Cited by 336Cardiovascular Function and Risk FactorsCardiovascular Disease and AdiposityDiabetes, Cardiovascular Risks, and Lipoproteins

The DOI matches its Crossref record; 39 of the 40 references it cites were found in a registry or an index.

Effects of isolated obesity on systolic and diastolic left ventricular function

Open access

Pascual, M, Pascual, D A, Soria, F, Vicente, T, Hernández, A M, Tébar, F J, Valdés, M·2003·Heart

DOI 10.1136/heart.89.10.1152PMC PMC1767886

Open this paper in CoChat — free account Open PDF

Abstract

Background: Obesity is associated with increased cardiovascular morbidity and mortality. A direct effect of isolated obesity on cardiac function is not well established. Objective: To determine the direct effect of different grades of isolated obesity on echocardiographic indices of systolic and diastolic left ventricular function. Methods: 48 obese and 25 normal weight women were studied. They had no other pathological conditions. Obesity was classed as slight (n = 17; body mass index (BMI) 25–29.9 kg/m 2), moderate (n = 20; BMI 30–34.9 kg/m 2), or severe (n = 11; BMI ⩾ 35 kg/m 2). Echocardiographic indices of systolic and diastolic function were obtained, and dysfunction was assumed when at least two values differed by ⩾ 2 SD from the normal weight group. Results: Ejection fraction (p < 0.05), fractional shortening (p < 0.05), and mean velocity of circumferential shortening (p < 0.05) were increased in slight and moderate obesity. Left ventricular dimensions were increased (p < 0.001) but relative wall thickness was unchanged. No obese patients met criteria for systolic dysfunction. In obese subjects, the mitral valve pressure half time (p < 0.01) and the left atrial diameter (p < 0.001) were increased and the deceleration slope was decreased (p < 0.01); all other diastolic variables were unchanged. No differences were found between obesity subgroups. Subclinical diastolic dysfunction was more prevalent among obese subjects (p = 0.002), being present in two with slight obesity (12%), seven with moderate obesity (35%), and five with severe obesity (45%). BMI correlated significantly with indices of left ventricular function. Conclusions: Subclinical left ventricular diastolic dysfunction is present in all grades of isolated obesity, correlates with BMI, and is associated with increased systolic function in the early stages of obesity.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/heart.89.10.1152

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Recommendations for Quantitation of the Left Ventricle by Two-Dimensional Echocardiography
Schiller, N. B., Shah, P. M., Crawford, M., DeMaria, A. N., Devereux, R. B., Feigenbaum, H., Gutgesell, H. P., Reichek, N., Sahn, D. J., Schnittger, I., et al. (1989) · Journal of the American Society of Echocardiography · doi:10.1016/s0894-7317(89)80014-8 · Cited by 8,110
Recommendations regarding quantitation in M-mode echocardiography: results of a survey of echocardiographic measurements.
Sahn, D. J., DeMaria, A. N., KISSLO, J. A., & Weyman, A. E. (1978) · Circulation · doi:10.1161/01.cir.58.6.1072 · Cited by 7,430
Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart study
Levy, D., Garrison, R. J., Savage, D. D., Kannel, W. B., & Castelli, W. P. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222203 · Cited by 5,699
Assessment of Diastolic Function of the Heart: Background and Current Applications of Doppler Echocardiography. Part II. Clinical Studies
Nishimura, R. A., Abel, M., Hatle, L. K., & Tajik, A. J. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65673-0 · Cited by 752
Cardiomyopathy of Overload
Epstein, F. H., & Katz, A. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001113220206 · Cited by 563
Noninvasive assessment of left ventricular diastolic function: Comparative analysis of Doppler echocardiographic and radionuclide angiographic techniques
Spirito, P., Maron, B. J., & Bonow, R. O. (1986) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(86)80461-2 · Cited by 424
Obesity and cardiac function.
DIVITIIS, O. D., Fazio, S., Petitto, M., Maddalena, G., Contaldo, F., & Mancini, M. (1981) · Circulation · doi:10.1161/01.cir.64.3.477 · Cited by 394
The effect of weight reduction on left ventricular mass. A randomized controlled trial in young, overweight hypertensive patients.
MacMahon, S. W., Wilcken, D., & Macdonald, G. (1986) · New England Journal of Medicine · doi:10.1056/nejm198602063140602 · Cited by 362
Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study
Manyari, D. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199012133232413 · Cited by 325
Cardiovascular Changes After Weight Reduction in Obesity Hypertension
Reisin, E., FROHLICH, E. D., Messerli, F. H., DRESLINSKI, G. R., DUNN, F. G., JONES, M. M., & BATSON, H. M. (1983) · Annals of Internal Medicine · doi:10.7326/0003-4819-98-3-315 · Cited by 263

