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Cited by 210Cardiovascular Function and Risk FactorsBariatric Surgery and OutcomesCardiovascular Disease and Adiposity

Effect of weight loss on cardiac chamber size, wall thickness and left ventricular function in morbid obesity

Alpert, Martin A., Terry, Boyd E., Kelly, Diana L.·1985·The American Journal of Cardiology
DOI 10.1016/0002-9149(85)90156-0
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Abstract

To determine cardiac chamber size, wall thickness and left ventricular (LV) systolic function in morbidly obese patients, M-mode and cross-sectional echocardiography was performed in 62 patients whose body weight was greater than or equal to twice their ideal weight but who were free from underlying organic heart disease and systemic hypertension. The initial clinical protocol consisted of a medical history, physical examination, electrocardiogram at rest, chest x-ray and echocardiogram. Thereafter, each patient underwent gastric restriction. Thirty-four patients returned for follow-up echocardiography 4.3 +/- 0.3 months after substantial weight loss was achieved. For the whole group (n = 62) and LV internal dimension in diastole was enlarged in 24 (39%), the right ventricular internal dimension was enlarged in 20 (32%), the left atrial dimension was enlarged in 25 (40%) and the ventricular septal and LV posterior wall thickness was increased in 35 (56%). In the 34 patients who returned for follow-up, mean body weight decreased significantly, from 135 +/- 8 to 79 +/- 6 kg (73 +/- 4% of the amount over ideal body weight). In the subgroup with low preoperative LV fractional shortening (n = 13), mean LV fractional shortening increased from 22 +/- 2% to 31 +/- 2% (p less than 0.01). This was accompanied by a significant decrease in the mean LV internal dimension in diastole and mean blood pressure. The results indicate that cardiac chamber enlargement, LV hypertrophy and LV systolic dysfunction occur frequently in morbidly obese patients and that LV systolic dysfunction in such persons may improve following substantial weight loss.

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  • Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects.

    “Many studies have shown increased LA dimensions in obese subjects compared with normal-weight control subjects (16, 17, 22, 140, 274, 371, 375).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [16]

  • Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension.

    “Weight loss achieved via life-style modifications or through bariatric surgery have both been consistently associated with reductions in LV dimensions, LV wall thickness, LV mass, and LA dimension (14, 16, 17, 169).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [16]

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Authors
Alpert, M. A., Terry, B. E., & Kelly, D. L.
Affiliations
University of Missouri (US)
Corresponding author
Alpert, Martin A.
ORCID
Alpert, Martin A.
Venue
The American Journal of Cardiology
Publisher
Elsevier BV
Published
1985-03
Volume
55
Issue
6
Pages
783-786
ISSN
0002-9149 (ISSN-L)
DOI
10.1016/0002-9149(85)90156-0
OpenAlex
W2034351482
Cited by
210
References
27
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 3 · 2016: 10 · 2015: 7 · 2014: 9 · 2013: 11 · 2012: 5
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The American Journal of Cardiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords
morbid obesity, weight loss, left ventricular systolic function, left ventricular hypertrophy, cardiac chamber enlargement, left atrial enlargement, right ventricular dilatation, gastric restriction, blood pressure reduction
MeSH terms
Adult, Body Weight, Cardiac Volume, Echocardiography, Female, Follow-Up Studies, Heart, Heart Ventricles, Humans, Male, Myocardial Contraction, Myocardium, Obesity

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