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Cited by 116Atrial Fibrillation Management and OutcomesPhysical Activity and HealthCardiac electrophysiology and arrhythmias

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Resting heart rate and physical activity as risk factors for lone atrial fibrillation: a prospective study of 309,540 men and women

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Thelle, Dag S, Selmer, Randi, Gjesdal, Knut, Sakshaug, Solveig, Jugessur, Astanand, Graff-Iversen, Sidsel, Tverdal, Aage, Nystad, Wenche·2013·Heart
DOI 10.1136/heartjnl-2013-303825
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Abstract

OBJECTIVE: To study the impact of resting heart rate and leisure time physical activity at middle age on long term risk of drug treated lone atrial fibrillation (AF). DESIGN: Longitudinal cohort study of 309 540 Norwegian men and women aged 40-45 years examined during 1985-1999 followed from 2005 through 2009. SETTING: Data from a national health screening programme were linked to the Norwegian Prescription Database (NorPD). PATIENTS: The cohort comprised 162 078 women and 147 462 men; 575 (0.4%) men and 288 women (0.2%) received flecainide and 568 men and 256 women sotalol and were defined as patients with AF. INTERVENTIONS: No interventions. MAIN OUTCOME MEASURES: The outcome was lone fibrillation defined by having at least one prescription of flecainide or sotalol registered in NorPD between 2005 and 2009. Cox proportional hazard regression models were used to assess time to first prescription. RESULTS: The risk for being prescribed these drugs increased with decreasing baseline resting heart. Adjusted hazard ratio (HR) per 10 beats/min decrease in resting heart rate for flecainide prescription was 1.26 in men (95% CI 1.17 to 1.35) and 1.15 (95% CI 1.05 to 1.27) in women. Similar effects were seen for sotalol in men, but not in women. Men who reported intensive physical activity were more often prescribed flecainide than those in the sedentary group (adjusted HR=3.14, 95% CI 2.17 to 4.54). CONCLUSIONS: This population based study supports the hypothesis that the risk of drug treated lone AF increases with declining resting heart rate in both sexes, and with increasing levels of self-reported physical activity in men.

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Metadata

Authors
Thelle, D. S., Selmer, R., Gjesdal, K., Sakshaug, S., Jugessur, A., Graff-Iversen, S., Tverdal, A., & Nystad, W.
Affiliations
  • Norwegian Institute of Public Health (NO)
  • Oslo University Hospital (NO)
  • Royal Children's Hospital (AU)
  • Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway
Corresponding author
Thelle, Dag S
ORCID
Venue
Heart
Publisher
BMJ
Published
2013-06-08
Volume
99
Issue
23
Pages
1755-1760
ISSN
  • 1355-6037 (ISSN-L)
  • 1468-201X
DOI
10.1136/heartjnl-2013-303825
OpenAlex
W2104581384
Cited by
116
References
28
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 8 · 2020: 11 · 2019: 10 · 2018: 13 · 2017: 9 · 2016: 17 · 2015: 15 · 2014: 9 · 2013: 2
FWCI
9.75
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • Heart (publishedVersion)
  • PubMed (publishedVersion)
  • NORA - Norwegian Open Research Archives (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Atrial Fibrillation Management and Outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
lone atrial fibrillation, resting heart rate, leisure-time physical activity, sedentary behavior, flecainide, sotalol, middle-aged adults, sex differences, cardiovascular risk factors
MeSH terms
Adult, Anti-Arrhythmia Agents, Atrial Fibrillation, Female, Flecainide, Heart Rate, Humans, Male, Middle Aged, Prognosis, Prospective Studies, Risk Factors, Sotalol, Exercise, Proportional Hazards Models, Early Diagnosis

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