Show all 40 references

Research works printed but not linked: 11

1996, Ciba Found Symp, 201, 90
1997, Ann Intern Med, 14, 3
1997, Arch Med Res, 28, 115
1933, Arch Intern Med, 52, 929
1990, Surgery, 108, 809
1993, Heart Dis Stroke, 2, 317
1999, Med Clin, 113, 721
1981, Int J Obes, 5, 97
1987, Hypertension, 2, 1140
1986, N Engl J Med, 302, 334
1989, Int J Obes, 13, 95

Sorted by citations

Clinical Implications of Obesity With Specific Focus on Cardiovascular Disease: A Statement for Professionals From the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: Endorsed by the American College of Cardiology Foundation
Klein, S., Burke, L. E., Bray, G. A., Blair, S., Allison, D. B., Pi-Sunyer, X., Hong, Y., & Eckel, R. H. (2004) · Circulation · doi:10.1161/01.cir.0000145546.97738.1e · Cited by 934
Cardiac remodeling in obesity
Abel, E. D., Litwin, S. E., & Sweeney, G. (2008) · Physiological Reviews · doi:10.1152/physrev.00017.2007 · Cited by 736
Alterations of Left Ventricular Myocardial Characteristics Associated With Obesity
Wong, C. Y., O’Moore-Sullivan, T., Leano, R., Byrne, N., Beller, E., & Marwick, T. H. (2004) · Circulation · doi:10.1161/01.cir.0000147184.13872.0f · Cited by 713
An Overview and Update on Obesity and the Obesity Paradox in Cardiovascular Diseases
Elagizi, A., Kachur, S. M., Lavie, C. J., Carbone, S., Pandey, A., Ortega, F. B., & Milani, R. V. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.003 · Cited by 718
Impact of Obesity and the Obesity Paradox on Prevalence and Prognosis in Heart Failure
Lavie, C. J., Alpert, M., Arena, R. A., Mehra, M. R., Milani, R. V., & Ventura, H. O. (2013) · JACC Heart Failure · doi:10.1016/j.jchf.2013.01.006 · Cited by 617
The medical complications of obesity
Malnick, S. D. H. (2006) · QJM · doi:10.1093/qjmed/hcl085 · Cited by 579
Obesity cardiomyopathy: evidence, mechanisms, and therapeutic implications
Ren, J. T., Wu, N. N., Wang, S., Sowers, J. R., & Zhang, Y. (2021) · Physiological Reviews · doi:10.1152/physrev.00030.2020 · Cited by 388
The Emerging Epidemic of Heart Failure with Preserved Ejection Fraction
Oktay, A. A., Rich, J. D., & Shah, S. J. (2013) · Current Heart Failure Reports · doi:10.1007/s11897-013-0155-7 · Cited by 374
Effect of Obesity and Overweight on Left Ventricular Diastolic Function
Russo, C., Jin, Z., Homma, S., Rundek, T., Elkind, M. S. V., Sacco, R. L., & Di Tullio, M. R. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.10.042 · Cited by 361
New strategies for heart failure with preserved ejection fraction: the importance of targeted therapies for heart failure phenotypes
Senni, M., Paulus, W. J., Gavazzi, A., Fraser, A. G., Dı́ez, J., Solomon, S. D., Smiseth, O. A., Guazzi, M., Lam, C. S. P., Maggioni, A. P., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu204 · Cited by 352
Altered Respiratory Physiology in Obesity
Parameswaran, K., Todd, D. C., & Soth, M. (2006) · Canadian Respiratory Journal · doi:10.1155/2006/834786 · Cited by 527
Obesity and Cardiovascular Disease: a Risk Factor or a Risk Marker?
Mandviwala, T., Khalid, U., & Deswal, A. M. (2016) · Current Atherosclerosis Reports · doi:10.1007/s11883-016-0575-4 · Cited by 329
Effects of Obesity on Cardiovascular Hemodynamics, Cardiac Morphology, and Ventricular Function
Alpert, M., Omran, J., & Bostick, B. P. (2016) · Current Obesity Reports · doi:10.1007/s13679-016-0235-6 · Cited by 301
Obesity and Heart Failure: Focus on the Obesity Paradox
Carbone, S., Lavie, C. J., & Arena, R. A. (2017) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2016.11.001 · Cited by 298
Obesity, metabolic dysfunction, and cardiac fibrosis: pathophysiological pathways, molecular mechanisms, and therapeutic opportunities
Cavalera, M., Wang, J., & Frangogiannis, N. G. (2014) · Translational research · doi:10.1016/j.trsl.2014.05.001 · Cited by 269
Update on Obesity and Obesity Paradox in Heart Failure
Lavie, C. J., Sharma, A., Alpert, M., Schutter, A. D., López-Jiménez, F. A., Milani, R. V., & Ventura, H. O. (2015) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2015.12.003 · Cited by 267
Obesity and heart failure: epidemiology, pathophysiology, clinical manifestations, and management
Alpert, M., Lavie, C. J., Agrawal, H., Aggarwal, K. B., & Kumar, S. (2014) · Translational research · doi:10.1016/j.trsl.2014.04.010 · Cited by 258
Impact of Obesity and Weight Loss on Cardiac Performance and Morphology in Adults
Alpert, M., Omran, J., Mehra, A., & Ardhanari, S. (2013) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2013.09.003 · Cited by 243
