMJ
- Published
- 2003-09-15
- Volume
- 89
- Issue
- 10
- Pages
- 1152-1156
- ISSN
- 1355-6037 (ISSN-L)
- 1468-201X
- PMC
- PMC1767886
- OpenAlex
- W2150530329
- Cited by
- 336
- References
- 40
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 10 · 2017: 13 · 2016: 31 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 16
- FWCI
- 6.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Heart (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- left ventricular function, systolic function, diastolic dysfunction, subclinical diastolic dysfunction, body mass index, ejection fraction, mitral inflow, left atrial diameter, women
- MeSH terms
- Adolescent, Adult, Diastole, Echocardiography, Female, Humans, Middle Aged, Obesity, Stroke Volume, Systole, Body Mass Index, Ventricular Dysfunction, Left
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