Obesity cardiomyopathy: pathogenesis and pathophysiology
Wong, C. Y., & Marwick, T. H. (2007) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio0943 · Cited by 243
Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes
Korakas, E., Ikonomidis, I., Kousathana, F., Balampanis, K., Kountouri, A., Raptis, A. E., Palaiodimou, L., Kokkinos, A. D., & Lambadiari, V. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00198.2020 · Cited by 226
Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis
Aghili, S. M. M., Ebrahimpur, M., Arjmand, B., Shadman, Z., Sani, M. P., Qorbani, M., Larijani, B. A., & Payab, M. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00776-8 · Cited by 246
Obesity and Cardiac Remodeling in Adults: Mechanisms and Clinical Implications
Alpert, M. A., Karthikeyan, K., Abdullah, O., & Ghadban, R. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.07.012 · Cited by 221
Management of cardiovascular diseases in patients with obesity
Lavie, C. J., Arena, R., Alpert, M. A., Milani, R. V., & Ventura, H. O. (2018) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2017.108 · Cited by 218
Cardiac function and obesity: Figure 1
Vasan, R. S. (2003) · Heart · doi:10.1136/heart.89.10.1127 · Cited by 210
Relation of Regional Fat Distribution to Left Ventricular Structure and Function
Neeland, I. J., Gupta, S. K., Ayers, C. R., Turer, A. T., Rame, J. E., Das, S. R., Berry, J. D., Khera, A., McGuire, D. K., Vega, G. L., et al. (2013) · Circulation Cardiovascular Imaging · doi:10.1161/circimaging.113.000532 · Cited by 192
The Adipokine Hypothesis of Heart Failure With a Preserved Ejection Fraction
Packer, M. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.06.055 · Cited by 213
The Interaction of Cardiorespiratory Fitness With Obesity and the Obesity Paradox in Cardiovascular Disease
Oktay, A. A., Lavie, C. J., Kokkinos, P. F., Parto, P., Pandey, A., & Ventura, H. O. (2017) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2017.05.005 · Cited by 172
The obesity paradox in the surgical population
Valentijn, T. M., Galal, W., Tjeertes, E. K. M., Hoeks, S. E., Verhagen, H. J. M., & Stolker, R. J. (2013) · The Surgeon · doi:10.1016/j.surge.2013.02.003 · Cited by 162
Abnormal myocardial deformation properties in obese, non-hypertensive children: an ambulatory blood pressure monitoring, standard echocardiographic, and strain rate imaging study
Salvo, G. D., Pacileo, G., del Giudice, E. M., Natale, F., Limongelli, G., Verrengia, M., Rea, A., Fratta, F., Castaldi, B., D’Andrea, A., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl163 · Cited by 155
An Overview of the Role of Adipokines in Cardiometabolic Diseases
Farkhondeh, T., Llorens, S., Pourbagher‐Shahri, A. M., Ashrafizadeh, M., Talebi, M., Shakibaei, M., & Samarghandian, S. (2020) · Molecules · doi:10.3390/molecules25215218 · Cited by 127
Impact of obesity on cardiac metabolism, fibrosis, and function
Mahajan, R., Lau, D. H., & Sanders, P. (2014) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2014.09.005 · Cited by 109
The effects of obesity and type 2 diabetes mellitus on cardiac structure and function in adolescents and young adults
Shah, A. S., Khoury, P. R., Dolan, L. M., Ippisch, H. M., Urbina, E. M., Daniels, S. R., & Kimball, T. R. (2010) · Diabetologia · doi:10.1007/s00125-010-1974-7 · Cited by 108
Remodeling and Fibrosis of the Cardiac Muscle in the Course of Obesity—Pathogenesis and Involvement of the Extracellular Matrix
Kruszewska, J., Cudnoch‐Jędrzejewska, A., & Czarzasta, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084195 · Cited by 113
Effect of Obesity on Left Ventricular Structure and Myocardial Systolic Function: Assesment by Tissue Doppler Imaging and Strain/Strain Rate Imaging
Tümüklü, M. M., Etikán, Í., Kısacık, B., & Kayıkçıoğlu, M. (2007) · Echocardiography · doi:10.1111/j.1540-8175.2007.00484.x · Cited by 102
Hemodynamic monitoring in obese patients: The impact of body mass index on cardiac output and stroke volume*
Stelfox, H. T., Ahmed, S. B., Ribeiro, R. A., Gettings, E. M., Pomerantsev, E. V., & Schmidt, U. H. (2006) · Critical Care Medicine · doi:10.1097/01.ccm.0000208358.27005.f4 · Cited by 100
Respiratory and haemodynamic effects of volume-controlled vs pressure-controlled ventilation during laparoscopy: a cross-over study with echocardiographic assessment
Balick-Weber, C.-C., Nicolas, P., Mona, M.-H., Blanchet, P., & Stéphan, F. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem166 · Cited by 99
Effects of Isolated Obesity on Left and Right Ventricular Function: A Tissue Doppler and Strain Rate Imaging Study
Orhan, A. L., Uslu, N., Dayı, Ş. Ü., Nurkalem, Z., Uzun, F., Erer, H. B., Hasdemir, H., Emre, A., Karakuş, G., Soran, O. Z., et al. (2010) · Echocardiography · doi:10.1111/j.1540-8175.2009.01024.x · Cited by 93
Preclinical Systolic and Diastolic Dysfunctions in Metabolically Healthy and Unhealthy Obese Individuals
Wang, Y., Liang, C., Gopal, D. M., Ayalon, N., Donohue, C., Santhanakrishnan, R., Sandhu, H., Perez, A. J., Downing, J., Gokce, N., et al. (2015) · Circulation Heart Failure · doi:10.1161/circheartfailure.114.002026 · Cited by 90
Obesity Cardiomyopathy: Is It a Reality? An Ultrasonic Tissue Characterization Study
Bello, V. D., Santini, F., Cori, A. D., Pucci, A. B. F., Palagi, C., Donne, M. G. D., Fierabracci, P., Marsili, A., Talini, E., Giannetti, M., et al. (2006) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2006.03.033 · Cited by 87
Cardiac and Metabolic Variables in Obese Dogs
Tropf, M. A., Nelson, O. L., Lee, P. M., & Weng, H. (2017) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.14775 · Cited by 86
Central obesity: Association with left ventricular dysfunction and mortality in the community
Ammar, K. A., Redfield, M. M., Mahoney, D. W., Johnson, M. P., Jacobsen, S. J., & Rodeheffer, R. J. (2008) · American Heart Journal · doi:10.1016/j.ahj.2008.06.018 · Cited by 85
Sexual dimorphism in activation of placental autophagy in obese women with evidence for fetal programming from a placenta-specific mouse model
Muralimanoharan, S., Gao, X., Weintraub, S. T., Myatt, L., & Maloyan, A. (2016) · Autophagy · doi:10.1080/15548627.2016.1156822 · Cited by 83
Obese mice exposed to psychosocial stress display cardiac and hippocampal dysfunction associated with local brain-derived neurotrophic factor depletion
Agrimi, J., Spalletti, C., Baroni, C., Keceli, G., Zhu, G., Caragnano, A., Matteucci, M., Chelko, S. P., Ramirez‐Correa, G. A., Bedja, D., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.08.042 · Cited by 85
Early Cardiac Abnormalities in Obese Children: Importance of Obesity Per Se Versus Associated Cardiovascular Risk Factors
van Putte‐Katier, N., Rooman, R., Haas, L. E. M., Verhulst, S. L., Desager, K. N., Ramet, J., & Suys, B. E. (2008) · Pediatric Research · doi:10.1203/pdr.0b013e318176182b · Cited by 82
The relative contribution of metabolic and structural abnormalities to diastolic dysfunction in obesity
Rayner, J. J., Banerjee, R., Holloway, C. J., Lewis, A., Peterzan, M. A., Francis, J. M., Neubauer, S., & Rider, O. J. (2017) · International Journal of Obesity · doi:10.1038/ijo.2017.239 · Cited by 78
Mechanisms of Coronary Dysfunction in Obesity and Insulin Resistance
Knudson, J. D., Dinçer, Ü. D., Bratz, I. N., Sturek, M. S., Dick, G. M., & Tune, J. D. (2007) · Microcirculation · doi:10.1080/10739680701282887 · Cited by 78
Abdominal Adiposity, General Obesity, and Subclinical Systolic Dysfunction in the Elderly: A Population-Based Cohort Study
Russo, C. A., Sera, F., Jin, Z., Palmieri, V., Homma, S., Rundek, T., Elkind, M. S. V., Sacco, R. L., & Tullio, M. R. D. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.521 · Cited by 70
Long-term high-fat diet-induced obesity decreases the cardiac leptin receptor without apparent lipotoxicity
do Nascimento, A. F., Luvizotto, R. D. A. M., Leopoldo, A. S., Lima‐Leopoldo, A. P., Seiva, F. R. F., Justulin, L. A., Dal‐Pai‐Silva, M., Okoshi, K., Wang, X., & Cicogna, A. C. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.03.015 · Cited by 69
Association of epicardial adipose tissue with proteomics, coronary flow reserve, cardiac structure and function, and quality of life in heart failure with preserved ejection fraction: insights from the PROMIS‐HFpEF study
Venkateshvaran, A., Faxén, U. L., Hage, C., Michaëlsson, E., Svedlund, S., Saraste, A., Beussink‐Nelson, L., Fermer, M. L., Gan, L., Tromp, J., et al. (2022) · European Journal of Heart Failure · doi:10.1002/ejhf.2709 · Cited by 67
The Effect of Surgical Weight Reduction on Left Ventricular Structure and Function in Severe Obesity
Hsuan, C., Huang, C., Lin, J., Lin, L., Lee, T., Tai, C., Yin, W., Tseng, W., Hsu, K., & Wu, C. (2010) · Obesity · doi:10.1038/oby.2010.42 · Cited by 61
Obesity and cardiovascular risk
Kotsis, V., Tsioufis, K. P., Antza, C., Seravalle, G., Coca, A., Sierra, C., Lurbe, E., Stabouli, S., Jelaković, B., Redón, J., et al. (2018) · Journal of Hypertension · doi:10.1097/hjh.0000000000001731 · Cited by 66
Impact of Obesity on the Risk of Heart Failure and Its Prognosis
Artham, S. M., Lavie, C. J., Patel, H. M., & Ventura, H. O. (2008) · Journal of the CardioMetabolic Syndrome · doi:10.1111/j.1559-4572.2008.00001.x · Cited by 59
Relationship between preclinical abnormalities of global and regional left ventricular function and insulin resistance in severe obesity: a Color Doppler Imaging Study
Bello, V. D., Santini, F., Cori, A. D., Pucci, A. B. F., Palagi, C., Donne, M. G. D., Giannetti, M., Talini, E., Nardi, C., Pedrizzetti, G., et al. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803206 · Cited by 58
Exercise effects on cardiac size and left ventricular diastolic function: relationships to changes in fitness, fatness, blood pressure and insulin resistance
Stewart, K. J., Ouyang, P., Bacher, A. C., Lima, S. D., & Shapiro, E. P. (2005) · Heart · doi:10.1136/hrt.2005.079962 · Cited by 58
Atrial Myocardial Deformation Properties in Obese Nonhypertensive Children
Salvo, G. D., Pacileo, G., del Giudice, E. M., Natale, F., Limongelli, G., Verrengia, M., Rea, A., Fratta, F., Castaldi, B., Gala, S., et al. (2007) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2007.05.028 · Cited by 55
Impact of Obesity on Diastolic Function in Subjects ≤16 Years of Age
Sharpe, J., Naylor, L. H., Jones, T. W., Davis, E. A., O’Driscoll, G., Ramsay, J., & GREEN, D. J. (2006) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2006.03.052 · Cited by 53
Different “Weight” of Cardiac and General Adiposity in Predicting Left Ventricle Morphology
Iacobellis, G., Pond, C. M., & Sharma, A. M. (2006) · Obesity · doi:10.1038/oby.2006.192 · Cited by 49
Update on childhood/adolescent obesity and its sequela
Kohut, T. J., Robbins, J., & Panganiban, J. A. (2019) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000786 · Cited by 52
Comorbidities and Differential Diagnosis in Heart Failure with Preserved Ejection Fraction
Campbell, R. T., & McMurray, J. J. V. (2014) · Heart Failure Clinics · doi:10.1016/j.hfc.2014.04.009 · Cited by 47
Impact of Body Mass Index on Left Ventricular Diastolic Dysfunction
Çil, H., Bulur, S., Türker, Y., Kaya, A., Alemdar, R., Karabacak, A., Aslantaş, Y., Ekinözü, İ., Albayrak, S., Özhan, H., et al. (2012) · Echocardiography · doi:10.1111/j.1540-8175.2012.01688.x · Cited by 46
Cardiac Remodeling in Obese Patients After Laparoscopic Sleeve Gastrectomy
Cavarretta, E., Casella, G., Calì, B., Dammaro, C., Biondi‐Zoccai, G., Iossa, A., Leonetti, F., Frati, G., & Basso, N. (2012) · World Journal of Surgery · doi:10.1007/s00268-012-1874-8 · Cited by 45
PV-LVNet: Direct left ventricle multitype indices estimation from 2D echocardiograms of paired apical views with deep neural networks
Ge, R., Yang, G., Chen, Y., Luo, L., Feng, C., Zhang, H., & Li, S. (2019) · Medical Image Analysis · doi:10.1016/j.media.2019.101554 · Cited by 45
Ca2+ mishandling and cardiac dysfunction in obesity and insulin resistance: Role of oxidative stress
Carvajal, K., Balderas‐Villalobos, J., Bello-Sánchez, M. D., Phillips-Farfán, B. V., Molina-Muñoz, T., Aldana-Quintero, H. A., & Gómez-Viquez, N. L. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.08.003 · Cited by 46
Relationship Between Adiponectin and Left Atrium Size in Uncomplicated Obese Patients: Adiponectin, a Link Between Fat and Heart
Ybarra, J., Resmini, E., Planas, F., Navarro-López, F., Webb, S. M., Pou, J. M., Vives, A. S., & Ballesta‐López, C. (2009) · Obesity Surgery · doi:10.1007/s11695-009-9924-5 · Cited by 44
Resistance Training and Diastolic Myocardial Tissue Velocities in Obese Children
Naylor, L. H., Watts, K., Sharpe, J., Jones, T. W., Davis, E. A., Thompson, A. M., George, K., Ramsay, J., O’Driscoll, G., & GREEN, D. J. (2008) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e318182a9e0 · Cited by 41
Epicardial Fat, Cardiac Dimensions, and Low-Grade Inflammation in Young Adult Monozygotic Twins Discordant for Obesity
Granér, M., Seppälä‐Lindroos, A., Rissanen, A., Hakkarainen, A., Lundbom, N. M. I., Kaprio, J. A., Nieminen, M. S., & Pietiläinen, K. H. (2012) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2011.12.023 · Cited by 42
Obesity is associated with left atrial enlargement, E/A reversal and left ventricular hypertrophy.
Movahed, M. R., & Saito, Y. (2008) · PubMed Central · Cited by 42
Cardiac Diastolic Dysfunction Is Prevalent in HIV-Infected Patients
Nayak, G. S., Ferguson, M. A., Tribble, D. R., Porter, C. K., Rapena, R., Marchicelli, M., & Decker, C. F. (2009) · AIDS Patient Care and STDs · doi:10.1089/apc.2008.0142 · Cited by 41
Association of body mass index and diastolic function in metabolically healthy obese with preserved ejection fraction
Rozenbaum, Z., Topilsky, Y., Khoury, S., Pereg, D., & Laufer‐Perl, M. (2018) · International Journal of Cardiology · doi:10.1016/j.ijcard.2018.08.008 · Cited by 41
Impact of body mass index on diastolic function in patients with normal left ventricular ejection fraction
AlJaroudi, W., Halley, C. M., Houghtaling, P. L., Agarwal, S. K., Menon, V., Rodriguez, L. L., Grimm, R. A., Thomas, J. D., & Jaber, W. A. (2012) · Nutrition and Diabetes · doi:10.1038/nutd.2012.14 · Cited by 39
Myocardial structure, function and ischaemic tolerance in a rodent model of obesity with insulin resistance
Wensley, I., Salaveria, K., Bulmer, A. C., Donner, D. G., & Toit, E. F. D. (2013) · Experimental Physiology · doi:10.1113/expphysiol.2013.074948 · Cited by 40
Daily exercise prevents diastolic dysfunction and oxidative stress in a female mouse model of western diet induced obesity by maintaining cardiac heme oxygenase-1 levels
Bostick, B., Aroor, A. R., Habibi, J., Durante, W., Ma, L., DeMarco, V. G., Garro, M., Hayden, M. R., Booth, F. W., & Sowers, J. R. (2016) · Metabolism · doi:10.1016/j.metabol.2016.09.005 · Cited by 41
Effect of Body Weight Loss on Cardiopulmonary Function Assessed by 6-Minute Walk Test and Arterial Blood Gas Analysis in Obese Dogs
Manens, J., Ricci, R., Damoiseaux, C., Gault, S., Contiero, B., Diez, M., & Clercx, C. (2013) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.12260 · Cited by 39
Following the Arterial Switch Operation, Obese Children have Risk Factors for Early Cardiovascular Disease
Pasquali, S. K., Marino, B. S., Powell, D. J., McBride, M. G., Paridon, S. M., Meyers, K. E. C., Mohler, E. R., Walker, S. A., Kren, S., & Cohen, M. S. (2010) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2009.00359.x · Cited by 39
Increased Heterogenity of Ventricular Repolarization in Obese Nonhypertensive Children
Nigro, G., Russo, V., Salvo, G. D., Crescenzo, I. D., Rago, A., Perrone, L., Golino, P., Russo, M. G., & Calabrò, R. (2010) · Pacing and Clinical Electrophysiology · doi:10.1111/j.1540-8159.2010.02889.x · Cited by 38
Estudo ecocardiográfico evolutivo das alterações anátomo-funcionais do coração em obesos submetidos à cirurgia bariátrica
da Cunha, L. D. C. B. P., da Cunha, C. L. P., de Souza, A. M., Neto, N. C., Pereira, R. S., & Suplicy, H. L. (2006) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2006001800011 · Cited by 37
Morphofunctional Evaluation of the Heart of Obese Patients Before and After Bariatric Surgery
Valezi, A. C., & Machado, V. H. S. (2011) · Obesity Surgery · doi:10.1007/s11695-011-0431-0 · Cited by 37
Is there a cardiomyopathy of obesity?
Owan, T., & Litwin, S. E. (2007) · Current Heart Failure Reports · doi:10.1007/s11897-007-0016-3 · Cited by 36
Influence of Body Mass Index on Outcomes of Patients Undergoing Surgery for Acute Aortic Dissection: A Propensity-Matched Analysis
Lio, A., Bovio, E., Nicolò, F., Saitto, G., Scafuri, A., Bassano, C., Chiariello, L., & Ruvolo, G. (2019) · Texas Heart Institute Journal · doi:10.14503/thij-17-6365 · Cited by 35
Cardiac remodeling and subclinical left ventricular dysfunction in adults with uncomplicated obesity: a cardiovascular magnetic resonance study
Liu, J., Li, J., Pu, H., He, W., Zhou, X., Tong, N., & Peng, L. (2021) · Quantitative Imaging in Medicine and Surgery · doi:10.21037/qims-21-724 · Cited by 35
Interactions of hypertension, obesity, left ventricular hypertrophy, and heart failure
daSilva‐deAbreu, A., Alhafez, B. A., Lavie, C. J., Milani, R. V., & Ventura, H. O. (2021) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000868 · Cited by 34
Structural and Functional Cardiac Abnormalities in Adolescent Girls with Poorly Controlled Type 2 Diabetes
WHALLEY, G. A., Gusso, S., Hofman, P. L., Cutfield, W. S., Poppe, K., Doughty, R. N., & Baldi, J. C. (2009) · Diabetes Care · doi:10.2337/dc08-2005 · Cited by 34
Obesity cardiomyopathy and systolic function: Obesity is not independently associated with dilated cardiomyopathy
Khan, M. F., & Movahed, M. R. (2012) · Heart Failure Reviews · doi:10.1007/s10741-012-9320-4 · Cited by 33
Advanced cardiac chemical exchange saturation transfer (cardioCEST) MRI for in vivo cell tracking and metabolic imaging
Pumphrey, A. L., Yang, Z., Ye, S., Powell, D. K., Thalman, S. W., Watt, D. S., Abdel‐Latif, A., Unrine, J. M., Thompson, K. L., Fornwalt, B. K., et al. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3451 · Cited by 33
Ventricular Diastolic Function of Ankylosing Spondylitis Patients by Using Conventional Pulsed Wave Doppler, Myocardial Performance Index and Tissue Doppler Imaging
Okan, T., Sarı, İ., Akar, S., Çeçe, H., Göldeli, Ö., Güneri, S., & Akkoç, N. (2007) · Echocardiography · doi:10.1111/j.1540-8175.2007.00541.x · Cited by 32
Dietary-Induced Obesity Hastens the Progression From Concentric Cardiac Hypertrophy to Pump Dysfunction in Spontaneously Hypertensive Rats
Majane, O. H. I., Vengethasamy, L., Toit, E. F. D., Makaula, S., Woodiwiss, A. J., & Norton, G. R. (2009) · Hypertension · doi:10.1161/hypertensionaha.108.127514 · Cited by 31
Impact of Obesity-Related Inflammation on Cardiac Metabolism and Function
Larsen, T. S., & Jansen, K. M. (2021) · Journal of Lipid and Atherosclerosis · doi:10.12997/jla.2021.10.1.8 · Cited by 31
The Impact of Isolated Obesity on Right Ventricular Function in Young Adults
Sökmen, A., Sokmen, G., Acar, G., Akçay, A., Köroğlu, S., Köleoğlu, M., Yalçıntaş, S., & Aydin, M. N. (2013) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20130142 · Cited by 30
Impact of Obesity on Coronary Microvascular Function in the Zucker Rat
Prakash, R., MINTZ, J. D., & Stepp, D. W. (2006) · Microcirculation · doi:10.1080/10739680600745919 · Cited by 31
Subclinical hypothyroidism and myocardial function in obese children
Brienza, C., Grandone, A., Salvo, G. D., Corona, A. M., Sessa, A. D., Pascotto, C., Calabrò, R., Toraldo, R., Perrone, L., & del Giudice, E. M. (2012) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2012.04.006 · Cited by 30
Is obesity predictive of cardiovascular dysfunction independent of cardiovascular risk factors?
DeVallance, E., Fournier, S., Donley, D., Bonner, D., Lee, K., Frisbee, J. C., & Chantler, P. D. (2014) · International Journal of Obesity · doi:10.1038/ijo.2014.111 · Cited by 29
The Conundrum of Patients with Obesity, Exercise Intolerance, Elevated Ventricular Filling Pressures and a Measured Ejection Fraction in the Normal Range
Packer, M. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1377 · Cited by 29
Metabolic and clinical comparative analysis of treadmill six-minute walking test and cardiopulmonary exercise testing in obese and eutrophic women
Thommazo‐Luporini, L. D., Jürgensen, S. P., Castello‐Simões, V., Catai, A. M., Arena, R. A., & Borghi‐Silva, A. (2012) · Brazilian Journal of Physical Therapy · doi:10.1590/s1413-35552012005000036 · Cited by 29
Short‐term Training Effects on Diastolic Function in Obese Persons With the Metabolic Syndrome
Baynard, T., Carhart, R. L., Ploutz‐Snyder, L. L., Weinstock, R. S., & Kanaley, J. A. (2008) · Obesity · doi:10.1038/oby.2008.212 · Cited by 29
Regional left ventricular function in individuals with mild to moderate renal insufficiency: The Multi-Ethnic Study of Atherosclerosis
Nasir, K., Rosen, B. D., Kramer, H., Edvardsen, T., Bluemke, D. A., Liu, K., & Lima, J. A. C. (2007) · American Heart Journal · doi:10.1016/j.ahj.2006.12.025 · Cited by 29
Right ventricular performance in severe obesity. Effect of weight loss
Maniscalco, M., Arciello, A., Zedda, A., Faraone, S., Verde, R., Giardiello, C., Cacciapuoti, F., Cacciapuoti, F., & Sofia, M. (2007) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2007.01783.x · Cited by 29
Central adiposity and left ventricular mass in obese children
Bonito, P. D., Capaldo, B., Forziato, C., Sanguigno, E., Fraia, T. D., Scilla, C., Cavuto, L., Saitta, F., Sibilio, G., & Moio, N. (2007) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2007.09.002 · Cited by 28
Challenges in Cardiac Risk Assessment in Bariatric Surgery Patients
Gugliotti, D., Grant, P., Jaber, W. A., Aboussouan, L. S., Bae, C. J., Sessler, D. I., Scahuer, P., & Kaw, R. K. (2007) · Obesity Surgery · doi:10.1007/s11695-007-9281-1 · Cited by 28
Subclinical Cardiac Dysfunction in Obesity Patients is Linked to Autonomic Dysfunction: Findings from the CARDIOBESE Study
Snelder, S. M., Laat, L. E. D. G., Biter, L. U., Cabezas, M. C., Pouw, N. M. C., Birnie, E., Klerk, B. M. B., Klaassen, R. A., Zijlstra, F., & van Dalen, B. M. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12942 · Cited by 28
Lack of Association between Obesity and Left Ventricular Systolic Dysfunction
Movahed, M. R., & Saito, Y. (2008) · Echocardiography · doi:10.1111/j.1540-8175.2008.00764.x · Cited by 26

Authors: Pascual, M., Pascual, D. A., Soria, F., Vicente, T., Hernández, A. M., Tébar, F. J., & Valdés, M.
Affiliations: Hospital Universitario Virgen de la Arrixaca (ES)
Corresponding author: Valdés, M
Venue: Heart
Publisher: BMJ
Published: 2003-09-15
Volume: 89
Issue: 10
Pages: 1152-1156
ISSN: 1355-6037 (ISSN-L)
1468-201X
DOI: 10.1136/heart.89.10.1152
PMC: PMC1767886
OpenAlex: W2150530329
Cited by: 336
References: 40
Citations by year: 2026: 5 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 11 · 2021: 16 · 2020: 16 · 2019: 17 · 2018: 10 · 2017: 13 · 2016: 31 · 2015: 13 · 2014: 18 · 2013: 20 · 2012: 16
FWCI: 6.83
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Heart (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: left ventricular function, systolic function, diastolic dysfunction, subclinical diastolic dysfunction, body mass index, ejection fraction, mitral inflow, left atrial diameter, women
MeSH terms: Adolescent, Adult, Diastole, Echocardiography, Female, Humans, Middle Aged, Obesity, Stroke Volume, Systole, Body Mass Index, Ventricular Dysfunction, Left

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of isolated obesity on systolic and diastolic left ventricular function

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks